The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Bcl11a is essential for normal lymphoid development
Abstract
Bcl11a (also called Evi9) functions as a myeloid or B cell proto-oncogene in mice and humans, respectively. Here we show that Bcl11a is essential for postnatal development and normal lymphopoiesis. Bcl11a mutant embryos lack B cells and have alterations in several types of T cells. Phenotypic and expression studies show that Bcl11a functions upstream of the transcription factors Ebf1 and Pax5 in the B cell pathway. Transplantation studies show that these defects in Bcl11a mutant mice are intrinsic to fetal liver precursor cells. Mice transplanted with Bcl11a-deficient cells died from T cell leukemia derived from the host. Thus, Bcl11a may also function as a non-autonomous T cell tumor suppressor gene.
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“However, its roles in other cell lineages, including B lymphocytes and the central nervous system, may present challenges (19, 20).”
From Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A (2013) · cites this paper as [19]
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Metadata
- Authors
- Liu, P., Keller, J. R., Ortiz, M., Tessarollo, L., Rachel, R. A., Nakamura, T., Jenkins, N. A., & Copeland, N. G.
- Affiliations
- National Cancer Institute (US)
- Science Applications International Corporation (United States) (US)
- Japanese Foundation For Cancer Research (JP)
- Corresponding author
- Copeland, Neal G
- Venue
- Nature Immunology
- Published
- 2003-04-28
- Volume
- 4
- Issue
- 6
- Pages
- 525-532
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W1998167494
- Cited by
- 351
- References
- 51
- Citations by year
- 2026: 12 · 2025: 12 · 2024: 21 · 2023: 14 · 2022: 14 · 2021: 19 · 2020: 16 · 2019: 15 · 2018: 14 · 2017: 13 · 2016: 26 · 2015: 19 · 2014: 15 · 2013: 24 · 2012: 17
- FWCI
- 3.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Funders
- National Institutes of Health (n01co12400-79-0-22)
- National Cancer Institute (N01CO12400)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Hematology › Acute Lymphoblastic Leukemia research
- Keywords
- BCL11A, lymphoid development, lymphocyte development, B cell development, T cell development, EBF1, PAX5, T-cell leukemia, tumor suppressor, proto-oncogenes, postnatal development
- MeSH terms
- Proto-Oncogene Mas, Animals, B-Lymphocytes, Carrier Proteins, DNA-Binding Proteins, Membrane Proteins, Mice, Inbred C57BL, Neoplasm Proteins, Nuclear Proteins, Receptors, Cell Surface, Repressor Proteins, Transcription Factors, Signal Transduction, Leukemia, T-Cell, Mice, Knockout, Lymphopoiesis, Mice, Receptor, Notch1
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