Cited by 509RNA Research and SplicingRNA regulation and diseaseNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.

Nova regulates brain-specific splicing to shape the synapse

Ule, Jernej, Ule, Aljaž, Spencer, Joanna, Williams, Alan, Hu, Jing-Shan, Cline, Melissa, Wang, Hui, Clark, Tyson, Fraser, Claire, Ruggiu, Matteo, Zeeberg, Barry R, Kane, David, Weinstein, John N, Blume, John, Darnell, Robert B·2005·Nature Genetics

DOI 10.1038/ng1610

Open this paper in CoChat — free account

Abstract

Alternative RNA splicing greatly increases proteome diversity and may thereby contribute to tissue-specific functions. We carried out genome-wide quantitative analysis of alternative splicing using a custom Affymetrix microarray to assess the role of the neuronal splicing factor Nova in the brain. We used a stringent algorithm to identify 591 exons that were differentially spliced in the brain relative to immune tissues, and 6.6% of these showed major splicing defects in the neocortex of Nova2-/- mice. We tested 49 exons with the largest predicted Nova-dependent splicing changes and validated all 49 by RT-PCR. We analyzed the encoded proteins and found that all those with defined brain functions acted in the synapse (34 of 40, including neurotransmitter receptors, cation channels, adhesion and scaffold proteins) or in axon guidance (8 of 40). Moreover, of the 35 proteins with known interaction partners, 74% (26) interact with each other. Validating a large set of Nova RNA targets has led us to identify a multi-tiered network in which Nova regulates the exon content of RNAs encoding proteins that interact in the synapse.

Integrity signals

Registry

Crossref · 10.1038/ng1610

Cites

49 of 49 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Finishing the euchromatic sequence of the human genome
International Human Genome Sequencing Consortium (2004) · Nature · doi:10.1038/nature03001 · Cited by 4,971
From molecular to modular cell biology.
Hartwell, L. H., Hopfield, J. J., Leibler, S., & Murray, A. W. (1999) · Nature · doi:10.1038/35011540 · Cited by 3,632
Light-Directed, Spatially Addressable Parallel Chemical Synthesis
Fodor, S. P. A., Read, J., Pirrung, M. C., Stryer, L., Lu, A. T., & Solas, D. W. (1991) · Science · doi:10.1126/science.1990438 · Cited by 2,697
Transcriptional regulatory code of a eukaryotic genome
Harbison, C. T., Gordon, D. B., Lee, T. I., Rinaldi, N. J., MacIsaac, K. D., Danford, T., Hannett, N. M., Tagne, J., Reynolds, D. B., Yoo, J. Y., et al. (2004) · Nature · doi:10.1038/nature02800 · Cited by 2,135
Metaplasticity: the plasticity of synaptic plasticity
Abraham, W. C., & Bear, M. F. (1996) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)80018-x · Cited by 1,833
Genome-Wide Survey of Human Alternative Pre-mRNA Splicing with Exon Junction Microarrays
Johnson, J. M., Castle, J. C., Garrett-Engele, P. W., Kan, Z., Loerch, P., Armour, C. D., Santos, R., Schadt, E. E., Stoughton, R. B., & Shoemaker, D. D. (2003) · Science · doi:10.1126/science.1090100 · Cited by 1,418
Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress.
Hentze, M. W., & Kühn, L. C. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8175 · Cited by 1,292
GoMiner: a resource for biological interpretation of genomic and proteomic data
Zeebèrg, B. R., Feng, W., Wang, G., Wang, M. D., Fojo, A. T., Sunshine, M., Narasimhan, S., Kane, D. W., Reinhold, W. C., Lababidi, S., et al. (2003) · Genome biology · doi:10.1186/gb-2003-4-4-r28 · Cited by 1,198
Self-citation
CLIP Identifies Nova-Regulated RNA Networks in the Brain
Ule, J., Jensen, K. B., Ruggiu, M., Mele, A., Ule, A., & Darnell, R. B. (2003) · Science · doi:10.1126/science.1090095 · Cited by 1,120
Self-citation
Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome
Brown, V., Jin, P., Ceman, S., Darnell, J. C., O'Donnell, W. T., Tenenbaum, S. A., Jin, X., Feng, Y., Wilkinson, K. D., Keene, J. D., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00568-2 · Cited by 1,109
Self-citation

Flagged first, then by citations

Show all 49 references

Research works printed but not linked: 1

Huang, C.S. et al. Long-term potentiation of slow synaptic inhibition induced by coincidence detection of excitation in the CA1 pyramidal neuron requires Nova-2 function. Cell (in the press).

