Opposing impacts on healthspan and longevity by limiting dietary selenium in telomere dysfunctional mice
Open accessAbstract
Summary: Selenium (Se) is a trace metalloid essential for life, but its nutritional and physiological roles during the aging process remain elusive. While telomere attrition contributes to replicative senescence mainly through persistent DNA damage response, such an aging process is mitigated in mice with inherently long telomeres. Here, weanling third generation telomerase RNA component knockout mice carrying short telomeres were fed a Se‐deficient basal diet or the diet supplemented with 0.15 ppm Se as sodium selenate to be nutritionally sufficient throughout their life. Dietary Se deprivation delayed wound healing and accelerated incidence of osteoporosis, gray hair, alopecia, and cataract, but surprisingly promoted longevity. Plasma micro RNA profiling revealed a circulating signature of Se deprivation, and subsequent ontological analyses predicted dominant changes in metabolism. Consistent with this observation, dietary Se deprivation accelerated age‐dependent declines in glucose tolerance, insulin sensitivity, and glucose‐stimulated insulin production in the mice. Moreover, DNA damage and senescence responses were enhanced and Pdx1 and MafA mRNA expression were reduced in pancreas of the Se‐deficient mice. Altogether, these results suggest a novel model of aging with conceptual advances, whereby Se at low levels may be considered a hormetic chemical and decouple healthspan and longevity.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The structural and functional roles of zinc, selenium, magnesium, copper, and manganese are crucial for antioxidant defence.
“Concerning the latter, the structural and functional roles of a few minerals such as zinc (Zn), selenium (Se), magnesium (Mg) copper (Cu) and manganese (Mn) is crucial (Table 5) [409,410,411,412,413,414,415,416,417,418,419,420].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [415]
Selenium deprivation in mice accelerates DNA damage, senescence, and aging-related processes.
“Furthermore, Se deprivation in mice has been found to accelerate DNA damage, senescence, and aging-related processes [415].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [415]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Asymptotically Efficient Rank Invariant Test Procedures
Peto, R., & Peto, J. (1972) · Journal of the Royal Statistical Society. Series A (General) · doi:10.2307/2344317 · Cited by 3,393 · see citing works
Cellular senescence: from physiology to pathology
Muñoz-Espín, D., & Serrano, M. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3823 · Cited by 2,818 · see citing works
Large-scale gene function analysis with the PANTHER classification system
Mi, H., Muruganujan, A., Casagrande, J. T., & Thomas, P. D. (2013) · Nature Protocols · doi:10.1038/nprot.2013.092 · Cited by 2,422 · see citing works
Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA
Blasco, M. A., Lee, H.-W., Hande, M. P., Samper, E., Lansdorp, P. M., DePinho, R. A., & Greider, C. W. (1997) · Cell · doi:10.1016/s0092-8674(01)80006-4 · Cited by 2,108 · see citing works
Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice
Rudolph, K. L., Chang, S., Lee, H.-W., Blasco, M., Gottlieb, G. J., Greider, C., & DePinho, R. A. (1999) · Cell · doi:10.1016/s0092-8674(00)80580-2 · Cited by 1,349 · cited 6× · see citing works
“…3 (G3) Terc / mice under the C57BL/6, 129/Sv and SJL mixed background display skin ulceration, alopecia and hair graying, but many other age-related disorders, including osteoporosis, body weight changes, shortened lifespan, and type II diabetes, do not appear until G4-G6 (Rudolph et al., 1999).”
