Human primary liver cancer–derived organoid cultures for disease modeling and drug screening
Broutier, Laura, Mastrogiovanni, Gianmarco, Verstegen, Monique MA, Francies, Hayley E, Gavarró, Lena Morrill, Bradshaw, Charles R, Allen, George E, Arnes-Benito, Robert +14 more·2017·Nature Medicine
DOI 10.1038/nm.4438
Cited by (1,001)
Items 101–200 of 1,001
- Circulating tumor cell-derived organoids: Current challenges and promises in medical research and precision medicinePrakash Priyadarshi Praharaj, Sujit K. Bhutia, Sunitha Nagrath, Rhonda Lynn Bitting, Gagan Deep · 2018 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- Three-dimensional bio-printing of primary human hepatocellular carcinoma for personalized medicineXie, Feihu, Sun, Lejia, Pang, Yuan, Xu, Gang, Jin, Bao, Xu, Haifeng, Lu, Xin, Xu, Yiyao, Du, Shunda, Wang, Yanan et al. · 2021 · Biomaterials
- Organoids in gastrointestinal diseases: From experimental models to clinical translationGünther, Claudia, Winner, Beate, Neurath, Markus F, Stappenbeck, Thaddeus S · 2022 · Gut
- Large‐Scale Production of LGR5‐Positive Bipotential Human Liver Stem CellsSchneeberger, Kerstin, Sánchez‐Romero, Natalia, Ye, Shicheng, van Steenbeek, Frank G., Oosterhoff, Loes A., Pla Palacin, Iris, Chen, Chen, van Wolferen, Monique E., van Tienderen, Gilles, Lieshout, Ruby et al. · 2020 · Hepatology
- High-affinity neoantigens correlate with better prognosis and trigger potent antihepatocellular carcinoma (HCC) activity by activating CD39 + CD8 + T cellsTing Liu, Jizhou Tan, Minhao Wu, Wenzhe Fan, Jialiang Wei, Bowen Zhu, Jian Ming Guo, Shutong Wang, Penghui Zhou, Hui Zhang et al. · 2020 · Gut
- Modeling Human Digestive Diseases With CRISPR-Cas9–Modified OrganoidsMasayuki Fujii, Hans C. Clevers, Toshiro Sato · 2018 · Gastroenterology
- Organoid based personalized medicine: from bench to bedsideYaqi Li, Peiyuan Tang, Sanjun Cai, Junjie Peng, Guoqiang Hua · 2020 · Cell Regeneration
- Patient-derived organoid (PDO) platforms to facilitate clinical decision makingLisa Liu, Lei Yu, Zhichao Li, Wujiao Li, Weiren Huang · 2021 · Journal of Translational Medicine
- Pharmaco-proteogenomic characterization of liver cancer organoids for precision oncologyShuyi Ji, Feng Li, Zile Fu, Gaohua Wu, Yingcheng Charles Wu, Youpei Lin, Dayun Lu, Yuanli Song, Peng Cui, Zijian Yang et al. · 2023 · Science Translational Medicine
- Innovations, challenges, and minimal information for standardization of humanized miceRenata Stripecke, Christian Münz, Jan Jacob Schuringa, Karl‐Dimiter Bissig, Brian W. Soper, Terrence Meeham, Li‐Chin Yao, James P. Di Santo, Michael A. Brehm, Estefanía Rodríguez et al. · 2020 · EMBO Molecular Medicine
- Human Lung Adenocarcinoma-Derived Organoid Models for Drug ScreeningZhichao Li, Youhui Qian, Wujiao Li, Lisa Liu, Lei Yu, Xia Liu, Guodong Wu, Youyu Wang, Weibin Luo, Fuyuan Fang et al. · 2020 · iScience
- Cancer Spheroids and Organoids as Novel Tools for Research and Therapy: State of the Art and Challenges to Guide Precision MedicineSanae El Harane, Bochra Zidi, Nadia El Harane, Karl‐Heinz Krause, Thomas Matthes, Olivier Preynat‐Seauve · 2023 · Cells
- Donafenib and GSK‐J4 Synergistically Induce Ferroptosis in Liver Cancer by Upregulating HMOX1 ExpressionChenyang Zheng, Bo Zhang, Yunyun Li, Kejia Liu, Wei Wei, Shuhang Liang, Hongrui Guo, Kun Ma, Yao Liu, Jiabei Wang et al. · 2023 · Advanced Science
