Student or educator? Sign up with your school email and get 6 months of Pro free.
Cited by 1,353

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Induced recruitment of NK cells to lymph nodes provides IFN-γ for TH1 priming

Martín-Fontecha, Alfonso, Thomsen, Lindy L, Brett, Sara, Gerard, Craig, Lipp, Martin, Lanzavecchia, Antonio, Sallusto, Federica·2004·Nature Immunology

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/ni1138

Cites

2 of 2 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 2 references

Research works printed but not linked: 50

  1. Banchereau, J. & Steinman, R.M. Dendritic cells and the control of immunity. Nature 392, 245–252 (1998). · DOI · Paper page
  2. Moingeon, P., Haensler, J. & Lindberg, A. Towards the rational design of Th1 adjuvants. Vaccine 19, 4363–4372 (2001). · DOI
  3. Medzhitov, R. & Janeway, C.A. Jr. Innate immune induction of the adaptive immune response. Cold Spring Harb. Symp. Quant. Biol. 64, 429–435 (1999). · DOI
  4. Rot, A. & von Andrian, U.H. Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells. Annu. Rev. Immunol. 22, 891–928 (2004). · DOI · Paper page
  5. von Andrian, U.H. & Mempel, T.R. Homing and cellular traffic in lymph nodes. Nat. Rev. Immunol. 3, 867–878 (2003). · DOI · Paper page
  6. Forster, R. et al. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell 99, 23–33 (1999). · DOI · Paper page
  7. Gunn, M.D. et al. Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization. J. Exp. Med. 189, 451–460 (1999). · DOI · Paper page
  8. Scimone, M.L. et al. CXCL12 mediates CCR7-independent homing of central memory cells, but not naive T cells, in peripheral lymph nodes. J. Exp. Med. 199, 1113–1120 (2004). · DOI
  9. Amsen, D. et al. Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells. Cell 117, 515–526 (2004). · DOI · Paper page
  10. Macatonia, S.E. et al. Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells. J. Immunol. 154, 5071–5079 (1995). · DOI · Paper page
  11. Cella, M. et al. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J. Exp. Med. 184, 747–752 (1996). · DOI · Paper page
  12. Snijders, A., Kalinski, P., Hilkens, C.M. & Kapsenberg, M.L. High-level IL-12 production by human dendritic cells requires two signals. Int. Immunol. 10, 1593–1598 (1998). · DOI · Paper page
  13. Afkarian, M. et al. T-bet is a STAT1-induced regulator of IL-12R expression in naive CD4+ T cells. Nat. Immunol. 3, 549–557 (2002). · DOI · Paper page
  14. Szabo, S.J., Sullivan, B.M., Peng, S.L. & Glimcher, L.H. Molecular mechanisms regulating Th1 immune responses. Annu. Rev. Immunol. 21, 713–758 (2003). · DOI · Paper page
  15. Moretta, L. et al. Human natural killer cells: their origin, receptors and function. Eur. J. Immunol. 32, 1205–1211 (2002). · doi:10.1002/1521-4141(200205)32:5<1205::aid-immu1205>3.0.co;2-y
  16. Diefenbach, A. & Raulet, D.H. Innate immune recognition by stimulatory immunoreceptors. Curr. Opin. Immunol. 15, 37–44 (2003). · DOI
  17. Cerwenka, A. & Lanier, L.L. Natural killer cells, viruses and cancer. Nat. Rev. Immunol. 1, 41–49 (2001). · DOI · Paper page
  18. Yokoyama, W.M., Kim, S. & French, A.R. The dynamic life of natural killer cells. Annu. Rev. Immunol. 22, 405–429 (2004). · DOI · Paper page
  19. Moretta, A. Natural killer cells and dendritic cells: rendezvous in abused tissues. Nat. Rev. Immunol. 2, 957–964 (2002). · DOI · Paper page
  20. Cooper, M.A., Fehniger, T.A., Fuchs, A., Colonna, M. & Caligiuri, M.A. NK cell and DC interactions. Trends Immunol. 25, 47–52 (2004). · DOI · Paper page
  21. Gerosa, F. et al. Reciprocal activating interaction between natural killer cells and dendritic cells. J. Exp. Med. 195, 327–333 (2002). · DOI · Paper page
  22. Ferlazzo, G. et al. Human dendritic cells activate resting natural killer (NK) cells and are recognized via the NKp30 receptor by activated NK cells. J. Exp. Med. 195, 343–351 (2002). · DOI · Paper page
  23. Piccioli, D., Sbrana, S., Melandri, E. & Valiante, N.M. Contact-dependent stimulation and inhibition of dendritic cells by natural killer cells. J. Exp. Med. 195, 335–341 (2002). · DOI · Paper page
  24. Mailliard, R.B. et al. Dendritic cells mediate NK cell help for Th1 and CTL responses: two-signal requirement for the induction of NK cell helper function. J. Immunol. 171, 2366–2373 (2003). · DOI · Paper page
  25. Scharton, T.M. & Scott, P. Natural killer cells are a source of interferon γ that drives differentiation of CD4+ T cell subsets and induces early resistance to Leishmania major in mice. J. Exp. Med. 178, 567–577 (1993). · DOI · Paper page
  26. Fehniger, T.A. et al. CD56bright natural killer cells are present in human lymph nodes and are activated by T cell–derived IL-2: a potential new link between adaptive and innate immunity. Blood 101, 3052–3057 (2003). · DOI · Paper page
  27. Ferlazzo, G. et al. The abundant NK cells in human secondary lymphoid tissues require activation to express killer cell Ig-like receptors and become cytolytic. J. Immunol. 172, 1455–1462 (2004). · DOI · Paper page