BackgroundInfluentialBroughton, S. J., Piper, M. D. W., Ikeya, T., Bass, T. M., Jacobson, J., Driege, Y., Martinez, P., Hafen, E., Withers, D. J., Leevers, S. J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405775102 · Cited by 822 · see citing works
Extending life span by increasing oxidative stress
Ristow, M., & Schmeisser, S. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.05.010 · Cited by 718 · see citing works
A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis
Niedernhofer, L. J., Garinis, G. A., Raams, A., Lalai, A. S., Robinson, A. R., Appeldoorn, E., Odijk, H., Oostendorp, R., Ahmad, A., van Leeuwen, W., et al. (2006) · Nature · doi:10.1038/nature05456 · Cited by 669 · see citing works
A liver-derived secretory protein, selenoprotein P, causes insulin resistance
Misu, H., Takamura, T., Takayama, H., Hayashi, H., Matsuzawa-Nagata, N., Kurita, S., Ishikura, K., Ando, H., Takeshita, Y., Ota, T., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.09.015 · Cited by 583 · see citing works
Reactive oxygen species enhance insulin sensitivity
Loh, K., Deng, H., Fukushima, A., Cai, X., Boivin, B., Galic, S., Bruce, C., Shields, B. J., Skiba, B., Ooms, L. M., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.08.009 · Cited by 581 · see citing works
Ho, Y., Magnenat, J.-L., Bronson, R. T., Cao, J., Gargano, M. D., Sugawara, M., & Funk, C. D. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.26.16644 · Cited by 562 · see citing works
Self-citationInactivation of specific β cell transcription factors in type 2 diabetes
Guo, S., Dai, C., Guo, M., Taylor, B., Harmon, J. S., Sander, M., Robertson, R. P., Powers, A. C., & Stein, R. (2013) · Journal of Clinical Investigation · doi:10.1172/jci65390 · Cited by 520 · see citing works
Disease states associated with telomerase deficiency appear earlier in mice with short telomeres
Herrera, E., Samper, E., Martín‐Caballero, J., Flores, J. M., Lee, H., & Blasco, M. A. (1999) · The EMBO Journal · doi:10.1093/emboj/18.11.2950 · Cited by 471 · cited 2× · see citing works
“, 2003) and then a C57BL/6J background (Herrera et al., 1999), whose telomeres average 40 and 25 kb, respectively.”
BackgroundEssential role of limiting telomeres in the pathogenesis of Werner syndrome
Chang, S., Multani, A. S., Cabrera, N. G., Naylor, M. L., Laud, P., Lombard, D., Pathak, S., Guarente, L., & DePinho, R. A. (2004) · Nature Genetics · doi:10.1038/ng1389 · Cited by 462 · see citing works
Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications
Lei, X. G., Zhu, J., Cheng, W.-H., Bao, Y., Ho, Y.-S., Reddi, A. R., Holmgren, A., & Arnér, E. S. J. (2015) · Physiological Reviews · doi:10.1152/physrev.00010.2014 · Cited by 437 · see citing works
Self-citationYuan, R., Tsaih, S., Petkova, S. B., de Evsikova, C. M., Xing, S., Marion, M. A., Bogue, M. A., Mills, K. D., Peters, L. L., Bult, C. J., et al. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00478.x · Cited by 414 · see citing works
Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing
Wong, K.-K., Maser, R. S., Bachoo, R. M., Menon, J., Carrasco, D. R., Gu, Y., Alt, F. W., & DePinho, R. A. (2003) · Nature · doi:10.1038/nature01385 · Cited by 375 · see citing works
Schoenmakers, E., Agostini, M., Mitchell, C., Schoenmakers, N., Papp, L., Rajanayagam, O., Padidela, R., Ceron-Gutierrez, L., Doffinger, R., Prevosto, C., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci43653 · Cited by 315 · see citing works
Reduction in glutathione peroxidase 4 increases life span through increased sensitivity to apoptosis
