The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer
Open accessAbstract
In atherosclerosis and Alzheimer's disease, deposition of the altered self components oxidized low-density lipoprotein (LDL) and amyloid-beta triggers a protracted sterile inflammatory response. Although chronic stimulation of the innate immune system is believed to underlie the pathology of these diseases, the molecular mechanisms of activation remain unclear. Here we show that oxidized LDL and amyloid-beta trigger inflammatory signaling through a heterodimer of Toll-like receptors 4 and 6. Assembly of this newly identified heterodimer is regulated by signals from the scavenger receptor CD36, a common receptor for these disparate ligands. Our results identify CD36-TLR4-TLR6 activation as a common molecular mechanism by which atherogenic lipids and amyloid-beta stimulate sterile inflammation and suggest a new model of TLR heterodimerization triggered by coreceptor signaling events.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Stewart and colleagues demonstrated that Aβ-mediated release of proinflammatory factors and neurotoxicity partially involved signaling through the CD36/ TLR4/TRL6 complex (108).”
From Microglia in Alzheimer's disease (2017) · cites this paper as [108]
In the citing paper
“CD36 mediates heterodimer formation of TLR4 and TLR6 (REF. 104), and this co-receptor complex upregulates the production of chemokines and cytokines such as pro-IL-1β through the activation of NF-κb.”
From Sterile inflammation: sensing and reacting to damage (2010) · cites this paper as [105]
In the citing paper
“The Soluble Aβ oligomers and Aβ fibrils can react to various receptors expressed by microglia, including CD14, CD36, CD47, α6β1 integrin, class A scavenger receptor, receptor for advanced glycosylation end products (RAGE) and TLRs (Stewart et al., 2010).”
From The role of microglia in retinal neurodegeneration: Alzheimer’s disease, parkinson, and glaucoma. (2017) · cites this paper as Stewart et al., 2010
In the citing paper
“The binding of Aβ to CD36 (cell surface microglial co-receptor) promotes the TLR4 and/or TLR6 phosphorylation and activation, resulting in the production of inflammatory cytokines and chemokines (Stewart et al., 2010).”
From The role of microglia in retinal neurodegeneration: Alzheimer’s disease, parkinson, and glaucoma. (2017) · cites this paper as Stewart et al., 2010
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Atherosclerosis--an inflammatory disease
Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725
Akira, S., & Takeda, K. (2004) · Nature reviews. Immunology · doi:10.1038/nri1391 · Cited by 8,312
Recognition of microorganisms and activation of the immune response
Medzhitov, R. (2007) · Nature · doi:10.1038/nature06246 · Cited by 2,862
The NALP3 inflammasome is involved in the innate immune response to amyloid-β
Halle, A., Hornung, V., Petzold, G. C., Stewart, C. R., Monks, B. G., Reinheckel, T., Fitzgerald, K. A., Latz, E., Moore, K. J., & Golenbock, D. T. (2008) · Nature Immunology · doi:10.1038/ni.1636 · Cited by 2,441
Self-citationOzinsky, A., Underhill, D. M., Fontenot, J. D., Hajjar, A. M., Smith, K. D., Wilson, C. B., Schroeder, L. A., & Aderem, A. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.250476497 · Cited by 2,086
Collaborative Induction of Inflammatory Responses by Dectin-1 and Toll-like Receptor 2
Gantner, B. N., Simmons, R. M., Canavera, S. J., Akira, S., & Underhill, D. M. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021787 · Cited by 1,682
TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β
