Human genetic disorders and knockout mice deficient in glycosaminoglycan
Open accessAbstract
Glycosaminoglycans (GAGs) are constructed through the stepwise addition of respective monosaccharides by various glycosyltransferases and maturated by epimerases and sulfotransferases. The structural diversity of GAG polysaccharides, including their sulfation patterns and sequential arrangements, is essential for a wide range of biological activities such as cell signaling, cell proliferation, tissue morphogenesis, and interactions with various growth factors. Studies using knockout mice of enzymes responsible for the biosynthesis of the GAG side chains of proteoglycans have revealed their physiological functions. Furthermore, mutations in the human genes encoding glycosyltransferases, sulfotransferases, and related enzymes responsible for the biosynthesis of GAGs cause a number of genetic disorders including chondrodysplasia, spondyloepiphyseal dysplasia, and Ehlers-Danlos syndromes. This review focused on the increasing number of glycobiological studies on knockout mice and genetic diseases caused by disturbances in the biosynthetic enzymes for GAGs.
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Cites
Functions of Cell Surface Heparan Sulfate Proteoglycans
Bernfield, M. R., Götte, M., Park, P. W., Reizes, O., Fitzgerald, M. L., Lincecum, J. M., & Zako, M. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.729 · Cited by 2,689 · see citing works
Chondroitinase ABC promotes functional recovery after spinal cord injury
Bradbury, E. J., Moon, L. D. F., Popat, R. J., King, V. R., Bennett, G. S., Patel, P. N., Fawcett, J. W., & McMahon, S. B. (2002) · Nature · doi:10.1038/416636a · Cited by 2,357 · see citing works
PROTEOGLYCANS: STRUCTURES AND INTERACTIONS
Kjellén, L., & Lindahl, U. (1991) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.60.070191.002303 · Cited by 1,724 · see citing works
MATRIX PROTEOGLYCANS: From Molecular Design to Cellular Function
Iozzo, R. V. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.609 · Cited by 1,639 · see citing works
Heparan sulphate proteoglycans fine-tune mammalian physiology
Bishop, J. R., Schuksz, M., & Esko, J. D. (2007) · Nature · doi:10.1038/nature05817 · Cited by 1,631 · see citing works
Proteoglycans: Structures And Interactions
Kjellén, L. (1991) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.60.1.443 · Cited by 1,602 · see citing works
Order Out of Chaos: Assembly of Ligand Binding Sites in Heparan Sulfate
Esko, J. D., & Selleck, S. B. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.110601.135458 · Cited by 1,495 · see citing works
The sweet and sour of cancer: glycans as novel therapeutic targets
Fuster, M. M., & Esko, J. D. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1649 · Cited by 1,389 · see citing works
Demystifying Heparan Sulfate–Protein Interactions
Xu, D., & Esko, J. D. (2014) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060713-035314 · Cited by 805 · see citing works
Specificities of heparan sulphate proteoglycans in developmental processes
Perrimon, N., & Bernfield, M. R. (2000) · Nature · doi:10.1038/35008000 · Cited by 713 · see citing works
Recent advances in the structural biology of chondroitin sulfate and dermatan sulfate
Sugahara, K., Mikami, T., Uyama, T., Mizuguchi, S., Nomura, K., & Kitagawa, H. (2003) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2003.09.011 · Cited by 694 · see citing works
Self-citationHeparan sulphate proteoglycans: the sweet side of development
Häcker, U., Nybakken, K. E., & Perrimon, N. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1681 · Cited by 683 · see citing works
Molecular Cloning and Characterization of Bif-1
Cuddeback, S. M., Yamaguchi, H., Komatsu, K., Miyashita, T., Yamada, M., Wu, C., Singh, S., & Wang, H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101527200 · Cited by 635 · see citing works
Biosynthesis and function of chondroitin sulfate
Mikami, T., & Kitagawa, H. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.06.006 · Cited by 505 · see citing works
Evidence for a 3-O-sulfated D-glucosamine residue in the antithrombin-binding sequence of heparin.
Lindahl, U., Bäckström, G., Thunberg, L., & Leder, I. G. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.11.6551 · Cited by 498 · see citing works
Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme
Forsberg, E., Pejler, G., Ringvall, M., Lunderius, C., Tomasini-Johansson, B. R., Kusche‐Gullberg, M., Eriksson, I., Ledin, J., Hellman, L., & Kjellén, L. (1999) · Nature · doi:10.1038/23488 · Cited by 481 · see citing works
Wang, L., Fuster, M. M., Sriramarao, P., & Esko, J. D. (2005) · Nature Immunology · doi:10.1038/ni1233 · Cited by 479 · see citing works
Regulation of Wnt Signaling and Embryo Patterning by an Extracellular Sulfatase
Dhoot, G. K., Gustafsson, M. K., Ai, X., Sun, W., Standiford, D. M., & Emerson, C. P. (2001) · Science · doi:10.1126/science.293.5535.1663 · Cited by 473 · see citing works
Bullock, S. L., Fletcher, J. M., Beddington, R. S. P., & Wilson, V. A. (1998) · Genes & Development · doi:10.1101/gad.12.12.1894 · Cited by 453 · see citing works
McCormick, C., Duncan, G., Goutsos, K. T., & Tufaro, F. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.2.668 · Cited by 450 · see citing works
Mammalian Brain Morphogenesis and Midline Axon Guidance Require Heparan Sulfate
Inatani, M., Irie, F., Plump, A. S., Tessier-Lavigne, M., & Yamaguchi, Y. (2003) · Science · doi:10.1126/science.1090497 · Cited by 431 · see citing works
Morimoto‐Tomita, M., Uchimura, K., Werb, Z., Hemmerich, S., & Rosen, S. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205131200 · Cited by 430 · see citing works
Lind, T., Tufaro, F., McCormick, C., Lindahl, U., & Lidholt, K. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.41.26265 · Cited by 429 · see citing works
Heparin is essential for the storage of specific granule proteases in mast cells
Humphries, D. E., Wong, G. W., Friend, D. S., Gurish, M. F., Qiu, W.-T., Huang, C. B., Sharpe, A. H., & Stevens, R. L. (1999) · Nature · doi:10.1038/23481 · Cited by 428 · see citing works
Disruption of Gastrulation and Heparan Sulfate Biosynthesis in EXT1-Deficient Mice
Lin, X., Wei, G., Shi, Z., Dryer, L., Esko, J. D., Wells, D. E., & Matzuk, M. M. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9798 · Cited by 427 · see citing works
Recent advances in the study of the biosynthesis and functions of sulfated glycosaminoglycans
Sugahara, K., & Kitagawa, H. (2000) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(00)00125-1 · Cited by 423 · see citing works
Self-citationThe putative tumour suppressor EXT1 alters the expression of cell-surface heparan sulfate
McCormick, C., Leduc, Y., Martindale, D., Mattison, K., Esford, L. E., Dyer, A., & Tufaro, F. (1998) · Nature Genetics · doi:10.1038/514 · Cited by 383 · see citing works
The Ehlers–Danlos syndrome, a disorder with many faces
De Paepe, A., & Malfait, F. (2012) · Clinical Genetics · doi:10.1111/j.1399-0004.2012.01858.x · Cited by 379 · see citing works
The perineuronal net and the control of CNS plasticity
Wang, D., & Fawcett, J. (2012) · Cell and Tissue Research · doi:10.1007/s00441-012-1375-y · Cited by 373 · see citing works
Persistent cortical plasticity by upregulation of chondroitin 6-sulfation
Miyata, S., Komatsu, Y., Yoshimura, Y., Taya, C., & Kitagawa, H. (2012) · Nature Neuroscience · doi:10.1038/nn.3023 · Cited by 365 · see citing works
The Molecular Diversity of Glycosaminoglycans Shapes Animal Development
Bülow, H. E., & Hobert, O. (2006) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.22.010605.093433 · Cited by 340 · see citing works
Ext1-Dependent Heparan Sulfate Regulates the Range of Ihh Signaling during Endochondral Ossification
Koziel, L., Kunath, M., Kelly, O., & Vortkamp, A. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.05.009 · Cited by 280 · see citing works
Chondroitin/dermatan sulfate in the central nervous system
Sugahara, K., & Mikami, T. (2007) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2007.08.015 · Cited by 274 · see citing works
Self-citationMultiple congenital dislocations associated with characteristics facial abnormality
Larsen, L. J., Schottstaedt, E. R., & Bost, F. C. (1950) · The Journal of Pediatrics · doi:10.1016/s0022-3476(50)80268-8 · Cited by 272 · see citing works
Genome-wide association study of recurrent early-onset major depressive disorder
Shi, J., Potash, J. B., Knowles, J. A., Weissman, M. M., Coryell, W. H., Scheftner, W. A., Lawson, W. B., DePaulo, J. R., Gejman, P. V., Sanders, A. R., et al. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.124 · Cited by 267 · see citing works
Heparin and Heparan Sulfate Biosynthesis
Sugahara, K., & Kitagawa, H. (2002) · IUBMB Life · doi:10.1080/15216540214928 · Cited by 260 · see citing works
Self-citation[Chondroitin sulfate proteoglycans in neural development and regeneration].
