Cited by 145Immunotherapy and Immune ResponsesImmune Response and InflammationT-cell and B-cell Immunology

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IL-1R signaling in dendritic cells replaces pattern-recognition receptors in promoting CD8(+) T cell responses to influenza A virus

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Pang, Iris K, Ichinohe, Takeshi, Iwasaki, Akiko·2013·Nature Immunology

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Abstract

Immune responses to vaccines require direct recognition of pathogen-associated molecular patterns (PAMPs) through pattern-recognition receptors (PRRs) on dendritic cells (DCs). Unlike vaccination, infection by a live pathogen often impairs DC function and inflicts additional damage on the host. Here we found that after infection with live influenza A virus, signaling through the interleukin 1 receptor (IL-1R) was required for productive priming of CD8(+) T cells, but signaling through the PRRs TLR7 and RIG-I was not. DCs activated by IL-1 in trans were both required and sufficient for the generation of virus-specific CD8(+) T cell immunity. Our data demonstrate a critical role for a bystander cytokine in the priming of CD8(+) T cells during infection with a live virus.

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Authors: Pang, I. K., Ichinohe, T., & Iwasaki, A.
Affiliations: Yale University (US)
Corresponding author: Iwasaki, Akiko
ORCID: Ichinohe, Takeshi
Iwasaki, Akiko
Venue: Nature Immunology
Publisher: Springer Science and Business Media LLC
Published: 2013-01-13
Volume: 14
Issue: 3
Pages: 246-253
ISSN: 1529-2908 (ISSN-L)
1529-2916
DOI: 10.1038/ni.2514
PMC: PMC3577947
OpenAlex: W2035396878
Cited by: 145
References: 44
Citations by year: 2026: 5 · 2025: 3 · 2024: 4 · 2023: 8 · 2022: 5 · 2021: 15 · 2020: 8 · 2019: 10 · 2018: 11 · 2017: 19 · 2016: 13 · 2015: 21 · 2014: 12 · 2013: 10
FWCI: 10.33
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Immunology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Japan Society for the Promotion of Science (23790506)
National Cancer Institute
National Institute of Allergy and Infectious Diseases (R01AI062428, R56AI062428, AI062428 AND U54 AI057160, U54AI057160)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: IL-1 signaling, dendritic cells, CD8+ T cell priming, influenza A virus infection, pattern recognition receptors, TLR7, RIG-I, innate immunity
MeSH terms: Roundabout Proteins, Animals, Cell Differentiation, Cell Movement, Dendritic Cells, Interleukin-1, Lymphocyte Activation, Membrane Glycoproteins, Membrane Proteins, Mice, Inbred C57BL, Nerve Tissue Proteins, Orthomyxoviridae Infections, Influenza A virus, Receptors, Cell Surface, Signal Transduction, Receptors, Interleukin-1, Mice, Knockout, CD8-Positive T-Lymphocytes, Receptors, Pattern Recognition, Toll-Like Receptor 7, Mice, Myeloid Differentiation Factor 88, Receptors, CCR7

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IL-1R signaling in dendritic cells replaces pattern-recognition receptors in promoting CD8(+) T cell responses to influenza A virus

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