Contextual Regulation of Inflammation: A Duet by Transforming Growth Factor-β and Interleukin-10

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

Fontenot, J. D., Gavin, M. A., & Rudensky, A. Y. (2003) · Nature Immunology · doi:10.1038/ni904 · Cited by 7,745 · see citing works

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992 · see citing works

Interleukin-10 and the Interleukin-10 Receptor

Moore, K. W., de Waal Malefyt, R., Coffman, R. L., & O'Garra, A. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.683 · Cited by 6,737 · see citing works

Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus

Shi, Y., & Massagué, J. (2003) · Cell · doi:10.1016/s0092-8674(03)00432-x · Cited by 5,860 · see citing works

Smad-dependent and Smad-independent pathways in TGF-β family signalling

Derynck, R., & Zhang, Y. E. (2003) · Nature · doi:10.1038/nature02006 · Cited by 5,370 · see citing works

The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., & Littman, D. R. (2006) · Cell · doi:10.1016/j.cell.2006.07.035 · Cited by 5,145 · see citing works

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

Chen, W., Jin, W., Hardegen, N. J., Lei, K.-J., Li, L., Marinos, N. J., McGrady, G., & Wahl, S. M. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030152 · Cited by 4,678 · see citing works

Interleukin-10-deficient mice develop chronic enterocolitis

Kühn, R., Löhler, J., Rennick, D. M., Rajewsky, K., & Müller, W. (1993) · Cell · doi:10.1016/0092-8674(93)80068-p · Cited by 4,248 · see citing works

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

Langrish, C. L., Chen, Y., Blumenschein, W. M., Mattson, J., Basham, B., Sedgwick, J. D., McClanahan, T., Kastelein, R. A., & Cua, D. J. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041257 · Cited by 4,099 · see citing works

TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells

Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M., & Stockinger, B. (2006) · Immunity · doi:10.1016/j.immuni.2006.01.001 · Cited by 3,605 · see citing works

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

Groux, H., O’Garra, A., Bigler, M., Rouleau, M., Antonenko, S. V., de Vries, J. E., & Roncarolo, M. G. (1997) · Nature · doi:10.1038/39614 · Cited by 3,588 · see citing works

N aturally A rising CD4+R egulatory T C ells for I mmunologic S elf -T olerance and N egative C ontrol of I mmune R esponses

Sakaguchi, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141122 · Cited by 3,293 · see citing works

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

Shull, M. M., Ormsby, I., Kier, A. B., Pawlowski, S., Diebold, R. J., Yin, M., Allen, R., Sidman, C., Proetzel, G., Calvin, D., et al. (1992) · Nature · doi:10.1038/359693a0 · Cited by 2,985 · see citing works

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

Cua, D. J., Sherlock, J., Chen, Y., Murphy, C. A., Joyce, B., Seymour, B., Lucian, L., To, W., Kwan, S., Churakova, T., et al. (2003) · Nature · doi:10.1038/nature01355 · Cited by 2,906 · see citing works

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

Fiorentino, D. F., Bond, M. W., & Mosmann, T. R. (1989) · The Journal of Experimental Medicine · doi:10.1084/jem.170.6.2081 · Cited by 2,733 · see citing works

A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism

Coombes, J. L., Siddiqui, K. R. R., Arancibia-Cárcamo, C. V., Hall, J. A., Sun, C., Belkaid, Y., & Powrie, F. M. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070590 · Cited by 2,708 · see citing works

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

Brunkow, M. E., Jeffery, E. W., Hjerrild, K. A., Paeper, B. W., Clark, L. B., Yasayko, S.-A., Wilkinson, J. E., Galas, D. J., Ziegler, S. F., & Ramsdell, F. (2001) · Nature Genetics · doi:10.1038/83784 · Cited by 2,628 · see citing works

TRANSFORMING GROWTH FACTOR-β REGULATION OF IMMUNE RESPONSES

Li, M. O., Wan, Y. Y., Sanjabi, S., Robertson, A.-K. L., & Flavell, R. A. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090737 · Cited by 2,199 · see citing works

IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

Zhou, L., Ivanov, I. I., Spolski, R. J., Min, R., Shenderov, K., Egawa, T., Levy, D. E., Leonard, W. J., & Littman, D. R. (2007) · Nature Immunology · doi:10.1038/ni1488 · Cited by 2,134 · see citing works

A Mechanism for Regulating Pulmonary Inflammation and Fibrosis: The Integrin αvβ6 Binds and Activates Latent TGF β1

Munger, J. S., Huang, X., Kawakatsu, H., Griffiths, M. J. D., Dalton, S. L., Wu, J., Pittet, J.-F., Kaminski, N., Garat, C., Matthay, M. A., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80545-0 · Cited by 2,076 · see citing works

Reciprocal T _H 17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid

Mucida, D., Park, Y., Kim, G., Turovskaya, O., Scott, I., Kronenberg, M., & Cheroutre, H. (2007) · Science · doi:10.1126/science.1145697 · Cited by 1,982 · see citing works

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

Kulkarni, A. B., Huh, C. G., Becker, D., Geiser, A., Lyght, M., Flanders, K. C., Roberts, A. B., Sporn, M. B., Ward, J. M., & Karlsson, S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.2.770 · Cited by 1,967 · see citing works

Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid

Sun, C., Hall, J. A., Blank, R. B., Bouladoux, N. J., Oukka, M., Mora, J. R., & Belkaid, Y. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070602 · Cited by 1,880 · see citing works

CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity

Belkaid, Y., Piccirillo, C. A., Méndez, S., Shevach, E. M., & Sacks, D. L. (2002) · Nature · doi:10.1038/nature01152 · Cited by 1,726 · see citing works

The Biological Functions of T Helper 17 Cell Effector Cytokines in Inflammation

Ouyang, W., Kolls, J. K., & Zheng, Y. (2008) · Immunity · doi:10.1016/j.immuni.2008.03.004 · Cited by 1,698 · see citing works

Making sense of latent TGFβ activation

Annes, J. P., Munger, J. S., & Rifkin, D. B. (2002) · Journal of Cell Science · doi:10.1242/jcs.00229 · Cited by 1,624 · see citing works

An Essential Role for Interleukin 10 in the Function of Regulatory T Cells That Inhibit Intestinal Inflammation

Asseman, C., Mauze, S., Leach, M. W., Coffman, R. L., & Powrie, F. M. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.7.995 · Cited by 1,617 · see citing works

Cell Contact–Dependent Immunosuppression by Cd4+Cd25+Regulatory T Cells Is Mediated by Cell Surface–Bound Transforming Growth Factor β

Nakamura, K., Kitani, A., & Strober, W. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.5.629 · Cited by 1,596 · see citing works

Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces

Rubtsov, Y. P., Rasmussen, J. P., Chi, E. Y., Fontenot, J., Castelli, L., Ye, X., Treuting, P., Siewe, L., Roers, A., Henderson, W. R., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.02.017 · Cited by 1,586 · see citing works

Retinoic acid imprints gut-homing specificity on T cells

Iwata, M., Hirakiyama, A., Eshima, Y., Kagechika, H., Kato, C., & Song, S.-Y. (2004) · Immunity · doi:10.1016/j.immuni.2004.08.011 · Cited by 1,541 · see citing works

TGF-β and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell–mediated pathology

McGeachy, M. J., Bak-Jensen, K. S., Chen, Y., Tato, C. M., Blumenschein, W., McClanahan, T., & Cua, D. J. (2007) · Nature Immunology · doi:10.1038/ni1539 · Cited by 1,520 · see citing works

Interleukin-2 Signaling via STAT5 Constrains T Helper 17 Cell Generation

Laurence, A., Tato, C. M., Davidson, T. S., Kanno, Y., Chen, Z., Yao, Z., Blank, R. B., Meylan, F., Siegel, R., Hennighausen, L., et al. (2007) · Immunity · doi:10.1016/j.immuni.2007.02.009 · Cited by 1,507 · see citing works

Resident Enteric Bacteria Are Necessary for Development of Spontaneous Colitis and Immune System Activation in Interleukin-10-Deficient Mice

Sellon, R. K., Tonkonogy, S., Schultz, M., Dieleman, L. A., Grenther, W., Balish, E., Rennick, D. M., & Sartor, R. B. (1998) · Infection and Immunity · doi:10.1128/iai.66.11.5224-5231.1998 · Cited by 1,483 · see citing works

Th17: An Effector CD4 T Cell Lineage with Regulatory T Cell Ties

Weaver, C. T., Harrington, L. E., Mangan, P. R., Gavrieli, M., & Murphy, K. M. (2006) · Immunity · doi:10.1016/j.immuni.2006.06.002 · Cited by 1,422 · see citing works

Inducing and expanding regulatory T cell populations by foreign antigen

Kretschmer, K., Apostolou, I., Hawiger, D., Khazaie, K., Nussenzweig, M. C., & von Boehmer, H. (2005) · Nature Immunology · doi:10.1038/ni1265 · Cited by 1,240 · see citing works

Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils

Takeda, K., Clausen, B. E., Kaisho, T., Tsujimura, T., Terada, N., Förster, I., & Akira, S. (1999) · Immunity · doi:10.1016/s1074-7613(00)80005-9 · Cited by 1,220 · see citing works

Homology of Cytokine Synthesis Inhibitory Factor (IL-10) to the Epstein-Barr Virus Gene BCRFI

Moore, K. W., Vieira, P., Fiorentino, D. F., Trounstine, M. L., Khan, T. A., & Mosmann, T. R. (1990) · Science · doi:10.1126/science.2161559 · Cited by 1,143 · see citing works

Cutting Edge: TGF-β Induces a Regulatory Phenotype in CD4+CD25− T Cells through Foxp3 Induction and Down-Regulation of Smad7

Fantini, M. C., Becker, C., Monteleone, G., Pallone, F., Galle, P. R., & Neurath, M. F. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.9.5149 · Cited by 1,137 · see citing works

TGF-β1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells

Marie, J. C., Letterio, J. J., Gavin, M. A., & Rudensky, A. Y. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20042276 · Cited by 986 · see citing works

Abrogation of TGFβ Signaling in T Cells Leads to Spontaneous T Cell Differentiation and Autoimmune Disease

Gorelik, L., & Flavell, R. A. (2000) · Immunity · doi:10.1016/s1074-7613(00)80170-3 · Cited by 959 · see citing works

In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-γ and TNF-α

Gazzinelli, R. T., Wysocka, M., Hieny, S. E., Scharton‐Kersten, T., Cheever, A. W., Kühn, R., Müller, W., Trinchieri, G., & Sher, A. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.2.798 · Cited by 928 · see citing works

Interleukin-10 determines viral clearance or persistence in vivo

Brooks, D. G., Trifilo, M. J., Edelmann, K. H., Teyton, L., McGavern, D. B., & Oldstone, M. B. A. (2006) · Nature Medicine · doi:10.1038/nm1492 · Cited by 920 · see citing works

A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells.

Powrie, F. M., Carlino, J. A., Leach, M. W., Mauze, S., & Coffman, R. L. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.6.2669 · Cited by 894 · see citing works

All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation

Benson, M. J., Pino-Lagos, K., Rosemblatt, M., & Noelle, R. J. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070719 · Cited by 847 · see citing works

Cytokine Signaling Modules in Inflammatory Responses

O’Shea, J. J., & Murray, P. J. (2008) · Immunity · doi:10.1016/j.immuni.2008.03.002 · Cited by 819 · see citing works

Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-β signals <i>in vivo</i>

Chen, M.-L., Pittet, M. J., Gorelik, L., Flavell, R. A., Weissleder, R., von Boehmer, H., & Khazaie, K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408197102 · Cited by 806 · see citing works

A dominant function for interleukin 27 in generating interleukin 10–producing anti-inflammatory T cells

Awasthi, A., Carrier, Y., Peron, J. P. S., Bettelli, E., Kamanaka, M., Flavell, R. A., Kuchroo, V. K., Oukka, M., & Weiner, H. L. (2007) · Nature Immunology · doi:10.1038/ni1541 · Cited by 804 · see citing works

Transforming Growth Factor-β Controls Development, Homeostasis, and Tolerance of T Cells by Regulatory T Cell-Dependent and -Independent Mechanisms

Li, M. O., Sanjabi, S., & Flavell, R. A. (2006) · Immunity · doi:10.1016/j.immuni.2006.07.011 · Cited by 794 · see citing works

Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10

Stumhofer, J. S., Silver, J. S., Laurence, A. D. J., Porrett, P. M., Harris, T. H., Turka, L. A., Ernst, M., Saris, C. J. M., O’Shea, J. J., & Hunter, C. A. (2007) · Nature Immunology · doi:10.1038/ni1537 · Cited by 777 · see citing works

Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice

Tang, Q., Adams, J. Y., Tooley, A. J., Bi, M., Fife, B. T., Serra, P., Santamaría, P., Locksley, R. M., Krummel, M. F., & Bluestone, J. A. (2005) · Nature Immunology · doi:10.1038/ni1289 · Cited by 774 · see citing works

Discovery and Biology of IL-23 and IL-27: Related but Functionally Distinct Regulators of Inflammation

Kastelein, R. A., Hunter, C. A., & Cua, D. J. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104758 · Cited by 758 · see citing works

Cutting Edge: Regulatory T Cells Induce CD4+CD25−Foxp3− T Cells or Are Self-Induced to Become Th17 Cells in the Absence of Exogenous TGF-β

Xu, L., Kitani, A., Fuss, I. J., & Strober, W. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.11.6725 · Cited by 733 · see citing works

The integrin αvβ8 mediates epithelial homeostasis through MT1-MMP–dependent activation of TGF-β1

Mu, D., Cambier, S., Fjellbirkeland, L., Baron, J. L., Munger, J. S., Kawakatsu, H., Sheppard, D., Broaddus, V. C., & Nishimura, S. L. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200109100 · Cited by 729 · see citing works