Ran, Q., Liang, H., Ikeno, Y., Qi, W., Prolla, T. A., Roberts, L. J., Wolf, N., VanRemmen, H., & Richardson, A. (2007) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/62.9.932 · Cited by 195 · see citing works
Characterization of Oxidative Guanine Damage and Repair in Mammalian Telomeres
Wang, Z., Rhee, D. B., Lü, J., Bohr, C. T., Fang, Z., Vallabhaneni, H., de Souza-Pinto, N. C., & Liu, Y. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000951 · Cited by 192 · see citing works
Labunskyy, V. M., Lee, B. C., Handy, D. E., Loscalzo, J., Hatfield, D. L., & Gladyshev, V. N. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3526 · Cited by 189 · see citing works
Risques, R. A., Lai, L. A., Brentnall, T. A., Li, L., Feng, Z., Gallaher, J. L., Mandelson, M. T., Potter, J. D., Bronner, M. P., & Rabinovitch, P. S. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.04.008 · Cited by 178 · see citing works
Cheng, W., Ho, Y., Ross, D. A., Valentine, B. A., Combs, G. F., & Lei, X. G. (1997) · Journal of Nutrition · doi:10.1093/jn/127.8.1445 · Cited by 159 · see citing works
Self-citationWang, X. D., Vatamaniuk, M. Z., Wang, S. K., Roneker, C. A., Simmons, R. A., & Lei, X. G. (2008) · Diabetologia · doi:10.1007/s00125-008-1055-3 · Cited by 159 · see citing works
Witwer, K. W., Watson, A. K., Blankson, J. N., & Clements, J. E. (2012) · Retrovirology · doi:10.1186/1742-4690-9-5 · Cited by 151 · see citing works
Self-citationMcCann, J. C., & Ames, B. N. (2011) · The FASEB Journal · doi:10.1096/fj.11-180885 · Cited by 125 · see citing works
Downey, C. M., Horton, C. R., Carlson, B. A., Parsons, T. E., Hatfield, D. L., Hallgrímsson, B., & Jirik, F. R. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000616 · Cited by 110 · see citing works
Selenoproteins Are Essential for Proper Keratinocyte Function and Skin Development
Sengupta, A., Lichti, U. F., Carlson, B. A., Ryscavage, A. O., Gladyshev, V. N., Yuspa, S. H., & Hatfield, D. L. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012249 · Cited by 109 · see citing works
Presence of telomeric G‐strand tails in the telomerase catalytic subunit TERT knockout mice
Yuan, X., Ishibashi, S., Hatakeyama, S., Saito, M., Nakayama, J., Nikaido, R., Haruyama, T., Watanabe, Y., Iwata, H., Iida, M., et al. (1999) · Genes to Cells · doi:10.1046/j.1365-2443.1999.00284.x · Cited by 105 · see citing works
The paradox of the insulin/IGF-1 signaling pathway in longevity
(2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.03.006 · Cited by 102 · see citing works
Stephens, S. B., Schisler, J. C., Hohmeier, H. E., An, J., Sun, A. Y., Pitt, G. S., & Newgard, C. B. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.05.011 · Cited by 102 · see citing works
Tissue‐specific insulin signaling in the regulation of metabolism and aging
Zhang, J., & Liu, F. (2014) · IUBMB Life · doi:10.1002/iub.1293 · Cited by 100 · see citing works
Seyedali, A., & Berry, M. J. (2014) · RNA · doi:10.1261/rna.043463.113 · Cited by 78 · see citing works
Differential responses to selenomethionine supplementation by sex and genotype in healthy adults
Combs, G. F., Jackson, M. I., Watts, J. C., Johnson, L. K., Zeng, H., Idso, J. P., Schomburg, L., Hoeg, A., Hoefig, C. S., Chiang, E. C., et al. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511004715 · Cited by 77 · see citing works
Self-citationCRL2 aids elimination of truncated selenoproteins produced by failed UGA/Sec decoding
Lin, H.-C., Ho, S.-C., Chen, Y.-Y., Khoo, K., Hsu, P., & Yen, H.-C. S. (2015) · Science · doi:10.1126/science.aab0515 · Cited by 75 · see citing works
