The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Bcl-6 directly represses the gene program of the glycolysis pathway
Open accessAbstract
Despite the increasing knowledge of the molecular events that induce the glycolysis pathway in effector T cells, very little is known about the transcriptional mechanisms that dampen the glycolysis program in quiescent cell populations such as memory T cells. Here we found that the transcription factor Bcl-6 directly repressed genes encoding molecules involved in the glycolysis pathway, including Slc2a1, Slc2a3, Pkm and Hk2, in type 1 helper T cells (TH1 cells) exposed to low concentrations of interleukin 2 (IL-2). Thus, Bcl-6 had a role opposing the IL-2-sensitive glycolytic transcriptional program that the transcription factors c-Myc and HIF-1α promote in effector T cells. Additionally, the TH1 lineage–specifying factor T-bet functionally antagonized the Bcl-6-dependent repression of genes encoding molecules in the glycolysis pathway, which links the molecular balance of these two factors to regulation of the metabolic gene program.
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Cites
The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation
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Bcl6 mediates the development of T follicular helper cells
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Glucose Metabolism Regulates T Cell Activation, Differentiation, and Functions
Palmer, C. S., Ostrowski, M., Balderson, B., Christian, N., & Crowe, S. M. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00001 · Cited by 988
Biology and regulation of IL-2: from molecular mechanisms to human therapy
Spolski, R., Li, P., & Leonard, W. J. (2018) · Nature Reviews Immunology · doi:10.1038/s41577-018-0046-y · Cited by 637
Glycolysis – a key player in the inflammatory response
Soto‐Heredero, G., Gómez de las Heras, M. M., Gabandé‐Rodríguez, E., Oller, J., & Mittelbrunn, M. (2020) · The FEBS Journal · doi:10.1111/febs.15327 · Cited by 641
Harnessing the plasticity of CD4+ T cells to treat immune-mediated disease
DuPage, M., & Bluestone, J. A. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2015.18 · Cited by 513
S-2-hydroxyglutarate regulates CD8(+) T-lymphocyte fate
Tyrakis, P. A., Palazon, A., Macias, D., Lee, K. L., Phan, A. T., Veliça, P., You, J., Chia, G. S., Sim, J., Doedens, A., et al. (2016) · Nature · doi:10.1038/nature20165 · Cited by 433
Metadata
- Authors
- Oestreich, K. J., Read, K. A., Gilbertson, S. E., Hough, K. P., McDonald, P. W., Krishnamoorthy, V., & Weinmann, A. S.
- Venue
- Nature Immunology
- Published
- 2014-09-07
- Volume
- 15
- Issue
- 10
- Pages
- 957-964
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2074425485
- Cited by
- 186
- References
- 14
- FWCI
- 8.04
- Type
- journal article
- Language
- en
- Open access
- green
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- Oestreich, K. J., Read, K. A., Gilbertson, S. E., Hough, K. P., McDonald, P. W., Krishnamoorthy, V., & Weinmann, A. S. (2014). Bcl-6 directly represses the gene program of the glycolysis pathway. Nature Immunology. https://doi.org/10.1038/ni.2985
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