Sorted by citations

Items 201–300 of 507

Reelin-Disabled-1 signaling in neuronal migration: splicing takes the stage
Gao, Z., & Godbout, R. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1171-6 · Cited by 53
Alternative Splicing of Alpha- and Beta-Synuclein Genes Plays Differential Roles in Synucleinopathies
Gámez‐Valero, A., & Beyer, K. (2018) · Genes · doi:10.3390/genes9020063 · Cited by 51
Splicing Programs and Cancer
Germann, S., Gratadou, L., Dutertre, M., & Auboeuf, D. (2011) · Journal of Nucleic Acids · doi:10.1155/2012/269570 · Cited by 54
Alternative splicing: An important mechanism in stem cell biology
Chen, K. (2015) · World Journal of Stem Cells · doi:10.4252/wjsc.v7.i1.1 · Cited by 50
A Small Molecule that Binds an RNA Repeat Expansion Stimulates Its Decay via the Exosome Complex
Angelbello, A. J., Benhamou, R. I., Rzuczek, S. G., Choudhary, S., Tang, Z., Chen, J. L., Roy, M., Wang, K. W., Yildirim, I., Jun, A. S., et al. (2020) · Cell chemical biology · doi:10.1016/j.chembiol.2020.10.007 · Cited by 49
The Role of RNA and RNA Processing in Neurodegeneration: Figure 1.
Gallo, J., Jin, P., Thornton, C. A., Lin, H., Robertson, J., D’Souza, I., & Schlaepfer, W. W. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3453-05.2005 · Cited by 49
Circ‐U2AF1 promotes human glioma via derepressing neuro‐oncological ventral antigen 2 by sponging hsa‐miR‐7‐5p
Li, G., Huang, M., Cai, Y., Yang, Y., Sun, X., & Ke, Y. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27591 · Cited by 48
The neuronal splicing factor Nova controls alternative splicing in N-type and P-type CaV2 calcium channels
Allen, S. E., Darnell, R. B., & Lipscombe, D. (2010) · Channels · doi:10.4161/chan.4.6.12868 · Cited by 48
Self-citation
The three as: Alternative splicing, alternative polyadenylation and their impact on apoptosis in immune function
Blake, D., & Lynch, K. W. (2021) · Immunological Reviews · doi:10.1111/imr.13018 · Cited by 49
Paraneoplastic and Other Autoimmune Encephalitides: Antineuronal Antibodies, T Lymphocytes, and Questions of Pathogenesis
Greenlee, J., Carlson, N. G., Abbatemarco, J., Herdlevær, I., Clardy, S. L., & Vedeler, C. A. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2021.744653 · Cited by 47
Identification of RNA-binding proteins that regulate FGFR2 splicing through the use of sensitive and specific dual color fluorescence minigene assays
Newman, E. A., Muh, S. J., Hovhannisyan, R. H., Warzecha, C. C., Jones, R. B., McKeehan, W. L., & Carstens, R. P. (2006) · RNA · doi:10.1261/rna.34906 · Cited by 49
RNA Regulation in Neurologic Disease and Cancer
Darnell, R. B. (2010) · Cancer Research and Treatment · doi:10.4143/crt.2010.42.3.125 · Cited by 45
Self-citation
αCP binding to a cytosine-rich subset of polypyrimidine tracts drives a novel pathway of cassette exon splicing in the mammalian transcriptome
Ji, X., Park, J. W., Bahrami‐Samani, E., Lin, L., Duncan-Lewis, C., Pherribo, G. J., Xing, Y., & Liebhaber, S. A. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw088 · Cited by 44
RNA metabolism and dysmyelination in schizophrenia
McInnes, L. A., & Lauriat, T. L. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.10.003 · Cited by 45
Human Brain Evolution: Harnessing the Genomics (R)evolution to Link Genes, Cognition, and Behavior
Konopka, G., & Geschwind, D. H. (2010) · Neuron · doi:10.1016/j.neuron.2010.10.012 · Cited by 44
Transcriptional response of the neuromuscular system to exercise training and potential implications for ALS
Ferraiuolo, L., de Bono, J. P., Heath, P. R., Holden, H. M., Kasher, P. R., Channon, K. M., Kirby, J., & Shaw, P. J. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06080.x · Cited by 45
The molecular evolution of the vertebrate behavioural repertoire
Grant, S. G. N. (2015) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2015.0051 · Cited by 48
Prolonged Induction of miR-212/132 and REST Expression in Rat Striatum Following Cocaine Self-Administration
