Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

Mosmann, T. R., & Coffman, R. L. (1989) · Annual Review of Immunology · doi:10.1146/annurev.iy.07.040189.001045 · Cited by 7,692

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992

Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

Harrington, L. E., Hatton, R. D., Mangan, P. R., Turner, H., Murphy, T. L., Murphy, K. M., & Weaver, C. T. (2005) · Nature Immunology · doi:10.1038/ni1254 · Cited by 4,742

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

Park, H., Li, Z., Yang, X. O., Chang, S. H., Nurieva, R., Wang, Y.-H., Wang, Y., Hood, L., Zhu, Z., Tian, Q., et al. (2005) · Nature Immunology · doi:10.1038/ni1261 · Cited by 4,265

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

Langrish, C. L., Chen, Y., Blumenschein, W. M., Mattson, J., Basham, B., Sedgwick, J. D., McClanahan, T., Kastelein, R. A., & Cua, D. J. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041257 · Cited by 4,099

TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells

Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M., & Stockinger, B. (2006) · Immunity · doi:10.1016/j.immuni.2006.01.001 · Cited by 3,605

Transforming growth factor-β induces development of the TH17 lineage

Mangan, P. R., Harrington, L. E., O'Quinn, D. B., Helms, W. S., Bullard, D. C., Elson, C. O., Hatton, R. D., Wahl, S. M., Schoeb, T. R., & Weaver, C. T. (2006) · Nature · doi:10.1038/nature04754 · Cited by 3,087

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

Cua, D. J., Sherlock, J., Chen, Y., Murphy, C. A., Joyce, B., Seymour, B., Lucian, L., To, W., Kwan, S., Churakova, T., et al. (2003) · Nature · doi:10.1038/nature01355 · Cited by 2,906

Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway

HEINRICH, P. C., BEHRMANN, I., MÜLLER-NEWEN, G., SCHAPER, F., & GRAEVE, L. (1998) · Biochemical Journal · doi:10.1042/bj3340297 · Cited by 2,130

Interleukin-23 Promotes a Distinct CD4 T Cell Activation State Characterized by the Production of Interleukin-17

Aggarwal, S., Ghilardi, N., Xie, M.-H., de Sauvage, F. J., & Gurney, A. L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207577200 · Cited by 1,848

Characterization of Early Peripheral Immune Responses in Patients with Sepsis and Septic Shock

Beltrán-García, J., Osca-Verdegal, R., Jávega, B., Herrera, G., O’Connor, J., García-López, E., Casabó-Vallés, G., Rodríguez, M. D. P., Ferreres, J., Carbonell, N., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10030525 · Cited by 24

Cell-Intrinsic gp130 Signaling on CD4+ T Cells Shapes Long-Lasting Antiviral Immunity

Harker, J. A., Wong, K. A., Dolgoter, A., & Zúñiga, E. I. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402402 · Cited by 26

REVIEWS IN BASIC AND CLINICAL GASTROENTEROLOGY

Lynch, J. P., Metz, D. C., Schuppan, D., Junker, Y., & Barisani, D. (2009) · Cited by 24

Reference Values for a Panel of Cytokinergic and Regulatory Lymphocyte Subpopulations

Sorrenti, V., Marenda, B., Fortinguerra, S., Cecchetto, C., Quartesan, R., Zorzi, G., Zusso, M., Giusti, P., & Buriani, A. (2016) · Immune Network · doi:10.4110/in.2016.16.6.344 · Cited by 25

IFNγ inhibits G-CSF induced neutrophil expansion and invasion of the CNS to prevent viral encephalitis

Ramakrishna, C., & Cantin, E. M. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1006822 · Cited by 24

cIAP1/2–TRAF2–SHP-1–Src–MyD88 Complex Regulates Lipopolysaccharide-Induced IL-27 Production through NF-κB Activation in Human Macrophages

