The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Thymic stromal lymphopoietin–elicited basophil responses promote eosinophilic esophagitis
Open accessAbstract
Eosinophilic esophagitis (EoE) is a food allergy–associated inflammatory disease characterized by esophageal eosinophilia. Current management strategies for EoE are nonspecific, and thus there is a need to identify specific immunological pathways that could be targeted to treat this disease. EoE is associated with polymorphisms in the gene that encodes thymic stromal lymphopoietin (TSLP), a cytokine that promotes allergic inflammation, but how TSLP might contribute to EoE disease pathogenesis has been unclear. Here, we describe a new mouse model of EoE-like disease that developed independently of IgE, but was dependent on TSLP and basophils, as targeting TSLP or basophils during the sensitization phase limited disease. Notably, therapeutic TSLP neutralization or basophil depletion also ameliorated established EoE-like disease. In human subjects with EoE, we observed elevated TSLP expression and exaggerated basophil responses in esophageal biopsies, and a gain-of-function TSLP polymorphism was associated with increased basophil responses in patients with EoE. Together, these data suggest that the TSLP-basophil axis contributes to the pathogenesis of EoE and could be therapeutically targeted to treat this disease.
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Human epithelial cells trigger dendritic cell–mediated allergic inflammation by producing TSLP
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Self-citationReslizumab for Poorly Controlled, Eosinophilic Asthma: A Randomized, Placebo-controlled Study
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Self-citationElemental diet is an effective treatment for eosinophilic esophagitis in children and adolescents
Markowitz, J. (2003) · The American Journal of Gastroenterology · doi:10.1016/s0002-9270(03)00054-6 · Cited by 563
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TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation
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Self-citationRole of thymic stromal lymphopoietin in allergy and beyond
Ebina-Shibuya, R., & Leonard, W. J. (2023) · Nature Reviews Immunology · doi:10.1038/s41577-022-00735-y · Cited by 289
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Research Progress in Atopic March
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Wheat allergy: diagnosis and management
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Self-citationSaunders, S. P., Moran, T., Floudas, A., Wurlod, F., Kaszlikowska, A., Salimi, M., Quinn, E. M., Oliphant, C. J., Núñez, G., McManus, R., et al. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.06.045 · Cited by 160
Metadata
- Authors
- Noti, M., Wojno, E. D. T., Kim, B. S., Siracusa, M. C., Giacomin, P. R., Nair, M. G., Benitez, A. J., Ruymann, K. R., Muir, A. B., Hill, D. A., Chikwava, K. R., Moghaddam, A. E., Sattentau, Q. J., Alex, A., Zhou, C., Yearley, J. H., Menard-Katcher, P., Kubo, M., Obata-Ninomiya, K., Karasuyama, H., Comeau, M. R., Brown-Whitehorn, T., de Waal Malefyt, R., Sleiman, P. M., Hakonarson, H., Cianferoni, A., Falk, G. W., Wang, M.-L., Spergel, J. M., & Artis, D.
- Venue
- Nature Medicine
- Published
- 2013-07-21
- Volume
- 19
- Issue
- 8
- Pages
- 1005-1013
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W1982237578
- Cited by
- 422
- References
- 57
- FWCI
- 43.71
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
