The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of Treg cells and macrophages in adipose tissue
Open accessAbstract
iNKT cells are CD1d-restricted lipid-sensing innate T cells that express the transcription factor PLZF. iNKT cells accumulate in adipose tissue, where they are anti-inflammatory, but the factors that contribute to their anti-inflammatory nature, and their targets in adipose tissue are unknown. Here we report that adipose tissue iNKT cells have a unique transcriptional program and produce interleukin 2 (IL-2) and IL-10. Unlike other iNKT cells, they lack PLZF, but express the transcription factor E4BP4, which controls their IL-10 production. Adipose iNKT cells are a tissue resident population that induces an anti-inflammatory phenotype in macrophages and, through production of IL-2, controls the number, proliferation and suppressor function of adipose regulatory T (Treg) cells. Thus, adipose tissue iNKT cells are unique regulators of immune homeostasis in this tissue.
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Cites
Obesity is associated with macrophage accumulation in adipose tissue
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Cited by
Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders
Choe, S. S., Huh, J. Y., Hwang, I. J., Kim, J. I., & Kim, J. B. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00030 · Cited by 1,206
Liver immunology and its role in inflammation and homeostasis
Robinson, M. W., Harmon, C., & O’Farrelly, C. (2016) · Cellular & Molecular Immunology · doi:10.1038/cmi.2016.3 · Cited by 1,151
Tissue-resident memory T cells: local specialists in immune defence
Mueller, S. N., & Mackay, L. K. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2015.3 · Cited by 1,006
Regulation of metabolism by the innate immune system
Lackey, D. E., & Olefsky, J. M. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.189 · Cited by 667
Panduro, M., Benoist, C., & Mathis, D. (2016) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095948 · Cited by 536
Metadata
- Authors
- Lynch, L., Michelet, X., Zhang, S., Brennan, P. J., Moseman, A., Lester, C., Besra, G., Vomhof-Dekrey, E. E., Tighe, M., Koay, H.-F., Godfrey, D. I., Leadbetter, E. A., Sant'Angelo, D. B., von Andrian, U., & Brenner, M. B.
- Venue
- Nature Immunology
- Published
- 2014-12-01
- Volume
- 16
- Issue
- 1
- Pages
- 85-95
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2069446125
- Cited by
- 386
- References
- 51
- FWCI
- 15.17
- Type
- journal article
- Language
- en
- Open access
- green
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- Lynch, L., Michelet, X., Zhang, S., Brennan, P. J., Moseman, A., Lester, C., Besra, G., Vomhof-Dekrey, E. E., Tighe, M., Koay, H.-F., Godfrey, D. I., Leadbetter, E. A., Sant'Angelo, D. B., von Andrian, U., & Brenner, M. B. (2015). Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of Treg cells and macrophages in adipose tissue. Nature Immunology. https://doi.org/10.1038/ni.3047
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