The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation
Open accessAbstract
Regulatory T cells (Treg cells) are essential for self-tolerance and immune homeostasis. Lack of effector T cell (Teff cell) function and gain of suppressive activity by Treg cells are dependent on the transcriptional program induced by Foxp3. Here we report that repression of SATB1, a genome organizer that regulates chromatin structure and gene expression, was crucial for the phenotype and function of Treg cells. Foxp3, acting as a transcriptional repressor, directly suppressed the SATB1 locus and indirectly suppressed it through the induction of microRNAs that bound the SATB1 3′ untranslated region. Release of SATB1 from the control of Foxp3 in Treg cells caused loss of suppressive function, establishment of transcriptional Teff cell programs and induction of Teff cell cytokines. Our data support the proposal that inhibition of SATB1-mediated modulation of global chromatin remodeling is pivotal for maintaining Treg cell functionality.
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Cites
Control of Regulatory T Cell Development by the Transcription Factor Foxp3
Hori, S., Nomura, T., & Sakaguchi, S. (2003) · Science · doi:10.1126/science.1079490 · Cited by 8,187
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
Fontenot, J. D., Gavin, M. A., & Rudensky, A. Y. (2003) · Nature Immunology · doi:10.1038/ni904 · Cited by 7,745
CD4 + Regulatory T Cells Control T H 17 Responses in a Stat3-Dependent Manner
Chaudhry, A., Rudra, D., Treuting, P., Samstein, R. M., Liang, Y., Kas, A., & Rudensky, A. Y. (2009) · Science · doi:10.1126/science.1172702 · Cited by 1,000
Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells
Zheng, Y., Josefowicz, S. Z., Kas, A., Chu, T.-T., Gavin, M. A., & Rudensky, A. Y. (2007) · Nature · doi:10.1038/nature05563 · Cited by 835
Foxp3 occupancy and regulation of key target genes during T-cell stimulation
Marson, A., Kretschmer, K., Frampton, G. M., Jacobsen, E. S., Polansky, J. K., MacIsaac, K. D., Levine, S. S., Fraenkel, E., von Boehmer, H., & Young, R. A. (2007) · Nature · doi:10.1038/nature05478 · Cited by 724
Effector T cell plasticity: flexibility in the face of changing circumstances
Murphy, K. M., & Stockinger, B. (2010) · Nature Immunology · doi:10.1038/ni.1899 · Cited by 482
Cited by
Lineage tracking reveals dynamic relationships of T cells in colorectal cancer
Zhang, L., Yu, X., Zheng, L., Zhang, Y., Li, Y., Fang, Q., Gao, R., Kang, B., Zhang, Q., Huang, J. Y., et al. (2018) · Nature · doi:10.1038/s41586-018-0694-x · Cited by 1,505
A Special Population of Regulatory T Cells Potentiates Muscle Repair
Burzyn, D., Kuswanto, W., Kolodin, D., Shadrach, J. L., Cerletti, M., Jang, Y., Sefik, E., Tan, T. G., Wagers, A. J., Benoist, C., et al. (2013) · Cell · doi:10.1016/j.cell.2013.10.054 · Cited by 1,234
“Included in the list of repressed genes is Satb1, which encodes a chromatin organizer that inhibits Treg suppressive activity (Beyer et al., 2011).”
Regulatory T cells in embryo implantation and the immune response to pregnancy
Robertson, S. A., Care, A. S., & Moldenhauer, L. M. (2018) · Journal of Clinical Investigation · doi:10.1172/jci122182 · Cited by 462
Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR
Zemmour, D., Zilionis, R., Kiner, E., Klein, A. M., Mathis, D., & Benoist, C. (2018) · Nature Immunology · doi:10.1038/s41590-018-0051-0 · Cited by 384
Kanno, Y., Vahedi, G., Hirahara, K., Singleton, K., & O'Shea, J. J. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075058 · Cited by 342
“Treg cell specific deletion of a transcription factor critical for other effector lineage, namely IRF4 for Th2 and Stat3 for Th17 cells, suggests that Treg cells elicit effector response-specific suppression by using components of the transcriptional machinery important for the “target” effector lineage (22, 23).”
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Metadata
- Authors
- Beyer, M., Thabet, Y., Müller, R.-U., Sadlon, T., Classen, S., Lahl, K., Basu, S., Zhou, X., Bailey-Bucktrout, S. L., Krebs, W., Schönfeld, E. A., Böttcher, J., Golovina, T., Mayer, C. T., Hofmann, A., Sommer, D., Debey-Pascher, S., Endl, E., Limmer, A., Hippen, K. L., Blazar, B. R., Balderas, R., Quast, T., Waha, A., Mayer, G., Famulok, M., Knolle, P. A., Wickenhauser, C., Kolanus, W., Schermer, B., Bluestone, J. A., Barry, S. C., Sparwasser, T., Riley, J. L., & Schultze, J. L.
- Venue
- Nature Immunology
- Published
- 2011-08-14
- Volume
- 12
- Issue
- 9
- Pages
- 898-907
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W1987742151
- Cited by
- 212
- References
- 6
- FWCI
- 6.63
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Beyer, M., Thabet, Y., Müller, R.-U., Sadlon, T., Classen, S., Lahl, K., Basu, S., Zhou, X., Bailey-Bucktrout, S. L., Krebs, W., Schönfeld, E. A., Böttcher, J., Golovina, T., Mayer, C. T., Hofmann, A., Sommer, D., Debey-Pascher, S., Endl, E., Limmer, A., . . . Schultze, J. L. (2011). Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation. Nature Immunology. https://doi.org/10.1038/ni.2084
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