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Cited by 351

The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.

IL-1 family nomenclature

Open access
Dinarello, Charles, Arend, William, Sims, John, Smith, Dirk, Blumberg, Hal, O'Neill, Luke, Goldbach-Mansky, Raphaela, Pizarro, Theresa, Hoffman, H, Bufler, Philip, Nold, Marcel, Ghezzi, Pietro, Mantovani, Alberto, Garlanda, Cecilia, Boraschi, Diana, Rubartelli, Anna, Netea, Mihai, van der Meer, Jos, Joosten, Leo, Mandrup-Poulsen, Tom, Donath, Marc, Lewis, Eli, Pfeilschifter, Josef, Martin, Michael, Kracht, Michael, Muehl, H, Novick, Daniela, Lukic, Miodrag, Conti, Bruno, Solinger, Alan, Kelk, Peyman, van de Veerdonk, Frank, Gabel, Chiristopher·2010·Nature Immunology
DOI 10.1038/ni1110-973
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Abstract

To the Editor: Newly cloned interleukin 1 (IL-1) family members1–3 were originally given an IL-1 family (IL-1F) designation4, but as functions have now been elucidated for several of these5,6, we propose that each now be assigned an individual interleukin designation. IL-1F6, IL-1F8 and IL-1F9 are encoded by distinct genes but use the same receptor complex (IL-1Rrp2 and AcP), are proinflammatory and deliver nearly identical signals7–12. We propose these be designated IL-36α, IL-36β and IL-36γ, respectively. IL-1F5 also binds to IL-1Rrp2 but antagonizes those cytokines in a manner analogous to that used by IL-1Ra to antagonize IL-1α and IL-1β7–9. We propose that IL-1F5 be renamed IL-36Ra (for ‘receptor antagonist’). In the IL-1 nomenclature, IL-1Ra is used for the natural product, whereas IL-1ra is used for the recombinant product; therefore, IL-36Ra is appropriate for natural IL-1F5. IL-1F7 produces anti-inflammatory effects by suppressing innate immune responses; it does this by decreasing the production of inflammatory cytokines induced by Toll-like receptor agonists as well as that of IL-1 and tumor necrosis factor13,14. We propose this IL-1 family member be renamed IL-37. IL-1F7 has various splice forms1,2,15,16, of which IL-1F7b is the most studied. We propose that IL-1F7a, IL-1F7b and so on be renamed IL-37a, IL-37b and so on. The one remaining IL-1 family member, for which no function has yet been demonstrated, is IL-1F10; however, as evidence of its properties remains limited, we suggest that it retain its IL-1F designation until a function is clearly identified, although it might be prudent to reserve the designation IL-38 for this eventuality.

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Metadata

Authors
Dinarello, C., Arend, W., Sims, J., Smith, D., Blumberg, H., O'Neill, L., Goldbach-Mansky, R., Pizarro, T., Hoffman, H., Bufler, P., Nold, M., Ghezzi, P., Mantovani, A., Garlanda, C., Boraschi, D., Rubartelli, A., Netea, M., van der Meer, J., Joosten, L., Mandrup-Poulsen, T., Donath, M., Lewis, E., Pfeilschifter, J., Martin, M., Kracht, M., Muehl, H., Novick, D., Lukic, M., Conti, B., Solinger, A., Kelk, P., van de Veerdonk, F., & Gabel, C.
Venue
Nature Immunology
Publisher
Springer Science and Business Media LLC
Published
2010-10-19
Volume
11
Issue
11
Pages
973-973
ISSN
  • 1529-2908 (ISSN-L)
  • 1529-2916
DOI
10.1038/ni1110-973
OpenAlex
W2097504851
Cited by
351
References
16
FWCI
9.54
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: IL-1 family nomenclature. https://app.cochat.ai/papers/10.1038/ni1110-973
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Dinarello, C., Arend, W., Sims, J., Smith, D., Blumberg, H., O'Neill, L., Goldbach-Mansky, R., Pizarro, T., Hoffman, H., Bufler, P., Nold, M., Ghezzi, P., Mantovani, A., Garlanda, C., Boraschi, D., Rubartelli, A., Netea, M., van der Meer, J., Joosten, L., . . . Gabel, C. (2010). IL-1 family nomenclature. Nature Immunology. https://doi.org/10.1038/ni1110-973

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