The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction
Open accessAbstract
Bitter taste receptors (TAS2Rs) on the tongue probably evolved to evoke signals for avoiding ingestion of plant toxins. We found expression of TAS2Rs on human airway smooth muscle (ASM) and considered these to be avoidance receptors for inhalants that, when activated, lead to ASM contraction and bronchospasm. TAS2R agonists such as saccharin, chloroquine and denatonium evoked increased intracellular calcium ([Ca2+]i) in ASM in a Gβγ–, phospholipase Cβ (PLCβ)- and inositol trisphosphate (IP3) receptor–dependent manner, which would be expected to evoke contraction. Paradoxically, bitter tastants caused relaxation of isolated ASM and dilation of airways that was threefold greater than that elicited by β-adrenergic receptor agonists. The relaxation induced by TAS2Rs is associated with a localized [Ca2+]i response at the cell membrane, which opens large-conductance Ca2+-activated K+ (BKCa) channels, leading to ASM membrane hyperpolarization. Inhaled bitter tastants decreased airway obstruction in a mouse model of asthma. Given the need for efficacious bronchodilators for treating obstructive lung diseases, this pathway can be exploited for therapy with the thousands of known synthetic and naturally occurring bitter tastants.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860
Cited by
The functions of human saliva: A review sponsored by the World Workshop on Oral Medicine VI
Dawes, C., Pedersen, A. M. L., Villa, A., Ekström, J., Proctor, G. B., Vissink, A., Aframian, D., McGowan, R., Aliko, A., Narayana, N., et al. (2015) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2015.03.004 · Cited by 572
A novel SCFA receptor, the microbiota, and blood pressure regulation
Pluznick, J. (2014) · Gut Microbes · doi:10.4161/gmic.27492 · Cited by 374
Agache, I., & Akdis, C. A. (2019) · Journal of Clinical Investigation · doi:10.1172/jci124611 · Cited by 313
Cholinergic chemosensory cells in the trachea regulate breathing
Krasteva, G., Canning, B. J., Hartmann, P., Veres, T. Z., Papadakis, T., Mühlfeld, C., Schliecker, K., Tallini, Y. N., Braun, A., Hackstein, H., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019418108 · Cited by 291
BitterDB: a database of bitter compounds
Wiener, A., Shudler, M., Levit, A., & Niv, M. Y. (2012) · Nucleic Acids Research · doi:10.1093/nar/gkr755 · Cited by 264
Severe asthma: Advances in current management and future therapy
Barnes, P. J. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.11.006 · Cited by 174
Prakash, Y. S. (2016) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00370.2016 · Cited by 136
Inhibiting a promiscuous GPCR: iterative discovery of bitter taste receptor ligands
Fierro, F., Peri, L., Hübner, H., Tabor-Schkade, A., Waterloo, L., Löber, S., Pfeiffer, T., Weikert, D., Dingjan, T., Margulis, E., et al. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04765-0 · Cited by 36
Pallante, L., Cannariato, M., Androutsos, L., Zizzi, E. A., Bompotas, A., Hada, X., Grasso, G., Kalogeras, A., Mavroudi, S., Di Benedetto, G., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-56893-7 · Cited by 12
Metadata
- Authors
- Deshpande, D. A., Wang, W. C. H., McIlmoyle, E. L., Robinett, K. S., Schillinger, R. M., An, S. S., Sham, J. S. K., & Liggett, S. B.
- Venue
- Nature Medicine
- Published
- 2010-10-24
- Volume
- 16
- Issue
- 11
- Pages
- 1299-1304
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2133302347
- Cited by
- 662
- References
- 1
- FWCI
- 33.02
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