Gu, W.-L., & Lu, P. (2007) · PubMed · Cited by 255 · see citing works
Multiple Isoforms of Heparan Sulfate d-Glucosaminyl 3-O-Sulfotransferase
Shworak, N. W., Liu, J., Petros, L. M., Zhang, L., Kobayashi, M., Copeland, N. G., Jenkins, N. A., & ROSENBERG, R. D. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.8.5170 · Cited by 252 · see citing works
Mice deficient in Ext2 lack heparan sulfate and develop exostoses
Stickens, D., Zak, B. M., Rougier, N., Esko, J. D., & Werb, Z. (2005) · Development · doi:10.1242/dev.02088 · Cited by 249 · see citing works
Ringvall, M., Ledin, J., Holmborn, K., Kuppevelt, T. H. V., Ellin, F., Eriksson, I., Olofsson, A.-M., Kjellén, L., & Forsberg, E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000359200 · Cited by 244 · see citing works
Multiple Isozymes of Heparan Sulfate/Heparin GlcNAcN-Deacetylase/GlcN N-Sulfotransferase
Aikawa, J.-I., Grobe, K., Tsujimoto, M., & Esko, J. D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009606200 · Cited by 237 · see citing works
Habuchi, H., Tanaka, M., Habuchi, O., Yoshida, K., Suzuki, H., Ban, K., & Kimata, K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.4.2859 · Cited by 236 · see citing works
Götting, C., Kühn, J., Zahn, R. C., Brinkmann, T., & Kleesiek, K. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.2000.4261 · Cited by 236 · see citing works
Superti‐Furga, A., Hästbacka, J., Wilcox, W. R., Cohn, D. H., van der Harten, H. J., Rossi, A., Blau, N., Rimoin, D. L., Steinmann, B. U., Lander, E. S., et al. (1996) · Nature Genetics · doi:10.1038/ng0196-100 · Cited by 235 · see citing works
Cloning and Expression of a Proteoglycan UDP-Galactose:β-Xylose β1,4-Galactosyltransferase I
Almeida, R., Levery, S. B., Mandel, U., Kresse, H., Schwientek, T., Bennett, E., & Clausen, H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.37.26165 · Cited by 234 · see citing works
Li, J., Gong, F., Hagner-McWhirter, Å., Forsberg, E., Åbrink, M., Kisilevsky, R., Zhang, X., & Lindahl, U. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c300219200 · Cited by 234 · see citing works
Mutations in orthologous genes in human spondyloepimetaphyseal dysplasia and the brachymorphic mouse
Haque, M. F. U., King, L. M., Krakow, D., Cantor, R. M., Rusiniak, M. E., Swank, R. T., Superti‐Furga, A., Haque, S., Abbas, H., Ahmad, W., et al. (1998) · Nature Genetics · doi:10.1038/2458 · Cited by 217 · see citing works
MacArthur, J. M., Bishop, J. R., Stanford, K. I., Wang, L., Bensadoun, A., Witztum, J. L., & Esko, J. D. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29154 · Cited by 216 · see citing works
Kitagawa, H., Shimakawa, H., & Sugahara, K. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.20.13933 · Cited by 211 · see citing works
Self-citationChondroitin sulfate proteoglycans in neural development and regeneration
Laabs, T. L., Carulli, D., Geller, H. M., & Fawcett, J. W. (2005) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.01.014 · Cited by 211 · see citing works
Influence of core protein sequence on glycosaminoglycan assembly
Esko, J. D., & Zhang, L. (1996) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(96)80034-0 · Cited by 208 · see citing works
Molecular Cloning and Expression of a Human Chondroitin Synthase
Kitagawa, H., Uyama, T., & Sugahara, K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106871200 · Cited by 206 · see citing works
Self-citationKlüppel, M., Wight, T. N., Chan, C. K., Hinek, A., & Wrana, J. L. (2005) · Development · doi:10.1242/dev.01948 · Cited by 198 · see citing works
Hästbacka, J., Superti‐Furga, A., Wilcox, W. R., Rimoin, D. L., Cohn, D. H., & Lander, E. S. (1996) · PubMed Central · Cited by 198 · see citing works
Hereditary multiple exostoses and heparan sulfate polymerization
Zak, B. M., Crawford, B. E., & Esko, J. D. (2002) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(02)00402-6 · Cited by 192 · see citing works
Biosynthesis of the Linkage Region of Glycosaminoglycans
Bai, X., Zhou, D., Brown, J. R., Crawford, B. E., Hennet, T., & Esko, J. D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m107339200 · Cited by 190 · see citing works
Kim, B.-T., Kitagawa, H., Tamura, J., Saito, T., Kusche‐Gullberg, M., Lindahl, U., & Sugahara, K. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.131188498 · Cited by 190 · see citing works
Self-citationLiu, J., Shworak, N. W., Sînaÿ, P., Schwartz, J. J., Zhang, L., Fritze, L. M. S., & ROSENBERG, R. D. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.8.5185 · Cited by 190 · see citing works
Thiele, H., Sakano, M., Kitagawa, H., Sugahara, K., Rajab, A., Höhne, W., Ritter, H., Leschik, G., Nürnberg, P., & Mundlos, S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400334101 · Cited by 190 · see citing works
Self-citationQuentin, E., Gladen, A., Rodén, L., & Kresse, H. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.4.1342 · Cited by 187 · see citing works
Xia, G., Chen, J., Tiwari, V., Ju, W., Li, J.-P., Malmström, A., Shukla, D., & Liu, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204209200 · Cited by 187 · see citing works
Properzi, G., Carulli, D., Asher, R. A., Muir, E. M., Camargo, L. M., Kuppevelt, T. H. V., ten Dam, G. B., Furukawa, Y., Mikami, T., Sugahara, K., et al. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.03876.x · Cited by 187 · see citing works
Self-citationCerebral hypoplasia and craniofacial defects in mice lacking heparan sulfate Ndst1 gene function
Grobe, K., Inatani, M., Pallerla, S. R., Castagnola, J., Yamaguchi, Y., & Esko, J. D. (2005) · Development · doi:10.1242/dev.01935 · Cited by 184 · see citing works
Kitagawa, H., Tone, Y., Tamura, J., Neumann, K., Ogawa, T., Oka, S., Kawasaki, T., & Sugahara, K. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.12.6615 · Cited by 178 · see citing works
Self-citationTornberg, J., Sykiotis, G. P., Keefe, K., Plummer, L., Hoang, X., Hall, J. E., Quinton, R., Seminara, S. B., Hughes, V., Van Vliet, G., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102284108 · Cited by 177 · see citing works
Presto, J., Thuveson, M., Carlsson, P., Busse, M., Wilén, M., Eriksson, I., Kusche‐Gullberg, M., & Kjellén, L. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705807105 · Cited by 175 · see citing works
The Molecular Phenotype of Heparan Sulfate in theHs2st−/− Mutant Mouse
Merry, C. L. R., Bullock, S. L., Swan, D., Backen, A. C., Lyon, M., Beddington, R. S. P., Wilson, V. A., & Gallagher, J. T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100379200 · Cited by 175 · see citing works
The EXT1/EXT2 tumor suppressors: catalytic activities and role in heparan sulfate biosynthesis
