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Cited by 616

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10

Open access
Sun, Jie, Madan, Rajat, Karp, Christopher L, Braciale, Thomas J·2009·Nature Medicine
DOI 10.1038/nm.1929
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Abstract

Activated antigen-specific T cells produce a variety of effector molecules for clearing infection but also contribute to inflammation and tissue injury. Here we report an anti-inflammatory property of antiviral CD8+ and CD4+ effector T cells (Teff cells) in the infected periphery during acute virus infection. We find that, during acute influenza infection, interleukin-10 (IL-10) is produced in the infected lungs in large amounts—exclusively by infiltrating virus-specific Teff cells, with CD8+ Teff cells contributing a larger fraction of the IL-10 produced. These Teff cells in the periphery simultaneously produce IL-10 and proinflammatory cytokines and express lineage markers characteristic of conventional T helper type 1 or T cytotoxic type 1 cells. Notably, blocking the action of the Teff cell–derived IL-10 results in enhanced pulmonary inflammation and lethal injury. Our results show that antiviral Teff cells exert regulatory functions—that is, they fine-tune the extent of lung inflammation and injury associated with influenza infection by producing an anti-inflammatory cytokine. We discuss the potential implications of these findings for infection with highly pathogenic influenza viruses.

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Metadata

Authors
Sun, J., Madan, R., Karp, C. L., & Braciale, T. J.
Venue
Nature Medicine
Publisher
Springer Science and Business Media LLC
Published
2009-02-22
Volume
15
Issue
3
Pages
277-284
ISSN
  • 1078-8956 (ISSN-L)
  • 1546-170X
DOI
10.1038/nm.1929
OpenAlex
W2087668602
Cited by
616
References
38
FWCI
31.26
Type
journal article
Language
en
Open access
bronze

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