The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Photovoltaic restoration of sight with high visual acuity
Open accessAbstract
Patients with retinal degeneration lose sight due to the gradual demise of photoreceptors. Electrical stimulation of surviving retinal neurons provides an alternative route for the delivery of visual information. We demonstrate that subretinal implants with 70-μm-wide photovoltaic pixels provide highly localized stimulation of retinal neurons in rats. The electrical receptive fields recorded in retinal ganglion cells were similar in size to the natural visual receptive fields. Similarly to normal vision, the retinal response to prosthetic stimulation exhibited flicker fusion at high frequencies, adaptation to static images and nonlinear spatial summation. In rats with retinal degeneration, these photovoltaic arrays elicited retinal responses with a spatial resolution of 64 ± 11 μm, corresponding to half of the normal visual acuity in healthy rats. The ease of implantation of these wireless and modular arrays, combined with their high resolution, opens the door to the functional restoration of sight in patients blinded by retinal degeneration.
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Self-citationThe role of fixational eye movements in visual perception
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Subretinal electronic chips allow blind patients to read letters and combine them to words
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Interim results from the international trial of Second Sight's visual prosthesis
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Next-generation probes, particles, and proteins for neural interfacing
Rivnay, J., Wang, H., Fenno, L., Deisseroth, K., & Malliaras, G. G. (2017) · Science Advances · doi:10.1126/sciadv.1601649 · Cited by 514
The Argus® II Retinal Prosthesis System
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Retinal stimulation strategies to restore vision: fundamentals and systems
Yue, L., Weiland, J. D., Roska, B., & Humayun, M. S. (2016) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2016.05.002 · Cited by 272
Photovoltaic Restoration of Central Vision in Atrophic Age-Related Macular Degeneration
Palanker, D., Le Mer, Y., Mohand-Said, S., Muqit, M., & Sahel, J. A. (2020) · Ophthalmology · doi:10.1016/j.ophtha.2020.02.024 · Cited by 227
Self-citationAn update on retinal prostheses
Ayton, L. N., Barnes, N., Dagnelie, G., Fujikado, T., Goetz, G., Hornig, R., Jones, B. W., Muqit, M. M. K., Rathbun, D. L., Stingl, K., et al. (2020) · Clinical Neurophysiology · doi:10.1016/j.clinph.2019.11.029 · Cited by 223
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Metadata
- Authors
- Lorach, H., Goetz, G., Smith, R., Lei, X., Mandel, Y., Kamins, T., Mathieson, K., Huie, P., Harris, J., Sher, A., & Palanker, D.
- Venue
- Nature Medicine
- Published
- 2015-04-27
- Volume
- 21
- Issue
- 5
- Pages
- 476-482
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2127137933
- Cited by
- 351
- References
- 50
- FWCI
- 13.06
- Type
- journal article
- Language
- en
- Open access
- green
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- Lorach, H., Goetz, G., Smith, R., Lei, X., Mandel, Y., Kamins, T., Mathieson, K., Huie, P., Harris, J., Sher, A., & Palanker, D. (2015). Photovoltaic restoration of sight with high visual acuity. Nature Medicine. https://doi.org/10.1038/nm.3851
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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