Kagan, J. C., Su, T., Horng, T., Chow, A. Y., Akira, S., & Medzhitov, R. M. (2008) · Nature Immunology · doi:10.1038/ni1569 · Cited by 1,310
Wyss-Coray (2006) · doi:10.1038/nm1484 · Cited by 1,284
Immortalization of murine microglial cells by a v-raf / v-myc carrying retrovirus
Blasi, E., Barluzzi, R., Bocchini, V., Mazzolla, R., & Bistoni, F. (1990) · Journal of Neuroimmunology · doi:10.1016/0165-5728(90)90073-v · Cited by 1,076
Kunjathoor, V., Febbraio, M., Podrez, E., Moore, K., Andersson, L., Koehn, S. L., Rhee, J. S., Silverstein, R., Hoff, H., & Freeman, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m209649200 · Cited by 1,064
Self-citation
Cited by
Sorted by citations
Items 401–500 of 1,001
Baranova, I. N., Vishnyakova, T. G., Bocharov, A. V., Leelahavanichkul, A., Kurlander, R. J., Chen, Z., Souza, A. C. P., Yuen, P. S. T., Star, R. A., Csákó, G., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100350 · Cited by 84
IRF2BP2 Reduces Macrophage Inflammation and Susceptibility to Atherosclerosis
Chen, H.-H., Keyhanian, K., Zhou, X., Vilmundarson, R. O., Almontashiri, N. A. M., Cruz, S. A., Pandey, N. R., Lerma Yap, N., Ho, T., Stewart, C. A., et al. (2015) · Circulation Research · doi:10.1161/circresaha.114.305777 · Cited by 91
Self-citationJukema, R., Ahmed, T. A.-H. N., & Tardif, J. (2019) · BMC Medicine · doi:10.1186/s12916-019-1433-3 · Cited by 82
Thomas, L. M., & Salter, R. D. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001231 · Cited by 86
Kochan, T. J., Singla, A., Tosi, J., & Kumar, A. (2012) · Infection and Immunity · doi:10.1128/iai.00149-12 · Cited by 81
Exosomes in immunoregulation of chronic lung diseases
Hough, K. P., Chanda, D., Duncan, S. R., Thannickal, V. J., & Deshane, J. S. (2016) · Allergy · doi:10.1111/all.13086 · Cited by 83
Koulis, C., Chen, Y., Hausding, C., Ahrens, I., Kyaw, T. S., Tay, C., Allen, T. J., Jandeleit-Dahm, K. A. M., Sweet, M. J., Akira, S., et al. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.302407 · Cited by 80
An update on the interactions between Alzheimer's disease, autophagy and inflammation
Bostancıklıoğlu, M. (2019) · Gene · doi:10.1016/j.gene.2019.04.040 · Cited by 78
Nuclear Receptors in the Control of the NLRP3 Inflammasome Pathway
Duez, H., & Pourcet, B. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.630536 · Cited by 85
The Links between Cardiovascular Diseases and Alzheimer's Disease
Leszek, J., Вячеславовна, М. Е., Belousov, D. M., Koutsouraki, E., Szczechowiak, K., Kobusiak−Prokopowicz, M., Mysiak, A., Diniz, B. S., Somasundaram, S. G., Kirkland, C. E., et al. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200729093724 · Cited by 93
Lin, J., Shou, X., Mao, X., Dong, J., Mohabeer, N., Kushwaha, K. K., Wang, L., Su, Y., Fang, H., & Li, D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062148 · Cited by 79
Microglia as a critical player in both developmental and late-life CNS pathologies
Derecki, N. C., Katzmarski, N., Kipnis, J., & Meyer-Luehmann, M. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1321-z · Cited by 78
Garcia-Bonilla, L., Racchumi, G., Murphy, M., Anrather, J., & Iadecola, C. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.2980-15.2015 · Cited by 77
TLR5 decoy receptor as a novel anti-amyloid therapeutic for Alzheimer’s disease
Chakrabarty, P., Li, A., Ladd, T. B., Strickland, M. R., Koller, E. J., Burgess, J. D., Funk, C. C., Cruz, P. E., Allen, M., Yaroshenko, M., et al. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20180484 · Cited by 80
