The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
C hemokines in I nnate and A daptive H ost D efense : Basic Chemokinese Grammar for Immune Cells
Abstract
▪ Abstract Chemokines compose a sophisticated communication system used by all our cell types, including immune cells. Chemokine messages are decoded by specific receptors that initiate signal transduction events leading to a multitude of cellular responses, leukocyte chemotaxis and adhesion in particular. Critical determinants of the in vivo activities of chemokines in the immune system include their presentation by endothelial cells and extracellular matrix molecules, as well as their cellular uptake via “silent” chemokine receptors (interceptors) leading either to their transcytosis or to degradation. These regulatory mechanisms of chemokine histotopography, as well as the promiscuous and overlapping receptor specificities of inflammation-induced chemokines, shape innate responses to infections and tissue damage. Conversely, the specific patterns of homeostatic chemokines, where each chemokine is perceived by a single receptor, are charting lymphocyte navigation routes for immune surveillance. This review presents our current understanding of the mechanisms that regulate the cellular perception and pathophysiologic meaning of chemokines.
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Cites
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Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
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The Biology of Chemokines and their Receptors
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Lineage relationship and protective immunity of memory CD8 T cell subsets
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Regulation of Dendritic Cell Migration to the Draining Lymph Node
Martín-Fontecha, A., Sebastiani, S., Höpken, U. E., Uguccioni, M., Lipp, M., Lanzavecchia, A., & Sallusto, F. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030448 · Cited by 878
Yang, D., Biragyn, A., Hoover, D. M., Lubkowski, J., & Oppenheim, J. J. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104603 · Cited by 572
Migratory properties of naive, effector, and memory CD8(+) T cells
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CCR7 Expression and Memory T Cell Diversity in Humans
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Cited by
The many roles of chemokines and chemokine receptors in inflammation
Charo, I. F., & Ransohoff, R. M. (2006) · New England Journal of Medicine · doi:10.1056/nejmra052723 · Cited by 2,523
The cellular and signaling networks linking the immune system and metabolism in disease
Osborn, O., & Olefsky, J. M. (2012) · Nature Medicine · doi:10.1038/nm.2627 · Cited by 1,551
Inflammatory and immune pathways in the pathogenesis of periodontal disease
Cekici, A., Kantarci, A., Hasturk, H., & Van Dyke, T. E. (2014) · Periodontology 2000 · doi:10.1111/prd.12002 · Cited by 1,415
“In addition to their cell-trafficking role, chemokines provide messages leading to other biological processes, such as angiogenesis, cell proliferation, apoptosis, tumor metastasis and host defense (48, 171, 200, 201, 267).”
BackgroundCCR7 and its ligands: balancing immunity and tolerance
Förster, R., Davalos-Misslitz, A. C., & Rot, A. (2008) · Nature Reviews Immunology · doi:10.1038/nri2297 · Cited by 1,410
Self-citationImmune cell migration in inflammation: present and future therapeutic targets
Luster, A. D., Alon, R., & von Andrian, U. H. (2005) · Nature Immunology · doi:10.1038/ni1275 · Cited by 1,313
Metadata
- Authors
- Rot, A., & von Andrian, U. H.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2004-04-01
- Volume
- 22
- Issue
- 1
- Pages
- 891-928
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2148740102
- Cited by
- 1,215
- References
- 11
- FWCI
- 5.27
- Type
- journal article
- Language
- en
- Open access
- closed
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