Stops along the RAS pathway in human genetic disease

Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF

Wan, P., Garnett, M. J., Roe, S. M., Lee, S., Niculescu‐Duvaz, D., Good, V. M., Cancer Genome Project, Jones, C. M., Marshall, C. J., Springer, C. J., et al. (2004) · Cell · doi:10.1016/s0092-8674(04)00215-6 · Cited by 2,799 · see citing works

BRAF mutation predicts sensitivity to MEK inhibition

Solit, D. B., Garraway, L. A., Pratilas, C. A., Sawai, A., Getz, G. A., Basso, A., Ye, Q., Lobo, J. M., She, Y., Osman, I., et al. (2005) · Nature · doi:10.1038/nature04304 · Cited by 1,317 · see citing works

Targeting the mitogen-activated protein kinase cascade to treat cancer

Sebolt, J. S., & Herrera, R. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1503 · Cited by 1,103 · see citing works

Coordinating ERK/MAPK signalling through scaffolds and inhibitors

Kölch, W. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1743 · Cited by 1,070 · see citing works

Dysregulation of the TSC-mTOR pathway in human disease

Inoki, K., Corradetti, M. N., & Guan, K. (2004) · Nature Genetics · doi:10.1038/ng1494 · Cited by 970 · see citing works

Germline KRAS mutations cause Noonan syndrome

Schubbert, S., Zenker, M., Rowe, S. L., Böll, S., Klein, C., Bollag, G., van der Burgt, I., Musante, L., Kalscheuer, V., Wehner, L.-E., et al. (2006) · Nature Genetics · doi:10.1038/ng1748 · Cited by 730 · see citing works

Germline mutations in HRAS proto-oncogene cause Costello syndrome

Aoki, Y., Niihori, T., Kawame, H., Kurosawa, K., Ohashi, H., Tanaka, Y., Filocamo, M., Kato, K., Suzuki, Y., Kure, S., et al. (2005) · Nature Genetics · doi:10.1038/ng1641 · Cited by 678 · see citing works

NF1 Tumor Suppressor Gene Function

Cichowski, K. M., & Jacks, T. (2001) · Cell · doi:10.1016/s0092-8674(01)00245-8 · Cited by 603 · see citing works

Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome

Niihori, T., Aoki, Y., Narumi, Y., Neri, G., Cavé, H., Verloès, A., Okamoto, N., Hennekam, R. C. M., Gillessen‐Kaesbach, G., Wieczorek, D., et al. (2006) · Nature Genetics · doi:10.1038/ng1749 · Cited by 597 · see citing works

Wild-Type and Mutant B-RAF Activate C-RAF through Distinct Mechanisms Involving Heterodimerization

Garnett, M. J., Rana, S., Paterson, H., Barford, D., & Marais, R. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.10.022 · Cited by 416 · see citing works

Mouse model of Noonan syndrome reveals cell type– and gene dosage–dependent effects of Ptpn11 mutation

Araki, T., Mohi, G., Ismat, F. A., Bronson, R. T., Williams, I. R., Kutok, J. L., Yang, W., Pao, L. I., Gilliland, D. G., Epstein, J. A., et al. (2004) · Nature Medicine · doi:10.1038/nm1084 · Cited by 415 · see citing works

COMPARTMENTALIZED RAS/MAPK SIGNALING

Mor, A., & Philips, M. R. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090723 · Cited by 400 · see citing works

NOONAN SYNDROME AND RELATED DISORDERS: Genetics and Pathogenesis

Tartaglia, M., & Gelb, B. D. (2005) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.6.080604.162305 · Cited by 355 · see citing works

PTPN11 (Shp2) Mutations in LEOPARD Syndrome Have Dominant Negative, Not Activating, Effects

Kontaridis, M. I., Swanson, K. D., David, F. S., Barford, D., & Neel, B. G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m513068200 · Cited by 340 · see citing works

Diverse Biochemical Properties of Shp2 Mutants

Keilhack, H., David, F. S., McGregor, M. J., Cantley, L. C., & Neel, B. G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504699200 · Cited by 299 · see citing works

Protein tyrosine phosphatases: from genes, to function, to disease

Tonks, N. K. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2039 · Cited by 1,685 · see citing works

Hyperactive Ras in developmental disorders and cancer

Schubbert, S., Shannon, K., & Bollag, G. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2109 · Cited by 1,583 · see citing works

Mitogen-Activated Protein Kinase Signaling in the Heart: Angels Versus Demons in a Heart-Breaking Tale

Rose, B. A., Force, T. L., & Wang, Y. (2010) · Physiological Reviews · doi:10.1152/physrev.00054.2009 · Cited by 720 · see citing works

Germline gain-of-function mutations in SOS1 cause Noonan syndrome

Roberts, A. E., Araki, T., Swanson, K. D., Montgomery, K. T., Schiripo, T. A., Joshi, V. A., Li, L., Yassin, Y., Tamburino, A. M., Neel, B. G., et al. (2007) · Nature Genetics · doi:10.1038/ng1926 · Cited by 605 · see citing works

Timing Is Everything: Making Neurons versus Glia in the Developing Cortex

Miller, F. D., & Gauthier, A. S. (2007) · Neuron · doi:10.1016/j.neuron.2007.04.019 · Cited by 588 · see citing works

BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas

Pfister, S. M., Janzarik, W. G., Remke, M., Ernst, A., Werft, W., Becker, N., Toedt, G., Wittmann, A., Kratz, C. P., Olbrich, H., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33656 · Cited by 518 · see citing works

Germline gain-of-function mutations in RAF1 cause Noonan syndrome

Razzaque, A. M., Nishizawa, T., Komoike, Y., Yagi, H., Furutani, M., Amo, R., Kamisago, M., Momma, K., Katayama, H., Nakagawa, M., et al. (2007) · Nature Genetics · doi:10.1038/ng2078 · Cited by 501 · see citing works

Germline loss-of-function mutations in SPRED1 cause a neurofibromatosis 1–like phenotype

Brems, H., Chmara, M., Sahbatou, M., Denayer, E., Taniguchi, K., Kato, R., Somers, R., Messiaen, L. M., Schepper, S. D., Fryns, J., et al. (2007) · Nature Genetics · doi:10.1038/ng2113 · Cited by 470 · see citing works

Ras oncogenes and their downstream targets

Rajalingam, K., Schreck, R., Rapp, U. R., & Albert, Š. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2007.01.012 · Cited by 458 · see citing works

Noonan syndrome and clinically related disorders

Tartaglia, M., Gelb, B. D., & Zenker, M. (2011) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2010.09.002 · Cited by 420 · see citing works

Noonan syndrome

van der Burgt, I. (2007) · Orphanet Journal of Rare Diseases · doi:10.1186/1750-1172-2-4 · Cited by 365 · see citing works

An Absence of Cutaneous Neurofibromas Associated with a 3-bp Inframe Deletion in Exon 17 of the NF1 Gene (c.2970-2972 delAAT): Evidence of a Clinically Significant NF1 Genotype-Phenotype Correlation

Upadhyaya, M., Huson, S., Davies, D. M., Thomas, N. S., Chuzhanova, N. A., Giovannini, S., Evans, D. G., Howard, E., Kerr, B. A., Griffiths, S., et al. (2006) · The American Journal of Human Genetics · doi:10.1086/510781 · Cited by 360 · see citing works

Portrait of the PI3K/AKT pathway in colorectal cancer

Danielsen, S. A., Eide, P. W., Nesbakken, A., Guren, T. K., Leithe, E., & Lothe, R. A. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.09.008 · Cited by 326 · see citing works

Protein tyrosine phosphatase function: the substrate perspective

Tiganis, T., & Bennett, A. M. (2007) · Biochemical Journal · doi:10.1042/bj20061548 · Cited by 299 · see citing works

Leopard syndrome

Sárközy, A., Digilio, M. C., & Dallapiccola, B. (2008) · Orphanet Journal of Rare Diseases · doi:10.1186/1750-1172-3-13 · Cited by 295 · see citing works

Deletion of ERK2 Mitogen-Activated Protein Kinase Identifies Its Key Roles in Cortical Neurogenesis and Cognitive Function

Samuels, I. S., Karlo, J. C., Faruzzi, A. N., Pickering, K., Herrup, K., Sweatt, J. D., Saitta, S. C., & Landreth, G. E. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0679-08.2008 · Cited by 278 · see citing works

Functional Specificity of Ras Isoforms: So Similar but So Different

Castellano, E., & Santos, E. (2011) · Genes & Cancer · doi:10.1177/1947601911408081 · Cited by 273 · see citing works

The cardiofaciocutaneous syndrome

Roberts, A., Allanson, J., Jadico, S. K., Kavamura, M. I., Noonan, J., Opitz, J. M., Young, T., & Neri, G. (2006) · Journal of Medical Genetics · doi:10.1136/jmg.2006.042796 · Cited by 271 · see citing works

Noonan Syndrome: Clinical Aspects and Molecular Pathogenesis

Tartaglia, M., Zampino, G., & Gelb, B. D. (2010) · Molecular Syndromology · doi:10.1159/000276766 · Cited by 251 · see citing works

MEK-ERK pathway modulation ameliorates disease phenotypes in a mouse model of Noonan syndrome associated with the Raf1L613V mutation

Wu, X., Simpson, J. A., Hong, J. H., Kim, K.-H., Thavarajah, N. K., Backx, P. H., Neel, B. G., & Araki, T. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44929 · Cited by 233 · see citing works

Extracellular Signal-Regulated Kinase 1 (ERK1) and ERK2 Play Essential Roles in Osteoblast Differentiation and in Supporting Osteoclastogenesis

Matsushita, T., Chan, Y. Y., Kawanami, A., Balmes, G. C., Landreth, G. E., & Murakami, S. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01549-08 · Cited by 232 · see citing works

Specific Functions for ERK/MAPK Signaling during PNS Development

Newbern, J. M., Li, X., Shoemaker, S. E., Zhou, J., Zhong, J., Wu, Y., Bonder, D. E., Hollenback, S. M., Coppola, G., Geschwind, D. H., et al. (2011) · Neuron · doi:10.1016/j.neuron.2010.12.003 · Cited by 216 · see citing works

MAP'ing CNS Development and Cognition: An ERKsome Process

Samuels, I. S., Saitta, S. C., & Landreth, G. E. (2009) · Neuron · doi:10.1016/j.neuron.2009.01.001 · Cited by 200 · see citing works

Protective Effects of GLP-1 on Glomerular Endothelium and Its Inhibition by PKCβ Activation in Diabetes

Mima, A., Hiraoka‐Yamamoto, J., Li, Q., Kitada, M., Li, C., Geraldes, P., Matsumoto, M., Mizutani, K., Park, K., Cahill, C., et al. (2012) · Diabetes · doi:10.2337/db11-1824 · Cited by 203 · see citing works

Expansion of the genotypic and phenotypic spectrum in patients with KRAS germline mutations

Zenker, M., Lehmann, K., Schulz, A., Barth, H., Hansmann, D., Koenig, R., Korinthenberg, R., Kreiß‐Nachtsheim, M., Meinecke, P., Morlot, S., et al. (2006) · Journal of Medical Genetics · doi:10.1136/jmg.2006.046300 · Cited by 202 · see citing works

Disorders of dysregulated signal traffic through the RAS‐MAPK pathway: phenotypic spectrum and molecular mechanisms

Tartaglia, M., & Gelb, B. D. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05790.x · Cited by 198 · see citing works

Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development

Newbern, J., Zhong, J., Wickramasinghe, R. S., Li, X., Wu, Y., Samuels, I., Cherosky, N., Karlo, J. C., O'Loughlin, B., Wikenheiser, J., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805239105 · Cited by 172 · see citing works

Function, regulation and pathological roles of the Gab/DOS docking proteins

Wöhrle, F. U., Daly, R. J., & Brummer, T. (2009) · Cell Communication and Signaling · doi:10.1186/1478-811x-7-22 · Cited by 171 · see citing works

ERK Inhibition Rescues Defects in Fate Specification of Nf1-Deficient Neural Progenitors and Brain Abnormalities

Wang, Y., Kim, E., Wang, X., Novitch, B. G., Yoshikawa, K., Chang, L.-S., & Zhu, Y. (2012) · Cell · doi:10.1016/j.cell.2012.06.034 · Cited by 151 · see citing works

Control of CNS Cell-Fate Decisions by SHP-2 and Its Dysregulation in Noonan Syndrome

Gauthier-Fisher, A., Furstoss, O., Araki, T., Chan, R., Neel, B. G., Kaplan, D. R., & Miller, F. D. (2007) · Neuron · doi:10.1016/j.neuron.2007.03.027 · