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Cited by 422

The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.

Thymic stromal lymphopoietin–elicited basophil responses promote eosinophilic esophagitis

Open access
Noti, Mario, Wojno, Elia D Tait, Kim, Brian S, Siracusa, Mark C, Giacomin, Paul R, Nair, Meera G, Benitez, Alain J, Ruymann, Kathryn R, Muir, Amanda B, Hill, David A, Chikwava, Kudakwashe R, Moghaddam, Amin E, Sattentau, Quentin J, Alex, Aneesh, Zhou, Chao, Yearley, Jennifer H, Menard-Katcher, Paul, Kubo, Masato, Obata-Ninomiya, Kazushige, Karasuyama, Hajime, Comeau, Michael R, Brown-Whitehorn, Terri, de Waal Malefyt, Rene, Sleiman, Patrick M, Hakonarson, Hakon, Cianferoni, Antonella, Falk, Gary W, Wang, Mei-Lun, Spergel, Jonathan M, Artis, David·2013·Nature Medicine
DOI 10.1038/nm.3281
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Abstract

Eosinophilic esophagitis (EoE) is a food allergy–associated inflammatory disease characterized by esophageal eosinophilia. Current management strategies for EoE are nonspecific, and thus there is a need to identify specific immunological pathways that could be targeted to treat this disease. EoE is associated with polymorphisms in the gene that encodes thymic stromal lymphopoietin (TSLP), a cytokine that promotes allergic inflammation, but how TSLP might contribute to EoE disease pathogenesis has been unclear. Here, we describe a new mouse model of EoE-like disease that developed independently of IgE, but was dependent on TSLP and basophils, as targeting TSLP or basophils during the sensitization phase limited disease. Notably, therapeutic TSLP neutralization or basophil depletion also ameliorated established EoE-like disease. In human subjects with EoE, we observed elevated TSLP expression and exaggerated basophil responses in esophageal biopsies, and a gain-of-function TSLP polymorphism was associated with increased basophil responses in patients with EoE. Together, these data suggest that the TSLP-basophil axis contributes to the pathogenesis of EoE and could be therapeutically targeted to treat this disease.

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Metadata

Authors
Noti, M., Wojno, E. D. T., Kim, B. S., Siracusa, M. C., Giacomin, P. R., Nair, M. G., Benitez, A. J., Ruymann, K. R., Muir, A. B., Hill, D. A., Chikwava, K. R., Moghaddam, A. E., Sattentau, Q. J., Alex, A., Zhou, C., Yearley, J. H., Menard-Katcher, P., Kubo, M., Obata-Ninomiya, K., Karasuyama, H., Comeau, M. R., Brown-Whitehorn, T., de Waal Malefyt, R., Sleiman, P. M., Hakonarson, H., Cianferoni, A., Falk, G. W., Wang, M.-L., Spergel, J. M., & Artis, D.
Venue
Nature Medicine
Publisher
Springer Science and Business Media LLC
Published
2013-07-21
Volume
19
Issue
8
Pages
1005-1013
ISSN
  • 1078-8956 (ISSN-L)
  • 1546-170X
DOI
10.1038/nm.3281
OpenAlex
W1982237578
Cited by
422
References
57
FWCI
43.71
Type
journal article
Language
en
Open access
green

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