The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88
Open accessAbstract
BAFF and APRIL are innate immune mediators that trigger immunoglobulin (Ig) G and IgA class switch recombination (CSR) in B cells by engaging the receptor TACI. The mechanism underlying CSR signaling by TACI remains unknown. Here, we found that the cytoplasmic domain of TACI encompasses a conserved motif that bound MyD88, an adaptor protein that activates NF-κB signaling pathways via a Toll-interleukin-1 receptor (TIR) domain. TACI lacks a TIR domain, yet triggered CSR via the DNA-editing enzyme AID by activating NF-κB through a TLR-like MyD88–IRAK-1-IRAK-4–TRAF6–TAK1 pathway. TACI-induced CSR was impaired in mice and humans lacking MyD88 or IRAK-4, indicating that MyD88 controls a B cell-intrinsic, TIR-independent, TACI-dependent pathway for Ig diversification.
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1 retracted
RETRACTED ARTICLE: DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL
Litinskiy, M. B., Nardelli, B., Hilbert, D. M., He, B., Schaffer, A., Casali, P., & Cerutti, A. (2002) · Nature Immunology · doi:10.1038/ni829 · Cited by 1,252
Self-citationRetractedTakeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141126 · Cited by 6,143
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MacLennan, I. C. M. (1994) · Annual Review of Immunology · doi:10.1146/annurev.immunol.12.1.117 · Cited by 1,729
Pyogenic Bacterial Infections in Humans with MyD88 Deficiency
von Bernuth, H., Picard, C., Jin, Z., Pankla, R., Xiao, H., Ku, C.-L., Chrabieh, M., Mustapha, I. B., Ghandil, P., Camcioglu, Y., et al. (2008) · Science · doi:10.1126/science.1158298 · Cited by 1,287
Self-citationThe CD40 Antigen and Its Ligand
Banchereau, J., Bazan, F., Blanchard, D., Brière, F., Galizzi, J., van Kooten, C., Liu, Y. J., Rousset, F., & Saeland, S. (1994) · Annual Review of Immunology · doi:10.1146/annurev.immunol.12.1.881 · Cited by 1,263
Mechanism and Regulation of Class Switch Recombination
Stavnezer, J., Guikema, J. E. J., & Schrader, C. E. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.26.021607.090248 · Cited by 1,132
TIRAP: an adapter molecule in the Toll signaling pathway
Horng, T., Barton, G. M., & Medzhitov, R. (2001) · Nature Immunology · doi:10.1038/ni0901-835 · Cited by 969
The Evolution of Adaptive Immune Systems
Cooper, M. D., & Alder, M. N. (2006) · Cell · doi:10.1016/j.cell.2006.02.001 · Cited by 873
Pyogenic Bacterial Infections in Humans with IRAK-4 Deficiency
Picard, C., Puel, A., Bonnet, M., Ku, C.-L., Bustamante, J., Yang, K., Soudais, C., Dupuis, S., Feinberg, J., Fieschi, C., et al. (2003) · Science · doi:10.1126/science.1081902 · Cited by 826
Self-citation
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Regulation of NF-κB by TNF family cytokines
Hayden, M. S., & Ghosh, S. (2014) · Seminars in Immunology · doi:10.1016/j.smim.2014.05.004 · Cited by 1,115
MyD88: a central player in innate immune signaling
Deguine, J., & Barton, G. M. (2014) · F1000Prime Reports · doi:10.12703/p6-97 · Cited by 692
B cell depletion therapies in autoimmune disease: advances and mechanistic insights
Lee, D. S. W., Rojas, O. L., & Gommerman, J. L. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-00092-2 · Cited by 658
Mucus Enhances Gut Homeostasis and Oral Tolerance by Delivering Immunoregulatory Signals
Shan, M., Gentile, M., Yeiser, J. R., Walland, A. C., Bornstein, V. U., Chen, K., He, B., Cassis, L., Bigas, A., Cols, M., et al. (2013) · Science · doi:10.1126/science.1237910 · Cited by 642
Self-citationOh, J. Z., Ravindran, R., Chassaing, B., Carvalho, F. A., Maddur, M. S., Bower, M., Hakimpour, P., Gill, K. P., Nakaya, H. I., Yarovinsky, F., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.08.009 · Cited by 541
Metadata
- Authors
- He, B., Santamaria, R., Xu, W., Cols, M., Chen, K., Puga, I., Shan, M., Xiong, H., Bussel, J. B., Chiu, A., Puel, A., Reichenbach, J., Marodi, L., Döffinger, R., Vasconcelos, J., Issekutz, A., Krause, J., Davies, G., Li, X., Grimbacher, B., Plebani, A., Meffre, E., Picard, C., Cunningham-Rundles, C., Casanova, J.-L., & Cerutti, A.
- Venue
- Nature Immunology
- Published
- 2010-08-01
- Volume
- 11
- Issue
- 9
- Pages
- 836-845
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2065152431
- Cited by
- 349
- References
- 52
- FWCI
- 9.75
- Type
- journal article
- Language
- en
- Open access
- green
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- He, B., Santamaria, R., Xu, W., Cols, M., Chen, K., Puga, I., Shan, M., Xiong, H., Bussel, J. B., Chiu, A., Puel, A., Reichenbach, J., Marodi, L., Döffinger, R., Vasconcelos, J., Issekutz, A., Krause, J., Davies, G., Li, X., . . . Cerutti, A. (2010). The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88. Nature Immunology. https://doi.org/10.1038/ni.1914
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