The many faces of IL-7: from lymphopoiesis to peripheral T cell maintenance

Fry, Terry J; Mackall, Crystal L

doi:10.4049/jimmunol.174.11.6571

Cited by 563T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisCytokine Signaling Pathways and Interactions

The many faces of IL-7: from lymphopoiesis to peripheral T cell maintenance

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Fry, Terry J, Mackall, Crystal L·2005·The Journal of Immunology

DOI 10.4049/jimmunol.174.11.6571

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Abstract

IL-7 is well known as a lymphopoietic cytokine, but recent studies have also identified a critical role for IL-7 in peripheral T cell homeostasis. IL-7 is well poised to serve as a homeostatic cytokine because it is produced by resting stromal cells, the IL-7R is present on most T cells, and IL-7 down-regulates its own receptor. These features allow IL-7 to signal large numbers of resting T cells and to be efficiently used when supplies are limiting. Consistent with this, in normal hosts, IL-7 is required for survival of naive T cell populations, and IL-7 contributes to homeostatic cycling of naive and memory cells. In addition, lymphopenic hosts accumulate increased levels of IL-7, and the supranormal levels are largely responsible for inducing homeostatic peripheral expansion in response to lymphopenia. Thus, IL-7 plays critical and nonredundant roles in both T cell lymphopoiesis and in maintaining and restoring peripheral T cell homeostasis.

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IL-7Rα is re-expressed at the memory stage, ensuring cell survival and proliferation in the memory T cell pool too.
“IL-7Rα is re-expressed at the memory stage, ensuring cell survival and proliferation in memory T cell pool too (156).”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [156]
IL-7 might increase thymic mass and lead to the emergence of recent thymic emigrants.
“A post-exercise surge in thymopoiesis is possible considering that skeletal muscle secretes IL-7 (Haugen et al. 2010) which might in turn increase thymic mass and lead to the emergence of recent thymic emigrants (Fry and Mackall 2005).”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Fry and Mackall 2005

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Authors: Fry, T. J., & Mackall, C. L.
Affiliations: National Institutes of Health (US)
ORCID: Fry, Terry J
Mackall, Crystal L
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 2005-06-01
Volume: 174
Issue: 11
Pages: 6571-6576
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.174.11.6571
OpenAlex: W1893260165
Cited by: 563
References: 74
Citations by year: 2026: 6 · 2025: 20 · 2024: 16 · 2023: 15 · 2022: 22 · 2021: 27 · 2020: 19 · 2019: 21 · 2018: 22 · 2017: 28 · 2016: 23 · 2015: 23 · 2014: 17 · 2013: 21 · 2012: 44
FWCI: 3.05
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
Keywords: IL-7, lymphocyte development, T cell homeostasis, naive T cells, memory T cells, lymphopenia, homeostatic proliferation, IL-7 receptor, stromal cells, T cell survival
MeSH terms: Animals, Homeostasis, Humans, Interleukin-7, T-Lymphocyte Subsets, Lymphopoiesis

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The many faces of IL-7: from lymphopoiesis to peripheral T cell maintenance

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