Sadakierska−Chudy, A., Frankowska, M., Miszkiel, J., Wydra, K., Jastrzębska, J., & Filip, M. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9817-2 · Cited by 46
Calcium Channel CaVα1 Splice Isoforms - Tissue Specificity and Drug Action
Lipscombe, D., & Andrade, A. (2015) · Current Molecular Pharmacology · doi:10.2174/1874467208666150507103215 · Cited by 44
The contribution of alternative splicing to genetic risk for psychiatric disorders
Reble, E., Dineen, A., & Barr, C. L. (2017) · Genes Brain & Behavior · doi:10.1111/gbb.12430 · Cited by 47
fus/TLS orchestrates splicing of developmental regulators during gastrulationPreprint
Dichmann, D. S., & Harland, R. M. (2012) · Genes & Development · doi:10.1101/gad.187278.112 · Cited by 45
The function of spliceosome components in open mitosis
Hofmann, J. C., Husedzinovic, A., & Gruß, O. J. (2010) · Nucleus · doi:10.4161/nucl.1.6.13328 · Cited by 44
Control of alternative pre-mRNA splicing by Ca++ signals
Xie, J. (2008) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2008.01.003 · Cited by 44
Alternative splicing interference by xenobiotics
Zaharieva, E. E., Chipman, J. K., & Soller, M. (2012) · Toxicology · doi:10.1016/j.tox.2012.01.014 · Cited by 46
Emerging technologies for amino acid nutrition research in the post-genome era
Wang, J., Wu, G., Zhou, H., & Wang, F. (2008) · Amino Acids · doi:10.1007/s00726-008-0193-8 · Cited by 44
Splicing factors control C. elegans behavioural learning in a single neuron by producing DAF-2c receptor
Tomioka, M., Naito, Y., Kuroyanagi, H., & Iino, Y. (2016) · Nature Communications · doi:10.1038/ncomms11645 · Cited by 40
Cleft lip and cleft palate (CL/P) in Esrp1 KO mice is associated with alterations in epithelial-mesenchymal crosstalk
Lee, S., Sears, M. J., Zhang, Z., Li, H., Salhab, I., Krebs, P., Xing, Y., Nah, H., Williams, T., & Carstens, R. P. (2020) · Development · doi:10.1242/dev.187369 · Cited by 47
Alternative RNA splicing complexes containing the scaffold attachment factor SAFB2
Sergeant, K. A., Bourgeois, C. F., Dalgliesh, C., Venables, J. P., Stévenin, J., & Elliott, D. J. (2007) · Journal of Cell Science · doi:10.1242/jcs.03344 · Cited by 43
Control of a neuronal morphology program by an RNA-binding zinc finger protein, UnkemptPreprint
Murn, J., Zarnack, K., Yang, Y. J., Durak, O., Murphy, E. A., Cheloufi, S., Gonzalez, D. M., Teplova, M., Curk, T., Zuber, J. A., et al. (2015) · Genes & Development · doi:10.1101/gad.258483.115 · Cited by 41
Self-citation
Stepwise assembly of the Nova -regulated alternative splicing network in the vertebrate brain
Irimia, M., Denuc, A., Burguera, D., Somorjai, I., Martín-Durán, J. M., Genikhovich, G., Jimenez-Delgado, S., Technau, U., Roy, S. W., Marfany, G., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012333108 · Cited by 47
De Novo Frameshift Variants in the Neuronal Splicing Factor NOVA2 Result in a Common C-Terminal Extension and Cause a Severe Form of Neurodevelopmental Disorder
Mattioli, F., Hayot, G., Drouot, N., Isidor, B., Courraud, J., Hinckelmann, M.-V., Mau‐Them, F. T., Sellier, C., Goldman, A. M., Telegrafi, A. B., et al. (2020) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2020.02.013 · Cited by 41
Heterogeneous nuclear ribonucleoprotein L-like (hnRNPLL) and elongation factor, RNA polymerase II, 2 (ELL2) are regulators of mRNA processing in plasma cells
Benson, M. J., Äijö, T., Chang, X., Gagnon, J. D., Pape, U. J., Anantharaman, V., Aravind, L., Pursiheimo, J., Oberdoerffer, S., Liu, X. S., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1214414109 · Cited by 44
miRNA regulons associated with synaptic function
Paschou, M., Paraskevopoulou, M. D., Vlachos, I. S., Koukouraki, P., Hatzigeorgiou, A. G., & Doxakis, E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046189 · Cited by 41
Regulation of membrane excitability: a convergence on voltage-gated sodium conductance