  28. Bjorkdahl, O. et al. Characterization of CC-chemokine receptor 7 expression on murine T cells in lymphoid tissues. Immunology 110, 170–179 (2003). · DOI
  29. Hsieh, C.S., Macatonia, S.E., O'Garra, A. & Murphy, K.M. T cell genetic background determines default T helper phenotype development in vitro. J. Exp. Med. 181, 713–721 (1995). · DOI · Paper page
  30. Szabo, S.J., Dighe, A.S., Gubler, U. & Murphy, K.M. Regulation of the interleukin (IL)-12R β2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J. Exp. Med. 185, 817–824 (1997). · DOI · Paper page
  31. Alpan, O., Bachelder, E., Isil, E., Arnheiter, H. & Matzinger, P. 'Educated' dendritic cells act as messengers from memory to naive T helper cells. Nat. Immunol. 5, 615–622 (2004). · DOI
  32. Frigerio, S. et al. β Cells are responsible for CXCR3-mediated T-cell infiltration in insulitis. Nat. Med. 8, 1414–1420 (2002). · DOI · Paper page
  33. Jiang, D. et al. Regulation of pulmonary fibrosis by chemokine receptor CXCR3. J. Clin. Invest. 114, 291–299 (2004). · DOI · Paper page
  34. Janatpour, M.J., Hudak, S., Sathe, M., Sedgwick, J.D. & McEvoy, L.M. Tumor necrosis factor–dependent segmental control of MIG expression by high endothelial venules in inflamed lymph nodes regulates monocyte recruitment. J. Exp. Med. 194, 1375–1384 (2001). · DOI
  35. Yoneyama, H. et al. Evidence for recruitment of plasmacytoid dendritic cell precursors to inflamed lymph nodes through high endothelial venules. Int. Immunol. 16, 915–928 (2004). · DOI · Paper page
  36. Yoneyama, H. et al. Pivotal role of dendritic cell–derived CXCL10 in the retention of T helper cell 1 lymphocytes in secondary lymph nodes. J. Exp. Med. 195, 1257–1266 (2002). · DOI
  37. Trinchieri, G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol. 3, 133–146 (2003). · DOI · Paper page
  38. Moser, M. & Murphy, K.M. Dendritic cell regulation of TH1-TH2 development. Nat. Immunol. 1, 199–205 (2000). · DOI · Paper page
  39. Snijders, A., Kalinski, P., Hilkens, C.M. & Kapsenberg, M.L. High-level IL-12 production by human dendritic cells requires two signals. Int. Immunol. 10, 1593–1598 (1998). · DOI · Paper page
  40. Grogan, J.L. et al. Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets. Immunity 14, 205–215 (2001). · DOI · Paper page
  41. Noben-Trauth, N., Hu-Li, J. & Paul, W.E. Conventional, naive CD4+ T cells provide an initial source of IL-4 during Th2 differentiation. J. Immunol. 165, 3620–3625 (2000). · DOI
  42. Granucci, F. et al. A contribution of mouse dendritic cell–derived IL-2 for NK cell activation. J. Exp. Med. 200, 287–295 (2004). · DOI
  43. Vitale, M. et al. The small subset of CD56brightCD16 natural killer cells is selectively responsible for both cell proliferation and interferon-γ production upon interaction with dendritic cells. Eur. J. Immunol. 34, 1715–1722 (2004). · DOI · Paper page
  44. Lanzavecchia, A. & Sallusto, F. Dynamics of T lymphocyte responses: intermediates, effectors, and memory cells. Science 290, 92–97 (2000). · DOI · Paper page
  45. Wakil, A.E., Wang, Z.E., Ryan, J.C., Fowell, D.J. & Locksley, R.M. Interferon γ derived from CD4+ T cells is sufficient to mediate T helper cell type 1 development. J. Exp. Med. 188, 1651–1656 (1998). · DOI
  46. Satoskar, A.R. et al. Mice lacking NK cells develop an efficient Th1 response and control cutaneous Leishmania major infection. J. Immunol. 162, 6747–6754 (1999). · doi:10.4049/jimmunol.162.11.6747
  47. O'Hagan, D.T. & Valiante, N.M. Recent advances in the discovery and delivery of vaccine adjuvants. Nat. Rev. Drug Discov. 2, 727–735 (2003). · DOI · Paper page
  48. Hancock, W.W. et al. Requirement of the chemokine receptor CXCR3 for acute allograft rejection. J. Exp. Med. 192, 1515–1520 (2000). · DOI · Paper page
  49. Lutz, M.B. et al. An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J. Immunol. Methods 223, 77–92 (1999). · DOI · Paper page
  50. Okada, T. et al. Chemokine requirements for B cell entry to lymph nodes and Peyer's patches. J. Exp. Med. 196, 65–75 (2002). · DOI · Paper page

Cited by

See all 1,353

Metadata

Authors
Martín-Fontecha, A., Thomsen, L. L., Brett, S., Gerard, C., Lipp, M., Lanzavecchia, A., & Sallusto, F.
Venue
Nature Immunology
Published
2004-11-07
Volume
5
Issue
12
Pages
1260-1265
ISSN
  • 1529-2908 (ISSN-L)
  • 1529-2916
OpenAlex
W2021377837
Cited by
1,353
References
2
FWCI
25.80
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Induced recruitment of NK cells to lymph nodes provides IFN-γ for TH1 priming. https://app.cochat.ai/papers/10.1038/ni1138
The paper
Martín-Fontecha, A., Thomsen, L. L., Brett, S., Gerard, C., Lipp, M., Lanzavecchia, A., & Sallusto, F. (2004). Induced recruitment of NK cells to lymph nodes provides IFN-γ for TH1 priming. Nature Immunology. https://doi.org/10.1038/ni1138

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.