Human primary liver cancer–derived organoid cultures for disease modeling and drug screening

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Items 601–700 of 1,001

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5. Advances in liver organoids: model systems for liver disease
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8. Leveraging patient derived models of FGFR2 fusion positive intrahepatic cholangiocarcinoma to identify synergistic therapies
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9. Development of bioinformatics and multi-omics analyses in organoids
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10. Biomaterials and bioengineering to guide tissue morphogenesis in epithelial organoids
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11. Stabilization of TGF‐β Receptor 1 by a Receptor‐Associated Adaptor Dictates Feedback Activation of the TGF‐β Signaling Pathway to Maintain Liver Cancer Stemness and Drug Resistance
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12. Establishment of an organoid bank of biliary tract and pancreatic cancers and its application for personalized therapy and future treatment
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13. Update on the Genetics of and Systemic Therapy Options for Combined Hepatocellular Cholangiocarcinoma
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14. What gastroenterologists and hepatologists should know about organoids in 2019
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15. Conversion Therapy of Intrahepatic Cholangiocarcinoma Is Associated with Improved Prognosis and Verified by a Case of Patient-Derived Organoid
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16. Single-cell sequencing and organoids: applications in organ development and disease
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17. Universal and Efficient Electroporation Protocol for Genetic Engineering of Gastrointestinal Organoids
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20. Application of Patient-Derived Cancer Organoids to Personalized Medicine
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22. RNA-sequencing of single cholangiocyte-derived organoids reveals high organoid-to organoid variability
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23. Modelling metastatic colonization of cholangiocarcinoma organoids in decellularized lung and lymph nodes
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26. Hepatic stellate cell stearoyl co-A desaturase activates leukotriene B4 receptor 2 - β-catenin cascade to promote liver tumorigenesis
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27. Development of an Extracellular Matrix Plate for Drug Screening Using Patient-Derived Tumor Organoids
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28. In-vitro model to mimic T cell subset change in human PDAC organoid co-culture
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29. Fisetin induces the upregulation of AKAP12 mRNA and anti-angiogenesis in a patient-derived organoid xenograft model
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30. Using Liver Organoids as Models to Study the Pathobiology of Rare Liver Diseases
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31. A functional personalised oncology approach against metastatic colorectal cancer in matched patient derived organoids
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33. MRI-based deep learning radiomics to differentiate dual-phenotype hepatocellular carcinoma from HCC and intrahepatic cholangiocarcinoma: a multicenter study
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34. Hypoxia induced δ-Catenin to enhance mice hepatocellular carcinoma progression via Wnt signaling
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35. TCGAbiolinksGUI: A graphical user interface to analyze cancer molecular and clinical data
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36. Brain Organoids: Tiny Mirrors of Human Neurodevelopment and Neurological Disorders
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37. Construction of in vitro patient‑derived tumor models to evaluate anticancer agents and cancer immunotherapy
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38. miR‐506‐loaded gelatin nanospheres target PENK and inactivate the ERK/Fos signaling pathway to suppress triple‐negative breast cancer aggressiveness
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39. Liver organoids: From fabrication to application in liver diseases
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40. Facilitation of Tumor Stroma-Targeted Therapy: Model Difficulty and Co-Culture Organoid Method
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41. Advancing hepatotoxicity assessment: current advances and future directions
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42. Epigenetic suppression of Nrf2–Slc40a1 axis induces ferroptosis and enhances immunotherapy in pancreatic cancer
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43. Matrix Metalloproteinase Response of Dendritic Cell, Gingival Epithelial Keratinocyte, and T-Cell Transwell Co-Cultures Treated with Porphyromonas gingivalis Hemagglutinin-B
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44. Dual Targeting of Sorafenib-Resistant HCC-Derived Cancer Stem Cells
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45. Organoids as research models for hepatocellular carcinoma
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46. Transforming primary human hepatocytes into hepatocellular carcinoma with genetically defined factors
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47. Patient Derived Ex-Vivo Cancer Models in Drug Development, Personalized Medicine, and Radiotherapy
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48. Scalable Production of Size-Controlled Cholangiocyte and Cholangiocarcinoma Organoids within Liver Extracellular Matrix-Containing Microcapsules
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50. Research progress and application of liver organoids for disease modeling and regenerative therapy
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51. Non‐Invasive Quality Control of Organoid Cultures Using Mesofluidic CSTR Bioreactors and High‐Content Imaging
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52. Hepatocellular-Carcinoma-Derived Organoids: Innovation in Cancer Research
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55. Preclinical Modelling of PDA: Is Organoid the New Black?
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56. Experimental Models for Preclinical Research in Hepatocellular Carcinoma
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57. Cholangiocarcinoma: bridging the translational gap from preclinical to clinical development and implications for future therapy
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58. Coating with flexible DNA network enhanced T-cell activation and tumor killing for adoptive cell therapy
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59. Patient-Derived Organoids in Precision Oncology – Towards a Science of and for the Individual?
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60. Organoid Models for Cancer Research—From Bed to Bench Side and Back
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62. Establishment and Long-Term Culture of Organoids Derived from Human Biliary Tract Carcinoma
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63. The power and the promise of organoid models for cancer precision medicine with next-generation functional diagnostics and pharmaceutical exploitation
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64. Patient-Derived Xenograft Models for Intrahepatic Cholangiocarcinoma and Their Application in Guiding Personalized Medicine
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66. Cholangiocarcinoma cell proliferation is enhanced in primary sclerosing cholangitis: A role for IL‐17A
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67. Efficient Establishment of Bile-Derived Organoids From Biliary Cancer Patients
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68. Human Hepatobiliary Organoids: Recent Advances in Drug Toxicity Verification and Drug Screening
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69. Phenotyping Tumor Heterogeneity through Proteogenomics: Study Models and Challenges
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70. WDR20 prevents hepatocellular carcinoma senescence by orchestrating the simultaneous USP12/46-mediated deubiquitination of c-Myc
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71. Stratifying nutritional restriction in cancer therapy: Next stop, personalized medicine
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72. Distinct EpCAM-Positive Stem Cell Niches Are Engaged in Chronic and Neoplastic Liver Diseases
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73. Non-invasive analysis of pancreas organoids in synthetic hydrogels defines material-cell interactions and luminal composition
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74. Evolution of precision oncology‐guided treatment paradigms
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75. Organoid Technology and Its Role for Theratyping Applications in Cystic Fibrosis
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76. Organoids as Reliable Breast Cancer Study Models: An Update
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77. An organoids biobank for recapitulating tumor heterogeneity and personalized medicine
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78. Organoids as a new approach for improving pediatric cancer research
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79. Construction of oral squamous cell carcinoma organoids in vitro 3D‐culture for drug screening
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85. Organoid research: new concepts and new technologies
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93. Bioengineered Organoids Offer New Possibilities for Liver Cancer Studies: A Review of Key Milestones and Challenges
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95. Chip collection of hepatocellular carcinoma based on O2 heterogeneity from patient tissue
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96. Tumor organoids for primary liver cancers: A systematic review of current applications in diagnostics, disease modeling, and drug screening
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98. Organoid culture to study epithelial cell differentiation and barrier formation in the colon: bridging the gap between monolayer cell culture and human subject research
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99. Bioengineering methods for organoid systems
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100. Focus on organoids: cooperation and interconnection with extracellular vesicles – Is this the future of in vitro modeling?
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