Lin, W.-H., & Baines, R. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8674-0 · Cited by 41
Alternative Splicing by NOVA Factors: From Gene Expression to Cell Physiology and Pathology
Meldolesi, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21113941 · Cited by 42
Involvement of Endocytosis and Alternative Splicing in the Formation of the Pathological Process in the Early Stages of Parkinson’s Disease
Alieva, A. K., Shadrina, M. I., Filatova, E. V., Karabanov, A. V., Illarioshkin, S. N., Limborska, S. A., & Slominsky, P. A. (2014) · BioMed Research International · doi:10.1155/2014/718732 · Cited by 41
Evolutionarily conserved A-to-I editing increases protein stability of the alternative splicing factor Nova1
Irimia, M., Denuc, A., Ferran, J. L., Pernaute, B., Puelles, L., Roy, S. W., Garcia-Fernàndez, J., & Marfany, G. (2012) · RNA Biology · doi:10.4161/rna.9.1.18387 · Cited by 38
Mass Spectrometric Analysis of Glycine Receptor-associated Gephyrin Splice Variants
Paarmann, I., Schmitt, B., Meyer, B., Karas, M., & Betz, H. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m607764200 · Cited by 40
Exon expression profiling reveals stimulus-mediated exon use in neural cells
McKee, A. E., Neretti, N., Carvalho, L. E., Meyer, C. A., Fox, E. A., Brodsky, A. S., & Silver, P. A. (2007) · Genome biology · doi:10.1186/gb-2007-8-8-r159 · Cited by 40
EventPointer: an effective identification of alternative splicing events using junction arrays
Romero, J. P., Muniategui, A., de Miguel, F. J., Aramburu, A., Montuenga, L. M., Pı́o, R., & Rubio, Á. (2016) · BMC Genomics · doi:10.1186/s12864-016-2816-x · Cited by 39
Neuronal RNA ‐binding proteins in health and disease
Lenzken, S. C., Achsel, T., Carrì, M. T., & Barabino, S. M. L. (2014) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1231 · Cited by 40
Evolution of genetic mechanisms regulating cortical neurogenesis
Espinós, A., Ortuño, E. F., Negri, E., & Borrell, V. (2022) · Developmental Neurobiology · doi:10.1002/dneu.22891 · Cited by 38
From Structure to Function of RNA Binding Domains
Lorkovic, Z. (2012) · CRC Press eBooks · doi:10.1201/9781498713368-15 · Cited by 38
The neurofibromatosis type I pre-mRNA is a novel target of CELF protein-mediated splicing regulation
Barron, V. A., Zhu, H., Hinman, M. N., Ladd, A. N., & Lou, H. J. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp766 · Cited by 37
SRPK1 inhibition in prostate cancer: A novel anti-angiogenic treatment through modulation of VEGF alternative splicing
Mavrou, A., & Oltean, S. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.03.013 · Cited by 37
Developing Global Insight into RNA RegulationPreprint
Darnell, R. B. (2006) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2006.71.002 · Cited by 36
Self-citation
Ribonucleoprotein complexes in neurologic diseases
Ule, J. (2008) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2008.09.018 · Cited by 38
Self-citation
TassDB: a database of alternative tandem splice sites
Hiller, M., Nikolajewa, S., Huse, K., Szafranski, K., Rosenstiel, P. C., Schuster, S., Backofen, R., & Platzer, M. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl762 · Cited by 36
Study of an RNA-Focused DNA-Encoded Library Informs Design of a Degrader of a r(CUG) Repeat Expansion
Gibaut, Q. M. R., Akahori, Y., Bush, J. A., Taghavi, A., Tanaka, T., Aikawa, H., Ryan, L. S., Paegel, B. M., & Disney, M. D. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.2c08883 · Cited by 35
GoldCLIP: Gel-Omitted Ligation-Dependent CLIP
Gu, J., Wang, M., Yang, Y., Qiu, D., Zhang, Y., Ma, J., Zhou, Y., Hannon, G. J., & Yu, Y. (2018) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2018.04.003 · Cited by 35
Long read sequencing reveals novel isoforms and insights into splicing regulation during cell state changes
Wright, D. J., Hall, N., Irish, N., Man, A., Glynn, W., Mould, A. W., Angeles, A. D. L., Angiolini, E., Swarbreck, D., Gharbi, K., et al. (2022) · BMC Genomics · doi:10.1186/s12864-021-08261-2 · Cited by 39
