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The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor
Open accessAbstract
Thymic output is a dynamic process, with high activity at birth punctuated by transient periods of involution during infection. Interferon-α (IFN-α) is a critical molecular mediator of pathogen-induced thymic involution, yet despite the importance of thymic involution, relatively little is known about the molecular integrators that establish sensitivity. Here we found that the microRNA network dependent on the endoribonuclease Dicer, and specifically microRNA miR-29a, was critical for diminishing the sensitivity of the thymic epithelium to simulated infection signals, protecting the thymus against inappropriate involution. In the absence of Dicer or the miR-29a cluster in the thymic epithelium, expression of the IFN-α receptor by the thymic epithelium was higher, which allowed suboptimal signals to trigger rapid loss of thymic cellularity.
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Taganov, K. D., Boldin, M. P., Chang, K.-J., & Baltimore, D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605298103 · Cited by 4,317
Requirement of bic/microRNA-155 for Normal Immune Function
Rodriguez, A., Vigorito, E., Clare, S., Warren, M. V., Couttet, P., Soond, D. R., van Dongen, S., Grocock, R. J., Das, P. P., Miska, E. A., et al. (2007) · Science · doi:10.1126/science.1139253 · Cited by 1,833
The Kinase Akt1 Controls Macrophage Response to Lipopolysaccharide by Regulating MicroRNAs
Androulidaki, A., Iliopoulos, D., Arranz, A., Doxaki, C., Schworer, S., Zacharioudaki, V., Margioris, A. N., Tsichlis, P. N., & Tsatsanis, C. (2009) · Immunity · doi:10.1016/j.immuni.2009.06.024 · Cited by 581
Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs
Yi, R., O'Carroll, D., Pasolli, H. A., Zhang, Z., Dietrich, F. S., Tarakhovsky, A., & Fuchs, E. (2006) · Nature Genetics · doi:10.1038/ng1744 · Cited by 555
MicroRNA Expression Is Required for Pancreatic Islet Cell Genesis in the Mouse
Lynn, F. C., Skewes-Cox, P., Kosaka, Y., McManus, M. T., Harfe, B. D., & German, M. S. (2007) · Diabetes · doi:10.2337/db07-0175 · Cited by 351
Cited by
Bartel, D. P. (2018) · Cell · doi:10.1016/j.cell.2018.03.006 · Cited by 3,751
Roles for MicroRNAs in Conferring Robustness to Biological Processes
Ebert, M. S., & Sharp, P. A. (2012) · Cell · doi:10.1016/j.cell.2012.04.005 · Cited by 1,564
Regulation of type I interferon signaling in immunity and inflammation: A comprehensive review
Chen, K., Liu, J., & Cao, X. (2017) · Journal of Autoimmunity · doi:10.1016/j.jaut.2017.03.008 · Cited by 312
MicroRNAs: New Regulators of Toll-Like Receptor Signalling Pathways
He, X., Jing, Z., & Cheng, G. (2014) · BioMed Research International · doi:10.1155/2014/945169 · Cited by 238
Negative regulation of type I IFN signaling
Arimoto, K.-I., Miyauchi, S., Stoner, S. A., Fan, J.-B., & Zhang, D.-E. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.2mir0817-342r · Cited by 117
Metadata
- Authors
- Papadopoulou, A. S., Dooley, J., Linterman, M. A., Pierson, W., Ucar, O., Kyewski, B., Zuklys, S., Hollander, G. A., Matthys, P., Gray, D. H. D., De Strooper, B., & Liston, A.
- Venue
- Nature Immunology
- Published
- 2011-12-18
- Volume
- 13
- Issue
- 2
- Pages
- 181-187
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2035528398
- Cited by
- 177
- References
- 5
- FWCI
- 5.00
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor. https://app.cochat.ai/papers/10.1038/ni.2193
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- Papadopoulou, A. S., Dooley, J., Linterman, M. A., Pierson, W., Ucar, O., Kyewski, B., Zuklys, S., Hollander, G. A., Matthys, P., Gray, D. H. D., De Strooper, B., & Liston, A. (2012). The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor. Nature Immunology. https://doi.org/10.1038/ni.2193
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