- Single‐Cell Transcriptome Analysis Uncovers Intratumoral Heterogeneity and Underlying Mechanisms for Drug Resistance in Hepatobiliary Tumor OrganoidsYan Zhao, Zhixuan Li, Yanjing Zhu, Jing Fu, Xiaofang Zhao, Yani Zhang, Shan Wang, Jianmin Wu, Kaiting Wang, Rui Ting Wu et al. · 2021 · Advanced Science
- Patient-Derived Cancer Organoids as Predictors of Treatment ResponseMaikel Verduin, Ann Hoeben, Dirk De Ruysscher, Marc Vooijs · 2021 · Frontiers in Oncology
- Recent advances in organoid development and applications in disease modelingSanchita Rauth, Saswati Karmakar, Surinder K. Batra, Moorthy Palanimuthu Ponnusamy · 2021 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- Human airway organoids and microplastic fibers: A new exposure model for emerging contaminantsAnna Winkler, Alessandro Cherubini, Francesco Rusconi, Nadia Santo, Laura Madaschi, Clelia Pistoni, Giorgia Moschetti, Maria Lucia Sarnicola, Mariacristina Crosti, Lorenzo Rosso et al. · 2022 · Environment International
- Mitochondrial Fusion Via OPA1 and MFN1 Supports Liver Tumor Cell Metabolism and GrowthMeng Li, Ling Wang, Yijin Wang, Shaoshi Zhang, Guoying Zhou, Ruby Lieshout, Buyun Ma, Jiaye Liu, Changbo Qu, Monique M. A. Verstegen et al. · 2020 · Cells
- The cancer-testis lncRNA lnc-CTHCC promotes hepatocellular carcinogenesis by binding hnRNP K and activating YAP1 transcriptionAnliang Xia, Wenwen Yuan, Qiang Wang, Jianbo Xu, Yayun Gu, Liansheng Zhang, Chen Chen, Zhangding Wang, Di Wu, Qifeng He et al. · 2022 · Nature Cancer
- Organoid cultures of early-onset colorectal cancers reveal distinct and rare genetic profilesHelen H N Yan, Hoi Cheong Siu, Siu Lun Ho, Sarah S K Yue, Yang Gao, Wai Yin Tsui, Dessy Chan, April Chan, Jason W.H. Wong, Alice H Y Man et al. · 2020 · Gut
- Harnessing the predictive power of preclinical models for oncology drug developmentHonkala, Alexander, Malhotra, Sanjay V., Kummar, Shivaani, Junttila, Melissa R. · 2022 · Nature Reviews Drug Discovery
- Cancer research using organoid technologyKretzschmar, Kai · 2021 · Journal of Molecular Medicine
- Colorectal cancer organoid-stroma biobank allows subtype-specific assessment of individualized therapy responsesFarin, Henner F., Mosa, Mohammed H., Ndreshkjana, Benardina, Grebbin, Britta M., Ritter, Birgit, Menche, Constantin, Kennel, Kilian B., Ziegler, Paul K., Szabó, Lili, Bollrath, Julia et al. · 2023 · Cancer Discovery
- Combined hepatocellular cholangiocarcinoma (cHCC-CC): an update of genetics, molecular biology, and therapeutic interventionsChara Stavraka, Hannah L. Rush, Paul J. Ross · 2018 · Journal of Hepatocellular Carcinoma
- Organoids are not organs: Sources of variation and misinformation in organoid biologyKim Bak Jensen, Melissa Helen Little · 2023 · Stem Cell Reports
- Human biomimetic liver microphysiology systems in drug development and precision medicineGough, Albert, Soto-Gutierrez, Alejandro, Vernetti, Lawrence, Ebrahimkhani, Mo R., Stern, Andrew M., Taylor, D. Lansing · 2021 · Nature Reviews Gastroenterology & Hepatology
- The drug-induced phenotypic landscape of colorectal cancer organoidsJohannes Betge, Niklas Rindtorff, Jan Sauer, Benedikt Rauscher, Clara Dingert, Haristi Gaitantzi, Frank Herweck, Kauthar Srour-Mhanna, Thilo Miersch, Erica Valentini et al. · 2022 · Nature Communications
