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Fast-degrading elastomer enables rapid remodeling of a cell-free synthetic graft into a neoartery
Open accessAbstract
Host remodeling is important for the success of medical implants, including vascular substitutes. Synthetic and tissue-engineered grafts have yet to show clinical effectiveness in arteries smaller than 5 mm in diameter. We designed cell-free biodegradable elastomeric grafts that degrade rapidly to yield neoarteries nearly free of foreign materials 3 months after interposition grafting in rat abdominal aorta. This design focuses on enabling rapid host remodeling. Three months after implantation, the neoarteries resembled native arteries in the following aspects: regular, strong and synchronous pulsation; a confluent endothelium and contractile smooth muscle layers; expression of elastin, collagen and glycosaminoglycan; and tough and compliant mechanical properties. Therefore, future studies employing large animal models more representative of human vascular regeneration are warranted before clinical translation. This cell-free approach represents a philosophical shift from the prevailing focus on cells in vascular tissue engineering and may have an impact on regenerative medicine in general.
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Metadata
- Authors
- Wu, W., Allen, R. A., & Wang, Y.
- Venue
- Nature Medicine
- Published
- 2012-06-24
- Volume
- 18
- Issue
- 7
- Pages
- 1148-1153
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2014593879
- Cited by
- 431
- References
- 39
- FWCI
- 25.55
- Type
- journal article
- Language
- en
- Open access
- green
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