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Cited by 356

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension

Open access
Kim, Jongmin, Kang, Yujung, Kojima, Yoko, Lighthouse, Janet K, Hu, Xiaoyue, Aldred, Micheala A, McLean, Danielle L, Park, Hyekyung, Comhair, Suzy A, Greif, Daniel M, Erzurum, Serpil C, Chun, Hyung J·2013·Nature Medicine
DOI 10.1038/nm.3040
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Abstract

Pulmonary arterial hypertension (PAH) is characterized by vascular remodeling associated with obliteration of pulmonary arterioles and formation of plexiform lesions composed of hyperproliferative endothelial and vascular smooth-muscle cells. Here we describe a microRNA (miRNA)-dependent association between apelin (APLN) and fibroblast growth factor 2 (FGF2) signaling in pulmonary artery endothelial cells (PAECs). APLN deficiency in these cells led to increased expression of FGF2 and its receptor FGFR1 as a consequence of decreased expression of miR-424 and miR-503, which directly target FGF2 and FGFR1. miR-424 and miR-503 were downregulated in PAH, exerted antiproliferative effects in PAECs and inhibited the capacity of PAEC-conditioned medium to induce the proliferation of pulmonary artery smooth-muscle cells. Reconstitution of miR-424 and miR-503 in vivo ameliorated pulmonary hypertension in experimental models. These studies identify an APLN-dependent miRNA-FGF signaling axis needed for the maintenance of pulmonary vascular homeostasis.

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Crossref · 10.1038/nm.3040

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Metadata

Authors
Kim, J., Kang, Y., Kojima, Y., Lighthouse, J. K., Hu, X., Aldred, M. A., McLean, D. L., Park, H., Comhair, S. A., Greif, D. M., Erzurum, S. C., & Chun, H. J.
Venue
Nature Medicine
Publisher
Springer Science and Business Media LLC
Published
2012-12-23
Volume
19
Issue
1
Pages
74-82
ISSN
  • 1078-8956 (ISSN-L)
  • 1546-170X
DOI
10.1038/nm.3040
OpenAlex
W2002925464
Cited by
356
References
39
FWCI
21.47
Type
journal article
Language
en
Open access
green

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