The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation
Open accessAbstract
The organization and dynamics of receptors and other molecules in the plasma membrane are not well understood. Here we analyzed the spatio-temporal dynamics of T cell antigen receptor (TCR) complexes and linker for activation of T cells (Lat), a key adaptor molecule in the TCR signaling pathway, in T cell membranes using high-speed photoactivated localization microscopy, dual-color fluorescence cross-correlation spectroscopy and transmission electron microscopy. In quiescent T cells, both molecules existed in separate membrane domains (protein islands), and these domains concatenated after T cell activation. These concatemers were identical to signaling microclusters, a prominent hallmark of T cell activation. This separation versus physical juxtapositioning of receptor domains and domains containing downstream signaling molecules in quiescent versus activated T cells may be a general feature of plasma membrane–associated signal transduction.
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Metadata
- Authors
- Lillemeier, B. F., Mörtelmaier, M. A., Forstner, M. B., Huppa, J. B., Groves, J. T., & Davis, M. M.
- Venue
- Nature Immunology
- Published
- 2009-12-13
- Volume
- 11
- Issue
- 1
- Pages
- 90-96
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2151497263
- Cited by
- 632
- References
- 41
- FWCI
- 20.24
- Type
- journal article
- Language
- en
- Open access
- green
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- Lillemeier, B. F., Mörtelmaier, M. A., Forstner, M. B., Huppa, J. B., Groves, J. T., & Davis, M. M. (2010). TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation. Nature Immunology. https://doi.org/10.1038/ni.1832
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