T Cell-Produced Transforming Growth Factor-β1 Controls T Cell Tolerance and Regulates Th1- and Th17-Cell Differentiation

Li, M. O., Wan, Y. Y., & Flavell, R. A. (2007) · Immunity · doi:10.1016/j.immuni.2007.03.014 · Cited by 728 · see citing works

Th17 Cell Differentiation: The Long and Winding Road

McGeachy, M. J., & Cua, D. J. (2008) · Immunity · doi:10.1016/j.immuni.2008.03.001 · Cited by 700 · see citing works

Foxp3 in control of the regulatory T cell lineage

Zheng, Y., & Rudensky, A. Y. (2007) · Nature Immunology · doi:10.1038/ni1455 · Cited by 699 · see citing works

TGF-β1 Plays an Important Role in the Mechanism of CD4+CD25+ Regulatory T Cell Activity in Both Humans and Mice

Nakamura, K., Kitani, A., Fuss, I. J., Pedersen, A., Harada, N., Nawata, H., & Strober, W. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.2.834 · Cited by 630 · see citing works

Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3− precursor cells in the absence of interleukin 10

Maynard, C. L., Harrington, L. E., Janowski, K. M., Oliver, J. R., Zindl, C. L., Rudensky, A. Y., & Weaver, C. T. (2007) · Nature Immunology · doi:10.1038/ni1504 · Cited by 599 · see citing works

IL-2 Is Essential for TGF-β to Convert Naive CD4+CD25− Cells to CD25+Foxp3+ Regulatory T Cells and for Expansion of These Cells

Zheng, S. G., Wang, J., Wang, P., Gray, J. D., & Horwitz, D. A. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.4.2018 · Cited by 597 · see citing works

Conventional T-bet+Foxp3− Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection

Jankovic, D. L., Kullberg, M. C., Feng, C. G., Goldszmid, R. S., Collazo, C. M., Wilson, M. D., Wynn, T. A., Kamanaka, M., Flavell, R. A., & Sher, A. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20062175 · Cited by 590 · see citing works

CD4+CD25−Foxp3− Th1 cells are the source of IL-10–mediated immune suppression in chronic cutaneous leishmaniasis

Anderson, C. F., Oukka, M., Kuchroo, V. K., & Sacks, D. L. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20061886 · Cited by 571 · see citing works

Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter

Wan, Y. Y., & Flavell, R. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501701102 · Cited by 568 · see citing works

Resolution of a chronic viral infection after interleukin-10 receptor blockade

Ejrnaes, M., Filippi, C. M., Martinic, M. M. A., Ling, E. M., Togher, L. M., Crotty, S., & von Herrath, M. G. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061462 · Cited by 549 · see citing works

Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27–stimulated T cells

Fitzgerald, D. C., Zhang, G.-X., El-Behi, M., Fonseca-Kelly, Z., Li, H., Yu, S., Saris, C. J. M., Gran, B., Ciric, B., & Rostami, A. (2007) · Nature Immunology · doi:10.1038/ni1540 · Cited by 529 · see citing works

Cutting Edge: IL-2 Is Essential for TGF-β-Mediated Induction of Foxp3+ T Regulatory Cells

Davidson, T. S., DiPaolo, R. J., Andersson, J., & Shevach, E. M. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.7.4022 · Cited by 520 · see citing works

T cells that cannot respond to TGF-β escape control by CD4+CD25+ regulatory T cells

Fahlén, L., Read, S., Gorelik, L., Hurst, S. D., Coffman, R. L., Flavell, R. A., & Powrie, F. M. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20040685 · Cited by 516 · see citing works

The role of IL-10 in promoting disease progression in Leishmaniasis

Kane, M. M., & Mosser, D. M. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.2.1141 · Cited by 514 · see citing works

Loss of integrin αvβ8 on dendritic cells causes autoimmunity and colitis in mice

Travis, M. A., Reizis, B., Melton, A. C., Masteller, E., Tang, Q., Proctor, J. M., Wang, Y., Bernstein, X., Huang, X., Reichardt, L. F., et al. (2007) · Nature · doi:10.1038/nature06110 · Cited by 503 · see citing works

Regulatory T Cells Reversibly Suppress Cytotoxic T Cell Function Independent of Effector Differentiation

Mempel, T. R., Pittet, M. J., Khazaie, K., Weninger, W., Weissleder, R., von Boehmer, H., & von Andrian, U. H. (2006) · Immunity · doi:10.1016/j.immuni.2006.04.015 · Cited by 489 · see citing works

The IL-27R (WSX-1) Is Required to Suppress T Cell Hyperactivity during Infection

Villarino, A. V., Hibbert, L., Lieberman, L. A., Wilson, E. H., Mak, T. W., Yoshida, H., Kastelein, R. A., Saris, C. J. M., & Hunter, C. A. (2003) · Immunity · doi:10.1016/s1074-7613(03)00300-5 · Cited by 484 · see citing works

Cellular Mechanisms of Fatal Early-Onset Autoimmunity in Mice with the T Cell-Specific Targeting of Transforming Growth Factor-β Receptor

Marie, J. C., Liggitt, D., & Rudensky, A. Y. (2006) · Immunity · doi:10.1016/j.immuni.2006.07.012 · Cited by 480 · see citing works

Generation Ex Vivo of TGF-β-Producing Regulatory T Cells from CD4+CD25− Precursors

Zheng, S. G., Gray, J. D., Ohtsuka, K., Yamagiwa, S., & Horwitz, D. A. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.8.4183 · Cited by 459 · see citing works

Signals mediated by transforming growth factor-β initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease

Veldhoen, M., Hocking, R. J., Flavell, R., & Stockinger, B. (2006) · Nature Immunology · doi:10.1038/ni1391 · Cited by 459 · see citing works

CD4 + CD25 + T regulatory cells control anti-islet CD8 + T cells through TGF-β–TGF-β receptor interactions in type 1 diabetes

Green, E. A., Gorelik, L., McGregor, C. M., Tran, E. H., & Flavell, R. A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1834400100 · Cited by 446 · see citing works

TGF-β regulates in vivo expansion of Foxp3-expressing CD4 + CD25 + regulatory T cells responsible for protection against diabetes

Peng, Y., Laouar, Y., Li, M. O., Green, E. A., & Flavell, R. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400810101 · Cited by 417 · see citing works

Expression of Interleukin-10 in Intestinal Lymphocytes Detected by an Interleukin-10 Reporter Knockin tiger Mouse

Kamanaka, M., Kim, S. T., Wan, Y. Y., Sutterwala, F. S., Lara-Tejero, M., Galán, J. E., Harhaj, E., & Flavell, R. A. (2006) · Immunity · doi:10.1016/j.immuni.2006.09.013 · Cited by 392 · see citing works

Autoreactive T Cells in Healthy Individuals

Danke, N. A., Koelle, D. M., Yee, C., Beheray, S., & Kwok, W. W. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.10.5967 · Cited by 377 · see citing works

IL-10 is required to prevent immune hyperactivity during infection with Trypanosoma cruzi