Busca, A., Konarski, Y., Gajanayaka, N., O’Hara, S., Angel, J. B., Kozlowski, M., & Kumar, A. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1700199 · Cited by 28

The impact of vitamin D3 intake on inflammatory markers in multiple sclerosis patients and their first-degree relatives

Hashemi, R., Hosseini-Asl, S. S., Arefhosseini, S. R., & Morshedi, M. (2020) · PLoS ONE · doi:10.1371/journal.pone.0231145 · Cited by 23

Adult Onset Still's Disease and Autoinflammation

Efthimiou, P., Moorthy, L. N., Mavragani, C. P., Skokos, D., & Fautrel, B. (2012) · International Journal of Inflammation · doi:10.1155/2012/964751 · Cited by 24

Interleukin‐12 family members and type I interferons in Th17‐mediated inflammatory disorders

Goriely, S., Cavoy, R., & Goldman, M. (2009) · Allergy · doi:10.1111/j.1398-9995.2009.02039.x · Cited by 24

T Cell Vaccinology: Beyond the Reflection of Infectious Responses

Pennock, N. D., Kedl, J. D., & Kedl, R. M. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.01.001 · Cited by 25

Cinnamaldehyde targets TLR-4 and inflammatory mediators in acetic-acid induced ulcerative colitis model

Momtaz, S., Navabakhsh, M., Bakouee, N., Dehnamaki, M., Rahimifard, M., Baeeri, M., Abdollahi, A., Abdollahi, M. R., Farzaei, M. H., & Abdolghaffari, A. H. (2021) · Biologia · doi:10.1007/s11756-021-00725-w · Cited by 23

Lack of association between IL27 gene variants and type 1 diabetes susceptibility

Santos, A. S., de Melo, M. E., Crisostomo, L. G., Fukui, R. T., Matioli, S. R., & Silva, M. E. R. (2013) · Cytokine · doi:10.1016/j.cyto.2012.12.003 · Cited by 23

Induction of Peripheral Tolerance in Ongoing Autoimmune Inflammation Requires Interleukin 27 Signaling in Dendritic Cells

Thomé, R., Moore, J. N., Mari, E. R., Rasouli, J., Hwang, D. H., Yoshimura, S., Ćirić, B., Zhang, G., & Rostami, A. M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01392 · Cited by 23

The Myeloid Receptor PILRβ Mediates the Balance of Inflammatory Responses through Regulation of IL-27 Production

Tato, C. M., Joyce-Shaikh, B., Banerjee, A., Chen, Y., Sathe, M., Ewald, S. E., Liu, M.-R., Gorman, D. M., McClanahan, T. K., Phillips, J. H., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031680 · Cited by 23

Enhanced STAT3 phosphorylation and PD-L1 expression in myeloid dendritic cells indicate impaired IL-27Ralpha signaling in type 1 diabetes

Paračková, Z., Vrabcová, P., Zentsová, I., Kayserová, J., Richtrova, I., Sojka, L., Štechová, K., Sumnik, Z., & Šedivá, A. (2020) · Scientific Reports · doi:10.1038/s41598-020-57507-8 · Cited by 22

Pulmonary paracoccidioidomycosis in AhR deficient hosts is severe and associated with defective Treg and Th22 responses

de Araújo, E. F., Preite, N. W., Veldhoen, M., Loures, F. V., & Calich, V. L. G. (2020) · Scientific Reports · doi:10.1038/s41598-020-68322-6 · Cited by 22

Decreased Interleukin-37 Expression in Vogt-Koyanagi-Harada Disease and Upregulation Following Immunosuppressive Treatment

Ye, Z., Wang, C., Tang, J., Zhou, Y. N., Bai, L., Liu, Y., Kijlstra, A., & Yang, P. (2014) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2014.0042 · Cited by 22

Immunoregulatory Function of IL-27 and TGF-β1 in Cardiac Allograft Transplantation

