The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Bcl11a is essential for normal lymphoid development
Abstract
Bcl11a (also called Evi9) functions as a myeloid or B cell proto-oncogene in mice and humans, respectively. Here we show that Bcl11a is essential for postnatal development and normal lymphopoiesis. Bcl11a mutant embryos lack B cells and have alterations in several types of T cells. Phenotypic and expression studies show that Bcl11a functions upstream of the transcription factors Ebf1 and Pax5 in the B cell pathway. Transplantation studies show that these defects in Bcl11a mutant mice are intrinsic to fetal liver precursor cells. Mice transplanted with Bcl11a-deficient cells died from T cell leukemia derived from the host. Thus, Bcl11a may also function as a non-autonomous T cell tumor suppressor gene.
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“However, its roles in other cell lineages, including B lymphocytes and the central nervous system, may present challenges (19, 20).”
From Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A (2013) · cites this paper as [19]
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Cites
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Human Fetal Hemoglobin Expression Is Regulated by the Developmental Stage-Specific Repressor BCL11A
Sankaran, V. G., Menne, T. F., Xu, J., Akie, T. E., Lettre, G., Van Handel, B., Mikkola, H. K. A., Hirschhorn, J. N., Cantor, A. B., & Orkin, S. H. (2008) · Science · doi:10.1126/science.1165409 · Cited by 919
BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis
Canver, M. C., Smith, E. C., Sher, F., Pinello, L., Sanjana, N. E., Shalem, O., Chen, D. D., Schupp, P. G., Vinjamur, D. S., Garcia, S. P., et al. (2015) · Nature · doi:10.1038/nature15521 · Cited by 886
Uda, M., Galanello, R., Sanna, S., Lettre, G., Sankaran, V. G., Chen, W., Usala, G., Busonero, F., Maschio, A., Albai, G., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711566105 · Cited by 672
An Erythroid Enhancer of BCL11A Subject to Genetic Variation Determines Fetal Hemoglobin Level
Bauer, D. E., Kamran, S. C., Lessard, S., Xu, J., Fujiwara, Y., Lin, C., Shao, Z., Canver, M. C., Smith, E. C., Pinello, L., et al. (2013) · Science · doi:10.1126/science.1242088 · Cited by 653
Lettre, G., Sankaran, V. G., Bezerra, M., Araujo, A. S., Uda, M., Sanna, S., Cao, A., Schlessinger, D., Costa, F. F., Hirschhorn, J. N., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804799105 · Cited by 577
Metadata
- Authors
- Liu, P., Keller, J. R., Ortiz, M., Tessarollo, L., Rachel, R. A., Nakamura, T., Jenkins, N. A., & Copeland, N. G.
- Affiliations
- National Cancer Institute (US)
- Science Applications International Corporation (United States) (US)
- Japanese Foundation For Cancer Research (JP)
- Corresponding author
- Copeland, Neal G
- Venue
- Nature Immunology
- Published
- 2003-04-28
- Volume
- 4
- Issue
- 6
- Pages
- 525-532
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W1998167494
- Cited by
- 351
- References
- 51
- Citations by year
- 2026: 12 · 2025: 12 · 2024: 21 · 2023: 14 · 2022: 14 · 2021: 19 · 2020: 16 · 2019: 15 · 2018: 14 · 2017: 13 · 2016: 26 · 2015: 19 · 2014: 15 · 2013: 24 · 2012: 17
- FWCI
- 3.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Funders
- National Institutes of Health (n01co12400-79-0-22)
- National Cancer Institute (N01CO12400)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Hematology › Acute Lymphoblastic Leukemia research
- Keywords
- BCL11A, lymphoid development, lymphocyte development, B cell development, T cell development, EBF1, PAX5, T-cell leukemia, tumor suppressor, proto-oncogenes, postnatal development
- MeSH terms
- Proto-Oncogene Mas, Animals, B-Lymphocytes, Carrier Proteins, DNA-Binding Proteins, Membrane Proteins, Mice, Inbred C57BL, Neoplasm Proteins, Nuclear Proteins, Receptors, Cell Surface, Repressor Proteins, Transcription Factors, Signal Transduction, Leukemia, T-Cell, Mice, Knockout, Lymphopoiesis, Mice, Receptor, Notch1
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