The quest to overcome resistance to EGFR-targeted therapies in cancer

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Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib

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Gefitinib or Carboplatin–Paclitaxel in Pulmonary Adenocarcinoma

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Gefitinib or Chemotherapy for Non–Small-Cell Lung Cancer with Mutated EGFR

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Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial

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Cetuximab Monotherapy and Cetuximab plus Irinotecan in Irinotecan-Refractory Metastatic Colorectal Cancer

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MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling

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Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group

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Acquired Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib Is Associated with a Second Mutation in the EGFR Kinase Domain

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Wild-Type KRAS Is Required for Panitumumab Efficacy in Patients With Metastatic Colorectal Cancer

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Clinical Resistance to STI-571 Cancer Therapy Caused by BCR-ABL Gene Mutation or Amplification

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Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib

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The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP

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Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR

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Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer

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Cetuximab Plus Irinotecan, Fluorouracil, and Leucovorin As First-Line Treatment for Metastatic Colorectal Cancer: Updated Analysis of Overall Survival According to Tumor KRAS and BRAF Mutation Status

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The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers

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Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA

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Detection of Mutations in EGFR in Circulating Lung-Cancer Cells

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MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib

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Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer

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Structures of Lung Cancer-Derived EGFR Mutants and Inhibitor Complexes: Mechanism of Activation and Insights into Differential Inhibitor Sensitivity

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Rational, biologically based treatment of EGFR-mutant non-small-cell lung cancer

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Novel mutant-selective EGFR kinase inhibitors against EGFR T790M

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A Specific Inhibitor of the Epidermal Growth Factor Receptor Tyrosine Kinase

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Clinical definition of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer.

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Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer

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Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance

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Understanding resistance to EGFR inhibitors—impact on future treatment strategies

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Oncogenic Transformation by Inhibitor-Sensitive and -Resistant EGFR Mutants

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Analysis of PTEN , BRAF , and EGFR Status in Determining Benefit From Cetuximab Therapy in Wild-Type KRAS Metastatic Colon Cancer

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Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab

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Mechanisms of acquired resistance to cetuximab: role of HER (ErbB) family members

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Identification of a mutation in the extracellular domain of the Epidermal Growth Factor Receptor conferring cetuximab resistance in colorectal cancer

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PTEN Loss Contributes to Erlotinib Resistance in EGFR-Mutant Lung Cancer by Activation of Akt and EGFR

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Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor–Resistant Disease

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Effectiveness of Tyrosine Kinase Inhibitors on “Uncommon” Epidermal Growth Factor Receptor Mutations of Unknown Clinical Significance in Non–Small Cell Lung Cancer

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Cetuximab and First-Line Taxane/Carboplatin Chemotherapy in Advanced Non–Small-Cell Lung Cancer: Results of the Randomized Multicenter Phase III Trial BMS099

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Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1

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MED12 Controls the Response to Multiple Cancer Drugs through Regulation of TGF-β Receptor Signaling

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FAS and NF-κB signalling modulate dependence of lung cancers on mutant EGFR

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EGF Receptor Signaling Is Essential for K-Ras Oncogene-Driven Pancreatic Ductal Adenocarcinoma

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Natural History and Molecular Characteristics of Lung Cancers Harboring EGFR Exon 20 Insertions

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Multi-Determinants Analysis of Molecular Alterations for Predicting Clinical Benefit to EGFR-Targeted Monoclonal Antibodies in Colorectal Cancer

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Second-generation irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs): A better mousetrap? A review of the clinical evidence

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HGF Rescues Colorectal Cancer Cells from EGFR Inhibition via MET Activation

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EGFR Mutation Heterogeneity and the Mixed Response to EGFR Tyrosine Kinase Inhibitors of Lung Adenocarcinomas

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Retreatment with erlotinib: Regain of TKI sensitivity following a drug holiday for patients with NSCLC who initially responded to EGFR-TKI treatment

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Non-small-cell lung cancer

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Co-occurring Genomic Alterations Define Major Subsets of KRAS -Mutant Lung Adenocarcinoma with Distinct Biology, Immune Profiles, and Therapeutic Vulnerabilities

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Patient-derived models of acquired resistance can identify effective drug combinations for cancer

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New horizons in tumor microenvironment biology: challenges and opportunities

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Covalent inhibitors in drug discovery: from accidental discoveries to avoided liabilities and designed therapies

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