SPINK5, the Defective Gene in Netherton Syndrome, Encodes Multiple LEKTI Isoforms Derived from Alternative Pre-mRNA Processing
Polcini, A. T., Bonnart, C., Micheloni, A., Cianfarani, F., Andrè, A., Zambruno, G., Hovnanian, A., & D’Alessio, M. (2005) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700015 · Cited by 35
Expression cloning in Xenopus identifies RNA-binding proteins as regulators of embryogenesis and Rbmx as necessary for neural and muscle development
Dichmann, D. S., Fletcher, R. B., & Harland, R. M. (2008) · Developmental Dynamics · doi:10.1002/dvdy.21590 · Cited by 38
Alternative splicing in endothelial cells: novel therapeutic opportunities in cancer angiogenesis
Matteo, A. D., Belloni, E., Pradella, D., Cappelletto, A., Volf, N., Zacchigna, S., & Ghigna, C. (2020) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01753-1 · Cited by 34
Alternative Pre-mRNA Splicing of the Mu Opioid Receptor Gene, OPRM1: Insight into Complex Mu Opioid Actions
Liu, S., Kang, W.-J., Abrimian, A., Xu, J., Cartegni, L., Majumdar, S., Hesketh, P. J., Bekker, A., & Pan, Y. (2021) · Biomolecules · doi:10.3390/biom11101525 · Cited by 34
High-resolution analysis of allelic imbalance in neuroblastoma cell lines by single nucleotide polymorphism arrays
Carr, J., Bown, N. P., Case, M. C., Hall, A. G., Lunec, J., & Tweddle, D. A. (2007) · Cancer Genetics and Cytogenetics · doi:10.1016/j.cancergencyto.2006.08.012 · Cited by 34
Technologies for the Global Discovery and Analysis of Alternative Splicing
Calarco, J. A., Saltzman, A. L., Ip, J. Y. Y., & Blencowe, B. J. (2007) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-77374-2_5 · Cited by 33
The role of RNA processing in the pathogenesis of motor neuron degeneration
Bäumer, D., Ansorge, O., Almeida, M., & Talbot, K. (2010) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399410001523 · Cited by 34
TDP-43 high throughput screening analyses in neurodegeneration: Advantages and pitfalls
Buratti, E., Romano, M., & Baralle, F. E. (2013) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2013.03.001 · Cited by 32
CLIPing the brain: Studies of protein–RNA interactions important for neurodegenerative disorders
Modic, M., Ule, J., & Sibley, C. R. (2013) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2013.04.002 · Cited by 34
Self-citation
Srsf7 Establishes the Juvenile Transcriptome through Age-Dependent Alternative Splicing in Mice
Kadota, Y., Jam, F. A., Yukiue, H., Terakado, I., Morimune, T., Tano, A., Tanaka, Y., Akahane, S., Fukumura, M., Tooyama, I., et al. (2020) · iScience · doi:10.1016/j.isci.2020.100929 · Cited by 32
Hypoxia‐dependent mRNA expression pattern of splicing factor YT521 and its impact on oncological important target gene expression
Hirschfeld, M., Zhang, B., Jaeger, M., Stamm, S., Erbes, T., Mayer, S., Tong, X., & Stickeler, E. (2013) · Molecular Carcinogenesis · doi:10.1002/mc.22045 · Cited by 33
ADAM15 gene structure and differential alternative exon use in human tissues
Kleino, I., Ortiz, R. M., & Huovila, A. J. (2007) · BMC Molecular Biology · doi:10.1186/1471-2199-8-90 · Cited by 36
Intronic motif pairs cooperate across exons to promote pre-mRNA splicing
Ke, S., & Chasin, L. A. (2010) · Genome biology · doi:10.1186/gb-2010-11-8-r84 · Cited by 34
How alternative splicing affects membrane-trafficking dynamics
Blue, R. E., Curry, E. G., Engels, N. M., Lee, E. Y., & Giudice, J. (2018) · Journal of Cell Science · doi:10.1242/jcs.216465 · Cited by 33
Upregulation of the alternative splicing factor NOVA2 in colorectal cancer vasculature
Gallo, S., Arcidiacono, M. V., Tisato, V., Piva, R., Penolazzi, L., Bosi, C., Feo, C. V., Gafà, R., & Secchiero, P. (2018) · OncoTargets and Therapy · doi:10.2147/ott.s171678 · Cited by 32
Upstream analysis of alternative splicing: a review of computational approaches to predict context-dependent splicing factors