- Patient-derived glioblastoma organoids as real-time avatars for assessing responses to clinical CAR-T cell therapyMeghan T. Logun, Xin Wang, Yusha Y. Sun, Stephen Joseph Bagley, Nannan Li, Arati Suvas Desai, Daniel Y. Zhang, MacLean P. Nasrallah, Emily Ling-Lin Pai, Bike Su Oner et al. · 2024 · Cell stem cell
- The role of molecular enrichment on future therapies in hepatocellular carcinomaJean‐Charles Nault, Peter R. Galle, Jens Uwe Marquardt · 2018 · Journal of Hepatology
- The CD39+ HBV surface protein-targeted CAR-T and personalized tumor-reactive CD8+ T cells exhibit potent anti-HCC activityFan Zou, Jizhou Tan, Ting Liu, Bingfeng Liu, Ya‐Ping Tang, Hui Zhang, Jiaping Li · 2021 · Molecular Therapy
- Inhibition of ERK1/2 in cancer-associated pancreatic stellate cells suppresses cancer–stromal interaction and metastasisZilong Yan, Kenoki Ohuchida, Shuang Fei, Biao Zheng, Weiyu Guan, Haimin Feng, Shin Kibe, Yohei Ando, Kazuhiro Koikawa, Toshiya Abe et al. · 2019 · Journal of Experimental & Clinical Cancer Research
- Functional precision oncology using patient-derived assays: bridging genotype and phenotypeAllard W. J. van Renterghem, Joris van de Haar, Emile E. Voest · 2023 · Nature Reviews Clinical Oncology
- 3D and organoid culture in research: physiology, hereditary genetic diseases and cancerSuarez-Martinez, Elisa, Suazo-Sanchez, Irene, Celis-Romero, Manuel, Carnero, Amancio · 2022 · Cell & Bioscience
- Patient‐derived organoids of bladder cancer recapitulate antigen expression profiles and serve as a personal evaluation model for CAR‐T cells <i>in vitro</i>Yu, Lei, Li, Zhichao, Mei, Hongbin, Li, Wujiao, Chen, Dong, Liu, Lisa, Zhang, Zhongfu, Sun, Yangyang, Song, Fei, Chen, Wei et al. · 2021 · Clinical & Translational Immunology
- Patient‐derived renal cell carcinoma organoids for personalized cancer therapyZhichao Li, Haibo Xu, Lei Yu, Jia Wang, Qian Meng, Hongbing Mei, Zhiming Cai, Wei Chen, Weiren Huang · 2022 · Clinical and Translational Medicine
- Activation and antitumor immunity of CD8 + T cells are supported by the glucose transporter GLUT10 and disrupted by lactic acidYing Liu, Feng Wang, Dongxue Peng, Dan Zhang, Luping Liu, Jun Wei, Jian Yuan, Luyao Zhao, Huimin Jiang, Tingting Zhang et al. · 2024 · Science Translational Medicine
- Hedgehog signaling promotes sorafenib resistance in hepatocellular carcinoma patient-derived organoidsSiqi Wang, Yang Wang, Xiaodong Xun, Changkun Zhang, Xiang Xiao, Qian Cheng, Shihua Hu, Zhao Li, Jiye Zhu · 2020 · Journal of Experimental & Clinical Cancer Research
- Hepatocellular Carcinoma: An Overview of the Changing Landscape of Treatment OptionsAndreas Koulouris, Christos Tsagkaris, Vasiliki Spyrou, Eleni V. Pappa, Aikaterini Troullinou, Michail Nikolaou · 2021 · Journal of Hepatocellular Carcinoma
- Modelling immune cytotoxicity for cholangiocarcinoma with tumour-derived organoids and effector T cellsGuoying Zhou, Ruby Lieshout, Gilles S. van Tienderen, Valeska de Ruiter, Martin E. van Royen, Patrick P.C. Boor, Luc Magré, Jyaysi Desai, Kübra Köten, Yik Y. Kan et al. · 2022 · British Journal of Cancer
- Evaluating cell lines as models for metastatic breast cancer through integrative analysis of genomic dataKe Liu, Patrick A. Newbury, Benjamin Scott Glicksberg, Billy Zeng, Shreya Paithankar, Eran R. Andrechek, Bin Chen · 2019 · Nature Communications
- Image-based high-content screening in drug discoverySean Lin, Kenji Schorpp, Ina Rothenaigner, Kamyar Hadian · 2020 · Drug Discovery Today
