The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.
Nanoclustering as a dominant feature of plasma membrane organization
Open accessAbstract
Early studies have revealed that some mammalian plasma membrane proteins exist in small nanoclusters. The advent of super-resolution microscopy has corroborated and extended this picture, and led to the suggestion that many, if not most, membrane proteins are clustered at the plasma membrane at nanoscale lengths. In this Commentary, we present selected examples of glycosylphosphatidyl-anchored proteins, Ras family members and several immune receptors that provide evidence for nanoclustering. We advocate the view that nanoclustering is an important part of the hierarchical organization of proteins in the plasma membrane. According to this emerging picture, nanoclusters can be organized on the mesoscale to form microdomains that are capable of supporting cell adhesion, pathogen binding and immune cell-cell recognition amongst other functions. Yet, a number of outstanding issues concerning nanoclusters remain open, including the details of their molecular composition, biogenesis, size, stability, function and regulation. Notions about these details are put forth and suggestions are made about nanocluster function and why this general feature of protein nanoclustering appears to be so prevalent.
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Cites
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Direct observation of the nanoscale dynamics of membrane lipids in a living cell
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Actin, Spectrin, and Associated Proteins Form a Periodic Cytoskeletal Structure in Axons
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Cited by
The Lateral Organization and Mobility of Plasma Membrane Components
Jacobson, K., Liu, P., & Lagerholm, B. C. (2019) · Cell · doi:10.1016/j.cell.2019.04.018 · Cited by 268
Self-citationJoensuu, M., Syed, P., Saber, S. H., Lanoue, V., Wallis, T. P., Rae, J., Blum, A., Gormal, R. S., Small, C., Sanders, S., et al. (2023) · The EMBO Journal · doi:10.15252/embj.2022112095 · Cited by 34
Erazo-Oliveras, A., Muñoz-Vega, M., Mlih, M., Thiriveedi, V., Salinas, M. L., Rivera-Rodríguez, J. M., Kim, E., Wright, R. C., Wang, X., Landrock, K. K., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39640-w · Cited by 27
Metadata
- Authors
- Garcia-Parajo, M. F., Cambi, A., Torreno-Pina, J. A., Thompson, N., & Jacobson, K.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2014-12-01
- Volume
- 127
- Issue
- 23
- Pages
- 4995-5005
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W2157246740
- Cited by
- 284
- References
- 74
- FWCI
- 7.79
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Garcia-Parajo, M. F., Cambi, A., Torreno-Pina, J. A., Thompson, N., & Jacobson, K. (2014). Nanoclustering as a dominant feature of plasma membrane organization. Journal of Cell Science. https://doi.org/10.1242/jcs.146340
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