de Haan, J. B., Bladier, C., Lotfi-Miri, M., Taylor, J. M., Hutchinson, P. E., Crack, P. J., Hertzog, P. J., & Kola, I. (2003) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2003.10.020 · Cited by 73 · see citing works
Reductions in serum IGF ‐1 during aging impair health span
Gong, Z., Kennedy, O. D., Sun, H., Wu, Y., Williams, G. A., Klein, L., Cardoso, L., Matheny, R. W., Hubbard, G. B., Ikeno, Y., et al. (2013) · Aging Cell · doi:10.1111/acel.12188 · Cited by 68 · see citing works
Ma, S., Lee, S., Kim, E. B., Park, T. J., Seluanov, A., Gorbunova, V. A., Buffenstein, R., Seravalli, J., & Gladyshev, V. N. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.10.014 · Cited by 68 · see citing works
Selenoprotein H Suppresses Cellular Senescence through Genome Maintenance and Redox Regulation
Wu, R. T. Y., Cao, L., Chen, B. P. C., & Cheng, W.-H. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.611970 · Cited by 55 · see citing works
Self-citationAbolhassani, M., Aloulou, N., Chaumette, M. T., Aparicio, T., Martin‐Garcia, N., Mansour, H., Gouvello, S. L., Delchier, J. C., & Sobhani, I. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1017 · Cited by 39 · see citing works
MicroRNA and Senescence: The Senectome, Integration and Distributed Control
Bilsland, A. E., Revie, J., & Keith, W. N. (2013) · Critical Reviews™ in Oncogenesis · doi:10.1615/critrevoncog.2013007197 · Cited by 29 · see citing works
González‐Suárez, E., Goytisolo, F. A., Flores, J. M., & Blasco, M. A. (2003) · PubMed · Cited by 23 · see citing works
Sunde, R. A., & Thompson, K. M. (2009) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2009.02.002 · Cited by 21 · see citing works
Holmström, A., Ryan, T., Zeng, H., Lei, K. Y., & Cheng, W. (2011) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2011.06.001 · Cited by 12 · see citing works
Self-citationSquires, J. E., Davy, P. M. C., Berry, M. J., & Allsopp, R. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2009.06.005 · Cited by 11 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Selenium, aging and aging-related diseases
Cai, Z., Zhang, J., & Li, H. (2019) · Aging Clinical and Experimental Research · doi:10.1007/s40520-018-1086-7 · Cited by 150 · see citing works
The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence
Varesi, A., Chirumbolo, S., Campagnoli, L. I. M., Pierella, E., Piccini, G. B., Carrara, A., Ricevuti, G., Scassellati, C., Bonvicini, C., & Pascale, A. (2022) · Antioxidants · doi:10.3390/antiox11071224 · Cited by 145 · see citing works
Uskoković, V., Iyer, M. A., & Wu, V. (2017) · Journal of Materials Chemistry B · doi:10.1039/c6tb03387c · Cited by 85 · see citing works
Impact of Selenium on Biomarkers and Clinical Aspects Related to Ageing. A Review
Alehagen, U., Opstad, T. B., Alexander, J., Larsson, A., & Aaseth, J. (2021) · Biomolecules · doi:10.3390/biom11101478 · Cited by 69 · see citing works
Selenium Deficiency Is Associated with Pro-longevity Mechanisms
Yim, S. H., Clish, C. B., & Gladyshev, V. N. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.05.001 · Cited by 69 · see citing works
Zhang, L., Zeng, H., & Cheng, W. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.05.067 · Cited by 66 · see citing works
Self-citationAssociation of dietary selenium intake with telomere length in middle-aged and older adults
Shu, Y., Wu, M., Yang, S., Wang, Y., & Li, H. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.01.014 · Cited by 48 · see citing works
