Cited by 351T-cell and B-cell ImmunologyDevelopmental Biology and Gene RegulationAcute Lymphoblastic Leukemia research

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Bcl11a is essential for normal lymphoid development

Liu, Pentao, Keller, Jonathan R, Ortiz, Mariaestela, Tessarollo, Lino, Rachel, Rivka A, Nakamura, Takuro, Jenkins, Nancy A, Copeland, Neal G·2003·Nature Immunology

DOI 10.1038/ni925

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Abstract

Bcl11a (also called Evi9) functions as a myeloid or B cell proto-oncogene in mice and humans, respectively. Here we show that Bcl11a is essential for postnatal development and normal lymphopoiesis. Bcl11a mutant embryos lack B cells and have alterations in several types of T cells. Phenotypic and expression studies show that Bcl11a functions upstream of the transcription factors Ebf1 and Pax5 in the B cell pathway. Transplantation studies show that these defects in Bcl11a mutant mice are intrinsic to fetal liver precursor cells. Mice transplanted with Bcl11a-deficient cells died from T cell leukemia derived from the host. Thus, Bcl11a may also function as a non-autonomous T cell tumor suppressor gene.

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Authors: Liu, P., Keller, J. R., Ortiz, M., Tessarollo, L., Rachel, R. A., Nakamura, T., Jenkins, N. A., & Copeland, N. G.
Affiliations: National Cancer Institute (US)
Science Applications International Corporation (United States) (US)
Japanese Foundation For Cancer Research (JP)
Corresponding author: Copeland, Neal G
ORCID: Liu, Pentao
Keller, Jonathan R
Tessarollo, Lino
Nakamura, Takuro
Jenkins, Nancy A
Venue: Nature Immunology
Publisher: Springer Science and Business Media LLC
Published: 2003-04-28
Volume: 4
Issue: 6
Pages: 525-532
ISSN: 1529-2908 (ISSN-L)
1529-2916
DOI: 10.1038/ni925
OpenAlex: W1998167494
Cited by: 351
References: 51
Citations by year: 2026: 12 · 2025: 12 · 2024: 21 · 2023: 14 · 2022: 14 · 2021: 19 · 2020: 16 · 2019: 15 · 2018: 14 · 2017: 13 · 2016: 26 · 2015: 19 · 2014: 15 · 2013: 24 · 2012: 17
FWCI: 3.64
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Immunology (publishedVersion)
PubMed (publishedVersion)
The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
Funders: National Institutes of Health (n01co12400-79-0-22)
National Cancer Institute (N01CO12400)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Health Sciences › Medicine › Hematology › Acute Lymphoblastic Leukemia research
Keywords: BCL11A, lymphoid development, lymphocyte development, B cell development, T cell development, EBF1, PAX5, T-cell leukemia, tumor suppressor, proto-oncogenes, postnatal development
MeSH terms: Proto-Oncogene Mas, Animals, B-Lymphocytes, Carrier Proteins, DNA-Binding Proteins, Membrane Proteins, Mice, Inbred C57BL, Neoplasm Proteins, Nuclear Proteins, Receptors, Cell Surface, Repressor Proteins, Transcription Factors, Signal Transduction, Leukemia, T-Cell, Mice, Knockout, Lymphopoiesis, Mice, Receptor, Notch1

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Bcl11a is essential for normal lymphoid development

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