Cited by 1,079Psoriasis: Treatment and PathogenesisT-cell and B-cell ImmunologyDermatology and Skin Diseases

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Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells

Duhen, Thomas, Geiger, Rebekka, Jarrossay, David, Lanzavecchia, Antonio, Sallusto, Federica·2009·Nature Immunology

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Abstract

Interleukin 22 (IL-22) is a cytokine produced by the T(H)-17 lineage of helper T cells and NK-22 subset of natural killer cells that acts on epithelial cells and keratinocytes and has been linked to skin homeostasis and inflammation. Here we characterize a population of human skin-homing memory CD4(+) T cells that expressed the chemokine receptors CCR10, CCR6 and CCR4 and produced IL-22 but neither IL-17 nor interferon-gamma (IFN-gamma). Clones isolated from this population produced IL-22 only and had low or undetectable expression of the T(H)-17 and T helper type 1 (T(H)1) transcription factors RORgammat and T-bet. The differentiation of T cells producing only IL-22 was efficiently induced in naive T cells by plasmacytoid dendritic cells in an IL-6- and tumor necrosis factor-dependent way. Our findings delineate a previously unknown subset of human CD4(+) effector T cells dedicated to skin pathophysiology.

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Trifari, S., Kaplan, C.D., Tran, E.H., Crellin, N.K. & Spitz, H. Identification of a human helper T cell population that produces abundant IL-22 and is distinct from TH-17, TH1 and TH2 cells. Nat. Immunol. advance online publication, doi:10.1038/ni1770 (5 July 2009). · DOI

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Authors: Duhen, T., Geiger, R., Jarrossay, D., Lanzavecchia, A., & Sallusto, F.
Affiliations: Institute for Research in Biomedicine (CH)
Corresponding author: Sallusto, Federica
ORCID: Duhen, Thomas
Jarrossay, David
Lanzavecchia, Antonio
Sallusto, Federica
Venue: Nature Immunology
Publisher: Springer Science and Business Media LLC
Published: 2009-07-05
Volume: 10
Issue: 8
Pages: 857-863
ISSN: 1529-2908 (ISSN-L)
1529-2916
DOI: 10.1038/ni.1767
OpenAlex: W2082450021
Cited by: 1,079
References: 53
Citations by year: 2026: 14 · 2025: 18 · 2024: 29 · 2023: 48 · 2022: 38 · 2021: 53 · 2020: 64 · 2019: 45 · 2018: 66 · 2017: 68 · 2016: 76 · 2015: 79 · 2014: 111 · 2013: 96 · 2012: 95
FWCI: 39.09
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute for Health and Care Research
European Commission
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
National Institutes of Health
Topics: Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Keywords: IL-22, IL-17, CD4+ T cells, CCR10, CCR6, CCR4, RORγ, T-bet, plasmacytoid dendritic cells, interleukin-6, TNF-α, T cell differentiation, skin inflammation, keratinocytes
MeSH terms: Interleukin-22, T-bet Transcription Factor, Cell Differentiation, T-Lymphocytes, Helper-Inducer, Humans, Immunologic Memory, Interleukins, Receptors, Thyroid Hormone, Skin, CD4-Positive T-Lymphocytes, T-Lymphocyte Subsets, Receptors, Retinoic Acid, Interleukin-17, T-Box Domain Proteins, Receptors, CCR4, Receptors, CCR6, Receptors, CCR10, Nuclear Receptor Subfamily 1, Group F, Member 3, In Vitro Techniques

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Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells

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