Senay, C., Lind, T., Muguruma, K., Tone, Y., Kitagawa, H., Sugahara, K., Lidholt, K., Lindahl, U., & Kusche‐Gullberg, M. (2000) · EMBO Reports · doi:10.1093/embo-reports/kvd045 · Cited by 172 · see citing works
Self-citationSULF1 and SULF2 regulate heparan sulfate-mediated GDNF signaling for esophageal innervation
Ai, X., Kitazawa, T., Do, A.-T., Kusche‐Gullberg, M., Labosky, P. A., & Emerson, C. P. (2007) · Development · doi:10.1242/dev.007674 · Cited by 169 · see citing works
Kitagawa, H., Izumikawa, T., Uyama, T., & Sugahara, K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302493200 · Cited by 169 · see citing works
Self-citationInactivating <i>PAPSS2</i> Mutations in a Patient with Premature Pubarche
Noordam, C., Dhir, V., McNelis, J. C., Schlereth, F., Hanley, N. A., Krone, N., Smeitink, J. A., Smeets, R., Sweep, F. C. G. J., Grinten, H. L. C.-V. D., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810489 · Cited by 169 · see citing works
FAM20B is a kinase that phosphorylates xylose in the glycosaminoglycan–protein linkage region
Koike, T., Izumikawa, T., Tamura, J., & Kitagawa, H. (2009) · Biochemical Journal · doi:10.1042/bj20090474 · Cited by 168 · see citing works
Bao, X., Moseman, E. A., Saito, H., Petryanik, B., Thiriot, A., Hatakeyama, S., Ito, Y., Kawashima, H., Yamaguchi, Y., Lowe, J. B., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.10.018 · Cited by 167 · see citing works
Cortes, M., Baria, A. T., & Schwartz, N. B. (2009) · Development · doi:10.1242/dev.030742 · Cited by 167 · see citing works
Aikawa, J.-I., & Esko, J. D. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.5.2690 · Cited by 166 · see citing works
Fan, G., Xiao, L., Cheng, L., Wang, X., Sun, B., & Hu, G. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01111-x · Cited by 165 · see citing works
Shworak, N. W., Liu, J., Fritze, L. M. S., Schwartz, J. J., Zhang, L., Logeart‐Avramoglou, D., & ROSENBERG, R. D. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.44.28008 · Cited by 163 · see citing works
Molecular cloning and expression of rat liver N-heparan sulfate sulfotransferase.
Hashimoto, Y., Orellana, A., Gil, G., & Hirschberg, C. B. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49598-7 · Cited by 161 · see citing works
Normal levels of anticoagulant heparan sulfate are not essential for normal hemostasis
HajMohammadi, S., Enjyoji, K., Princivalle, M., Christi, P., Lech, M., Beeler, D. L., Rayburn, H., Schwartz, J. J., Barzegar, S., de Agostini, A. I., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci15809 · Cited by 158 · see citing works
Molecular Basis for the Progeroid Variant of Ehlers-Danlos Syndrome
Okajima, T., Fukumoto, S., Furukawa, K., Urano, T., & Furukawa, K. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.41.28841 · Cited by 157 · see citing works
A member of a family of sulfate-activating enzymes causes murine brachymorphism
Kurima, K., Warman, M. L., Krishnan, S., Domowicz, M. S., Krueger, R. C., Deyrup, A. T., & Schwartz, N. B. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.15.8681 · Cited by 156 · see citing works
Loss-of-function mutations of CHST14 in a new type of Ehlers-Danlos syndrome
Miyake, N., Kosho, T., Mizumoto, S., Furuichi, T., Hatamochi, A., Nagashima, Y., Arai, E., Takahashi, K., Kawamura, R., Wakui, K., et al. (2010) · Human Mutation · doi:10.1002/humu.21300 · Cited by 156 · see citing works
Self-citationAutism-like socio-communicative deficits and stereotypies in mice lacking heparan sulfate
Irie, F., Badie-Mahdavi, H., & Yamaguchi, Y. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1117881109 · Cited by 153 · see citing works
Molecular Cloning and Identification of 3′-Phosphoadenosine 5′-Phosphosulfate Transporter
Kamiyama, S., Suda, T., Ueda, R., Suzuki, M., Okubo, R., Kikuchi, N., Chiba, Y., Goto, S., Toyoda, H., Saigo, K., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302439200 · Cited by 150 · see citing works
Eriksson, I., Pikas, D. S., Ek, B., Lindahl, U., & Kjellén, L. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34079-6 · Cited by 148 · see citing works
Izumikawa, T., Koike, T., Shiozawa, S., Sugahara, K., Tamura, J., & Kitagawa, H. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m707549200 · Cited by 147 · see citing works
Self-citationKobayashi, M., Sugumaran, G., Liu, J., Shworak, N. W., Silbert, J. E., & ROSENBERG, R. D. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.15.10474 · Cited by 146 · see citing works
Okajima, T., Yoshida, K., Kondo, T., & Furukawa, K. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.33.22915 · Cited by 143 · see citing works
Malfait, F., Kariminejad, A., Van Damme, T., Gauche, C., Syx, D., Merhi-Soussi, F., Gulberti, S., Symoens, S., Vanhauwaert, S., Willaert, A., et al. (2013) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2013.04.016 · Cited by 142 · see citing works
Undersulfated chondroitin sulfate in the cartilage matrix of brachymorphic mice
Orkin, R. W., Pratt, R. M., & Martin, G. R. (1976) · Developmental Biology · doi:10.1016/0012-1606(76)90069-5 · Cited by 142 · see citing works
Loss of Dermatan-4-Sulfotransferase 1 Function Results in Adducted Thumb-Clubfoot Syndrome
Dündar, M., Müller, T., Zhang, Q., Pan, J., Steinmann, B. U., Vodopiutz, J., Gruber, R. W., Sonoda, T., Krabichler, B., Utermann, G., et al. (2009) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2009.11.010 · Cited by 142 · see citing works
Biosynthesis of Dermatan Sulfate
Maccarana, M., Olander, B., Malmström, J. A., Tiedemann, K., Aebersold, R. H., Lindahl, U., Li, J., & Malmström, A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513373200 · Cited by 142 · see citing works
The role of glypicans in Hedgehog signaling
Filmus, J., & Capurro, M. (2014) · Matrix Biology · doi:10.1016/j.matbio.2013.12.007 · Cited by 140 · see citing works
Hiraoka, N., Nakagawa, H., Ong, E., Akama, T. O., Fukuda, M. N., & Fukuda, M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002443200 · Cited by 139 · see citing works
Habuchi, H., Nagai, N., Sugaya, N., Atsumi, F., Stevens, R. L., & Kimata, K. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m607434200 · Cited by 139 · see citing works
Nakajima, M., Mizumoto, S., Miyake, N., Kogawa, R., Iida, A., Ito, H., Kitoh, H., Hirayama, A., Mitsubuchi, H., Miyazaki, O., et al. (2013) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2013.04.003 · Cited by 137 · see citing works
Self-citationForlino, A. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi079 · Cited by 137 · see citing works
Biosynthesis of dermatan sulfate. I. Formation of L-iduronic acid residues.