Carazo, F., Romero, J. P., & Rubio, Á. (2018) · Briefings in Bioinformatics · doi:10.1093/bib/bby005 · Cited by 30
Repair of pre-mRNA splicing
Nlend, R. N., Meyer, K., & Schümperli, D. (2010) · RNA Biology · doi:10.4161/rna.7.4.12206 · Cited by 30
Genome-wide analysis of familial dysautonomia and kinetin target genes with patient olfactory ecto-mesenchymal stem cells
Boone, N., Bergon, A., Loriod, B., Devèze, A., Nguyen, C., Axelrod, F. B., & Ibrahim, E. C. (2011) · Human Mutation · doi:10.1002/humu.22010 · Cited by 30
Proteomic Analysis of Mouse Cortex Postsynaptic Density following Neonatal Brain Hypoxia-Ischemia
Shao, G., Wang, Y., Guan, S., Burlingame, A. L., Lu, F., Knox, R. N., Ferriero, D. M., & Jiang, X. (2017) · Developmental Neuroscience · doi:10.1159/000456030 · Cited by 29
Distant coupling between RNA editing and alternative splicing of the osmosensitive cation channel Tmem63b
Wu, D., Zang, Y., Shi, Y., Ye, C., Cai, W.-M., Tang, X.-H., Zhao, L., Liu, Y., Gan, Z., Chen, G., et al. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.016049 · Cited by 29
The SR Family Proteins B52 and dASF/SF2 Modulate Development of the Drosophila Visual System by Regulating Specific RNA Targets
Gabut, M., Déjardin, J., Tazi, J., & Soret, J. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01876-06 · Cited by 27
Physiological genomics in PG and beyond: October to December 2005
Liang, M., & Ventura, B. (2005) · Physiological Genomics · doi:10.1152/physiolgenomics.00278.2005 · Cited by 28
Combinatorial Mutagenesis of MBNL1 Zinc Fingers Elucidates Distinct Classes of Regulatory Events
Purcell, J., Oddo, J. C., Wang, E. T., & Berglund, J. A. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.00274-12 · Cited by 29
Identification of Qk as a Glial Precursor Cell Marker that Governs the Fate Specification of Neural Stem Cells to a Glial Cell Lineage
Takeuchi, A., Takahashi, Y., Iida, K., Hosokawa, M., Irie, K., Ito, M., Brown, J. B., Ohno, K., Nakashima, K., & Hagiwara, M. (2020) · Stem Cell Reports · doi:10.1016/j.stemcr.2020.08.010 · Cited by 25
Genetics of Gene Expression in CNS
Pandey, A. K., & Williams, R. W. (2014) · International review of neurobiology · doi:10.1016/b978-0-12-801105-8.00008-4 · Cited by 27
mRNA Processing: An Emerging Frontier in the Regulation of Pancreatic β Cell Function
Moss, N. D., & Sussel, L. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.00983 · Cited by 24
Patterns of sequence conservation in presynaptic neural genes
Hadley, D., Murphy, T., Valladares, O., Hannenhalli, S. S., Ungar, L., Kim, J., & Bućan, M. (2006) · Genome biology · doi:10.1186/gb-2006-7-11-r105 · Cited by 26
Context-dependent splicing regulation
Ke, S., & Chasin, L. A. (2011) · RNA Biology · doi:10.4161/rna.8.3.14458 · Cited by 29
Alternative Splicing in CKD
Stevens, M., & Oltean, S. (2016) · Journal of the American Society of Nephrology · doi:10.1681/asn.2015080908 · Cited by 25
Precise Targeted Cleavage of a r(CUG) Repeat Expansion in Cells by Using a Small-Molecule–Deglycobleomycin Conjugate
Angelbello, A. J., DeFeo, M. E., Glinkerman, C. M., Boger, D. L., & Disney, M. D. (2020) · ACS Chemical Biology · doi:10.1021/acschembio.0c00036 · Cited by 26
ExOrthist: a tool to infer exon orthologies at any evolutionary distance
Márquez, Y., Mantica, F., Cozzuto, L., Burguera, D., Hermoso, A., Ponomarenko, J. V., Roy, S. W., & Irimia, M. (2021) · Genome biology · doi:10.1186/s13059-021-02441-9 · Cited by 22
Bcl-x Pre-mRNA Splicing Regulates Brain Injury after Neonatal Hypoxia-Ischemia
Xiao, Q., Ford, A. L., Xu, J., Yan, P., Lee, K., Gonzales, E. R., West, T., Holtzman, D. M., & Lee, J. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2617-12.2012 · Cited by 24
TOX4 and NOVA1 Proteins Are Partners of the LEDGF PWWP Domain and Affect HIV-1 Replication
Morchikh, M., Naughtin, M., Nunzio, F. D., Xavier, J., Charneau, P., Jacob, Y., & Lavigne, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081217 · Cited by 27