Cao, L., Zhang, L., Zeng, H., Wu, R. T. Y., Wu, T.-L., & Cheng, W. (2017) · Journal of Nutrition · doi:10.3945/jn.117.247775 · Cited by 44 · see citing works
Self-citationOpstad, T. B., Alexander, J., Aaseth, J., Larsson, A. O., Seljeflot, I., & Alehagen, U. (2022) · Nutrients · doi:10.3390/nu14163346 · Cited by 37 · see citing works
Dietary Selenium Supplementation Ameliorates Female Reproductive Efficiency in Aging Mice
Yang, H., Qazi, I. H., Pan, B., Angel, C., Guo, S., Yang, J., Zhang, Y., Ming, Z., Zeng, C., Meng, Q., et al. (2019) · Antioxidants · doi:10.3390/antiox8120634 · Cited by 31 · see citing works
Zhang, Y., Liu, J., Li, X., Zhou, G., Sang, Y., Zhang, M., Gao, L., Xue, J., Zhao, M., Yu, H., et al. (2022) · Food and Chemical Toxicology · doi:10.1016/j.fct.2022.113556 · Cited by 26 · see citing works
Five threads: How U-shaped thinking weaves together dogs, men, selenium, and prostate cancer risk
Waters, D. J., & Chiang, E. C. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.12.039 · Cited by 26 · see citing works
Altered dietary selenium influences brain iron content and behavioural outcomes
Sharma, S. K., Bansal, M. P., & Sandhir, R. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112011 · Cited by 25 · see citing works
Huang, Y., Wu, T.-L., Zeng, H., & Cheng, W. (2021) · Journal of Nutrition · doi:10.1093/jn/nxab053 · Cited by 21 · see citing works
Self-citationSelenium status and type 2 diabetes risk
Huang, Y., Combs, G. F., Wu, T.-L., Zeng, H., & Cheng, W. (2022) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2022.109400 · Cited by 21 · see citing works
Self-citationSiard, M. H., Harris, P. A., Moffett-Krotky, A. D., Ireland, J. L., Betancourt, A., Barker, V. D., McMurry, K. E., Reedy, S. E., & Adams, A. A. (2020) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2020.110013 · Cited by 20 · see citing works
Zhang, K., Li, S., Zhao, Q., Li, J., Han, Y., Qin, Y., Zhang, J., & Tang, C. (2022) · Journal of Nutrition · doi:10.1093/jn/nxac016 · Cited by 19 · see citing works
Gan, F., Zhou, Y., Hu, Z., Hou, L., Chen, X., Xu, S., & Huang, K. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.11.221 · Cited by 18 · see citing works
Li, M., Zhang, Y., Zhou, J., & Liu, H. (2022) · Antioxidants · doi:10.3390/antiox11112105 · Cited by 16 · see citing works
Wang, Q., Zhan, S., Han, F., Liu, Y., Wu, H., & Huang, Z. (2021) · Biological Trace Element Research · doi:10.1007/s12011-021-02851-7 · Cited by 15 · see citing works
Qazi, I. H., Cao, Y., Yang, H., Angel, C., Pan, B., Zhou, G., & Han, H. (2020) · Biological Trace Element Research · doi:10.1007/s12011-020-02192-x · Cited by 15 · see citing works
Antonyak, H., Iskra, R., Panas, N., & Lysiuk, R. (2018) · Healthy ageing and longevity · doi:10.1007/978-3-030-03742-0_3 · Cited by 11 · see citing works
Oral Recombinant Methioninase Inhibits Diabetes Onset in Mice on a High-fat Diet
Tashiro, Y., Han, Q., TAN, Y., Sugisawa, N., Yamamoto, J., Nishino, H., Inubushi, S., Sun, Y., Zhu, G., LIM, H., et al. (2020) · In Vivo · doi:10.21873/invivo.11865 · Cited by 10 · see citing works
Cadmium, Cellular Senescence, and Cancer
Tan, H. W., Seen, D. L. T., Xu, Y., & Lau, A. T. Y. (2023) · Reviews of Environmental Contamination and Toxicology · doi:10.1007/s44169-023-00042-0 · Cited by 8 · see citing works
Tian, F., Kennedy, E. M., Hermetz, K. E., Burt, A., Everson, T. M., Punshon, T., Jackson, B. P., Hao, K., Chen, J., Karagas, M. R., et al. (2021) · Epigenetics · doi:10.1080/15592294.2021.2003044 · Cited by 10 · see citing works
