Essential role of limiting telomeres in the pathogenesis of Werner syndrome
Chang, Sandy, Multani, Asha S, Cabrera, Noelia G, Naylor, Maria L, Laud, Purnima, Lombard, David, Pathak, Sen, Guarente, Leonard, DePinho, Ronald A·2004·Nature Genetics
DOI 10.1038/ng1389
Cited by (462)
Items 201–300 of 462
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- Telomeres do the (un)twist: Helicase actions at chromosome terminiAlejandro Chavez, Amy M. Tsou, F Brad Johnson · 2009 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Telomeres: Dysfunction, Maintenance, Aging and CancerPan Liao, Bo Yan, Conglin Wang, Ping Lei · 2023 · Aging and Disease
- No Time to Age: Uncoupling Aging from Chronological TimeDana Larocca, Jieun Lee, Michael D. West, Ivan Labat, Hal Sternberg · 2021 · Genes
- Modeling Werner Syndrome in Drosophila melanogasterLynne S. Cox, David J. Clancy, Ivan Boubriak, Robert D. C. Saunders · 2007 · Annals of the New York Academy of Sciences
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- Research on Werner Syndrome: Trends from Past to Present and Future ProspectsKyoshiro Tsuge, Akira Shimamoto · 2022 · Genes
- The DNA structure and sequence preferences of WRN underlie its function in telomeric recombination eventsDeanna N. Edwards, Amrita Machwe, Li Chen, Vilhelm A. Bohr, David K. Orren · 2015 · Nature Communications
- Vascular senescence and ageing: a role for the MEOX proteins in promoting endothelial dysfunctionJosette M. Northcott, Michael Paul Czubryt, Jeffrey T. Wigle · 2017 · Canadian Journal of Physiology and Pharmacology
- Multiple roads to the aging phenotype: insights from the molecular dissection of progerias through DNA microarray analysisTomas A. Prolla · 2004 · Mechanisms of Ageing and Development
- Telomerase deficiency and telomere dysfunction inhibit mammary tumors induced by polyomavirus middle T oncogeneMariela Jaskelioff, Wenbo Song, Jian‐Chuan Xia, C Liu, J Kramer, Shigeo Koido, Sandra J Gendler, Stuart K. Calderwood, Jianlin Gong · 2009 · Oncogene
- Helicases as Prospective Targets for Anti-Cancer TherapyRigu Gupta, Robert M. Brosh · 2008 · Anti-Cancer Agents in Medicinal Chemistry
- RecQ Helicase Somatic Alterations in CancerMegha K. Thakkar, Jamie Lee, Stefan Meyer, Vivian Y. Chang · 2022 · Frontiers in Molecular Biosciences
- WRN Protein and Werner SyndromeJianyuan Luo · 2010 · North American Journal of Medicine and Science
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- Human pluripotent stem cell-based models suggest preadipocyte senescence as a possible cause of metabolic complications of Werner and Bloom SyndromesKim Jee Goh, Jianhua Chen, Nuno Rocha, Robert K. Semple · 2020 · Scientific Reports
- Premature aging in genetic diseases: what conclusions can be drawn for physiological agingFilip Milosic, Markus Hengstschläger, Selma Osmanagic‐Myers · 2024 · Frontiers in Aging
- Ectopic hTERT expression facilitates reprograming of fibroblasts derived from patients with Werner syndrome as a WS cellular modelShuyan Wang, Zhongfeng Liu, Yanxia Ye, Bingnan Li, Tiantian Liu, Weiqi Zhang, Guang‐Hui Liu, Y.Alex Zhang, Jing Tao Qu, Dawei Xu et al. · 2018 · Cell Death and Disease
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