Texier, L. L., Thébault, P., Carvalho‐Gaspar, M., Vignard, V., Mérieau, E., Usal, C., Cuturi, M. C., Wood, K. J., & Chiffoleau, E. (2012) · Transplantation · doi:10.1097/tp.0b013e31825b0c38 · Cited by 22

Monocyte-derived dendritic cells in multiple sclerosis: The effect of bacterial infection

Correale, J. D., & Farez, M. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2007.08.011 · Cited by 22

Toxoplasma gondii and multiple sclerosis: A systematic review and meta‐analysis

Cicero, C. E., Allibrio, F. E., Giuliano, L., Luna, J., Preux, P., & Nicoletti, A. S. Q. (2021) · European Journal of Neurology · doi:10.1111/ene.15055 · Cited by 22

Therapeutic potential of IL-27 in systemic lupus erythematosus

Pan, H., Tao, J., & Ye, D. (2010) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728221003769911 · Cited by 22

Environmental control of Th17 differentiation

Quintana, F. J., & Weiner, H. L. (2009) · European Journal of Immunology · doi:10.1002/eji.200839198 · Cited by 22

Activation of eosinophils by IL-12 family cytokine IL-27: Implications of the pleiotropic roles of IL-27 in allergic responses

Hu, S., Wong, C. K., & Lam, C. W. K. (2010) · Immunobiology · doi:10.1016/j.imbio.2010.03.004 · Cited by 22

New pieces in the puzzle: How does interferon‐β really work in multiple sclerosis?

Mitsdoerffer, M., & Kuchroo, V. K. (2009) · Annals of Neurology · doi:10.1002/ana.21722 · Cited by 22

IL-22-Expressing Murine Lymphocytes Display Plasticity and Pathogenicity in Reporter Mice

Shen, W., Hixon, J. A., McLean, M. H., Li, W., & Durum, S. K. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00662 · Cited by 22

Host and Toxoplasma gondii genetic and non-genetic factors influencing the development of ocular toxoplasmosis: A systematic review

Fernández, C., Jaimes, J., Ortiz, M. C. M., & Ramírez, J. D. (2016) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2016.06.053 · Cited by 21

Iron oxide nanoparticles attenuate T helper 17 cell responses in vitro and in vivo

Hsiao, Y.-P., Shen, C., Huang, C., Lin, Y., & Jan, T. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.03.007 · Cited by 21

Differing Outcome of Experimental Autoimmune Encephalitis in Macrophage/Neutrophil- and T Cell-Specific gp130-Deficient Mice

Holz, K., Prinz, M., Brendecke, S. M., Hölscher, A., Deng, F., Mitrücker, H.-W., Rose‐John, S., & Hölscher, C. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00836 · Cited by 21

IL-27 and autoimmune rheumatologic diseases: The good, the bad, and the ugly

Shahi, A., Afzali, S., Salehi, S., Aslani, S., Mahmoudi, M., Jamshidi, A., & Amirzargar, A. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106538 · Cited by 21

Methylmercury chloride exposure aggravates proinflammatory mediators and Notch-1 signaling in CD14+ and CD40+ cells and is associated with imbalance of neuroimmune function in BTBR T+ Itpr3tf/J mice

Ahmad, S. F., Bakheet, S. A., Ansari, M. A., Nadeem, A., Alobaidi, A. F., Attia, S. M., Alhamed, A. S., Aldossari, A. A., & Mahmoud, M. A. (2020) · NeuroToxicology · doi:10.1016/j.neuro.2020.10.014 · Cited by 21

Toxoplasma gondii

Montoya, J. G., Boothroyd, J. C., & Kovacs, J. A. (2010) · Elsevier eBooks · doi:10.1016/b978-0-443-06839-3.00279-4 · Cited by 21

Plasmacytoid dendritic cell-derived IFNα modulates Th17 differentiation during early Bordetella pertussis infection in mice