Malmström, A., & Fransson, L. (1975) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)41532-9 · Cited by 136 · see citing works
Normal levels of anticoagulant heparan sulfate are not essential for normal hemostasis
HajMohammadi, S., Enjyoji, K., Princivalle, M., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200315809 · Cited by 136 · see citing works
Heparan sulfate 6-O-endosulfatases: discrete in vivo activities and functional co-operativity
Lamanna, W. C., Baldwin, R. J., Padva, M., Kalus, I., ten Dam, G., Kuppevelt, T. H. V., Gallagher, J. T., FIGURA, K. V., Dierks, T., & Merry, C. L. R. (2006) · Biochemical Journal · doi:10.1042/bj20060848 · Cited by 134 · see citing works
Secreted Sulfatases Sulf1 and Sulf2 Have Overlapping yet Essential Roles in Mouse Neonatal Survival
Holst, C. R., Bou-Reslan, H., Gore, B. B., Wong, K. G., Grant, D., Chalasani, S., Carano, R. A. D., Frantz, G. D., Tessier‐Lavigne, M., Bolon, B. N., et al. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000575 · Cited by 133 · see citing works
Pratt, T., Conway, C. D., Tian, N. M. M.-L., Price, D. J., & Mason, J. O. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0505-06.2006 · Cited by 133 · see citing works
Venkatachalam, K. V. (2003) · IUBMB Life · doi:10.1080/1521654031000072148 · Cited by 131 · see citing works
Mikami, T., Mizumoto, S., Kago, N., Kitagawa, H., & Sugahara, K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306044200 · Cited by 130 · see citing works
Self-citationExtracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways
Otsuki, S., Hanson, S. R., Miyaki, S., Grogan, S. P., Kinoshita, M., Asahara, H., Wong, C., & Lotz, M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913897107 · Cited by 129 · see citing works
Molecular Cloning and Expression of Human ChondroitinN-Acetylgalactosaminyltransferase
Uyama, T., Kitagawa, H., Tamura, J., & Sugahara, K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111434200 · Cited by 128 · see citing works
Self-citationMolecular Cloning and Expression of Chinese Hamster Ovary Cell Heparan-sulfate 2-Sulfotransferase
Kobayashi, M., Habuchi, H., Yoneda, M., Habuchi, O., & Kimata, K. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.21.13980 · Cited by 127 · see citing works
Molecular Cloning and Expression of Chick Chondrocyte Chondroitin 6-Sulfotransferase
Fukuta, M., Uchimura, K., Nakashima, K., Kato, M., Kimata, K., Shinomura, T., & Habuchi, O. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.31.18575 · Cited by 124 · see citing works
Defect in 3'-phosphoadenosine 5'-phosphosulfate formation in brachymorphic mice.
Sugahara, K., & Schwartz, N. B. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.12.6615 · Cited by 124 · see citing works
Self-citationvon Holst, A., Sirko, S., & Faissner, A. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0422-06.2006 · Cited by 124 · see citing works
Faulty Initiation of Proteoglycan Synthesis Causes Cardiac and Joint Defects
Baasanjav, S., Al‐Gazali, L., Hashiguchi, T., Mizumoto, S., Fischer‐Zirnsak, B., Horn, D., Seelow, D., Ali, B. R., Aziz, S., Langer, R. D., et al. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.05.021 · Cited by 123 · see citing works
Self-citationXYLT1 Mutations in Desbuquois Dysplasia Type 2
Bui, C., Huber, C., Tüysüz, B., Alanay, Y., Bôle‐Feysot, C., Leroy, J. G., Mortier, G. R., Nitschké, P., Münnich, A., & Cormier‐Daire, V. (2014) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2014.01.020 · Cited by 122 · see citing works
Malfait, F., Syx, D., Vlummens, P., Symoens, S., Nampoothiri, S., Hermanns-Lê, T., Van Laer, L., & De Paepe, A. (2010) · Human Mutation · doi:10.1002/humu.21355 · Cited by 122 · see citing works
6-Sulphated Chondroitins Have a Positive Influence on Axonal Regeneration
Lin, R., Rosahl, T. W., Whiting, P. J., Fawcett, J. W., & Kwok, J. C. F. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021499 · Cited by 121 · see citing works
Xu, D., Tiwari, V., Xia, G., Clément, C., Shukla, D., & Liu, J. (2005) · Biochemical Journal · doi:10.1042/bj20040908 · Cited by 120 · see citing works
Sugaya, N., Habuchi, H., Nagai, N., Ashikari‐Hada, S., & Kimata, K. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m705948200 · Cited by 120 · see citing works
Seidler, D. G., Faiyaz-Ul-Haque, M., Hansen, U., Yip, G. W., Zaidi, S. H. E., Teebi, A. S., Kiesel, L., & Götte, M. (2006) · Journal of Molecular Medicine · doi:10.1007/s00109-006-0046-4 · Cited by 118 · see citing works
Evers, M. R., Xia, G., Kang, H.-G., Schachner, M., & Baenziger, J. U. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105848200 · Cited by 117 · see citing works
Hiraoka, S., Furuichi, T., Nishimura, G., Shibata, S., Yanagishita, M., Rimoin, D. L., Superti‐Furga, A., Nikkels, P. G. J., Ogawa‐Tominaga, M., Katsuyama, K., et al. (2007) · Nature Medicine · doi:10.1038/nm1655 · Cited by 117 · see citing works
Genetic alteration of endothelial heparan sulfate selectively inhibits tumor angiogenesis
Fuster, M. M., Wang, L., Castagnola, J., Sikora, L., Reddi, K., Lee, P. H. A., Radek, K. A., Schuksz, M., Bishop, J. R., Gallo, R. L., et al. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200610086 · Cited by 116 · see citing works
Uyama, T., Kitagawa, H., Tanaka, J., Tamura, J., Ogawa, T., & Sugahara, K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209446200 · Cited by 115 · see citing works
Self-citationSato, T., Gotoh, M., Kiyohara, K., Akashima, T., Iwasaki, H., Kameyama, A., Mochizuki, H., Yada, T., Inaba, N., Togayachi, A., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m208886200 · Cited by 114 · see citing works
Izumikawa, T., Uyama, T., Okuura, Y., Sugahara, K., & Kitagawa, H. (2007) · Biochemical Journal · doi:10.1042/bj20061876 · Cited by 111 · see citing works
Self-citationMolecular Cloning and Expression of Chondroitin 4-Sulfotransferase
Yamauchi, S., Mita, S., Matsubara, T., Fukuta, M., Habuchi, H., Kimata, K., & Habuchi, O. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.12.8975 · Cited by 111 · see citing works
Faiyaz‐Ul‐Haque, M., Zaidi, S. H. E., Al‐Ali, M., Al‐Mureikhi, M. S., Kennedy, S., Al‐Thani, G., Tsui, L., & Teebi, A. S. (2004) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.30005 · Cited by 111 · see citing works
Chondroitin sulphate N-acetylgalactosaminyl-transferase-1 inhibits recovery from neural injury
Takeuchi, K., Yoshioka, N., Onaga, S. H., Watanabe, Y., Miyata, S., Wada, Y., Kudo, C., Okada, M., Ohko, K., Oda, K., et al. (2013) · Nature Communications · doi:10.1038/ncomms3740 · Cited by 109 · see citing works
Ohtake, S., Ito, Y., Fukuta, M., & Habuchi, O. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104922200 · Cited by 109 · see citing works
Maccarana, M., Kalamajski, S., Kongsgaard, M., Magnusson, S. P., Oldberg, Å., & Malmström, A. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00430-09 · Cited by 109 · see citing works
Three Recessive Mutations Producing Disproportionate Dwarfing in Mice
