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Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity
Open accessAbstract
The inflammasome adaptor ASC contributes to innate immunity through the activation of caspase-1. Here we found that signaling pathways dependent on the kinases Syk and Jnk were required for the activation of caspase-1 via the ASC-dependent inflammasomes NLRP3 and AIM2. Inhibition of Syk or Jnk abolished the formation of ASC specks without affecting the interaction of ASC with NLRP3. ASC was phosphorylated during inflammasome activation in a Syk- and Jnk-dependent manner, which suggested that Syk and Jnk are upstream of ASC phosphorylation. Moreover, phosphorylation of Tyr144 in mouse ASC was critical for speck formation and caspase-1 activation. Our results suggest that phosphorylation of ASC controls inflammasome activity through the formation of ASC specks.
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Cites
Gout-associated uric acid crystals activate the NALP3 inflammasome
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NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
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NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice
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The intestinal epithelium: central coordinator of mucosal immunity
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Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome
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Metadata
- Authors
- Hara, H., Tsuchiya, K., Kawamura, I., Fang, R., Hernandez-Cuellar, E., Shen, Y., Mizuguchi, J., Schweighoffer, E., Tybulewicz, V., & Mitsuyama, M.
- Venue
- Nature Immunology
- Published
- 2013-11-03
- Volume
- 14
- Issue
- 12
- Pages
- 1247-1255
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W1974412717
- Cited by
- 381
- References
- 50
- FWCI
- 12.10
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hara, H., Tsuchiya, K., Kawamura, I., Fang, R., Hernandez-Cuellar, E., Shen, Y., Mizuguchi, J., Schweighoffer, E., Tybulewicz, V., & Mitsuyama, M. (2013). Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity. Nature Immunology. https://doi.org/10.1038/ni.2749
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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