Wu, V., Smith, A. A., You, H., Nguyen, T. A., Ferguson, R., Taylor, M., Park, J. E., Llontop, P., Youngman, K. R., & Abramson, T. (2015) · Mucosal Immunology · doi:10.1038/mi.2015.101 · Cited by 21

Immune targeting and host-protective effects of the latent stage of Toxoplasma gondii

Eberhard, J. N., Shallberg, L. A., Winn, A., Chandrasekaran, S., Giuliano, C. J., Merritt, E. F., Willis, E., Konradt, C., Christian, D. A., Aldridge, D. L., et al. (2025) · Nature Microbiology · doi:10.1038/s41564-025-01967-z · Cited by 20

IL-10 and ICOS Differentially Regulate T Cell Responses in the Brain during Chronic Toxoplasma gondii Infection

O’Brien, C. A., Batista, S. J., Still, K. M., & Harris, T. H. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1801229 · Cited by 20

The IL‐27/IL‐27R axis is altered in CD4+ and CD8+ T lymphocytes from multiple sclerosis patients

Clénet, M., Laurent, C., Lemaître, F., Farzam‐kia, N., Tastet, O., Devergne, O., Lahav, B., Girard, M., Duquette, P., Prat, A., et al. (2021) · Clinical & Translational Immunology · doi:10.1002/cti2.1262 · Cited by 20

IFN-γ production by brain-resident cells activates cerebral mRNA expression of a wide spectrum of molecules critical for both innate and T cell-mediated protective immunity to control reactivation of chronic infection with Toxoplasma gondii

Suzuki, Y., Lutshumba, J., Chen, K. C., Abdelaziz, M. H., Sa, Q., & Ochiai, E. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1110508 · Cited by 20

A protective role of IL-30 via STAT and ERK signaling pathways in macrophage-mediated inflammation

Liu, X., Wang, Z., Ye, N., Chen, Z., Zhou, X., Teng, X., Huang, N., Liu, N., Zhang, N., Guan, T., et al. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.03.136 · Cited by 20

Epstein Barr Virus-Induced 3 (EBI3) Together with IL-12 Negatively Regulates T Helper 17-Mediated Immunity to Listeria monocytogenes Infection

Chung, Y., Yamazaki, T., Kim, B. S., Zhang, Y., Reynolds, J. M., Martínez, G., Chang, S. H., Lim, H., Birkenbach, M. P., & Dong, C. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003628 · Cited by 20

Regulation of Proinflammatory Th17 Responses during Trypanosoma cruzi Infection by IL-12 Family Cytokines

Cobb, D. A., & Smeltz, R. B. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103478 · Cited by 20

Interleukin (IL)‐17 versus IL‐27: opposite effects on tumor necrosis factor‐α‐mediated chemokine production in human keratinocytes

Fujiwara, S., Nagai, H., Oniki, S., Yoshimoto, T., & Nishigori, C. (2011) · Experimental Dermatology · doi:10.1111/j.1600-0625.2011.01384.x · Cited by 20

Steroid-like signalling by interferons: making sense of specific gene activation by cytokines

Johnson, H. M., Noon-Song, E. N., Kemppainen, K. M., & Ahmed, C. M. I. (2012) · Biochemical Journal · doi:10.1042/bj20112187 · Cited by 21

Immunological Characterization of Intraocular Lymphoid Follicles in a Spontaneous Recurrent Uveitis Model

Kleinwort, K. J. H., Amann, B., Hauck, S. M., Feederle, R., Sekundo, W., & Deeg, C. A. (2016) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.16-19787 · Cited by 20

Influenza infection directly alters innate IL-23 and IL-12p70 and subsequent IL-17A and IFN-γ responses to pneumococcus in vitro in human monocytes

Loughran, S. T., Power, P., Maguire, P. T., McQuaid, S., Buchanan, P., Jónsdóttir, I., Newman, R. W., Harvey, R., & JOHNSON, P. A. (2018) · PLoS ONE · doi:10.1371/journal.pone.0203521 · Cited by 21