LANE, P. W., & Dickie, M. M. (1968) · Journal of Heredity · doi:10.1093/oxfordjournals.jhered.a107725 · Cited by 108 · see citing works
Pönighaus, C., Ambrosius, M., Casanova, J. C., Prante, C., Kühn, J., Esko, J. D., Kleesiek, K., & Goötting, C. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m611665200 · Cited by 108 · see citing works
Mizumoto, S., Ikegawa, S., & Sugahara, K. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.r112.437038 · Cited by 107 · see citing works
Self-citationGulberti, S., Lattard, V., Fondeur‐Gelinotte, M., Jacquinet, J., Mulliert, G., Netter, P., Magdalou, J., Ouzzine, M., & Fournel‐Gigleux, S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411552200 · Cited by 106 · see citing works
Heparan sulfate biosynthetic gene Ndst1 is required for FGF signaling in early lens development
Pan, Y., Woodbury, A., Esko, J. D., Grobe, K., & Zhang, X. (2006) · Development · doi:10.1242/dev.02679 · Cited by 105 · see citing works
Hermanns, P., Unger, S., Rossi, A., Aytés, A. P., Cortina, H., Bonafé, L., Boccone, L., Setzu, V., Dutoit, M., Sangiorgi, L., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.05.006 · Cited by 103 · see citing works
Müller, T., Mizumoto, S., Suresh, I., Komatsu, Y., Vodopiutz, J., Dündar, M., Straub, V. W., Lingenhel, A., Melmer, A., Lechner, S., et al. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt227 · Cited by 103 · see citing works
Self-citationMolecular Characterization and Expression of Heparan-sulfate 6-Sulfotransferase
Habuchi, H., Kobayashi, M., & Kimata, K. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.15.9208 · Cited by 102 · see citing works
Heparan Sulfate Is Required for Embryonic Stem Cells to Exit from Self-renewal
Kraushaar, D. C., Yamaguchi, Y., & Wang, L. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.066837 · Cited by 102 · see citing works
Vissers, L. E. L. M., Lausch, E. U., Unger, S., Campos‐Xavier, B., Gilissen, C., Rossi, A., del Rosario, M., Venselaar, H., Knoll, U., Nampoothiri, S., et al. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.04.002 · Cited by 100 · see citing works
Li, Y., Laue, K., Temtamy, S. A., Aglan, M., Kotan, L. D., Yigit, G., Canan, H., Pawlik, B., Nürnberg, G., Wakeling, E. L., et al. (2010) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.10.003 · Cited by 99 · see citing works
Loss of heparan sulfate glycosaminoglycan assembly in podocytes does not lead to proteinuria
Chen, S., Wassenhove-McCarthy, D. J., Yamaguchi, Y., Holzman, L. B., Kuppevelt, T. H. V., Jenniskens, G. J., Wijnhoven, T. J. M., Woods, A. C., & McCarthy, K. J. (2008) · Kidney International · doi:10.1038/ki.2008.159 · Cited by 99 · see citing works
Axelsson, J. B., Xu, D., Kang, B. N., Nussbacher, J. K., Handel, T. M., Ley, K. F., Sriramarao, P., & Esko, J. D. (2012) · Blood · doi:10.1182/blood-2012-03-417139 · Cited by 99 · see citing works
Tian, J., Ling, L., Shboul, M., Lee, H., O’Connor, B. D., Merriman, B., Nelson, S. F., Cool, S. M., Ababneh, O. H., Al-Hadidy, A. M., et al. (2010) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.11.005 · Cited by 97 · see citing works
Important role of heparan sulfate in postnatal islet growth and insulin secretion
Takahashi, I., Noguchi, N., Nata, K., Yamada, S., Kaneiwa, T., Mizumoto, S., Ikeda, T., Sugihara, K., Asano, M., Yoshikawa, T., et al. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.03.140 · Cited by 97 · see citing works
Self-citationNadanaka, S., Zhou, S., Kagiyama, S., Shoji, N., Sugahara, K., Sugihara, K., Asano, M., & Kitagawa, H. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.416909 · Cited by 97 · see citing works
Self-citationMolecular cloning and expression of human chondroitin 6-sulfotransferase
Fukuta, M., Kobayashi, Y., Uchimura, K., Kimata, K., & Habuchi, O. (1998) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(98)00089-x · Cited by 96 · see citing works
Biosynthesis of Heparin/Heparan Sulfate
Li, J., Hagner-McWhirter, Å., Kjellén, L., Palgi, J., Jalkanen, M., & Lindahl, U. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.44.28158 · Cited by 96 · see citing works
Pan, Y., Carbe, C., Powers, A., Zhang, E. E., Esko, J. D., Grobe, K., Feng, G., & Zhang, X. (2007) · Development · doi:10.1242/dev.014829 · Cited by 96 · see citing works
Ohto, T., Uchida, H., Yamazaki, H., Keino‐Masu, K., Matsui, A., & Masu, M. (2002) · Genes to Cells · doi:10.1046/j.1356-9597.2001.00502.x · Cited by 94 · see citing works
Chondroitin sulfate synthase 1 (Chsy1) is required for bone development and digit patterning
Wilson, D. G., Phamluong, K., Lin, W. Y., Barck, K. H., Carano, R. A. D., Diehl, L. J., Peterson, A. S., Martin, F., & Solloway, M. J. (2012) · Developmental Biology · doi:10.1016/j.ydbio.2012.01.005 · Cited by 94 · see citing works
Gene Trap Disruption of the Mouse Heparan Sulfate 6- O -Endosulfatase Gene, Sulf2
Lum, D. H., Tan, J., Rosen, S. D., & Werb, Z. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01279-06 · Cited by 91 · see citing works
Chondroitin Sulfate Synthase-3
Yada, T., Sato, T., Kaseyama, H., Gotoh, M., Iwasaki, H., Kikuchi, N., Kwon, Y., Togayachi, A., Kudo, T., Watanabe, H., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304421200 · Cited by 89 · see citing works
Kosho, T., Miyake, N., Hatamochi, A., Takahashi, J., Kato, H., Miyahara, T., Igawa, Y., Yasui, H., Ishida, T., Ono, K., et al. (2010) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.33498 · Cited by 88 · see citing works
Chondroitin Sulfate Synthase-2
Yada, T., Gotoh, M., Sato, T., Shionyu, M., Gō, M., Kaseyama, H., Iwasaki, H., Kikuchi, N., Kwon, Y., Togayachi, A., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303657200 · Cited by 88 · see citing works
Matsumoto, Y., Irie, F., Inatani, M., Tessier‐Lavigne, M., & Yamaguchi, Y. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0700-07.2007 · Cited by 87 · see citing works
Kraushaar, D. C., Rai, S., Condac, E., Nairn, A. V., Zhang, S., Yamaguchi, Y., Moremen, K. W., Dalton, S., & Wang, L. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.368241 · Cited by 87 · see citing works
Uchimura, K., Kadomatsu, K., Nishimura, H., Muramatsu, H., Nakamura, E., Kurosawa, N., Habuchi, O., El-Fasakhany, F. M., Yoshikai, Y., & Muramatsu, T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m104719200 · Cited by 86 · see citing works
Two Dermatan Sulfate Epimerases Form Iduronic Acid Domains in Dermatan Sulfate
Pacheco, B., Malmström, A., & Maccarana, M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m809339200 · Cited by 86 · see citing works
Defect in 3′-phosphoadenosine 5′-phosphosulfate synthesis in brachymorphic mice
Sugahara, K., & Schwartz, N. B. (1982) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(82)90064-9 · Cited by 85 · see citing works
Self-citationIn Vitro Heparan Sulfate Polymerization
Kim, B.-T., Kitagawa, H., Tanaka, J., Tamura, J., & Sugahara, K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304831200 · Cited by 85 · see citing works
Self-citationBiosynthesis of dermatan sulfate. II. Substrate specificity of the C-5 uronosyl epimerase.
