MyD88: a central player in innate immune signaling

Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway

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CpG Motifs in Bacterial DNA and Their Immune Effects

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Unresponsiveness of MyD88-deficient mice to endotoxin.

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Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function.

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MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways.

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Oncogenically active MYD88 mutations in human lymphoma

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Toll-like Receptor Signaling

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Toll-like receptors control activation of adaptive immune responses

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Crystal Structure of the TLR1-TLR2 Heterodimer Induced by Binding of a Tri-Acylated Lipopeptide

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Pyogenic Bacterial Infections in Humans with MyD88 Deficiency

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Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

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TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β

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MyD88: an adapter that recruits IRAK to the IL-1 receptor complex.

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TICAM-1, an adaptor molecule that participates in Toll-like receptor 3–mediated interferon-β induction

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IRAK (Pelle) Family Member IRAK-2 and MyD88 as Proximal Mediators of IL-1 Signaling

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Cutting Edge: TLR2-Deficient and MyD88-Deficient Mice Are Highly Susceptible to Staphylococcus aureus Infection1

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Helical Assembly in the MyD88-IRAK4-IRAK2 Complex in TLR/IL-1R Signalling

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TRAM is specifically involved in the Toll-like receptor 4–mediated MyD88-independent signaling pathway

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Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4

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TIRAP: an adapter molecule in the Toll signaling pathway

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Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6

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Human lupus autoantibody–DNA complexes activate DCs through cooperation of CD32 and TLR9

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Phosphoinositide-Mediated Adaptor Recruitment Controls Toll-like Receptor Signaling

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Structural basis for signal transduction by the Toll/interleukin-1 receptor domains

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The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors

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The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9

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Structural Basis of Toll-Like Receptor 3 Signaling with Double-Stranded RNA

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MyD88, an Adapter Protein Involved in Interleukin-1 Signaling

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Drosophila Toll and IL-1 receptor

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Crystal Structure of Human Toll-Like Receptor 3 (TLR3) Ectodomain

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Cutting Edge: MyD88 Is Required for Resistance to Toxoplasma gondii Infection and Regulates Parasite-Induced IL-12 Production by Dendritic Cells1

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The smallest known non-avian theropod dinosaur

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Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling

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Inhibition of Interleukin 1 Receptor/Toll-like Receptor Signaling through the Alternatively Spliced, Short Form of MyD88 Is Due to Its Failure to Recruit IRAK-4

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Expanding TRAF function: TRAF3 as a tri-faced immune regulator

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Ligand-induced conformational changes allosterically activate Toll-like receptor 9

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Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands

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An Oligomeric Signaling Platform Formed by the Toll-like Receptor Signal Transducers MyD88 and IRAK-4

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Infectious Diseases in Patients with IRAK-4, MyD88, NEMO, or IκBα Deficiency

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The molecular structure of the Toll-like receptor 3 ligand-binding domain

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Bifurcation of Toll-Like Receptor 9 Signaling by Adaptor Protein 3

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A comprehensive map of the toll‐like receptor signaling network

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Structural Reorganization of the Toll-Like Receptor 8 Dimer Induced by Agonistic Ligands

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The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88

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Noncanonical Autophagy Is Required for Type I Interferon Secretion in Response to DNA-Immune Complexes

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Dominant and recessive mutations define functional domains of Toll, a transmembrane protein required for dorsal-ventral polarity in the Drosophila embryo.

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Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis

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UNC93B1 mediates differential trafficking of endosomal TLRs

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Death Domain Assembly Mechanism Revealed by Crystal Structure of the Oligomeric PIDDosome Core Complex

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The Fas–FADD death domain complex structure reveals the basis of DISC assembly and disease mutations

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Nucleotide sequence and expression of a cDNA encoding MyD88, a novel myeloid differentiation primary response gene induced by IL6.

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A Promiscuous Lipid-Binding Protein Diversifies the Subcellular Sites of Toll-like Receptor Signal Transduction

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Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling

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MyD88-mediated stabilization of interferon-γ-induced cytokine and chemokine mRNA

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High prevalence of oncogenic MYD88 and CD79B mutations in diffuse large B-cell lymphomas presenting at immune-privileged sites

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Trafficking of endosomal Toll-like receptors

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MyD88S, a splice variant of MyD88, differentially modulates NF‐κB‐ and AP‐1‐dependent gene expression

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Crystal Structure of the Toll/Interleukin-1 Receptor Domain of Human IL-1RAPL

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Macrophage Differentiation Marker MyD88 Is a Member of the Toll/IL-1 Receptor Family

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MyD88 Adaptor-Like Is Not Essential for TLR2 Signaling and Inhibits Signaling by TLR3

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Overexpression of the Toll-Like Receptor (TLR) Signaling Adaptor MYD88, but Lack of Genetic Mutation, in Myelodysplastic Syndromes

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Two Human MYD88 Variants, S34Y and R98C, Interfere with MyD88-IRAK4-Myddosome Assembly

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Pyogenic Bacterial Infections in Humans With MyD88 Deficiency

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Toll-like Receptor-Deficient Mice Reveal How Innate Immune Signaling Influences Salmonella Virulence Strategies

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Cutting Edge: A TLR9 Cytoplasmic Tyrosine Motif Is Selectively Required for Proinflammatory Cytokine Production

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Pillars Article: MyD88: An Adapter That Recruits IRAK to the IL-1 Receptor Complex. Immunity. 1997. 7: 837–847

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Gut Microbiota as a Trigger for Metabolic Inflammation in Obesity and Type 2 Diabetes

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Cross Talk Pathways Between Coagulation and Inflammation

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Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the role of nutrition

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The emerging mechanisms and functions of microautophagy

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NLRP12-PANoptosome activates PANoptosis and pathology in response to heme and PAMPs

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CAR T Cell Therapy for Solid Tumors: Bright Future or Dark Reality?

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Major pathways involved in macrophage polarization in cancer

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The Role of TLRs in Anti-cancer Immunity and Tumor Rejection

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Recent clinical trends in Toll‐like receptor targeting therapeutics

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Urate‐induced immune programming: Consequences for gouty arthritis and hyperuricemia

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Molecular Mechanisms for the Vicious Cycle between Insulin Resistance and the Inflammatory Response in Obesity

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CAR-T Therapies in Solid Tumors: Opportunities and Challenges

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Mettl14 mediates the inflammatory response of macrophages in atherosclerosis through the NF-κB/IL-6 signaling pathway

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An examination of the LPS-TLR4 immune response through the analysis of molecular structures and protein–protein interactions

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New Aspects of Lipotoxicity in Nonalcoholic Steatohepatitis

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Toll-like receptors: potential targets for lupus treatment

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The Role of Carbohydrates in the Lipopolysaccharide (LPS)/Toll-Like Receptor 4 (TLR4) Signalling

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Myeloid Differentiation Primary Response Protein 88 (MyD88): The Central Hub of TLR/IL-1R Signaling

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Inflammatory Role of TLR-MyD88 Signaling in Multiple Sclerosis

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Toll-like receptor-guided therapeutic intervention of human cancers: molecular and immunological perspectives

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Toll-like receptors and their therapeutic potential in Parkinson’s disease and α-synucleinopathies

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Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA‐MeDALL hypothesis

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NF-κB Signaling in Ovarian Cancer

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