Komleva, Y. K., Chernykh, A., Lopatina, O. L., Gorina, Y. V., Lokteva, I., Salmina, A. B., & Gollasch, M. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.618395 · Cited by 83
The TREM2-DAP12 signaling pathway in Nasu–Hakola disease: a molecular genetics perspective
Humphrey, M. B., Xing, J., & Titus, A. (2015) · Research and Reports in Biochemistry · doi:10.2147/rrbc.s58057 · Cited by 77
S100 proteins in cartilage: Role in arthritis
Yammani, R. R. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.01.006 · Cited by 77
Role of Toll-Like Receptor 4 on Osteoblast Metabolism and Function
Alonso‐Pérez, A., Franco‐Trepat, E., Guillán‐Fresco, M., Mora, A. J., López, V., Pino, J., Gualillo, O., & Gómez, R. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00504 · Cited by 78
Fatty-acid-mediated hypothalamic inflammation and epigenetic programming
César, H., & Pisani, L. P. (2016) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2016.08.008 · Cited by 80
Cucchi, D., Camacho‐Muñoz, D., Certo, M., Pucino, V., Nicolaou, A., & Mauro, C. (2020) · Cell Stress · doi:10.15698/cst2020.01.209 · Cited by 78
Modified Lipoproteins Induce Arterial Wall Inflammation During Atherogenesis
Lorey, M. B., Öörni, K., & Kovanen, P. T. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.841545 · Cited by 82
Targeting Toll-like receptors: Emerging therapeutics for multiple sclerosis management
Gambuzza, M. E., Licata, N., Palella, E., Celi, D., Cuzzola, V. F., Italiano, D., Marino, S., & Bramanti, P. (2011) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2011.08.010 · Cited by 78
Isolated Amyloid-β(1–42) Protofibrils, But Not Isolated Fibrils, Are Robust Stimulators of Microglia
Paranjape, G. S., Gouwens, L. K., Osborn, D. C., & Nichols, M. R. (2012) · ACS Chemical Neuroscience · doi:10.1021/cn2001238 · Cited by 79
Nicholls, H. T., Kowalski, G. M., Kennedy, D. J., Risis, S., Zaffino, L. A., Watson, N., Kanellakis, P., Watt, M. J., Bobik, A., Bonen, A., et al. (2011) · Diabetes · doi:10.2337/db10-1353 · Cited by 79
The effect of oxidized phospholipids on phenotypic polarization and function of macrophages
Serbulea, V., DeWeese, D. E., & Leitinger, N. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.02.035 · Cited by 79
PUFA-Induced Metabolic Enteritis as a Fuel for Crohn’s Disease
Schwärzler, J., Mayr, L., Vila, A. V., Grabherr, F., Niederreiter, L., Philipp, M., Grander, C., Meyer, M., Jukic, A., Tröger, S., et al. (2022) · Gastroenterology · doi:10.1053/j.gastro.2022.01.004 · Cited by 82
Immune Activation in Alzheimer Disease
Mary, A., Mancuso, R., & Heneka, M. T. (2024) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101921-035222 · Cited by 82
Hyperlipidemia, tissue factor, coagulation, and simvastatin
Owens, A. P., Byrnes, J. R., & Mackman, N. (2013) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2013.07.003 · Cited by 78
Efficacy and mechanism of cGAMP to suppress Alzheimer’s disease by elevating TREM2
Xu, Q., Xu, W., Cheng, H., Yuan, H., & Tan, X. (2019) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2019.07.004 · Cited by 75
Das, R. C., Rauf, A., Akhter, S., Islam, M. N., Emran, T. B., Mitra, S., Khan, I. N., & Mubarak, M. S. (2021) · Molecules · doi:10.3390/molecules26123696 · Cited by 79
de Almeida, P. E., Roque, N. R., Magalhães, K. G., Mattos, K. A., Teixeira, L., Maya‐Monteiro, C. M., de Almeida, C. J. G., Castro-Faria-Neto, H. C., Ryffel, B., Quesniaux, V. F. J., et al. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.10.008 · Cited by 75
Gruber, S., Hendrikx, T., Tsiantoulas, D., Ozsvár-Kozma, M., Göderle, L., Mallat, Z., Witztum, J. L., Shiri‐Sverdlov, R., Nitschke, L., & Binder, C. J. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.02.027 · Cited by 75