Huang, Y., Lu, H., Zhang, L., Olivier, A. K., Wu, T., Hsu, C., LeGrand, C., Zeng, H., Curran, S., Wang, Q., et al. (2025) · Aging Cell · doi:10.1111/acel.70130 · Cited by 7 · see citing works
Self-citationCao, L., Pechan, T., Lee, S. G., & Cheng, W. (2021) · Journal of Nutrition · doi:10.1093/jn/nxab290 · Cited by 6 · see citing works
Self-citationBak, N. K., Mackay, T. F. C., Morgante, F., Nielsen, K. L., Nielsen, J. L., Kristensen, T. N., & Rohde, P. D. (2025) · Heredity · doi:10.1038/s41437-025-00797-3 · Cited by 5 · see citing works
Cheng, W., & Combs, G. F. (2018) · British Journal Of Nutrition · doi:10.1017/s0007114518001228 · Cited by 4 · see citing works
Self-citationSelenoproteins and Epigenetic Regulation in Mammals
Lu, H.-Y., Somuncu, B., Zhu, J., Müftüoğlu, M., & Cheng, W.-H. (2019) · Springer eBooks · doi:10.1007/978-3-319-55530-0_31 · Cited by 3 · see citing works
Self-citationThe association between dietary selenium intake and telomere length in hypertension
Liang, C., Zhao, R., Du, J., Zhao, G., & Zhang, Y. (2024) · Journal of Clinical Hypertension · doi:10.1111/jch.14861 · Cited by 2 · see citing works
Placental Telomere Length: Linking Maternal Nutrition to Transgenerational Healthy Aging?
Cheng, W. (2020) · Journal of Nutrition · doi:10.1093/jn/nxaa277 · Cited by 2 · see citing works
Self-citationSelenoproteins and Epigenetic Regulation in Mammals
Lu, H., Somuncu, B., Zhu, J., Müftüoğlu, M., & Cheng, W. (2017) · Springer eBooks · doi:10.1007/978-3-319-31143-2_31-1 · Cited by 1 · see citing works
Self-citationUskoković, V. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4452789
Tian, T., Cai, W., Li, W., Ma, Y., Lei, L., Yue, Z., & Pan, Y. (2026) · Biological Trace Element Research · doi:10.1007/s12011-026-04988-9
Huang, Y., & Cheng, W.-H. (2026) · Biological Trace Element Research · doi:10.1007/s12011-026-05106-5
Self-citationApalowo, O. E., Adewole, T. S., Yusuf, I. F., & Schilling, M. W. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1908597
- Authors
- Wu, R. T., Cao, L., Mattson, E., Witwer, K. W., Cao, J., Zeng, H., He, X., Combs, G. F., & Cheng, W.
- Affiliations
- University of Maryland, College Park (US)
- Mississippi State University (US)
- Johns Hopkins University (US)
- Agricultural Research Service (US)
- Corresponding author
- Cheng, Wen‐Hsing
- Venue
- Aging Cell
- Publisher
- Wiley
- Published
- 2016-09-21
- Volume
- 16
- Issue
- 1
- Pages
- 125-135
- ISSN
- 1474-9718 (ISSN-L)
- 1474-9726
- PMC
- PMC5242309
- OpenAlex
- W2522797895
- Cited by
- 37
- References
- 45
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 6 · 2021: 5 · 2020: 5 · 2019: 5 · 2018: 5 · 2017: 3
- FWCI
- 4.54
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Aging Cell (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Agriculture
- Agricultural Research Service (5450‐51000‐050‐00D, 3062‐51000‐053‐00D)
- Johns Hopkins University
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Keywords
- dietary selenium, selenium deficiency, telomere dysfunction, aging, longevity, healthspan, replicative senescence, DNA damage response, wound healing, osteoporosis, gray hair, cataract, miRNA expression profiling, glucose tolerance, insulin sensitivity, pancreatic beta cells, PDX1, MafA, hormesis
- MeSH terms
- Animals, Body Weight, Diet, Glucose, Health, Histones, Insulin, Longevity, Male, Mice, Inbred C57BL, Pancreas, Phenotype, RNA, RNA, Messenger, Selenium, Down-Regulation, Survival Analysis, Telomere, Telomerase, Gene Expression Profiling, MicroRNAs, Genomic Instability, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