- Pluripotent-Stem-Cell-Derived Hepatic Cells: Hepatocytes and Organoids for Liver Therapy and RegenerationAntonietta Messina, Eléanor Luce, Marwa Hussein, Anne Dubart‐Kupperschmitt · 2020 · Cells
- Liver organoid as a 3D in vitro model for drug validation and toxicity assessmentAnastasia Brooks, Xiaowen Liang, Yonglong Zhang, Chun‐Xia Zhao, Michael Stephen Roberts, Haolu Wang, Lei Zhang, Dorothy H. Crawford · 2021 · Pharmacological Research
- Anticancer drug discovery using multicellular tumor spheroid modelsMichele Zanoni, Sara Pignatta, Chiara Arienti, Massimiliano Bonafè, Anna Tesei · 2019 · Expert Opinion on Drug Discovery
- Organ-on-a-chip platforms for accelerating the evaluation of nanomedicineXi Chen, Yu Shrike Zhang, Xinping Zhang, Changsheng Liu · 2020 · Bioactive Materials
- An organoid-based screen for epigenetic inhibitors that stimulate antigen presentation and potentiate T-cell-mediated cytotoxicityZhou, Zhuolong, Van der Jeught, Kevin, Fang, Yuanzhang, Yu, Tao, Li, Yujing, Ao, Zheng, Liu, Sheng, Zhang, Lu, Yang, Yang, Eyvani, Haniyeh et al. · 2021 · Nature Biomedical Engineering
- Building consensus on the application of organoid-based drug sensitivity testing in cancer precision medicine and drug developmentXiang, Dongxi, He, Aina, Zhou, Rong, Wang, Yonggang, Xiao, Xiuying, Gong, Ting, Kang, Wenyan, Lin, Xiaolin, Wang, Xiaochen, PDO-based DST Consortium11 et al. · 2024 · Theranostics
- Modeling Cell Communication in Cancer With Organoids: Making the Complex SimpleElena Fiorini, Lisa Veghini, Vincenzo Corbo · 2020 · Frontiers in Cell and Developmental Biology
- A pan-cancer organoid platform for precision medicineLarsen, Brian M., Kannan, Madhavi, Langer, Lee F., Leibowitz, Benjamin D., Bentaieb, Aicha, Cancino, Andrea, Dolgalev, Igor, Drummond, Bridgette E., Dry, Jonathan R., Ho, Chi-Sing et al. · 2021 · Cell Reports
- Patient-Derived Head and Neck Cancer Organoids Recapitulate EGFR Expression Levels of Respective Tissues and Are Responsive to EGFR-Targeted Photodynamic TherapyElse Driehuis, Sacha Spelier, Irati Beltrán Hernández, Remco de Bree, Stefan M. Willems, Hans C. Clevers, Sabrina Oliveira · 2019 · Journal of Clinical Medicine
- Micro‐Engineered Organoid‐on‐a‐Chip Based on Mesenchymal Stromal Cells to Predict Immunotherapy Responses of HCC PatientsZhengyu Zou, Zhun Lin, Chenglin Wu, Jizhou Tan, Jie Zhang, Yanwen Peng, Kunsong Zhang, Jiaping Li, Minhao Wu, Yuanqing Zhang · 2023 · Advanced Science
- Glioblastoma Organoids: Pre-Clinical Applications and Challenges in the Context of ImmunotherapyEliane Klein, Ann‐Christin Hau, Anaïs Oudin, Anna Golebiewska, Simone P. Niclou · 2020 · Frontiers in Oncology
- Organoids in image-based phenotypic chemical screensLukonin, Ilya, Zinner, Marietta, Liberali, Prisca · 2021 · Experimental & Molecular Medicine
- Mimicking tumor hypoxia and tumor-immune interactions employing three-dimensional in vitro modelsSomshuvra Bhattacharya, Kristin Calar, Pilar de la Puente · 2020 · Journal of Experimental & Clinical Cancer Research
- Organoids: a novel modality in disease modelingZahra Heydari, Farideh Moeinvaziri, Tarun Agarwal, Paria Pooyan, Anastasia I. Shpichka, Tapas K. Maiti, Peter S. Timashev, Hossein Baharvand, Massoud Vosough · 2021 · Bio-Design and Manufacturing