Novel neuronal proteolipid protein isoforms encoded by the human myelin proteolipid protein 1 gene
Sarret, C., Combes, P., Micheau, P., Gélot, A., Boespflug‐Tanguy, O., & Vaurs‐Barrière, C. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.12.047 · Cited by 24
Evolutionary impact of limited splicing fidelity in mammalian genes
Zhang, C., Krainer, A. R., & Zhang, M. Q. (2007) · Trends in Genetics · doi:10.1016/j.tig.2007.08.001 · Cited by 24
NOVA1 promotes NSCLC proliferation and invasion by activating Wnt/β-catenin signaling
Qu, L., Tian, Y., Wang, F., & Li, Z. (2022) · BMC Cancer · doi:10.1186/s12885-022-10164-8 · Cited by 22
The Musashi proteins MSI1 and MSI2 are required for photoreceptor morphogenesis and vision in mice
Sundar, J. C., Matalkah, F. K., Jeong, B., Stoilov, P., & Ramamurthy, V. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.015714 · Cited by 23
Regulation of mammalian pre-mRNA splicing
Hui, J. (2009) · Science in China Series C Life Sciences · doi:10.1007/s11427-009-0037-0 · Cited by 25
Whole transcriptome RNA sequencing data from blood leukocytes derived from Parkinson's disease patients prior to and following deep brain stimulation treatment
Soreq, L., Salomonis, N., Guffanti, A., Bergman, H., Israel, Z. H., & Soreq, H. (2014) · Genomics Data · doi:10.1016/j.gdata.2014.11.009 · Cited by 23
Loss-of-function mutation in PRMT9 causes abnormal synapse development by dysregulation of RNA alternative splicing
Shen, L., Ma, X., Wang, Y., Wang, Z., Zhang, Y., Pham, H. Q. H., Tao, X., Cui, Y., Wei, J., Lin, D., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-47107-9 · Cited by 23
From single splicing events to thousands: the ambiguous step forward in splicing research
Buratti, E., Baralle, M., & Baralle, F. E. (2012) · Briefings in Functional Genomics · doi:10.1093/bfgp/els048 · Cited by 22
Postmortem brain tissue as an underutilized resource to study the molecular pathology of neuropsychiatric disorders across different ethnic populations
Vornholt, E., Luo, D., Qiu, W., McMichael, G. O., Liu, Y., Gillespie, N. A., Ma, C., & Vladimirov, V. I. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.04.015 · Cited by 23
Genome-Wide Activities of RNA Binding Proteins That Regulate Cellular Changes in the Epithelial to Mesenchymal Transition (EMT)
Bebee, T. W., Cieply, B. W., & Carstens, R. P. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-1221-6_8 · Cited by 23
Functional and Mechanistic Insights From Genome-Wide Studies of Splicing Regulation in the Brain
Ule, J., & Darnell, R. B. (2007) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-77374-2_9 · Cited by 21
Self-citation
Cell type-specific CLIP reveals that NOVA regulates cytoskeleton interactions in motoneurons
Yuan, Y., Xie, S., Darnell, J. C., Darnell, A., Saito, Y., Phatnani, H. P., Murphy, E. A., Zhang, C., Maniatis, T., & Darnell, R. B. (2018) · Genome biology · doi:10.1186/s13059-018-1493-2 · Cited by 21
Self-citation
Duplicated Gephyrin Genes Showing Distinct Tissue Distribution and Alternative Splicing Patterns Mediate Molybdenum Cofactor Biosynthesis, Glycine Receptor Clustering, and Escape Behavior in Zebrafish
Ogino, K., Ramsden, S. L., Keib, N., Schwarz, G., Harvey, R. J., & Hirata, H. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.125500 · Cited by 21
Integrating many co-splicing networks to reconstruct splicing regulatory modules
Dai, C., Li, W., Liu, J., & Zhou, X. J. (2012) · BMC Systems Biology · doi:10.1186/1752-0509-6-s1-s17 · Cited by 20
Reverse engineering human neurodegenerative disease using pluripotent stem cell technology
Liu, Y., & Deng, W. (2015) · Brain Research · doi:10.1016/j.brainres.2015.09.023 · Cited by 23
Splicing in the Human Brain
Zaghlool, A., Ameur, A., Cavelier, L. B., & Feuk, L. (2014) · International review of neurobiology · doi:10.1016/b978-0-12-801105-8.00005-9 · Cited by 22