Biswas, S., Zimman, A., Gao, D., Byzova, T. V., & Podrez, E. A. (2017) · Circulation Research · doi:10.1161/circresaha.117.311069 · Cited by 77
Macrophage Autophagy in Atherosclerosis
Maiuri, M. C., Grassia, G., Platt, A. M., Carnuccio, R., Ialenti, A., & Maffia, P. (2013) · Mediators of Inflammation · doi:10.1155/2013/584715 · Cited by 72
Poon, C. H., Wang, Y., Fung, M., Zhang, C., & Lim, L. W. (2020) · Aging and Disease · doi:10.14336/ad.2019.1026 · Cited by 76
Complement System in Alzheimer’s Disease
Shah, A., Kishore, U., & Shastri, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413647 · Cited by 76
The IRG1–itaconate axis protects from cholesterol-induced inflammation and atherosclerosis
Cyr, Y., Bozal, F. K., Durán, J. G. B., Newman, A. A. C., Amadori, L., Smyrnis, P., Gourvest, M., Das, D., Gildea, M. A., Kaur, R., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2400675121 · Cited by 79
Self-citationCarcinoma cells misuse the host tissue damage response to invade the brain
Chuang, H., van Rossum, D., Sieger, D., Siam, L., Klemm, F., Bleckmann, A., Bayerlová, M., Farhat, K., Scheffel, J., Schulz, M., et al. (2013) · Glia · doi:10.1002/glia.22518 · Cited by 74
CD36 initiates the secretory phenotype during the establishment of cellular senescence
Chong, M., Yin, T., Chen, R., Xiang, H., Yuan, L., Ding, Y., Pan, C. C., Tang, Z., Alexander, P. B., Li, Q., et al. (2018) · EMBO Reports · doi:10.15252/embr.201745274 · Cited by 76
The Contribution of Cholesterol and Its Metabolites to the Pathophysiology of Breast Cancer
Baek, A. E., & Nelson, E. R. (2016) · Hormones and Cancer · doi:10.1007/s12672-016-0262-5 · Cited by 71
Dodd, C. E., Pyle, C. J., Glowinski, R. M., Rajaram, M. V. S., & Schlesinger, L. S. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600856 · Cited by 74
Role of pyruvate kinase M2 in oxidized LDL-induced macrophage foam cell formation and inflammation
Kumar, A., Gupta, P., Rana, M., Chandra, T., Dikshit, M., & Barthwal, M. K. (2020) · Journal of Lipid Research · doi:10.1194/jlr.ra119000382 · Cited by 75
Lee, E. Y., Srinivasan, Y., de Anda, J., Nicastro, L. K., Tükel, Ç., & Wong, G. C. L. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01629 · Cited by 70
DAMPs and Innate Immune Training
Jentho, E., & Weis, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.699563 · Cited by 73
Solbakken, M. H., Tørresen, O. K., Nederbragt, A. J., Seppola, M., Gregers, T. F., Jakobsen, K. S., & Jentoft, S. (2016) · Scientific Reports · doi:10.1038/srep25211 · Cited by 72
Microglia Ontology and Signaling
ElAli, A., & Rivest, S. (2016) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2016.00072 · Cited by 75
CD36 signaling in vascular redox stress
Yang, M., & Silverstein, R. L. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.02.021 · Cited by 76
Singh, R. K., Haka, A. S., Asmal, A., Barbosa-Lorenzi, V. C., Grosheva, I., Chin, H. F., Xiong, Y., Hla, T., & Maxfield, F. R. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.313200 · Cited by 74
Finding a Toll on the Route: The Fate of Osteoclast Progenitors After Toll-Like Receptor Activation
Souza, P. P. C., & Lerner, U. H. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01663 · Cited by 67
“Thus, TLR4, as an example, can recognize MAMPs such as lipopolysaccharide LPS (41) and lipid A (42), as well as DAMPs such as serum amyloid A (43), S100A8/S100A9 (44), oxidized low-density lipoprotein and amyloid β (45), in addition to several other MAMPs and DAMPs.”