Malmström, A. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)43635-0 · Cited by 84 · see citing works
Molecular Cloning and Characterization of Chondroitin-4-O-sulfotransferase-3
Kang, H. G., Evers, M. R., Xia, G., Baenziger, J., & Schachner, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204907200 · Cited by 84 · see citing works
Heparan Sulfate 2-O-Sulfotransferase Is Required for Triglyceride-rich Lipoprotein Clearance
Stanford, K. I., Wang, L., Castagnola, J., Song, D., Bishop, J. R., Brown, J. R., Lawrence, R., Bai, X., Habuchi, H., Tanaka, M., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.063701 · Cited by 84 · see citing works
Kalus, I., Salmen, B., Viebahn, C., FIGURA, K. V., Schmitz, D., D’Hooge, R., & Dierks, T. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00558.x · Cited by 82 · see citing works
Altered Heparan Sulfate Structure in Mice with Deleted NDST3 Gene Function
Pallerla, S. R., Lawrence, R., Lewejohann, L., Pan, Y., Fischer, T. M., Schlomann, U., Zhang, X., Esko, J. D., & Grobe, K. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709774200 · Cited by 81 · see citing works
Gotoh, M., Sato, T., Akashima, T., Iwasaki, H., Kameyama, A., Mochizuki, H., Yada, T., Inaba, N., Zhang, Y., Kikuchi, N., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203619200 · Cited by 81 · see citing works
Tone, Y., Pedersen, L. C., Yamamoto, T., Izumikawa, T., Kitagawa, H., Nishihara, J., Tamura, J., Negishi, M., & Sugahara, K. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709556200 · Cited by 81 · see citing works
Self-citationChondroitin sulfate N-acetylgalactosaminyltransferase-1 is required for normal cartilage development
Watanabe, Y., Takeuchi, K., Onaga, S. H., Sato, M., Tsujita, M., Abe, M., Natsume, R., Li, M., Furuichi, T., Saeki, M., et al. (2010) · Biochemical Journal · doi:10.1042/bj20100847 · Cited by 80 · see citing works
Langsdorf, A. E., Do, A.-T., Kusche‐Gullberg, M., Emerson, C. P., & Ai, X. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.08.053 · Cited by 80 · see citing works
Unger, S., Lausch, E. U., Rossi, A., Mégarbané, A., Sillence, D. O., Alcausin, M. B., Aytés, A. P., Mendoza‐Londono, R., Nampoothiri, S., Afroze, B., et al. (2010) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.33641 · Cited by 80 · see citing works
Izumikawa, T., Sato, B., & Kitagawa, H. (2014) · Scientific Reports · doi:10.1038/srep03701 · Cited by 79 · see citing works
Koike, T., Izumikawa, T., Sato, B., & Kitagawa, H. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.520536 · Cited by 79 · see citing works
Foley, E. M., Gordts, P. L. S. M., Stanford, K. I., Gonzales, J. C., Lawrence, R., Stoddard, N., & Esko, J. D. (2013) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.113.301637 · Cited by 77 · see citing works
Gotoh, M., Yada, T., Sato, T., Akashima, T., Iwasaki, H., Mochizuki, H., Inaba, N., Togayachi, A., Kudo, T., Watanabe, H., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202601200 · Cited by 77 · see citing works
In Vitro Polymerization of Heparan Sulfate Backbone by the EXT Proteins
Busse, M., & Kusche‐Gullberg, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m308314200 · Cited by 77 · see citing works
Schreml, J., Durmaz, B., Çoğulu, Ö., Keupp, K., Beleggia, F., Pohl, E., Milz, E., Çöker, M., Uçar, S. K., Nürnberg, G., et al. (2013) · Human Genetics · doi:10.1007/s00439-013-1351-y · Cited by 76 · see citing works
Izumikawa, T., Kanagawa, N., Watamoto, Y., Okada, M., Saeki, M., Sakano, M., Sugahara, K., Sugihara, K., Asano, M., & Kitagawa, H. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.100941 · Cited by 75 · see citing works
Self-citationCartault, F., Munier, P., Jacquemont, M.-L., Vellayoudom, J., Doray, B., Payet, C., Randrianaivo, H., Laville, J.-M., Munnich, A., & Cormier-Daire, V. (2015) · European Journal of Human Genetics · doi:10.1038/ejhg.2014.60 · Cited by 75 · see citing works
STEEL, H. H., & KOHL, E. J. (1972) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-197254010-00007 · Cited by 73 · see citing works
Razi, N., & Lindahl, U. (1995) · PubMed · doi:10.1074/jbc.270.19.11267 · Cited by 72 · see citing works
Conway, C. D., Howe, K. M., Nettleton, N. K., Price, D. J., Mason, J. O., & Pratt, T. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.2579-10.2011 · Cited by 70 · see citing works
Mis, E. K., Liem, K. F., Kong, Y., Schwartz, N. B., Domowicz, M. S., & Weatherbee, S. D. (2013) · Developmental Biology · doi:10.1016/j.ydbio.2013.10.014 · Cited by 69 · see citing works
Li, J., Gong, F., Darwish, K., Jalkanen, M., & Lindahl, U. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011783200 · Cited by 69 · see citing works
Shimizu, K., Okamoto, N., Miyake, N., Taira, K., Sato, Y., Matsuda, K., Akimaru, N., Ohashi, H., Wakui, K., Fukushima, Y., et al. (2011) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.34115 · Cited by 68 · see citing works
Sato, T., Kudo, T., Ikehara, Y., Ogawa, H., Hirano, T., Kiyohara, K., Hagiwara, K., Togayachi, A., Ema, M., Takahashi, S., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.159244 · Cited by 68 · see citing works
A role for a lithium-inhibited Golgi nucleotidase in skeletal development and sulfation
Frederick, J. P., Tafari, A. T., Wu, S.-M., Megosh, L. C., Chiou, S.-T., Irving, R. P., & York, J. D. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801182105 · Cited by 67 · see citing works
Huegel, J., Mundy, C., Sgariglia, F., Nygren, P., Billings, P. C., Yamaguchi, Y., Koyama, E., & Pacifici, M. (2013) · Developmental Biology · doi:10.1016/j.ydbio.2013.02.008 · Cited by 66 · see citing works
Glycosaminoglycans are functional ligands for receptor for advanced glycation end‐products in tumors
Mizumoto, S., & Sugahara, K. (2013) · FEBS Journal · doi:10.1111/febs.12156 · Cited by 66 · see citing works
Self-citationBrachyolmia: Radiographic and genetic evidence of heterogeneity
Shohat, M., Lachman, R. S., Gruber, H. E., & Rimoin, D. L. (1989) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320330214 · Cited by 66 · see citing works
Crawford, B. E., Olson, S. K., Esko, J. D., & Pinhal, M. A. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100880200 · Cited by 66 · see citing works
Lack ofl-Iduronic Acid in Heparan Sulfate Affects Interaction with Growth Factors and Cell Signaling
Jia, J., Maccarana, M., Zhang, X. L., Bespalov, M. M., Lindahl, U., & Li, J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m809577200 · Cited by 65 · see citing works
Undersulfation of Heparan Sulfate Restricts Differentiation Potential of Mouse Embryonic Stem Cells
Forsberg, M., Holmborn, K., Kundu, S., Dagälv, A., Kjellén, L., & Forsberg‐Nilsson, K. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.337030 · Cited by 64 · see citing works
Zak, B. M., Schuksz, M., Koyama, E., Mundy, C., Wells, D. E., Yamaguchi, Y., Pacifici, M., & Esko, J. D. (2011) · Bone · doi:10.1016/j.bone.2011.02.001 · Cited by 63 · see citing works
Matsumoto, Y., Matsumoto, K., Irie, F., Fukushi, J., Stallcup, W. B., & Yamaguchi, Y. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.105338 · Cited by 63 · see citing works
Condac, E., Silasi‐Mansat, R., Kosanke, S. D., Schoeb, T. R., Towner, R. A., Lupu, F., Cummings, R. D., & Hinsdale, M. E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700908104 · Cited by 63 · see citing works
Izumikawa, T., Okuura, Y., Koike, T., Sakoda, N., & Kitagawa, H. (2011) · Biochemical Journal · doi:10.1042/bj20101456 · Cited by 60 · see citing works
Reijmers, R. M., Groen, R. W. J., Kuil, A., Weijer, K. C., Kimberley, F. C., Medema, J. P., Kuppevelt, T. H. V., Li, J., Spaargaren, M., & Pals, S. T. (2011) · Blood · doi:10.1182/blood-2010-12-325522 · Cited by 59 · see citing works
Götte, M., Spillmann, D., Yip, G. W., Versteeg, E., Echtermeyer, F. G., van Kuppevelt, T. H., & Kiesel, L. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddm372 · Cited by 58 · see citing works
Phenotypic and genotypic overlap between atelosteogenesis type 2 and diastrophic dysplasia
Rossi, A., van der Harten, H. J., Beemer, F. A., Kleijer, W. J., GITZELMANN, R., Steinmann, B. U., & Superti‐Furga, A. (1996) · Human Genetics · doi:10.1007/s004390050279 · Cited by 57 · see citing works
Desbuquois dysplasia, a reevaluation with abnormal and “normal” hands: Radiographic manifestations
Faivre, L. O., Cormier‐Daire, V., Eliott, A. M., Field, F. M., Münnich, A., MAROTEAUX, P., Merrer, M. F. L., & Lachman, R. S. (2003) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.20440 · Cited by 56 · see citing works
Pallerla, S. R., Pan, Y., Zhang, X., Esko, J. D., & Grobe, K. (2006) · Developmental Dynamics · doi:10.1002/dvdy.21038 · Cited by 56 · see citing works
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Varki, A. (2017) · Glycobiology · doi:10.1093/glycob/cww086 · Cited by 2,635 · see citing works
“As an example, null alleles preventing the synthesis of the core glycosaminoglycan backbone of heparan sulfate causes embryonic lethality (421) (422) , but the prevention of proper sulfation of this backbone can give living mice with specific defects (422) (423) (424) (425) (426) (427) .”