Interleukin 27 polymorphisms, their association with insulin resistance and their contribution to subclinical atherosclerosis. The GEA Mexican study

Vargas‐Alarcón, G., Pérez‐Hernández, N., Rodrı́guez-Pérez, J. M., Fragoso, J. M., Posadas‐Romero, C., López-Bautista, F., Vázquez-Vázquez, C., & Posadas‐Sánchez, R. (2018) · Cytokine · doi:10.1016/j.cyto.2018.11.028 · Cited by 20

Global Transcriptome Profiling of Multiple Porcine Organs Reveals Toxoplasma gondii-Induced Transcriptional Landscapes

He, J.-J., Ma, J., Wang, J., Zhang, F.-K., Li, J., Zhai, B., Wang, Z.-X., Elsheikha, H. M., & Zhu, X.-Q. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01531 · Cited by 19

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Tormo, A. J., Beaupré, L. A., Elson, G., Crabé, S., & Gauchat, J. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1201460 · Cited by 19

IL-27 inhibits pathophysiological intraocular neovascularization due to laser burn

Hasegawa, E., Oshima, Y., Takeda, A., Saeki, K., Yoshida, H., Sonoda, K., & Ishibashi, T. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.1110603 · Cited by 19

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Daba, T. M., Zhao, Y., & Pan, Z. (2019) · Current Drug Targets · doi:10.2174/1389450120666190618124722 · Cited by 19

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Ivanov, S., & Lindén, A. (2007) · Expert Review of Respiratory Medicine · doi:10.1586/17476348.1.2.279 · Cited by 19

Flt3 Ligand Is Essential for Survival and Protective Immune Responses during Toxoplasmosis

Dupont, C. D., Pritchard, G. H., Hidano, S., Christian, D. A., Wagage, S., Muallem, G., Wojno, E. D. T., & Hunter, C. A. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500690 · Cited by 19

The Goldilocks model of immune symbiosis with Mycobacteria and Candida colonizers

Robinson, R., & Huppler, A. R. (2017) · Cytokine · doi:10.1016/j.cyto.2017.05.015 · Cited by 19

SOCS, SPRED, and NR4a: Negative regulators of cytokine signaling and transcription in immune tolerance

Yoshimura, A., Aki, D., & Ito, M. (2021) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.97.016 · Cited by 19

gp130 on macrophages/granulocytes modulates inflammation during experimental tuberculosis

Sodenkamp, J., Behrends, J., Förster, I., Müller, W., Ehlers, S., & Hölscher, C. (2010) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2010.10.010 · Cited by 18

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Miyazaki, Y., Shimanoe, Y., Wang, S., & Yoshida, H. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.06.038 · Cited by 19

Antimelanoma Immunotherapy: Clinical and Preclinical Applications of Il-12 Family Members

Nagai, H., Oniki, S., Fujiwara, S., Yoshimoto, T., & Nishigori, C. (2010) · Immunotherapy · doi:10.2217/imt.10.46 · Cited by 18

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Fasnacht, N., Greweling‐Pils, M. C., Bollati‐Fogolín, M., Schippers, A., & Müller, W. (2009) · European Journal of Immunology · doi:10.1002/eji.200838710 · Cited by 18

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Zhang, R., Li, Q., Chuang, P. Y., Lu, G., Liu, R., Yang, J., Peng, L., Dai, Y., Zheng, Z., Qi, C., et al. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.05.001 · Cited by 18

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Wang, H., Zhou, B.-H., Cao, J.-W., Zhao, J., Zhao, W., & Tan, P. (2016) · Biological Trace Element Research · doi:10.1007/s12011-016-0749-5 · Cited by 18

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Maia, M. M., Meira, C. D. S., Pereira‐Chioccola, V. L., de Hippólito, D. D. C., Silva, V. O., Brandão, C. C., Frederico, F. B., Siqueira, R. C., & de Mattos, L. C. (2017) · Parasite Immunology · doi:10.1111/pim.12462 · Cited by 18