BackgroundZhao, J. Z., Cai, B., Shao, Z., Zhang, L., Zheng, Y., Ma, C., Yi, F., Liu, B., & Gao, C. (2021) · Cell Death and Differentiation · doi:10.1038/s41418-021-00803-1 · Cited by 73
Thrombospondin 1 activates the macrophage Toll-like receptor 4 pathway
Li, Y., Qi, X., Tong, X., & Wang, S. (2013) · Cellular and Molecular Immunology · doi:10.1038/cmi.2013.32 · Cited by 72
Atheroprotective effects of conjugated linoleic acid
Bruen, R., Fitzsimons, S., & Belton, O. (2016) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12948 · Cited by 71
Pattern recognition receptor‐mediated inflammation in diabetic vascular complications
Wang, X., Antony, V., Wang, Y., Wu, G., & Liang, G. (2020) · Medicinal Research Reviews · doi:10.1002/med.21711 · Cited by 73
Macrophage SR-BI regulates LPS-induced pro-inflammatory signaling in mice and isolated macrophages
Cai, L., Wang, Z., Meyer, J. M., Ji, A., & van der Westhuyzen, D. R. (2012) · Journal of Lipid Research · doi:10.1194/jlr.m023234 · Cited by 76
The renaissance of lipoprotein(a): Brave new world for preventive cardiology?
Ellis, K. L., Boffa, M. B., Sahebkar, A., Koschinsky, M. L., & Watts, G. F. (2017) · Progress in Lipid Research · doi:10.1016/j.plipres.2017.09.001 · Cited by 71
Microglia Receptors in Animal Models of Traumatic Brain Injury
Younger, D., Murugan, M., Rao, K. V. R., Wu, L., & Chandra, N. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1428-7 · Cited by 69
Molecular mechanism of action responsible for carrageenan-induced inflammatory response
Myers, M. J., Deaver, C. M., & Lewandowski, A. (2019) · Molecular Immunology · doi:10.1016/j.molimm.2019.02.020 · Cited by 70
Toll-like receptors in Alzheimer's disease
Momtazmanesh, S., Perry, G. L., & Rezaei, N. (2020) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2020.577362 · Cited by 73
He, P., Gelissen, I. C., & Ammit, A. J. (2020) · Respiratory Research · doi:10.1186/s12931-020-01515-9 · Cited by 72
Kapétanovic, R., Bokil, N. J., & Sweet, M. J. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.02.005 · Cited by 70
Bi, W., Li, D.-X., Xu, Y., Xu, S., Li, J., Zhao, X., & Wang, J. (2015) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2015.02.001 · Cited by 72
Zhou, M.-S., Chadipiralla, K., Mendez, A. J., Jaimes, E. A., Silverstein, R. L., Webster, K. A., & Raij, L. R. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00042.2013 · Cited by 78
Sharif, O., Matt, U., Saluzzo, S., Lakovits, K., Haslinger, I., Furtner, T., Doninger, B., & Knapp, S. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202270 · Cited by 68
Molecular and genetic inflammation networks in major human diseases
Zhao, Y., Forst, C. V., Sayegh, C. E., Wang, I., Yang, X., & Zhang, B. (2016) · Molecular BioSystems · doi:10.1039/c6mb00240d · Cited by 72
Frederiksen, H. R., Haukedal, H., & Freude, K. (2019) · BioMed Research International · doi:10.1155/2019/7420189 · Cited by 63
The innate immune system in Alzheimer's disease
Boutajangout, A., & Wisniewski, T. (2013) · International Journal of Cell Biology · doi:10.1155/2013/576383 · Cited by 69
Neuroimmune contributions to Alzheimer’s disease: a focus on human data
Haage, V., & De Jager, P. L. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01637-0 · Cited by 74
Parks, B. W., Black, L. L., Zimmerman, K. A., Metz, A. E., Steele, C. H., Murphy-Ullrich, J. E., & Kabarowski, J. H. S. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m035352 · Cited by 69
Transfusion-Related Acute Lung Injury: The Work of DAMPs*
Land, W. G. (2013) · Transfusion Medicine and Hemotherapy · doi:10.1159/000345688 · Cited by 69
Malondialdehyde epitopes are sterile mediators of hepatic inflammation in hypercholesterolemic mice
Busch, C. J., Hendrikx, T., Weismann, D., Jäckel, S., Walenbergh, S. M. A., Rendeiro, A. F., Weißer, J., Puhm, F., Hladik, A., Göderle, L., et al. (2016) · Hepatology · doi:10.1002/hep.28970 · Cited by 69