Hunter, C. A., Neyer, L., Slifer, T. R., Kanaly, S. T., Grünig, G., Fort, M., Rennick, D. M., & Araujo, F. G. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.7.3311 · Cited by 352 · see citing works

Role of Toll-like Receptors in Spontaneous Commensal-Dependent Colitis

Rakoff-Nahoum, S., Hao, L., & Medzhitov, R. M. (2006) · Immunity · doi:10.1016/j.immuni.2006.06.010 · Cited by 343 · see citing works

Absence of integrin-mediated TGFβ1 activation in vivo recapitulates the phenotype of TGFβ1-null mice

Yang, Z., Mu, Z., Dabovic, B., Jurukovski, V., Yu, D., Sung, J. J., Xiong, X., & Munger, J. S. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200611044 · Cited by 321 · see citing works

T Cell–specific Inactivation of the Interleukin 10 Gene in Mice Results in Enhanced T Cell Responses but Normal Innate Responses to Lipopolysaccharide or Skin Irritation

Roers, A., Siewe, L., Strittmatter, E., Deckert, M., Schlüter, D., Stenzel, W., Gruber, A. D., Krieg, T. M., Rajewsky, K., & Müller, W. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20041789 · Cited by 309 · see citing works

Transforming Growth Factor (TGF)-β1–producing Regulatory T Cells Induce Smad-mediated Interleukin 10 Secretion That Facilitates Coordinated Immunoregulatory Activity and Amelioration of TGF-β1–mediated Fibrosis

Kitani, A., Fuss, I. J., Nakamura, K., Kumaki, F., Usui, T., & Strober, W. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030917 · Cited by 260 · see citing works

Disruption of T Cell Homeostasis in Mice Expressing a T Cell–Specific Dominant Negative Transforming Growth Factor β II Receptor

Lucas, P. J., Kim, S., Melby, S. J., & Gress, R. E. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.7.1187 · Cited by 244 · see citing works

Autoimmunity associated with TGF-beta1-deficiency in mice is dependent on MHC class II antigen expression.

Letterio, J. J., Geiser, A. G., Kulkarni, A. B., Dang, H., Kong, L., Nakabayashi, T., Mackall, C. L., GRESS, R. E., & Roberts, A. B. (1996) · Journal of Clinical Investigation · doi:10.1172/jci119017 · Cited by 232 · see citing works

CD4+CD25− T Cells That Express Latency-Associated Peptide on the Surface Suppress CD4+CD45RBhigh-Induced Colitis by a TGF-β-Dependent Mechanism

Oida, T., Zhang, X., Goto, M., Hachimura, S., Totsuka, M., Kaminogawa, S., & Weiner, H. L. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.5.2516 · Cited by 227 · see citing works

Ulcerative colitis and autoimmunity induced by loss of myeloid αv integrins

Lacy‐Hulbert, A., Smith, A. M., Tissire, H., Barry, M., Crowley, D. G., Bronson, R. T., Roes, J., Savill, J., & Hynes, R. O. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707421104 · Cited by 225 · see citing works

Role of IL-17 and regulatory T lymphocytes in a systemic autoimmune disease

Lohr, J. G., Knoechel, B., Wang, J. J., Villarino, A. V., & Abbas, A. K. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061341 · Cited by 223 · see citing works

Interleukin‐10 derived from macrophages and/or neutrophils regulates the inflammatory response to LPS but not the response to CpG DNA

Siewe, L., Bollati‐Fogolín, M., Wickenhauser, C., Krieg, T. M., Müller, W., & Roers, A. (2006) · European Journal of Immunology · doi:10.1002/eji.200636012 · Cited by 126 · see citing works

TGF‐β1 production by CD4+CD25+ regulatory T cells is not essential for suppression of intestinal inflammation

Kullberg, M. C., Hay, V., Cheever, A. W., Mamura, M., Sher, A., Letterio, J. J., Shevach, E. M., & Piccirillo, C. A. (2005) · European Journal of Immunology · doi:10.1002/eji.200526106 · Cited by 118 · see citing works

Beta 2-microglobulin-deficient background ameliorates lethal phenotype of the TGF-beta 1 null mouse.

Kobayashi, S., Yoshida, K., Ward, J. M., Letterio, J. J., Longenecker, G., Yaswen, L. R., Mittleman, B. B., Mozes, E., Roberts, A. B., Karlsson, S., et al. (1999) · PubMed · Cited by 65 · see citing works

β2-Microglobulin-Deficient Background Ameliorates Lethal Phenotype of the TGF-β1 Null Mouse

Kobayashi, S., Yoshida, K., Ward, J. M., Letterio, J. J., Longenecker, G., Yaswen, L. R., Mittleman, B. B., Mozes, E., Roberts, A. B., Karlsson, S., et al. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.7.4013 · Cited by 58 · see citing works

Stochastic Monoallelic Expression of IL-10 in T Cells

Calado, D. P., Paixão, T., Holmberg, D., & Haury, M. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.8.5358 · Cited by 51 · see citing works

Pathogen-Specific CD8 T Cell Responses Are Directly Inhibited by IL-10

Biswas, P. S., Pedicord, V. A., Ploß, A., Menet, E., Leiner, I. M., & Pamer, E. G. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.7.4520 · Cited by 47 · see citing works

Germ-free and barrier-raised TGFβ1-deficient mice have similar inflammatory lesions

Boivin, G. P., Ormsby, I., Jones‐Carson, J., O’Toole, B. A., & Doetschman, T. (1997) · Transgenic Research · doi:10.1023/a:1018490007745 · Cited by 39 · see citing works

ENDOCRINE EXPRESSION OF THE ACTIVE FORM OF TGF-β1 IN THE TGF-β1 NULL MICE FAILS TO AMELIORATE LETHAL PHENOTYPE

Longenecker, G., Thyagarajan, T., Nagineni, C. N., Flanders, K. C., Factor, V. M., Miller, G., Ward, J. M., Nalça, A., Rangnekar, V. M., Thorgeirsson, S. S., et al. (2002) · Cytokine · doi:10.1006/cyto.2002.1025 · Cited by 20 · see citing works

Transforming Growth Factor-β Signaling in Immunity and Cancer

Batlle, E., & Massagué, J. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.024 · Cited by 2,366 · see citing works

Renal and Extrarenal Effects of Gum Arabic (Acacia Senegal) - What Can be Learned from Animal Experiments?