Authors: Ule, J., Ule, A., Spencer, J., Williams, A., Hu, J.-S., Cline, M., Wang, H., Clark, T., Fraser, C., Ruggiu, M., Zeeberg, B. R., Kane, D., Weinstein, J. N., Blume, J., & Darnell, R. B.
Affiliations: Howard Hughes Medical Institute (US)
University of Amsterdam (NL)
Affymetrix (United States) (US)
SRA International (United States) (US)
National Institutes of Health (US)
Corresponding author: Darnell, Robert B
ORCID: Ule, Jernej
Ule, Aljaž
Cline, Melissa
Wang, Hui
Clark, Tyson
Ruggiu, Matteo
Kane, David
Weinstein, John N
Blume, John
Darnell, Robert B
Venue: Nature Genetics
Publisher: Springer Science and Business Media LLC
Published: 2005-07-24
Volume: 37
Issue: 8
Pages: 844-852
ISSN: 1061-4036 (ISSN-L)
1546-1718
DOI: 10.1038/ng1610
OpenAlex: W2118823143
Cited by: 509
References: 49
Citations by year: 2026: 7 · 2025: 16 · 2024: 16 · 2023: 9 · 2022: 12 · 2021: 14 · 2020: 20 · 2019: 13 · 2018: 17 · 2017: 18 · 2016: 19 · 2015: 22 · 2014: 30 · 2013: 25 · 2012: 38
FWCI: 17.19
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Genetics (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: alternative splicing, synapses, neocortex, exon skipping, protein-protein interaction network, axon guidance, neurotransmitter receptors, cation channels, adhesion proteins, scaffold proteins, tissue-specific splicing
MeSH terms: Neuro-Oncological Ventral Antigen, Animals, Antigens, Neoplasm, Nerve Tissue Proteins, Synapses, RNA-Binding Proteins, Alternative Splicing, Mice, Knockout, Neocortex, Oligonucleotide Array Sequence Analysis, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Nova regulates brain-specific splicing to shape the synapse

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks