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Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells
Abstract
Interleukin 22 (IL-22) is a cytokine produced by the T(H)-17 lineage of helper T cells and NK-22 subset of natural killer cells that acts on epithelial cells and keratinocytes and has been linked to skin homeostasis and inflammation. Here we characterize a population of human skin-homing memory CD4(+) T cells that expressed the chemokine receptors CCR10, CCR6 and CCR4 and produced IL-22 but neither IL-17 nor interferon-gamma (IFN-gamma). Clones isolated from this population produced IL-22 only and had low or undetectable expression of the T(H)-17 and T helper type 1 (T(H)1) transcription factors RORgammat and T-bet. The differentiation of T cells producing only IL-22 was efficiently induced in naive T cells by plasmacytoid dendritic cells in an IL-6- and tumor necrosis factor-dependent way. Our findings delineate a previously unknown subset of human CD4(+) effector T cells dedicated to skin pathophysiology.
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“Th17 and Th22 subsets are pivotal to tackle extracellular pathogens, such as extracellular bacteria and fungi, and they both lack CXCR3 and express CCR6 and CCR4 [152-154].”
From Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) (2021) · cites this paper as [154]
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“However, Th17 can be distinguished by the expression of the killer-cell lectin-like receptor CD161 (KLRB1) [155,156], while Th22 expresses the skin-homing receptor CCR10 [154].”
From Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) (2021) · cites this paper as [154]
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Metadata
- Authors
- Duhen, T., Geiger, R., Jarrossay, D., Lanzavecchia, A., & Sallusto, F.
- Affiliations
- Institute for Research in Biomedicine (CH)
- Corresponding author
- Sallusto, Federica
- Venue
- Nature Immunology
- Published
- 2009-07-05
- Volume
- 10
- Issue
- 8
- Pages
- 857-863
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2082450021
- Cited by
- 1,079
- References
- 53
- Citations by year
- 2026: 14 · 2025: 18 · 2024: 29 · 2023: 48 · 2022: 38 · 2021: 53 · 2020: 64 · 2019: 45 · 2018: 66 · 2017: 68 · 2016: 76 · 2015: 79 · 2014: 111 · 2013: 96 · 2012: 95
- FWCI
- 39.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute for Health and Care Research
- European Commission
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- National Institutes of Health
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- IL-22, IL-17, CD4+ T cells, CCR10, CCR6, CCR4, RORγ, T-bet, plasmacytoid dendritic cells, interleukin-6, TNF-α, T cell differentiation, skin inflammation, keratinocytes
- MeSH terms
- Interleukin-22, T-bet Transcription Factor, Cell Differentiation, T-Lymphocytes, Helper-Inducer, Humans, Immunologic Memory, Interleukins, Receptors, Thyroid Hormone, Skin, CD4-Positive T-Lymphocytes, T-Lymphocyte Subsets, Receptors, Retinoic Acid, Interleukin-17, T-Box Domain Proteins, Receptors, CCR4, Receptors, CCR6, Receptors, CCR10, Nuclear Receptor Subfamily 1, Group F, Member 3, In Vitro Techniques
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