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Kelly, A. M., & McLoughlin, R. M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00767 · Cited by 18

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Coppock, G., Aronson, L. R., Park, J., Qiu, C., Park, J., DeLong, J. H., Radaelli, E., Suszták, K., & Hunter, C. A. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1901463 · Cited by 19

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Idro, R., Ogwang, R., Barragán, A., Raimondo, J. V., & Masocha, W. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.791488 · Cited by 18

Committed Tc17 cells are phenotypically and functionally resistant to the effects of IL‐27

Behi, M. E., Dai, H., Magalhaes, J. G., Hwang, D. H., Zhang, G., Rostami, A. M., & Ćirić, B. (2014) · European Journal of Immunology · doi:10.1002/eji.201344360 · Cited by 20

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Nagai, H., Oniki, S., Fujiwara, S., Xu, M., Mizoguchi, I., Yoshimoto, T., & Nishigori, C. (2010) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/187153010790827920 · Cited by 18

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Guerrero-García, J. D. J. (2017) · Neurología · doi:10.1016/j.nrl.2017.07.021 · Cited by 18

Toxoplasma gondii

Montoya, J. G., Boothroyd, J. C., & Kovacs, J. A. (2015) · Elsevier eBooks · doi:10.1016/b978-1-4557-4801-3.00280-0 · Cited by 18

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Lai, S., Wu, X., Liu, Y., Liu, B., Wu, H., & Ma, K. (2024) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2024.100928 · Cited by 18

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Böhme, J., Roßnagel, C., Jacobs, T., Behrends, J., Hölscher, C., & Erdmann, H. (2015) · Immunology · doi:10.1111/imm.12565 · Cited by 17

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Grufman, H., Yndigegn, T., Gonçalves, I., Nilsson, J. Å., & Șchiopu, A. (2018) · Cytokine · doi:10.1016/j.cyto.2017.11.002 · Cited by 17

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Rolvering, C., Zimmer, A. D., Ginolhac, A., Margue, C., Kirchmeyer, M., Servais, F., Hermanns, H. M., Hergovits, S., Nazarov, P. V., Nicot, N., et al. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.ma1217-495r · Cited by 17

The role of astrocytes in multiple sclerosis pathogenesis

Guerrero-García, J. D. J. (2020) · Neurología (English Edition) · doi:10.1016/j.nrleng.2017.07.018 · Cited by 17

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Gaber, W., Sayed, S., Rady, H. M., & Mohey, A. M. (2012) · The Egyptian Rheumatologist · doi:10.1016/j.ejr.2012.04.002 · Cited by 17

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Zhang, D., Jia, K., Wang, R., Li, T., Zhao, N., Yang, L., & Yang, L. (2016) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2016.03.004 · Cited by 17

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Madan, U., Verma, B., & Awasthi, A. (2024) · European Journal of Immunology · doi:10.1002/eji.202350847 · Cited by 16

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Kato, H., & Fox, D. A. (2010) · Clinical and Translational Science · doi:10.1111/j.1752-8062.2010.00233.x · Cited by 16

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Neto, M. F., & Figueiredo, M. L. (2017) · Arthritis · doi:10.1155/2017/6365857 · Cited by 16

Gal-1 regulates dendritic cells-induced Treg/Th17 balance though NF-κB/RelB-IL-27 pathway

Lu, H., Dai, X., Xu, L., Sun, Y., Gao, Y., & Zhang, C. (2019) · Annals of Translational Medicine · doi:10.21037/atm.2019.11.02 · Cited by 16

Molecular biochemical aspects of salt (sodium chloride) in inflammation and immune response with reference to hypertension and type 2 diabetes mellitus

Das, U. N. (2021) · Lipids in Health and Disease · doi:10.1186/s12944-021-01507-8 · Cited by 16

Effects on apoptosis and cell cycle arrest contribute to the antitumor responses of interleukin-27 mediated by retrovirus in human pancreatic carcinoma cells

Shan, B. (2012) · Oncology Reports · doi:10.3892/or.2012.1663 · Cited by 16

IL-27: a potential biomarker for responders to glatiramer acetate therapy

Mindur, J. E., Valenzuela, R. M., Yadav, S. K., Boppana, S., Dhib-Jalbut, S. S., & Ito, K. (2016) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2016.07.004 · Cited by 16

Suppression of interleukin-17 by type I interferons: a contributing factor in virus-induced immunosuppression?