Nasir, O. (2013) · Kidney & Blood Pressure Research · doi:10.1159/000350152 · Cited by 2,331 · see citing works

Intestinal homeostasis and its breakdown in inflammatory bowel disease

Maloy, K. J., & Powrie, F. M. (2011) · Nature · doi:10.1038/nature10208 · Cited by 1,876 · see citing works

The development of allergic inflammation

Galli, S. J., Tsai, M., & Piliponsky, A. M. (2008) · Nature · doi:10.1038/nature07204 · Cited by 1,839 · see citing works

Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications

Wang, Y., Chen, X., Cao, W., & Shi, Y. (2014) · Nature Immunology · doi:10.1038/ni.3002 · Cited by 1,452 · see citing works

Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation

Solinas, G., Germano, G., Mantovani, A., & Allavena, P. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0609385 · Cited by 1,418 · see citing works

Regulation of the Inflammatory Response in Cardiac Repair

Frangogiannis, N. G. (2012) · Circulation Research · doi:10.1161/circresaha.111.243162 · Cited by 1,196 · see citing works

IL-4 inhibits TGF-β-induced Foxp3+ T cells and, together with TGF-β, generates IL-9+ IL-10+ Foxp3− effector T cells

Dardalhon, V., Awasthi, A., Kwon, H., Galileos, G., Gao, W., Sobel, R. A., Mitsdoerffer, M., Strom, T. B., Elyaman, W., Ho, I.-C., et al. (2008) · Nature Immunology · doi:10.1038/ni.1677 · Cited by 1,122 · see citing works

Natural and Adaptive Foxp3+ Regulatory T Cells: More of the Same or a Division of Labor?

de Lafaille, M. A. C., & Lafaille, J. J. (2009) · Immunity · doi:10.1016/j.immuni.2009.05.002 · Cited by 1,057 · see citing works

Interleukin-10 Signaling in Regulatory T Cells Is Required for Suppression of Th17 Cell-Mediated Inflammation

Chaudhry, A., Samstein, R. M., Treuting, P., Liang, Y., Pils, M. C., Heinrich, J.-M., Jack, R. S., Wunderlich, F. T., Brüning, J. C., Müller, W., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.03.018 · Cited by 980 · see citing works

Th17 and regulatory T cells in mediating and restraining inflammation

Littman, D. R., & Rudensky, A. Y. (2010) · Cell · doi:10.1016/j.cell.2010.02.021 · Cited by 1,039 · see citing works

IL-37 is a fundamental inhibitor of innate immunity

Nold, M. F., Nold‐Petry, C. A., Zepp, J. A., Palmer, B. E., Bufler, P., & Dinarello, C. A. (2010) · Nature Immunology · doi:10.1038/ni.1944 · Cited by 850 · see citing works

Cytokine Signaling Modules in Inflammatory Responses

O’Shea, J. J., & Murray, P. J. (2008) · Immunity · doi:10.1016/j.immuni.2008.03.002 · Cited by 819 · see citing works

Cytokine Networks in the Pathophysiology of Inflammatory Bowel Disease

Friedrich, M., Pohin, M., & Powrie, F. M. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.017 · Cited by 750 · see citing works

Th17 Cell Differentiation: The Long and Winding Road

McGeachy, M. J., & Cua, D. J. (2008) · Immunity · doi:10.1016/j.immuni.2008.03.001 · Cited by 700 · see citing works

Apoptotic Cells Promote Their Own Clearance and Immune Tolerance through Activation of the Nuclear Receptor LXR

A-González, N., Bensinger, S. J., Hong, C., Beceiro, S., Bradley, M. N., Zelcer, N., Deniz, J. M., Ramírez, C. M., Díaz, M., Gallardo, G., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.06.018 · Cited by 674 · see citing works

Anti-inflammatory and pro-inflammatory roles of TGF-β, IL-10, and IL-22 in immunity and autoimmunity

Sanjabi, S., Zenewicz, L. A., Kamanaka, M., & Flavell, R. A. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2009.04.008 · Cited by 656 · see citing works

Immunity and immunopathology to viruses: what decides the outcome?

Rouse, B. T., & Sehrawat, S. (2010) · Nature reviews. Immunology · doi:10.1038/nri2802 · Cited by 621 · see citing works

Pathophysiology of Myocardial Infarction

Frangogiannis, N. G. (2015) · Comprehensive physiology · doi:10.1002/cphy.c150006 · Cited by 717 · see citing works

The Molecular Basis for the Pharmacokinetics and Pharmacodynamics of Curcumin and Its Metabolites in Relation to Cancer

Heger, M., van Golen, R. F., Broekgaarden, M., & Michel, M. C. (2013) · Pharmacological Reviews · doi:10.1124/pr.110.004044 · Cited by 581 · see citing works

The Biology of Intestinal Immunoglobulin A Responses

Cerutti, A., & Rescigno, M. (2008) · Immunity · doi:10.1016/j.immuni.2008.05.001 · Cited by 548 · see citing works

Dental Pulp Defence and Repair Mechanisms in Dental Caries

Farges, J., Alliot‐Licht, B., Renard, E., Ducret, M., Gaudin, A., Smith, A. J., & Cooper, P. R. (2015) · Mediators of Inflammation · doi:10.1155/2015/230251 · Cited by 535 · see citing works

Mesenchymal Stem Cell-Based Immunomodulation: Properties and Clinical Application

Wang, M., Yuan, Q., & Xie, L. (2018) · Stem Cells International · doi:10.1155/2018/3057624 · Cited by 506 · see citing works

Molecular Choreography of Acute Exercise

Contrepois, K., Wu, S., Moneghetti, K. J., Hornburg, D., Ahadi, S., Tsai, M.-S., Metwally, A. A., Wei, E., Lee-McMullen, B., Quijada, J. V., et al. (2020) · Cell · doi:10.1016/j.cell.2020.04.043 · Cited by 502 · see citing works

Pathogenesis and Pathophysiology of Pneumococcal Meningitis

Mook-Kanamori, B. B., Geldhoff, M., van der Poll, T., & van de Beek, D. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00008-11 · Cited by 492 · see citing works

Enhanced preclinical antitumor activity of M7824, a bifunctional fusion protein simultaneously targeting PD-L1 and TGF-β

Lan, Y., Zhang, D., Xu, C., Hance, K. W., Marelli, B., Qi, J., Yu, H., Qin, G., Sircar, A., Hernández, V. M., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aan5488 · Cited by 494 · see citing works

Immune Regulation of Cancer

Disis, M. L. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.27.2146 · Cited by 485 · see citing works

Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling

Boniface, K., Bak‐Jensen, K. S., Li, Y., Blumenschein, W. M., McGeachy, M. J., McClanahan, T. K., McKenzie, B. S., Kastelein, R. A., Cua, D. J., & Malefyt, R. D. W. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20082293 · Cited by 474 · see citing works

Inflammatory Response Mechanisms of the Dentine–Pulp Complex and the Periapical Tissues

Galler, K. M., Weber, M., Korkmaz, Y., Widbiller, M., & Feuerer, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031480 · Cited by 457 · see citing works

The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance

Villagra, A., Cheng, F., Wang, H.-W., Suarez, I., Glozak, M., Maurin, M., Nguyen, D., Wright, K. L., Atadja, P. W., Bhalla, K., et al. (2009) · Nature Immunology · doi:10.1038/ni.1673 · Cited by 455 · see citing works

A Novel Probiotic Mixture Exerts a Therapeutic Effect on Experimental Autoimmune Encephalomyelitis Mediated by IL-10 Producing Regulatory T Cells