- Patient-derived organoids in translational oncology and drug screeningYang, Ruixin, Yu, Yingyan · 2023 · Cancer Letters
- Assembly of functionalized silk together with cells to obtain proliferative 3D cultures integrated in a network of ECM-like microfibersUlrika Johansson, Mona Widhe, Nancy Dekki Shalaly, Irene Linares Arregui, Linnea Nilebäck, Christos Panagiotis Tasiopoulos, Carolina Åstrand, Per‐Olof Berggren, Christian T. Gasser, My Hedhammar · 2019 · Scientific Reports
- The Use of Stem Cell-Derived Organoids in Disease Modeling: An UpdateJoseph H. Azar, Hisham F. Bahmad, Darine Daher, Maya M. Moubarak, Ola Hadadeh, Alissar Monzer, Samar Al Bitar, Mohamed Jamal, Mohamed Al‐Sayegh, Wassim G. Abou-Kheir · 2021 · International Journal of Molecular Sciences
- Long-term live imaging and multiscale analysis identify heterogeneity and core principles of epithelial organoid morphogenesisLotta Hof, Till Moreth, Michael Koch, Tim Liebisch, Marina Kurtz, Julia Tarnick, Susanna M. Lissek, Monique M. A. Verstegen, Luc J. W. van der Laan, Meritxell Huch et al. · 2021 · BMC Biology
- Genome-Scale CRISPR screen identifies LAPTM5 driving lenvatinib resistance in hepatocellular carcinomaJiaomeng Pan, Mao Zhang, Liangqing Dong, Shuyi Ji, Juan Zhang, Shu Jie Zhang, Youpei Lin, Xiaoying Wang, Zhen‐Bin Ding, Shuang–Jian Qiu et al. · 2022 · Autophagy
- Data analysis guidelines for single-cell RNA-seq in biomedical studies and clinical applicationsMin‐Ying Su, Tao Pan, Qiu-Zhen Chen, Weiwei Zhou, Yi Gong, Gang Xu, Huan-Yu Yan, Si Li, Qiao-Zhen Shi, Ya Zhang et al. · 2022 · Military Medical Research
- Hypoxia-responsive PPARGC1A/BAMBI/ACSL5 axis promotes progression and resistance to lenvatinib in hepatocellular carcinomaQiangnu Zhang, Lingfeng Xiong, Teng Wei, Quan Liu, Lesen Yan, Jiaojuan Chen, Lu Dai, Lulin Shi, Wenjian Zhang, Jilin Yang et al. · 2023 · Oncogene
- Patient-derived organoids: a promising model for personalized cancer treatmentHuayu Yang, Lejia Sun, Meixi Liu, Yilei Mao · 2018 · Gastroenterology report
- Microfluidic Organoids-on-a-Chip: Quantum Leap in Cancer ResearchFahriye Düzağaç, Gloria Saorin, Lorenzo Memeo, Vincenzo Canzonieri, Flavio Rizzolio · 2021 · Cancers
- iPSC-Derived Liver Organoids: A Journey from Drug Screening, to Disease Modeling, Arriving to Regenerative MedicineOlgasi, Cristina, Cucci, Alessia, Follenzi, Antonia · 2020 · International Journal of Molecular Sciences
- Evolution of the Experimental Models of CholangiocarcinomaAnnamaria Massa, Chiara Varamo, Francesca Vita, Simona Tavolari, Caterina Peraldo Neia, Giovanni Brandi, Alessandro Rizzo, Giuliana Cavalloni, Massimo Aglietta · 2020 · Cancers
- Organoids: development and applications in disease models, drug discovery, precision medicine, and regenerative medicineQigu Yao, Sheng Cheng, Qiaoling Pan, Jiong Yu, Guoqiang Cao, Lanjuan Li, Hongcui Cao · 2024 · MedComm
- Immunotherapy of Glioblastoma: Current Strategies and Challenges in Tumor Model DevelopmentBernarda Majc, Metka Novak, Nataša Kopitar‐Jerala, Anahid Jewett, Barbara Breznik · 2021 · Cells
- Clinical translation of patient-derived tumour organoids- bottlenecks and strategiesMalia Alexandra Foo, Ming You, Shing Leng Chan, Gautam Sethi, Glenn Kunnath Bonney, Wei Peng Yong, Edward Kai‐Hua Chow, Eliza Li Shan Fong, Lingzhi Wang, Boon-Cher Goh · 2022 · Biomarker Research