Tilg, H., Moschen, A. R., & Kaser, A. (2009) · European Cytokine Network · doi:10.1684/ecn.2009.0141 · Cited by 16

Genes Related to Antiviral Activity, Cell Migration, and Lysis Are Differentially Expressed in CD4 + T Cells in Human T Cell Leukemia Virus Type 1-Associated Myelopathy/Tropical Spastic Paraparesis Patients

Pinto, M. T., Malta, T. M., Rodrigues, E. S., Pinheiro, D. G., Panepucci, R. A., Malmegrim, K. C. R., Sousa, A. D. P. A., Takayanagui, O. M., Tanaka, Y., Covas, D. T., et al. (2013) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2013.0109 · Cited by 16

IL‐27 acts as a priming signal for IL‐23 but not IL‐12 production on human antigen‐presenting cells

Zeitvogel, J., Werfel, T., & Wittmann, M. (2012) · Experimental Dermatology · doi:10.1111/j.1600-0625.2012.01484.x · Cited by 15

Endogenous IL-27 during toxoplasmosis limits early monocyte responses and their inflammatory activation by pathological T cells

Aldridge, D. L., Moodley, D., Park, J., Phan, A. T., Rausch, M. P., White, K., Ren, Y., Golin, K., Radaelli, E., Kedl, R. M., et al. (2024) · mBio · doi:10.1128/mbio.00083-24 · Cited by 15

Impact of Interleukin-27p28 on T and B Cell Responses during Toxoplasmosis

Park, J., DeLong, J. H., Knox, J. J., Konradt, C., Wojno, E. D. T., & Hunter, C. A. (2019) · Infection and Immunity · doi:10.1128/iai.00455-19 · Cited by 15

Antimicrobial Immune Response

Ortega-Villaizan, M. D. M., & Chico, V. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.87657 · Cited by 15

Interleukin 27 induces differentiation of neural C6-precursor cells into astrocytes

Koch, M., May, U., Kuhns, S., Drechsler, H., Adam, N., Hattermann, K., Wirtz, S. J., Rose‐John, S., & Scheller, J. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.10.053 · Cited by 15

Regulation of Protective and Pathogenic Th17 Responses

Alber, G., & Kamradt, T. (2007) · Current Immunology Reviews · doi:10.2174/157339507779802223 · Cited by 15

Activation and IL-10 production of specific CD4+ T cells are regulated by IL-27 during chronic infection with Plasmodium chabaudi

Sukhbaatar, O., Kimura, D., Miyakoda, M., Nakamae, S., Kimura, K., Hara, H., Yoshida, H., Inoue, S., & Yui, K. (2019) · Parasitology International · doi:10.1016/j.parint.2019.101994 · Cited by 15

Interleukin-27 prevents LPS-induced inflammatory osteolysis by inhibiting osteoclast formation and function.