Lavasani, S., Dzhambazov, B. M., Nouri, M., Fåk, F., Buske, S., Molin, G., Thorlacius, H., Alenfall, J., Jeppsson, B. W., & Weström, B. R. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009009 · Cited by 450 · see citing works

TIM-3 Expression Characterizes Regulatory T Cells in Tumor Tissues and Is Associated with Lung Cancer Progression

Gao, X., Zhu, Y., Li, G., Huang, H., Zhang, G., Fengming, W., Sun, J., Yang, Q., Zhang, X., & Lu, B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030676 · Cited by 406 · see citing works

From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines

Banchereau, J., Pascual, V., & O’Garra, A. (2012) · Nature Immunology · doi:10.1038/ni.2406 · Cited by 401 · see citing works

Anti-inflammatory mechanisms of bioactive milk proteins in the intestine of newborns

Chatterton, D. E. W., Nguyen, D. N., Bering, S. B., & Sangild, P. T. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.04.028 · Cited by 401 · see citing works

Cellular and molecular basis for the regulation of inflammation by TGF-

Yoshimura, A., Wakabayashi, Y., & Mori, T. (2010) · The Journal of Biochemistry · doi:10.1093/jb/mvq043 · Cited by 394 · see citing works

Il10 Deficiency Rebalances Innate Immunity to Mitigate Alzheimer-Like Pathology

Guillot-Sestier, M.-V., Doty, K. R., Gate, D., Rodriguez, J., Leung, B. P., Rezai-Zadeh, K., & Town, T. (2015) · Neuron · doi:10.1016/j.neuron.2014.12.068 · Cited by 363 · see citing works

Regulatory T cells and immune regulation of allergic diseases: roles of IL-10 and TGF-β

Palomares, Ó., Martín‐Fontecha, M., Lauener, R. P., Traidl‐Hoffmann, C., Cavkaytar, Ö., Akdis, M., & Akdiş, C. A. (2014) · Genes and Immunity · doi:10.1038/gene.2014.45 · Cited by 348 · see citing works

Oxidative stress and inflammatory response in dermal toxicity of single-walled carbon nanotubes

Murray, A. R., Kisin, E. R., Leonard, S. S., Young, S., Kommineni, C., Kagan, V. E., Castranova, V., & Shvedova, A. A. (2008) · Toxicology · doi:10.1016/j.tox.2008.12.023 · Cited by 344 · see citing works

Recent advances in inflammatory bowel disease: mucosal immune cells in intestinal inflammation

Cader, M. Z., & Kaser, A. (2013) · Gut · doi:10.1136/gutjnl-2012-303955 · Cited by 337 · see citing works

Mechanisms and treatment of allergic disease in the big picture of regulatory T cells

Akdiş, C. A., & Akdiş, M. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.02.030 · Cited by 332 · see citing works

Control of immune response by amino acid metabolism

Grohmann, U., & Bronte, V. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00915.x · Cited by 311 · see citing works

<i>Bifidobacterium</i> alters the gut microbiota and modulates the functional metabolism of T regulatory cells in the context of immune checkpoint blockade

Sun, S., Luo, L., Liang, W., Yin, Q., Guo, J., Rush, A. M., Lv, Z., Liang, Q., Fischbach, M. A., Sonnenburg, J. L., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1921223117 · Cited by 277 · see citing works

IL-10 Potentiates Differentiation of Human Induced Regulatory T Cells via STAT3 and Foxo1

Hsu, P. S., Santner‐Nanan, B., Hu, M., Skarratt, K. K., Lee, C. H., Stormon, M., Wong, M., Fuller, S. J., & Nanan, R. K. H. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402898 · Cited by 288 · see citing works

Vitamin D in inflammatory diseases

Wöbke, T. K., Sorg, B. L., & Steinhilber, D. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00244 · Cited by 285 · see citing works

Adipose stem cells: biology and clinical applications for tissue repair and regeneration

Kokai, L. E., Marra, K. G., & Rubin, J. P. (2013) · Translational research · doi:10.1016/j.trsl.2013.11.009 · Cited by 281 · see citing works

Acute Inflammation in Tissue Healing

Soliman, A. M., & Barreda, D. R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010641 · Cited by 283 · see citing works

Therapeutic Potential of Targeting the Th17/Treg Axis in Autoimmune Disorders.

Fasching, P., Stradner, M., Graninger, W., Dejaco, C., & Fessler, J. (2017) · Molecules · doi:10.3390/molecules22010134 · Cited by 254 · see citing works

Modulation of Immune Tolerance via Siglec-Sialic Acid Interactions

Lübbers, J., Rodríguez, E., & van Kooyk, Y. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02807 · Cited by 261 · see citing works

Dendritic cells as gatekeepers of tolerance

Waisman, A., Lukas, D., Clausen, B. E., & Yogev, N. (2016) · Seminars in Immunopathology · doi:10.1007/s00281-016-0583-z · Cited by 253 · see citing works

Flavonoids in Inflammatory Bowel Disease: A Review

Vezza, T., Rodríguez‐Nogales, A., Algieri, F., Utrilla, M. P., Rodríguez‐Cabezas, M. E., & Gálvez, J. (2016) · Nutrients · doi:10.3390/nu8040211 · Cited by 242 · see citing works

Induction of Interleukin-10 Producing Dendritic Cells As a Tool to Suppress Allergen-Specific T Helper 2 Responses

Schülke, S. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00455 · Cited by 238 · see citing works

Safety, Antitumor Activity, and Immune Activation of Pegylated Recombinant Human Interleukin-10 (AM0010) in Patients With Advanced Solid Tumors

Naing, A., Papadopoulos, K. P., Autio, K. A., Ott, P. A., Patel, M. R., Wong, D. J. L., Falchook, G. S., Pant, S., Whiteside, M., Rasco, D., et al. (2016) · Journal of Clinical Oncology · doi:10.1200/jco.2016.68.1106 · Cited by 221 · see citing works

Protective Functions of Reactive Astrocytes Following Central Nervous System Insult

Linnerbauer, M., & Rothhammer, V. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.573256 · Cited by 221 · see citing works

Cell type-specific regulation of IL-10 expression in inflammation and disease

Hedrich, C. M., & Bream, J. H. (2010) · Immunologic Research · doi:10.1007/s12026-009-8150-5 · Cited by 220 · see citing works

Regulatory dendritic cells: there is more than just immune activation

Schmidt, S. V., Niño‐Castro, A., & Schultze, J. L. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00274 · Cited by 213 · see citing works

Systemic but Not Local Infections Elicit Immunosuppressive IL-10 Production by Natural Killer Cells

Perona‐Wright, G., Mohrs, K., Szaba, F. M., Kummer, L. W., Madan, R., Karp, C. L., Johnson, L. L., Smiley, S. T., & Mohrs, M. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2009.11.003 · Cited by 209 · see citing works

The ubiquitin‐editing enzyme A20 requires RNF11 to downregulate NF‐κB signalling

Shembade, N., Parvatiyar, K., Harhaj, N. S., & Harhaj, E. W. (2009) · The EMBO Journal · doi:10.1038/emboj.2008.285 · Cited by 211 · see citing works

