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Molecular modeling, organ culture and reverse genetics for a newly identified human rhinovirus C
Open accessAbstract
A recently recognized human rhinovirus species C (HRV-C) is associated with up to half of HRV infections in young children. Here we propagated two HRV-C isolates ex vivo in organ culture of nasal epithelial cells, sequenced a new C15 isolate and developed the first, to our knowledge, reverse genetics system for HRV-C. Using contact points for the known HRV receptors, intercellular adhesion molecule-1 (ICAM-1) and low-density lipoprotein receptor (LDLR), inter- and intraspecies footprint analyses predicted a unique cell attachment site for HRV-Cs. Antibodies directed to binding sites for HRV-A and -B failed to inhibit HRV-C attachment, consistent with the alternative receptor footprint. HRV-A and HRV-B infected HeLa and WisL cells but HRV-C did not. However, HRV-C RNA synthesized in vitro and transfected into both cell types resulted in cytopathic effect and recovery of functional virus, indicating that the viral attachment mechanism is a primary distinguishing feature of HRV-C.
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Cited by
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Tapparel, C., Siegrist, F., Petty, T. J., & Kaiser, L. (2013) · Infection, Genetics and Evolution · doi:10.1016/j.meegid.2012.10.016 · Cited by 444
Bochkov, Y. A., Watters, K., Ashraf, S., Griggs, T. F., Devries, M. K., Jackson, D. J., Palmenberg, A. C., & Gern, J. E. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1421178112 · Cited by 422
Self-citationHuman Rhinovirus Species and Season of Infection Determine Illness Severity
Lee, W.-M., Lemanske, R. F., Evans, M. D., Vang, F., Pappas, T., Gangnon, R., Jackson, D. J., & Gern, J. E. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201202-0330oc · Cited by 310
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Metadata
- Authors
- Bochkov, Y. A., Palmenberg, A. C., Lee, W.-M., Rathe, J. A., Amineva, S. P., Sun, X., Pasic, T. R., Jarjour, N. N., Liggett, S. B., & Gern, J. E.
- Venue
- Nature Medicine
- Published
- 2011-04-10
- Volume
- 17
- Issue
- 5
- Pages
- 627-632
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2158725700
- Cited by
- 203
- References
- 0
- FWCI
- 16.20
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bochkov, Y. A., Palmenberg, A. C., Lee, W.-M., Rathe, J. A., Amineva, S. P., Sun, X., Pasic, T. R., Jarjour, N. N., Liggett, S. B., & Gern, J. E. (2011). Molecular modeling, organ culture and reverse genetics for a newly identified human rhinovirus C. Nature Medicine. https://doi.org/10.1038/nm.2358
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