- 3D cancer models: One step closer to in vitro human studiesNicoletta Manduca, Ester Maccafeo, Ruggero D. Maria, Antonella Sistigu, Martina Musella · 2023 · Frontiers in Immunology
- Engineering Precision MedicineWujin Sun, Junmin Lee, Shiming Zhang, Cole Benyshek, Mehmet R. Dokmeci, Ali Khademhosseini · 2018 · Advanced Science
- Patient-derived organoids in human cancer: a platform for fundamental research and precision medicineShanqiang Qu, Rongyang Xu, Guozhong Yi, Zhiyong Li, Huayang Zhang, Songtao Qi, Guanglong Huang · 2024 · Molecular Biomedicine
- Three-dimensional cell culture: from evolution to revolutionSharmin Alhaque, Michael Themis, Hassan Rashidi · 2018 · Philosophical Transactions of the Royal Society B Biological Sciences
- Genetics of Hepatocellular Carcinoma: Approaches to Explore Molecular DiversityStefano Caruso, Daniel R. O’Brien, Sean Patrick Cleary, Lewis Rowland Roberts, Jessica Zucman‐Rossi · 2020 · Hepatology
- Bioprinting of in vitro tumor models for personalized cancer treatment: a reviewShuangshuang Mao, Yuan Pang, Tiankun Liu, Yongchun Shao, Jianyu He, Huayu Yang, Yilei Mao, Wei Sun · 2020 · Biofabrication
- Replacement, Reduction, and Refinement of Animal Experiments in Anticancer Drug Development: The Contribution of 3D In Vitro Cancer Models in the Drug Efficacy AssessmentElena Maria Tosca, Davide Ronchi, Daniele Facciolo, Paolo Magni · 2023 · Biomedicines
- High-throughput microfluidic systems accelerated by artificial intelligence for biomedical applicationsJianhua Zhou, Jianpei Dong, Hongwei Hou, Lü Huang, Jinghong Li · 2024 · Lab on a Chip
- Obesity, sleep apnea, and cancerIsaac Almendros, Miguel Ángel Martínez‐García, Ramón Farré, David Gozal · 2020 · International Journal of Obesity
- Analysis of off-tumour toxicities of T-cell-engaging bispecific antibodies via donor-matched intestinal organoids and tumouroidsMarius F. Harter, Timothy Recaldin, Régine Gérard, Blandine Avignon, Yannik Bollen, Cinzia Esposito, Karolina Guja-Jarosz, Kristina Kromer, Adrian M. Filip, Julien Aubert et al. · 2023 · Nature Biomedical Engineering
- Human organoids as 3D in vitro platforms for drug discovery: opportunities and challengesDaisong Wang, Rémi Villenave, Nadine Stokar‐Regenscheit, Hans C. Clevers · 2025 · Nature Reviews Drug Discovery
- Functional Characterization of Organoids Derived From Irreversibly Damaged Liver of Patients With NASHMcCarron, Sarah, Bathon, Brooke, Conlon, Donna M., Abbey, Deepti, Rader, Daniel J., Gawronski, Katerina, Brown, Christopher D., Olthoff, Kim M., Shaked, Abraham, Raabe, Tobias D. · 2021 · Hepatology
- ACADL plays a tumor-suppressor role by targeting Hippo/YAP signaling in hepatocellular carcinomaXiaofang Zhao, Wenhao Qin, Youhai Jiang, Zhishi Yang, Bo Yuan, Rongyang Dai, Hao Shen, Yao Chen, Jing Fu, Hongyang Wang · 2020 · npj Precision Oncology
- Breakthroughs and challenges of organoid models for assessing cancer immunotherapy: a cutting-edge tool for advancing personalised treatmentsQian Wang, Fangwei Yuan, Xianglin Zuo, Ming Li · 2025 · Cell Death Discovery
- Advanced human developmental toxicity and teratogenicity assessment using human organoid modelsLi, Minghui, Gong, Jing, Gao, Lixiong, Zou, Ting, Kang, Jiahui, Xu, Haiwei · 2022 · Ecotoxicology and Environmental Safety
- Organoids and organs-on-chips: insights into predicting the efficacy of systemic treatment in colorectal cancerJialong Zhu, Linlin Ji, Yitian Chen, Huiyu Li, Mengxi Huang, Zhe Dai, Jing Wang, Dan Xiang, Gongbo Fu, Zengjie Lei et al. · 2023 · Cell Death Discovery