Cellular and Molecular Mediators of Neuroinflammation in Alzheimer Disease
Yang, S. (2019) · International Neurourology Journal · doi:10.5213/inj.1938184.092 · Cited by 72
Regen, T., van Rossum, D., Scheffel, J., Kastriti, M. E., Revelo, N. H., Prinz, M., Brück, W., & Hanisch, U. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.10.009 · Cited by 70
Huang, Q., & Pope, R. M. (2010) · Journal of Leukocyte Biology · doi:10.1189/jlb.0310126 · Cited by 69
Cao, D., Luo, J., Chen, D., Xu, H., Shi, H., Jing, X., & Zang, W. (2016) · Scientific Reports · doi:10.1038/srep23132 · Cited by 72
Microglial LOX-1 reacts with extracellular HSP60 to bridge neuroinflammation and neurotoxicity
Zhang, D., Sun, L., Zhu, H., Wang, L., Wu, W., Xie, J., & Gu, J. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.07.019 · Cited by 67
Dehn, S., & Thorp, E. B. (2017) · The FASEB Journal · doi:10.1096/fj.201700450r · Cited by 68
Bifurcation of signalling in human innate immune pathways to NF-kB and IRF family activation
Kusiak, A., & Brady, G. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115246 · Cited by 68
Myeloid cells in atherosclerosis
Koltsova, E. K., Hedrick, C. C., & Ley, K. F. (2013) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e328363d298 · Cited by 69
The Biphasic Role of Microglia in Alzheimer's Disease
Mizuno, T. (2012) · International Journal of Alzheimer s Disease · doi:10.1155/2012/737846 · Cited by 73
Proatherogenic Macrophage Activities Are Targeted by the Flavonoid Quercetin
Lara-Guzmán, O. J., Tabares-Guevara, J. H., León-Varela, Y. M., Álvarez, R., Roldán, M., Sierra, J. A., Londoño‐Londoño, J., & Ramírez‐Pineda, J. R. (2012) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.112.196147 · Cited by 67
Neuroinflammation in Alzheimer's disease: an understanding of physiology and pathology
Obulesu, M., & Jhansilakshmi, M. (2013) · International Journal of Neuroscience · doi:10.3109/00207454.2013.831852 · Cited by 66
Microglial toll-like receptors and Alzheimer’s disease
Su, F., Bai, F., Zhou, H., & Zhang, Z. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.10.010 · Cited by 69
Cui, Y., Wang, Y., Zhao, D., Feng, X., Zhang, L., & Liu, C. (2018) · Cell Biology International · doi:10.1002/cbin.11060 · Cited by 68
Adorni, M. P., Ruscica, M., Ferri, N., Bernini, F., & Zimetti, F. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00120 · Cited by 67
Role of Plant-Derived Compounds in the Molecular Pathways Related to Inflammation
Olędzka, A. J., & Czerwińska, M. E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054666 · Cited by 74
Trained innate immunity and atherosclerosis
Bekkering, S., Joosten, L. A. B., van der Meer, J. W. M., Netea, M. G., & Riksen, N. P. (2013) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000023 · Cited by 66
High glucose induces upregulation of scavenger receptors and promotes maturation of dendritic cells
Lu, H., Yao, K., Huang, D., Sun, A., Zou, Y., Qian, J., & Ge, J. (2013) · Cardiovascular Diabetology · doi:10.1186/1475-2840-12-80 · Cited by 66
Urrutia, P. J., Hirsch, É. C., González-Billault, C. E., & Núñez, M. T. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14005 · Cited by 68
Therapeutic Potential of Ursolic Acid to Manage Neurodegenerative and Psychiatric Diseases
Ramos-Hryb, A. B., Pazini, F. L., Kaster, M. P., & Rodrigues, A. L. S. (2017) · CNS Drugs · doi:10.1007/s40263-017-0474-4 · Cited by 66
Håversen, L., Sundelin, J. P., Mardinoğlu, A., Rutberg, M., Ståhlman, M., Wilhelmsson, U., Hultén, L. M., Pekny, M., Fogelstrand, P., Bentzon, J. F., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-34659-2 · Cited by 64
Chen, T., Huang, W., Qian, J., Luo, W., Shan, P., Cai, Y., Lin, K., Wu, G., & Liang, G. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.102706 · Cited by 67