TGF-β Function in Immune Suppression

Yoshimura, A., & Muto, G. (2010) · Current topics in microbiology and immunology · doi:10.1007/82_2010_87 · Cited by 200 · see citing works

Roles of Pro- and Anti-Inflammatory Cytokines in the Pathogenesis of SLE

Su, D., Lu, Z., Shen, M., Li, X., & Sun, L. (2012) · BioMed Research International · doi:10.1155/2012/347141 · Cited by 197 · see citing works

Histone deacetylases and the immunological network: implications in cancer and inflammation

Villagra, A., Sotomayor, E. M., & Seto, E. (2009) · Oncogene · doi:10.1038/onc.2009.334 · Cited by 193 · see citing works

Opposing Effects of TGF-β and IL-15 Cytokines Control the Number of Short-Lived Effector CD8+ T Cells

Sanjabi, S., Mosaheb, M. M., & Flavell, R. A. (2009) · Immunity · doi:10.1016/j.immuni.2009.04.020 · Cited by 193 · see citing works

Breakpoint regions and homologous synteny blocks in chromosomes have different evolutionary histories

Larkin, D. M., Pape, G., Donthu, R., Auvil, L., Welge, M., & Lewin, H. A. (2009) · Genome Research · doi:10.1101/gr.086546.108 · Cited by 184 · see citing works

Dendritic Cells As Inducers of Peripheral Tolerance

Iberg, C. A., Jones, A., & Hawiger, D. (2017) · Trends in Immunology · doi:10.1016/j.it.2017.07.007 · Cited by 178 · see citing works

Dual inhibition of TGF‐β and PD‐L1: a novel approach to cancer treatment

Gulley, J. L., Schlom, J., Barcellos‐Hoff, M. H., Wang, X., Seoane, J., Audhuy, F., Lan, Y., Dussault, I., & Moustakas, A. (2021) · Molecular Oncology · doi:10.1002/1878-0261.13146 · Cited by 178 · see citing works

Effects of Rehmannia glutinosa on growth performance, immunological parameters and disease resistance to Aeromonas hydrophila in common carp (Cyprinus carpio L.)

Wang, J., Meng, X., Lu, R., Wu, C., Luo, Y.-T., Yan, X., Li, X., Kong, X., & Nie, G.-X. (2014) · Aquaculture · doi:10.1016/j.aquaculture.2014.10.004 · Cited by 175 · see citing works

TGF-beta signal transduction: biology, function and therapy for diseases

Tie, Y., Tang, F., Peng, D., Zhang, Y., & Shi, H. (2022) · Molecular Biomedicine · doi:10.1186/s43556-022-00109-9 · Cited by 178 · see citing works

Anti‐inflammatory cytokines and risk of type 2 diabetes

Herder, C., Carstensen, M., & Ouwens, D. M. (2013) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12155 · Cited by 171 · see citing works

Mechanisms of immune tolerance relevant to food allergy

Vickery, B. P., Scurlock, A. M., Jones, S. M., & Burks, A. W. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.12.1116 · Cited by 172 · see citing works

Regulation of Interleukin-10 Expression

Rutz, S., & Ouyang, W. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-94-024-0921-5_5 · Cited by 166 · see citing works

TGF-β and IL-6 signals modulate chromatin binding and promoter occupancy by acetylated FOXP3

Samanta, A., Li, B., Song, X., Bembas, K., Zhang, G., Katsumata, M., Saouaf, S. J., Wang, Q., Hancock, W. W., Shen, Y., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806726105 · Cited by 162 · see citing works

Over‐expression of forkhead box P3 and its association with receptor activator of nuclear factor‐κ B ligand, interleukin (IL) ‐17, IL‐10 and transforming growth factor‐β during the progression of chronic periodontitis

Dutzan, N., Gamonal, J. A., Silva, A., Sanz, M., & Vernal, R. (2009) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2009.01390.x · Cited by 162 · see citing works

The Utility of Paradoxical Components in Biological Circuits

Hart, Y., & Alon, U. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.01.004 · Cited by 151 · see citing works

Natural and Induced Tolerogenic Dendritic Cells

Iberg, C. A., & Hawiger, D. (2020) · Journal of Immunology · doi:10.4049/jimmunol.1901121 · Cited by 135 · see citing works

Colonization of germ-free mice with a mixture of three lactobacillus strains enhances the integrity of gut mucosa and ameliorates allergic sensitization

Kozáková, H., Schwarzer, M., Tučková, L., Šrůtková, D., Czarnowska, E., Rosiak, I., Hudcovic, T., Schabussová, I., Hermanová, P. P., Zakostelska, Z. J., et al. (2015) · Cellular and Molecular Immunology · doi:10.1038/cmi.2015.09 · Cited by 159 · see citing works

Macrophage Proinflammatory Activation and Deactivation

Valledor, A. F., Comalada, M., Santamaria‐Babí, L. F., Lloberas, J., & Celada, A. (2010) · Advances in immunology · doi:10.1016/b978-0-12-380995-7.00001-x · Cited by 159 · see citing works

The Dual Role of Myeloperoxidase in Immune Response

Arnhold, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218057 · Cited by 161 · see citing works

Vaccination Strategies to Promote Mucosal Antibody Responses

Chen, K., & Cerutti, A. (2010) · Immunity · doi:10.1016/j.immuni.2010.09.013 · Cited by 155 · see citing works

Immunomodulatory Functions of BTLA and HVEM Govern Induction of Extrathymic Regulatory T Cells and Tolerance by Dendritic Cells

Jones, A., Bourque, J., Kuehm, L. M., Opejin, A., Teague, R. M., Gross, C. J., & Hawiger, D. (2016) · Immunity · doi:10.1016/j.immuni.2016.10.008 · Cited by 154 · see citing works

Smad6-specific recruitment of Smurf E3 ligases mediates TGF-β1-induced degradation of MyD88 in TLR4 signalling

Lee, Y. S., Park, J. S., Kim, J. H., Jung, S. M., Lee, J. Y., Kim, S., & Park, S. H. (2011) · Nature Communications · doi:10.1038/ncomms1469 · Cited by 149 · see citing works

Injury‐Activated Transforming Growth Factor β Controls Mobilization of Mesenchymal Stem Cells for Tissue Remodeling

Wan, M., Li, C., Zhen, G., Jiao, K., He, W., Jia, X., Wang, W., Shi, C., Xing, Q., Chen, Y.-F., et al. (2012) · Stem Cells · doi:10.1002/stem.1208 · Cited by 141 · see citing works

Divergent roles of histone deacetylase 6 (HDAC6) and histone deacetylase 11 (HDAC11) on the transcriptional regulation of IL10 in antigen presenting cells

Cheng, F., Lienlaf, M., Perez-Villarroel, P., Wang, H.-W., Lee, C., Woan, K., Woods, D., Knox, T., Bergman, J., Pinilla-Ibarz, J., et al. (2014) · Molecular Immunology · doi:10.1016/j.molimm.2014.02.019 · Cited by 140 · see citing works