Li, X., Luo, W. F., Hu, J., Chen, Y., Yu, T., Yang, J., Dong, S., Tian, X., & Sun, L. J. (2019) · Europe PMC (PubMed Central) · Cited by 15

An Overview of Cytokine Regulation of Inflammation and Immunity

Meager, A., & Wadhwa, M. (2013) · Wiley eBooks · doi:10.1002/9780470015902.a0024658 · Cited by 16

Gut Microbiome-Related Anti-Inflammatory Effects of Aryl Hydrocarbon Receptor Activation on Inflammatory Bowel Disease

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Impact of Locally Administered Carboxydextran‐Coated Super‐Paramagnetic Iron Nanoparticles on Cellular Immune Function

Pedro, L., Harmer, Q. J., Mayes, E. L., & Shields, J. D. (2019) · Small · doi:10.1002/smll.201900224 · Cited by 14

The Inhibition of Group II Innate Lymphoid Cell Response by IL‐27 in Allergic Rhinitis

Luo, X., Zeng, Q., Li, Y., Tang, Y., Liu, W., & Luo, R. (2020) · Journal of Immunology Research · doi:10.1155/2020/6661524 · Cited by 14

Interleukin 27 signaling pathways in regulation of immune and autoimmune responses

Yoshida, H., & Miyazaki, Y. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.05.020 · Cited by 14

Metabolites: deciphering the molecular language between DCs and their environment

Minarrieta, L., Ghorbani, P., Sparwasser, T. D., & Berod, L. (2016) · Seminars in Immunopathology · doi:10.1007/s00281-016-0609-6 · Cited by 15

Innate Immunity in Coronary Disease. The Role of Interleukin-12 Cytokine Family in Atherosclerosis

Posadas‐Sánchez, R., & Vargas‐Alarcón, G. (2018) · Revista de investigaci�n Cl�nica · doi:10.24875/ric.17002335 · Cited by 14

IL-27 plasma level in relapsing remitting multiple sclerosis subjects: The double-faced cytokine

Naderi, S., Hejazi, Z., Shajarian, M., Alsahebfosoul, F., Etemadifar, M., & Sedaghat, N. (2016) · Journal of Immunoassay and Immunochemistry · doi:10.1080/15321819.2016.1195746 · Cited by 14

Interleukin-27 and Autoimmune Disorders: A Compressive Review of Immunological Functions

Yazdanpanah, E., Pazoki, A., Dadfar, S., Nemati, M. H., Siadati, S. M. S., Tarahomi, M., Orooji, N., Haghmorad, D., & Oksenych, V. (2024) · Biomolecules · doi:10.3390/biom14121489 · Cited by 13

EBI3 is pivotal for the initiation of experimental autoimmune uveitis

Takeda, A., Hasegawa, E., Fukuhara, T., Hirakawa, S., Yamada, H., Yang, Y., Yoshimura, T., Hisatomi, T., Oshima, Y., Yoshida, H., et al. (2014) · Experimental Eye Research · doi:10.1016/j.exer.2014.06.004 · Cited by 13

Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17–producing T cells

Batten, M., Li, J., Yi, S., Kljavin, N. M., Danilenko, D. M., Lucas, S., Lee, J., de Sauvage, F. J., & Ghilardi, N. (2006) · Nature Immunology · doi:10.1038/ni1375 · Cited by 835

Induction of regulatory Tr1 cells and inhibition of TH17 cells by IL-27

Pot, C., Apétoh, L., Awasthi, A., & Kuchroo, V. K. (2011) · Seminars in Immunology · doi:10.1016/j.smim.2011.08.003 · Cited by 175

All in the family: IL-27 suppression of TH-17 cells

Colgan, J. D., & Rothman, P. B. (2006) · Nature Immunology · doi:10.1038/ni0906-899 · Cited by 53

IL-27 Blocks RORc Expression to Inhibit Lineage Commitment of Th17 Cells

Diveu, C., McGeachy, M. J., Boniface, K., Stumhofer, J. S., Sathe, M., Joyce-Shaikh, B., Chen, Y., Tato, C. M., McClanahan, T. K., Malefyt, R. D. W., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0801162 · Cited by 346

IL‐27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STAT1

Neufert, C. F., Becker, C., Wirtz, S. J., Fantini, M. C., Weigmann, B., Galle, P. R., & Neurath, M. F. (2007) · European Journal of Immunology · doi:10.1002/eji.200636896 · Cited by 191