Metabolic Regulation of Glia and Their Neuroinflammatory Role in Alzheimer's Disease
Kumari, P., Sood, A., & Fernandes, V. (2021) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-021-01147-7 · Cited by 68
The Epigenetic Memory of Monocytes and Macrophages as a Novel Drug Target in Atherosclerosis
Bekkering, S., Joosten, L. A. B., van der Meer, J. W. M., Netea, M. G., & Riksen, N. P. (2015) · Clinical Therapeutics · doi:10.1016/j.clinthera.2015.01.008 · Cited by 65
Neuroinflammation and Copper in Alzheimer’s Disease
Choo, X. Y., Alukaidey, L., White, A. R., & Grubman, A. (2013) · International Journal of Alzheimer s Disease · doi:10.1155/2013/145345 · Cited by 70
CD36 Deficiency Impairs the Small Intestinal Barrier and Induces Subclinical Inflammation in Mice
Cifarelli, V., Ivanov, S., Xie, Y., Son, N.-H., Saunders, B. T., Pietka, T., Shew, T. M., Yoshino, J., Sundaresan, S., Davidson, N., et al. (2016) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2016.09.001 · Cited by 65
Modulation of β-Amyloid Fibril Formation in Alzheimer’s Disease by Microglia and Infection
Brown, M. R., Radford, S. E., & Hewitt, E. W. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.609073 · Cited by 67
Guillou, A., Troha, K., Wang, H., Franc, N. C., & Buchon, N. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005961 · Cited by 64
TLR4 inhibitor TAK-242 attenuates the adverse neural effects of diet-induced obesity
Moser, V. A., Uchoa, M. F., & Pike, C. J. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1340-0 · Cited by 65
Autophagy in neuroinflammatory diseases
Muller, S., Brun, S., René, F., Seze, J. D., Loeffler, J., & Jeltsch‐David, H. (2017) · Autoimmunity Reviews · doi:10.1016/j.autrev.2017.05.015 · Cited by 66
Targeting danger-associated molecular patterns after myocardial infarction
van Hout, G. P. J., Arslan, F., Pasterkamp, G., & Hoefer, I. E. (2015) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2016.1088005 · Cited by 67
Metadata
- Authors
- Stewart, C. R., Stuart, L. M., Wilkinson, K., van Gils, J. M., Deng, J., Halle, A., Rayner, K. J., Boyer, L., Zhong, R., Frazier, W. A., Lacy-Hulbert, A., Khoury, J. E., Golenbock, D. T., & Moore, K. J.
- Affiliations
- Harvard University (US)
- University of Massachusetts Chan Medical School (US)
- Washington University in St. Louis (US)
- Corresponding author
- Moore, Kathryn J
- ORCID
- Venue
- Nature Immunology
- Published
- 2009-12-27
- Volume
- 11
- Issue
- 2
- Pages
- 155-161
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- PMC
- PMC2809046
- OpenAlex
- W2045772297
- Cited by
- 1,513
- References
- 42
- Citations by year
- 2026: 53 · 2025: 69 · 2024: 107 · 2023: 74 · 2022: 108 · 2021: 96 · 2020: 102 · 2019: 97 · 2018: 99 · 2017: 94 · 2016: 98 · 2015: 108 · 2014: 81 · 2013: 92 · 2012: 104
- FWCI
- 33.44
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Wellcome Trust (068089)
- National Institute on Aging (R01AG20255, R01AG020255, R01AG032349)
- National Institute of Allergy and Infectious Diseases (R01AI079198)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK043351)
- National Institute of Neurological Disorders and Stroke (R01NS059005)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Keywords
- CD36, TLR4, TLR6, sterile inflammation, oxidized LDL, amyloid-beta, atherosclerosis, Alzheimer's disease, innate immune activation
- MeSH terms
- Animals, Cell Line, Humans, Inflammation, Lipoproteins, LDL, Mice, Inbred C57BL, Blotting, Western, Signal Transduction, Gene Expression, Amyloid beta-Peptides, Microglia, Mice, Knockout, Chemokines, CD36 Antigens, Reverse Transcriptase Polymerase Chain Reaction, Immunoprecipitation, Atherosclerosis, Toll-Like Receptor 4, Toll-Like Receptor 6, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