BackgroundThe GAGOme: a cell-based library of displayed glycosaminoglycans
Chen, Y., Narimatsu, Y., Clausen, T. M., Gomes, C., Karlsson, R. T. G., Steentoft, C., Spliid, C. B., Gustavsson, T., Salanti, A., Persson, A., et al. (2018) · Nature Methods · doi:10.1038/s41592-018-0086-z · Cited by 143 · see citing works
Global mapping of glycosylation pathways in human-derived cells
Huang, Y., Aoki, K., Akase, S., Ishihara, M., Liu, Y., Yang, G., Kizuka, Y., Mizumoto, S., Tiemeyer, M., Gao, X., et al. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.02.023 · Cited by 114 · see citing works
Self-citationPaganini, C., Costantini, R., Superti‐Furga, A., & Rossi, A. (2019) · FEBS Journal · doi:10.1111/febs.14984 · Cited by 70 · see citing works
Joshi, H. J., Hansen, L. H., Narimatsu, Y., Freeze, H. H., Henrissat, B., Bennett, E., Wandall, H. H., Clausen, H., & Schjoldager, K. T.-B. G. (2018) · Glycobiology · doi:10.1093/glycob/cwy015 · Cited by 62 · see citing works
Biosynthesis of glycosaminoglycans: associated disorders and biochemical tests
Sasarman, F., Maftei, C., Campeau, P. M., Brunel‐Guitton, C., Mitchell, G. A., & Allard, P. (2015) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-015-9903-z · Cited by 59 · see citing works
Congenital Disorders of Deficiency in Glycosaminoglycan Biosynthesis
Mizumoto, S., & Yamada, S. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.717535 · Cited by 55 · see citing works
Self-citationPaganini, C., Monti, L., Costantini, R., Besio, R., Lecci, S., Biggiogera, M., Tian, K., Schwartz, J., Huber, C., Cormier‐Daire, V., et al. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.11.002 · Cited by 51 · see citing works
Drug‐Mediated Regulation of Glycosaminoglycan Biosynthesis
Ghiselli, G. (2016) · Medicinal Research Reviews · doi:10.1002/med.21429 · Cited by 43 · see citing works
Identification of biallelic EXTL3 mutations in a novel type of spondylo-epi-metaphyseal dysplasia
Guo, L. Z., Elcioglu, N. H., Mizumoto, S., Wang, Z., Noyan, B., Albayrak, H. M., Yamada, S., Matsumoto, N., Miyake, N., Nishimura, G., et al. (2017) · Journal of Human Genetics · doi:10.1038/jhg.2017.38 · Cited by 39 · see citing works
Self-citationRitelli, M., Chiarelli, N., Zoppi, N., Dordoni, C., Quinzani, S., Traversa, M., Venturini, M., Calzavara-Pinton, P., & Colombi, M. (2015) · Molecular Genetics and Metabolism Reports · doi:10.1016/j.ymgmr.2014.11.005 · Cited by 37 · see citing works
Cederlund, A. A., & Aspden, R. M. (2022) · Journal of The Royal Society Interface · doi:10.1098/rsif.2022.0364 · Cited by 36 · see citing works
Disturbed Laminar Blood Flow Vastly Augments Lipoprotein Retention in the Artery Wall
Steffensen, L. B., Mortensen, M. B., Kjølby, M., Hagensen, M. K., Oxvig, C., & Bentzon, J. F. (2015) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.115.305874 · Cited by 35 · see citing works
Hu, B., Xu, C., Cao, P., Tian, Y., Zhang, Y., Shi, C., Xu, J., Yuan, W., & Chen, H. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26215 · Cited by 35 · see citing works
Song, Y., Zhang, F., & Linhardt, R. J. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-70115-4_4 · Cited by 31 · see citing works
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Tian, Y., Ma, P., Liu, C., Yang, X., Crawford, D. M., Yan, W., Bai, D., Qin, C., & Wang, X. (2015) · European Journal Of Oral Sciences · doi:10.1111/eos.12222 · Cited by 31 · see citing works
Mizumoto, S., Yamada, S., & Sugahara, K. (2015) · BioMed Research International · doi:10.1155/2015/861752 · Cited by 27 · see citing works
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Wu, J., Tian, Y., Han, L., Liu, C., Sun, T., Li, L., Yu, Y., Lamichhane, B., D’Souza, R. N., Millar, S. E., et al. (2020) · BMC Biology · doi:10.1186/s12915-020-00813-4 · Cited by 25 · see citing works
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Ma, P., Yan, W., Tian, Y., Wang, J., Feng, J. Q., Qin, C., Cheng, Y. L., & Wang, X. (2016) · Scientific Reports · doi:10.1038/srep29814 · Cited by 24 · see citing works
Hayes, A. J., & Melrose, J. (2020) · Advanced Therapeutics · doi:10.1002/adtp.202000151 · Cited by 23 · see citing works
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Habicher, J., Haitina, T., Eriksson, I., Holmborn, K., Dierker, T., Ahlberg, P., & Ledin, J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121957 · Cited by 22 · see citing works
Liao, W., Yen, H., Liao, C.-K., Tseng, T.-J., Lan, C., & Liu, C. (2019) · Europe PMC (PubMed Central) · Cited by 21 · see citing works
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Minami, K., Morimoto, H., Morioka, H., Imakiire, A., Kinoshita, M., Yamamoto, R., Hirato, T., & Sonoda, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911724 · Cited by 19 · see citing works
Ben‐Mahmoud, A., Ben‐Salem, S., Al‐Sorkhy, M., John, A., Ali, B. R., & Al‐Gazali, L. (2018) · Clinical Genetics · doi:10.1111/cge.13236 · Cited by 20 · see citing works
Kodama, K., Takahashi, H., Oiji, N., Nakano, K., Okamura, T., Niimi, K., Takahashi, E., Guo, L. Z., Ikegawa, S., & Furuichi, T. (2020) · FEBS Open Bio · doi:10.1002/2211-5463.12859 · Cited by 19 · see citing works
Adhikara, I. M., Yagi, K., Mayasari, D. S., Suzuki, Y., Ikeda, K., Ryanto, G. R. T., Sasaki, N., Rikitake, Y., Nadanaka, S., Kitagawa, H., et al. (2021) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.315789 · Cited by 18 · see citing works
Chen, C., Seward, C. H., Song, Y., Inamdar, M., Leddy, A. M., Zhang, H., Yoo, J., Kao, W., Pawlowski, H., & Stubbs, L. J. (2022) · Developmental Biology · doi:10.1016/j.ydbio.2022.08.002 · Cited by 13 · see citing works
Takahashi, I., Yamada, S., & Nata, K. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.10.008 · Cited by 13 · see citing works
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Cao, C., Liu, Y., Wang, Q., Zhao, J., Shi, M., & Zheng, J.-N. (2020) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20209021 · Cited by 12 · see citing works
Chondroitin sulfate in tissue remodeling: Therapeutic implications for pulmonary fibrosis
Kai, Y., Yoneyama, H., Yoshikawa, M., Kimura, H., & Muro, S. (2021) · Respiratory Investigation · doi:10.1016/j.resinv.2021.05.012 · Cited by 12 · see citing works
