The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system
Abstract
Studies have focused on the events that influence the development of interleukin 17 (IL-17)-producing T helper cells (T(H)-17 cells) associated with autoimmunity, such as experimental autoimmune encephalitis, but relatively little is known about the cytokines that antagonize T(H)-17 cell effector responses. Here we show that IL-27 receptor-deficient mice chronically infected with Toxoplasma gondii developed severe neuroinflammation that was CD4+ T cell dependent and was associated with a prominent IL-17 response. In vitro, treatment of naive primary T cells with IL-27 suppressed the development T(H)-17 cells induced by IL-6 and transforming growth factor-beta, which was dependent on the intracellular signaling molecule STAT1 but was independent of inhibition of IL-6 signaling mediated by the suppressor protein SOCS3. Thus IL-27, a potent inhibitor of T(H)-17 cell development, may be a useful target for treating inflammatory diseases mediated by these cells.
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“In addition to favoring the differentiation of naïve T cells to Th1 cells via IFN-γ induction, IL-27 can also inhibit the differentiation of Th17 cells (57).”
From Macrophage Cytokines: Involvement in Immunity and Infectious Diseases (2014) · cites this paper as [57]
In the citing paper
“In addition to favoring the differentiation of naïve T cells to Th1 cells via IFN-γ induction, IL-27 can also inhibit the differentiation of Th17 cells (57).”
From Macrophage Cytokines: Involvement in Immunity and Infectious Diseases (2014) · cites this paper as [57]
Citations
Cites
Mosmann, T. R., & Coffman, R. L. (1989) · Annual Review of Immunology · doi:10.1146/annurev.iy.07.040189.001045 · Cited by 7,692
Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992
Harrington, L. E., Hatton, R. D., Mangan, P. R., Turner, H., Murphy, T. L., Murphy, K. M., & Weaver, C. T. (2005) · Nature Immunology · doi:10.1038/ni1254 · Cited by 4,742
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
Park, H., Li, Z., Yang, X. O., Chang, S. H., Nurieva, R., Wang, Y.-H., Wang, Y., Hood, L., Zhu, Z., Tian, Q., et al. (2005) · Nature Immunology · doi:10.1038/ni1261 · Cited by 4,265
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
Langrish, C. L., Chen, Y., Blumenschein, W. M., Mattson, J., Basham, B., Sedgwick, J. D., McClanahan, T., Kastelein, R. A., & Cua, D. J. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041257 · Cited by 4,099
Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M., & Stockinger, B. (2006) · Immunity · doi:10.1016/j.immuni.2006.01.001 · Cited by 3,605
Transforming growth factor-β induces development of the TH17 lineage
Mangan, P. R., Harrington, L. E., O'Quinn, D. B., Helms, W. S., Bullard, D. C., Elson, C. O., Hatton, R. D., Wahl, S. M., Schoeb, T. R., & Weaver, C. T. (2006) · Nature · doi:10.1038/nature04754 · Cited by 3,087
Cua, D. J., Sherlock, J., Chen, Y., Murphy, C. A., Joyce, B., Seymour, B., Lucian, L., To, W., Kwan, S., Churakova, T., et al. (2003) · Nature · doi:10.1038/nature01355 · Cited by 2,906
Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
HEINRICH, P. C., BEHRMANN, I., MÜLLER-NEWEN, G., SCHAPER, F., & GRAEVE, L. (1998) · Biochemical Journal · doi:10.1042/bj3340297 · Cited by 2,130
Aggarwal, S., Ghilardi, N., Xie, M.-H., de Sauvage, F. J., & Gurney, A. L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207577200 · Cited by 1,848
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Milner, J. D. (2011) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.12516956.14414069
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Wang, W., Hu, J., Qi, H., Zhang, T., Wang, M., Zhang, L., & Xiang, J. (2022) · Research Square · doi:10.21203/rs.3.rs-2346227/v1
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O’Hara, S. (2012) · uO Research (University of Ottawa) · doi:10.20381/ruor-5966
TH17 Cytokines in Primary Mucosal Immunity
Kolls, J. K., & Khader, S. A. (2011) · Springer eBooks · doi:10.1007/978-1-4419-9371-7_13
Rahimi, Z., Yaghobi, R., Afshari, A., Roozbeh, J., Mokhtari, M. J., & Hosseini, A. M. (2022) · Figshare · doi:10.6084/m9.figshare.18070648
Immunomodulation de l'arthrite expérimentale par les cellules dendritiques tolérogènes.
Quentin, J. (2011) · theses.fr (ABES) · doi:10.70675/df771e9dzc254z4ad5za2c0z0fdf279aae87
Tamargo, M. G. D. A. (2011) · theses.fr (ABES) · doi:10.70675/8febaec4z61f1z41f7z9621zf9a3ffc15ed7
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Bittich-Fahmi, F. (2020) · theses.fr (ABES) · doi:10.70675/d1b9dbd9z19f2z4867za42azda708dec47a1
Azarsız, E., Şenol, H. D., Topyıldız, E., Gülen, F., & Demir, E. (2026) · Allergologia et Immunopathologia · doi:10.15586/aei.v54i3.1564
Eastham, S., Ward, A., Moscrop, C., Hill, D. G., Morrin, A. S., Dimonte, S., Young, A., Jones, S. A., Liu, J., Dick, A. D., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.07.13.738174
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Metadata
- Authors
- Stumhofer, J. S., Laurence, A., Wilson, E. H., Huang, E., Tato, C. M., Johnson, L. M., Villarino, A. V., Huang, Q., Yoshimura, A., Sehy, D., Saris, C. J. M., O'Shea, J. J., Hennighausen, L., Ernst, M., & Hunter, C. A.
- Affiliations
- University of Pennsylvania (US)
- National Institutes of Health (US)
- Kyushu University (JP)
- Amgen (United States) (US)
- Ludwig Cancer Research (BE)
- Corresponding author
- Hunter, Christopher A
- ORCID
- Venue
- Nature Immunology
- Published
- 2006-08-13
- Volume
- 7
- Issue
- 9
- Pages
- 937-945
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W1999561404
- Cited by
- 955
- References
- 60
- Citations by year
- 2026: 5 · 2025: 17 · 2024: 20 · 2023: 25 · 2022: 25 · 2021: 27 · 2020: 43 · 2019: 28 · 2018: 31 · 2017: 37 · 2016: 41 · 2015: 38 · 2014: 48 · 2013: 73 · 2012: 67
- FWCI
- 32.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (AI 42334, 1-T32-AI-055428, R01AI041158, R01AI042334, AI41158, T32AI055428)
- National Institute of Neurological Disorders and Stroke (R01NS072298)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Keywords
- IL-27, IL-17, Th17 cells, neuroinflammation, Toxoplasma gondii, experimental autoimmune encephalitis, STAT1 signaling, SOCS3, interleukin-6, TGF-beta, CD4+ T cells, autoimmunity, chronic infection
- MeSH terms
- Suppressor of Cytokine Signaling 3 Protein, Animals, Central Nervous System, Encephalitis, T-Lymphocytes, Helper-Inducer, Interleukins, Lymphocyte Activation, Toxoplasma, CD4 Antigens, Interleukin-6, Toxoplasmosis, Cerebral, Receptors, Cytokine, Receptors, Interleukin, Mice, Knockout, Interleukin-17, STAT1 Transcription Factor, Suppressor of Cytokine Signaling Proteins, Mice
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