The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Tumorigenicity as a clinical hurdle for pluripotent stem cell therapies
Open accessAbstract
Human pluripotent stem cells (PSCs) are a leading candidate for cell-based therapies because of their capacity for unlimited self renewal and pluripotent differentiation. These advances have recently culminated in the first-in-human PSC clinical trials by Geron, Advanced Cell Technology and the Kobe Center for Developmental Biology for the treatment of spinal cord injury and macular degeneration. Despite their therapeutic promise, a crucial hurdle for the clinical implementation of human PSCs is their potential to form tumors in vivo. In this Perspective, we present an overview of the mechanisms underlying the tumorigenic risk of human PSC–based therapies and discuss current advances in addressing these challenges.
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The tumorigenicity of human embryonic and induced pluripotent stem cells
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Self-citationThe histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells
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Cited by
Induced pluripotent stem cell technology: a decade of progress.
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Shattering barriers toward clinically meaningful MSC therapies
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Induced pluripotent stem cells (iPSCs): molecular mechanisms of induction and applications
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Prospects for gene-engineered T cell immunotherapy for solid cancers
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Metadata
- Authors
- Lee, A. S., Tang, C., Rao, M. S., Weissman, I. L., & Wu, J. C.
- Venue
- Nature Medicine
- Published
- 2013-08
- Volume
- 19
- Issue
- 8
- Pages
- 998-1004
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W1986543208
- Cited by
- 727
- References
- 9
- FWCI
- 22.86
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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