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Rios, J. J., Denton, K., Russell, J. L., Kozlitina, J., Ferreira, C. R., Lewanda, A. F., Mayfield, J. E., Moresco, E. M. Y., Ludwig, S. M., Tang, M., et al. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4323 · Cited by 11 · see citing works
Yamaguchi, K., Asakura, K., Imamura, M., Kawai, G., Sakamoto, T., Furihata, T., Linhardt, R. J., Igarashi, K., Toida, T., & Higashi, K. (2018) · Biochemical Journal · doi:10.1042/bcj20180672 · Cited by 11 · see citing works
Adhikara, I. M., Yagi, K., Mayasari, D. S., Ikeda, K., Kitagawa, H., Miyata, O., Igarashi, M., Hatakeyama, K., Asada, Y., Hirata, K., et al. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.12.068 · Cited by 11 · see citing works
Disease-specific glycosaminoglycan patterns in the extracellular matrix of human lung and brain
Ennemoser, M., Pum, A., & Kungl, A. J. (2021) · Carbohydrate Research · doi:10.1016/j.carres.2021.108480 · Cited by 11 · see citing works
Xu, Q., Lin, W. Y., Tao, C., Huang, X., & Li, J. (2020) · Biochemistry and Cell Biology · doi:10.1139/bcb-2019-0227 · Cited by 9 · see citing works
Yang, L., Gong, H., Feng, L., Mao, D., Xiao, Y., Wang, Y., & Huang, L. (2020) · FEBS Open Bio · doi:10.1002/2211-5463.13062 · Cited by 9 · see citing works
Chondroitin/dermatan sulfate glycosyltransferase genes are essential for craniofacial development
Habicher, J., Varshney, G. K., Waldmann, L., Snitting, D., Allalou, A., Zhang, H., Ghanem, A., Öhman‐Mägi, C., Dierker, T., Kjellén, L., et al. (2022) · PLoS Genetics · doi:10.1371/journal.pgen.1010067 · Cited by 8 · see citing works
Disaccharide Analysis of Glycosaminoglycans From Twenty‐Four Organs of Young and Aged Mice
Tykesson, E., Eriksson, M., Li, J., & Maccarana, M. (2025) · Proteoglycan Research · doi:10.1002/pgr2.70023 · Cited by 6 · see citing works
DSE inhibits melanoma progression by regulating tumor immune cell infiltration and VCAN
Xia, L., Feng, M., Ren, Y., Hao, X., Jiao, Q., Xu, Q., Wang, Y., Wang, Q., & Gong, N. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01676-8 · Cited by 6 · see citing works
Munz, C. M., Kreher, H., Erdbeer, A., Richter, S., Westphal, D., Yi, B., Behrendt, R., Stanke, N., Lindel, F., & Lindemann, D. (2022) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2022.07.004 · Cited by 5 · see citing works
Ouidja, M. O., Biard, D. S. F., Huynh, M. B., Laffray, X., Gómez-Henao, W., Chantepie, S., Douaron, G. L., Rebergue, N., Maïza, A., Merrick, H., et al. (2024) · PubMed Central · doi:10.1042/ebc20240106 · Cited by 4 · see citing works
Drugs affecting glycosaminoglycan metabolism
Ghiselli, G., & Maccarana, M. (2016) · Drug Discovery Today · doi:10.1016/j.drudis.2016.05.010 · Cited by 4 · see citing works
Epigenetic mechanism of carbohydrate sulfotransferase 3 ( CHST3 ) downregulation in the aging brainPreprint
Baidoe‐Ansah, D., Sakib, M. S., Jia, S., Fischer, A., Kaushik, R., & Dityatev, A. E. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/741355 · Cited by 3 · see citing works
Uijtdewilligen, P. J. E., Versteeg, E. M. M., van de Westerlo, E. M. A., van der Vlag, J., Daamen, W. F., & Kuppevelt, T. H. V. (2018) · BioMed Research International · doi:10.1155/2018/9873471 · Cited by 2 · see citing works
Ouidja, M. O., Biard, D. S. F., Chantepie, S., Laffray, X., Douaron, G. L., Huynh, M. B., Rebergue, N., Maïza, A., Rubio, K., González-Velasco, Ó., et al. (2022) · medRxiv · doi:10.1101/2022.04.18.22273971 · Cited by 2 · see citing works
Skeletal Disorders Linked to GAG Synthesis
Huber, C., Guasto, A., Dubail, J., & Cormier‐Daire, V. (2024) · Biology of extracellular matrix · doi:10.1007/978-3-031-70835-0_5 · Cited by 1 · see citing works
Ye, J., Suizu, F., Yamakawa, K., Yoneyama, H., Kondo, J., Kato, M., Nishiyama, A., Yahagi, N., & Kadota, K. (2025) · Scientific Reports · doi:10.1038/s41598-025-09445-6 · Cited by 1 · see citing works
Glycosaminoglycan Biosynthesis and Function in Zebrafish Development : Sugars Shaping Skeletons
Habicher, J. (2015) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Mizumoto, S. (2018) · Trends in Glycoscience and Glycotechnology · doi:10.4052/tigg.1812.2j
Self-citationTechnologies to Elucidate Functions of Glycans
Furukawa, K., Ohmi, Y., Kondo, Y., Ohkawa, Y., Tajima, O., Furukawa, K., Honke, K., Inokuchi, J., Gu, J., Kadomatsu, K., et al. (2019) · Springer eBooks · doi:10.1007/978-981-13-5856-2_4
Rebergue, N. (2022) · theses.fr (ABES) · doi:10.70675/1625c958z4f5az4c53zb053z9743a765c9ac
Temtamy Preaxial Brachydactyly Syndrome (TPBS)
(2026) · Elsevier eBooks · doi:10.1016/b978-3-437-15042-5.00223-x
- Authors
- Mizumoto, S., Yamada, S., & Sugahara, K.
- Affiliations
- Meijo University (JP)
- Hokkaido University (JP)
- Corresponding author
- Mizumoto, Shuji
- Sugahara, Kazuyuki
- Venue
- BioMed Research International
- Publisher
- Wiley
- Published
- 2014
- Volume
- 2014
- Pages
- 1-24
- ISSN
- 1110-7243 (ISSN-L)
- 2314-6133
- 2314-6141
- PMC
- PMC4122003
- OpenAlex
- W2159046800
- Cited by
- 54
- References
- 262
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 7 · 2021: 7 · 2020: 8 · 2019: 4 · 2018: 8 · 2017: 3 · 2016: 4 · 2015: 6 · 2014: 1
- FWCI
- 0.47
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- BioMed Research International (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Ministry of Education, Culture, Sports, Science, and Technology (24110501, 26110719, 24590071, 25860037)
- Japan Society for the Promotion of Science (24110501, 26110719, 24590071, 25860037)
- Japan Heart Foundation (24110501, 26110719, 24590071, 25860037)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Health Sciences › Medicine › Physiology › Lysosomal Storage Disorders Research
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Keywords
- glycosaminoglycans, glycosaminoglycan synthesis, knockout mice, glycosyltransferases, sulfotransferase, proteoglycans, chondrodysplasia, spondyloepiphyseal dysplasia, Ehlers-Danlos syndrome, genetic disorders, sulfation patterns, glycobiology
- MeSH terms
- Animals, Ehlers-Danlos Syndrome, Glycosaminoglycans, Humans, Morphogenesis, Mutation, Osteochondrodysplasias, Signal Transduction, Glycosyltransferases, Mice, Knockout, Cell Proliferation
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