Cited by 168Inflammasome and immune disordersImmune Response and InflammationMitochondrial Function and Pathology

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Mitochondrial control of the NLRP3 inflammasome

Kepp, Oliver, Galluzzi, Lorenzo, Kroemer, Guido·2011·Nature Immunology

DOI 10.1038/ni0311-199

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Background
Persistent Mitochondrial Dysfunction Linked to Prolonged Organ Dysfunction in Pediatric Sepsis
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Role of glial cells in innate immunity and their role in CNS demyelination
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NLRP inflammasome as a key role player in the pathogenesis of environmental toxicants
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Capsular Polysaccharide Is Involved in NLRP3 Inflammasome Activation by Klebsiella pneumoniae Serotype K1
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Endothelial MKK3 Is a Critical Mediator of Lethal Murine Endotoxemia and Acute Lung Injury
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“New evidence suggests that mitochondria play a critical role in inflammatory responses (32, 33).”
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Reduced mitochondrial activity in colonocytes facilitates AMPKα2‐dependent inflammation
Heller, S., Penrose, H. M., Cable, C., Biswas, D., Nakhoul, H. N., Baddoo, M., Flemington, E. F., Crawford, S. E., & Savkovic, S. D. (2017) · The FASEB Journal · doi:10.1096/fj.201600976r · Cited by 43
“Additionally, IBD pathophysiology is driven by extensive mucosal injury due to infiltrated inflammatory cells, leading to elevated ROS (6, 9, 10), which could trigger inflammasome-mediated cytokine production (11, 12).”
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“Although inflammatory cytokines can suppress mitochondrial function, mitochondria themselves can activate the NLPR3 (NACHT, LRR, and PYD domains-containing protein 3) inflammasome (66), leading to a cascade that results in increased levels of lungs and circulation inflammatory cytokines in patients with PH (36).”
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LPS-induced mitochondrial dysfunction regulates innate immunity activation and α-synuclein oligomerization in Parkinson's disease
Esteves, A. R., Silva, D. F., Banha, D., Candeias, E., Guedes, B., & Cardoso, S. M. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102714 · Cited by 38
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Mitochondrial activity contributes to impaired renal metabolic homeostasis and renal pathology in STZ-induced diabetic mice
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“Mitochondria serve as a key regulatory hub of multiple cellular processes (12, 20, 26, 32, 46).”
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Oxidative stress promotes ventilator-induced lung injury through activating NLRP3 inflammasome and TRPM2 channel
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The effect of photodynamic therapy on tumor cell expression of major histocompatibility complex (MHC) class I and MHC class I‐related molecules
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“In addition, western blotting confirmed the ability of the NLRP3 shRNA lentivirus to reduce NLRP3 levels, as well as the production of active caspase 1 and active IL-1β in the mouse hippocampus compared with that of the Scrambled group (Supplementary Figs.”
Influential
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Molecular pathogenesis in chronic obstructive pulmonary disease and therapeutic potential by targeting AMP‐activated protein kinase
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Resveratrol alleviates acute lung injury in mice by promoting Pink1/Parkin-related mitophagy and inhibiting NLRP3 inflammasome activation
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Peroxyauraptenol Inhibits Inflammation and NLRP3 Inflammasome Activation by Inhibiting Reactive Oxygen Species Generation and Preserving Mitochondrial Integrity
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Cicadidae Periostracum Attenuates Atopic Dermatitis Symptoms and Pathology via the Regulation of NLRP3 Inflammasome Activation
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“ROS may lead to programmed cell death, by increasing the cytosolic concentration of proapoptotic factors, but are also crucial NLRP3 inflammasome activators [44, 45].”
Background
Spirodalesol analog 8A inhibits NLRP3 inflammasome activation and attenuates inflammatory disease by directly targeting adaptor protein ASC
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“8A specifically targets ASC It is well established that mitochondrial dysfunction, exemplified by the overproduction of ROS, is essential for the assembly of the NLRP3 inflammasome (18,19).”
Background
Ragweed pollen extract intensifies lipopolysaccharide‐induced priming of NLRP 3 inflammasome in human macrophages
Varga, A., Budai, M. M., Milesz, S., Bácsi, A., Tőzsér, J., & Benkő, S. (2012) · Immunology · doi:10.1111/imm.12052 · Cited by 27
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Implication of the NLRP3 Inflammasome in Bovine Age-Related Sarcopenia
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Lactobacillus paracasei KW3110 Prevents Inflammatory-Stress-Induced Mitochondrial Dysfunction in Mouse Macrophages
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Hit-to-Lead Optimization of the Natural Product Oridonin as Novel NLRP3 Inflammasome Inhibitors with Potent Anti-Inflammation Activity
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“Furthermore, mitochondrial dysfunction is involved in inflammasome activation following various stimuli [83].”
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Astrogliopathy and oligodendrogliopathy are early events in CNS demyelination
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“…the retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are among the main pathogen recognition receptors which play a fundamental role in mediating an efficient immune response to microorganisms (Akira, 2003; Bielig et al., 2011; Kepp et al., 2011; Lam- kanfi, 2011; Shaw et al., 2011).”
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Immunomodulatory Effects of Danshen (Salvia miltiorrhiza) in BALB/c Mice
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The protective effects of Ziziphora tenuior L. against chlorpyrifos induced toxicity: Involvement of inflammatory and cell death signaling pathways
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Authors: Kepp, O., Galluzzi, L., & Kroemer, G.
Affiliations: Université Paris-Sud (FR)
Inserm (FR)
Corresponding author: Kroemer, Guido
ORCID: Kepp, Oliver
Galluzzi, Lorenzo
Kroemer, Guido
Venue: Nature Immunology
Publisher: Springer Science and Business Media LLC
Published: 2011-02-15
Volume: 12
Issue: 3
Pages: 199-200
ISSN: 1529-2908 (ISSN-L)
1529-2916
DOI: 10.1038/ni0311-199
OpenAlex: W1981120301
Cited by: 168
References: 12
Citations by year: 2026: 4 · 2025: 4 · 2024: 10 · 2023: 8 · 2022: 16 · 2021: 9 · 2020: 17 · 2019: 12 · 2018: 8 · 2017: 12 · 2016: 14 · 2015: 10 · 2014: 12 · 2013: 16 · 2012: 11
FWCI: 5.72
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Keywords: mitochondria, NLRP3 inflammasome, innate immunity, inflammatory cytokines, inflammasome regulation, mitochondrial function
MeSH terms: NLR Family, Pyrin Domain-Containing 3 Protein, Animals, Carrier Proteins, Humans, Immunity, Innate, Mitochondria, Models, Biological, Signal Transduction, Cytokines, Inflammasomes

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