- Revolutionizing Disease Modeling: The Emergence of Organoids in Cellular SystemsSilva-Pedrosa, Rita, Salgado, António José, Ferreira, Pedro Eduardo · 2023 · Cells
- A pancreatic cancer organoid platform identifies an inhibitor specific to mutant KRASXiaohua Duan, Tuo Zhang, Lingling Feng, Neranjan de Silva, Benjamin C. Greenspun, Xing Wang, Jenna E. Moyer, M. Laura Martin, Rohit Chandwani, Olivier Elemento et al. · 2023 · Cell stem cell
- LGR5 marks targetable tumor-initiating cells in mouse liver cancerWanlu Cao, Meng Li, Jiaye Liu, Shaoshi Zhang, Lisanne Noordam, Monique M. A. Verstegen, Ling Wang, Buyun Ma, Shan Li, Wenshi Wang et al. · 2020 · Nature Communications
- Microvascularized tumor organoids-on-chips: advancing preclinical drug screening with pathophysiological relevanceJungeun Lim, Hanna Ching, Jeong‐Kee Yoon, Noo Li Jeon, YongTae Kim · 2021 · Nano Convergence
- Untangling the web of intratumour heterogeneityZheqi Li, Marco Seehawer, Kornélia Polyák · 2022 · Nature Cell Biology
- Role of Patient-Derived Models of Cancer in Translational OncologyK. Idrisova, Hans‐Uwe Simon, Marina O. Gomzikova · 2022 · Cancers
- Animal models of cholangiocarcinomaEmilien J. Loeuillard, Samantha R. Fischbach, Gregory James Gores, Sumera Irie Ilyas · 2018 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Targeting tumor lineage plasticity in hepatocellular carcinoma using an anti-CLDN6 antibody-drug conjugateFan-En Kong, Guangmeng Li, Yun-Qiang Tang, Shaoyan Xi, Jane Ho Chun Loong, Meimei Li, Haolong Li, Wei Cheng, Wenjie Zhu, Jia-Qiang Mo et al. · 2021 · Science Translational Medicine
- Drug screening and genome editing in human pancreatic cancer organoids identifies drug-gene interactions and candidates for off-label therapyChristian Hirt, Tijmen H. Booij, Linda Grob, Patrik Simmler, Nora C. Toussaint, David Keller, Doreen Taube, Vanessa Ludwig, Alexander Goryachkin, Chantal Pauli et al. · 2022 · Cell Genomics
- Construction of tumor organoids and their application to cancer research and therapyJiajing Lv, Xuan Du, Miaomiao Wang, Jiacan Su, Yan Wei, Can Xu · 2024 · Theranostics
- Phosphorylation regulates cullin-based ubiquitination in tumorigenesisYifan Chen, Xuejing Shao, Ji Cao, Hong Zhu, Bo Yang, Qiaojun He, Meidan Ying · 2020 · Acta Pharmaceutica Sinica B
- Recent methods of droplet microfluidics and their applications in spheroids and organoidsYihe Wang, Mengqi Liu, Yu Zhang, Hong Liu, Lin Ge Han · 2023 · Lab on a Chip
- Organoid models for translational pancreatic cancer researchHervé Tiriac, Dennis Plenker, Lindsey A. Baker, David Arthur Tuveson · 2019 · Current Opinion in Genetics & Development
- Exosomes in the Tumor Microenvironment: From Biology to Clinical ApplicationsVitor Rodrigues da Costa, Rodrigo Pinheiro Araldi, Hugo Vigerelli, Fernanda D’Ámelio, Thais Biude Mendes, Vivian Fonseca Gonzaga, Bruna de Oliveira Policiquio, Gabriel Avelar Colozza‐Gama, Cristiane Wenceslau Valverde, Irina Kerkis · 2021 · Cells
- Clinical relevance of biomarkers in cholangiocarcinoma: critical revision and future directionsRocı́o I.R. Macı́as, Vincenzo Cardinale, Timothy James Kendall, Matias Antonio Avila, Maria Guido, Cédric Coulouarn, Chiara Braconi, Adam Enver Frampton, John A. Bridgewater, Diletta Overi et al. · 2022 · Gut