Bifidobacterium animalis in combination with human origin of Lactobacillus plantarum ameliorate neuroinflammation in experimental model of multiple sclerosis by altering CD4+ T cell subset balance

Salehipour, Z., Haghmorad, D., Sankian, M., Rastin, M., Nosratabadi, R., Dallal, M. M. S., Tabasi, N. S., Khazaee, M., Nasiraie, L. R., & Mahmoudi, M. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.08.117 · Cited by 139 · see citing works

Filarial Lymphedema Is Characterized by Antigen-Specific Th1 and Th17 Proinflammatory Responses and a Lack of Regulatory T Cells

Babu, S., Bhat, S. Q., Kumar, N. P., Lipira, A. B., Kumar, S., Karthik, C., Kumaraswami, V., & Nutman, T. B. (2009) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0000420 · Cited by 132 · see citing works

TGF-β and kynurenines as the key to infectious tolerance

Belladonna, M. L., Orabona, C., Grohmann, U., & Puccetti, P. (2009) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2008.11.006 · Cited by 127 · see citing works

Targeting innate immunity for neurodegenerative disorders of the central nervous system

Andreasson, K. I., Bachstetter, A. D., Colonna, M., Ginhoux, F., Holmes, C., Lamb, B., Landreth, G., Lee, D. C., Low, D., Lynch, M. A., et al. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13667 · Cited by 126 · see citing works

Intrahepatic IL-10 Maintains NKG2A+Ly49− Liver NK Cells in a Functionally Hyporesponsive State

Lassen, M. G., Lukens, J. R., Dolina, J. S., Brown, M. G., & Hahn, Y. S. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0901362 · Cited by 125 · see citing works

CD4+CD28null T cells in coronary artery disease: when helpers become killers

Dumitriu, I. E., Araguás, E. T., BABOONIAN, C., & Kaski, J. C. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn248 · Cited by 125 · see citing works

Transforming growth factor-β signaling: emerging stem cell target in metastatic breast cancer?

Tan, A. R., Alexe, G., & Reiß, M. (2008) · Breast Cancer Research and Treatment · doi:10.1007/s10549-008-0184-1 · Cited by 124 · see citing works

Inhibitors of clathrin-dependent endocytosis enhance TGFβ signaling and responses

Chen, C., Hou, W., Liu, I., Hsiao, G., Huang, S. S., & Huang, J. S. (2009) · Journal of Cell Science · doi:10.1242/jcs.038729 · Cited by 124 · see citing works

TGF-β Promotes Immune Responses in the Presence of Mesenchymal Stem Cells

Xu, C., Yu, P., Han, X., Du, L., Gan, J., Wang, Y., & Shi, Y. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1302164 · Cited by 124 · see citing works

Plasmodium falciparum–Mediated Induction of Human CD25hiFoxp3hi CD4 T Cells Is Independent of Direct TCR Stimulation and Requires IL-2, IL-10 and TGFβ

Scholzen, A., Mittag, D., Rogerson, S. J., Cooke, B. M., & Plebanski, M. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000543 · Cited by 121 · see citing works

Immune following suppression mesenchymal stem cell transplantation in the ischemic brain is mediated by TGF-β

Yoo, S., Chang, D., Lee, H. S., Kim, G., Park, J., Ryu, B., Joe, E.-H., Lee, Y., Kim, S., & Suh‐Kim, H. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.06.001 · Cited by 120 · see citing works

Enhanced Th17 phenotype in individuals with generalized anxiety disorder

Vieira, M. M. M., Ferreira, T. B., Pacheco, P. A. F., Barros, P. O., Almeida, C. R. M., Araújo-Lima, C. F., Silva-Filho, R. G., Hygino, J., Andrade, R. M., Linhares, U. C., et al. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.07.018 · Cited by 118 · see citing works

The differential production of cytokines by human Langerhans cells and dermal CD14+ DCs controls CTL priming

Banchereau, J., Thompson-Snipes, L., Zurawski, S., Blanck, J.-P., Cao, Y., Clayton, S., Gorvel, J., Zurawski, G., & Klechevsky, E. (2012) · Blood · doi:10.1182/blood-2011-08-371245 · Cited by 118 · see citing works

Pathophysiology of Myocardial Infarction

Frangogiannis, N. G. (2015) · Comprehensive physiology · doi:10.1002/j.2040-4603.2015.tb00664.x · Cited by 117 · see citing works

Tumor necrosis factor–alpha, transforming growth factor–β1, and interleukin-10 gene polymorphisms: implication in protection or susceptibility to dengue hemorrhagic fever

Perez, A. B., Sierra, B., Garcı́a, G., Aguirre, E., Babel, N., Álvarez, M., Sanchez, L., Valdés, L., Volk, H., & Guzmán, M. G. (2010) · Human Immunology · doi:10.1016/j.humimm.2010.08.004 · Cited by 113 · see citing works

Milk-Derived Transforming Growth Factor-β and the Infant Immune Response

Penttila, I. (2010) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2009.11.016 · Cited by 108 · see citing works

Paradoxical Signaling by a Secreted Molecule Leads to Homeostasis of Cell Levels

Hart, Y., Reich-Zeliger, S., Antebi, Y. E., Zaretsky, I., Mayo, A., Alon, U. S., & Friedman, N. (2014) · Cell · doi:10.1016/j.cell.2014.07.033 · Cited by 106 · see citing works

A novel role for histone deacetylase 6 in the regulation of the tolerogenic STAT3/IL-10 pathway in APCs

Cheng, F., Lienlaf, M., Wang, H.-W., Perez-Villarroel, P., Lee, C., Woan, K., Rock-Klotz, J., Sahakian, E., Woods, D., Pinilla-Ibarz, J., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302778 · Cited by 106 · see citing works

Cytokine production by human odontoblast-like cells upon Toll-like receptor-2 engagement

Farges, J., Carrouel, F., Keller, J., Baudouin, C., Msika, P., Bleicher, F., & Staquet, M. (2010) · Immunobiology · doi:10.1016/j.imbio.2010.08.006 · Cited by 105 · see citing works

TGF-b Directly Targets Effector T Cells

(2015)

The Interrelated Roles of TGF-β and IL-10 in the Regulation of Experimental Colitis

Fuss, I. J., Boirivant, M., Lacy, B. E., & Strober, W. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.2.900 · Cited by 259 · see citing works

Regulation of TGF-β Response During T Cell Activation Is Modulated by IL-10

Cottrez, F., & Groux, H. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.2.773 · Cited by 178 · see citing works

TRANSFORMING GROWTH FACTOR-β REGULATION OF IMMUNE RESPONSES

Li, M. O., Wan, Y. Y., Sanjabi, S., Robertson, A.-K. L., & Flavell, R. A. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090737 · Cited by 2,199 · see citing works

Cellular and molecular basis for the regulation of inflammation by TGF-

Yoshimura, A., Wakabayashi, Y., & Mori, T. (2010) · The Journal of Biochemistry · doi:10.1093/jb/mvq043 · Cited by 394 · see citing works