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Optical Coherence Tomography
Open accessAbstract
A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micrometers and can detect reflected signals as small as ∼10 -10 of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.
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Cited by
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Pampaloni, F., Reynaud, E. G., & Stelzer, E. H. K. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2236 · Cited by 2,817
Clinically applicable deep learning for diagnosis and referral in retinal disease
De Fauw, J., Ledsam, J. R., Romera-Paredes, B., Nikolov, S., Tomasev, N., Blackwell, S., Askham, H., Glorot, X., O’Donoghue, B., Visentin, D., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0107-6 · Cited by 2,639
Going deeper than microscopy: the optical imaging frontier in biology
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Controlling waves in space and time for imaging and focusing in complex media
Mosk, A. P., Lagendijk, A., Lerosey, G., & Fink, M. (2012) · Nature Photonics · doi:10.1038/nphoton.2012.88 · Cited by 1,536
Supernormal vision and high-resolution retinal imaging through adaptive optics
Liang, J., Williams, D. R., & Miller, D. T. (1997) · Journal of the Optical Society of America A · doi:10.1364/josaa.14.002884 · Cited by 1,454
Metadata
- Authors
- Huang, D., Swanson, E. A., Lin, C. P., Schuman, J. S., Stinson, W. G., Chang, W., Hee, M. R., Flotte, T., Gregory, K., Puliafito, C. A., & Fujimoto, J. G.
- Venue
- Science
- Published
- 1991-11-22
- Volume
- 254
- Issue
- 5035
- Pages
- 1178-1181
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2418802570
- Cited by
- 13,788
- References
- 0
- FWCI
- 10.63
- Type
- journal article
- Language
- en
- Open access
- green
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- Huang, D., Swanson, E. A., Lin, C. P., Schuman, J. S., Stinson, W. G., Chang, W., Hee, M. R., Flotte, T., Gregory, K., Puliafito, C. A., & Fujimoto, J. G. (1991). Optical Coherence Tomography. Science. https://doi.org/10.1126/science.1957169
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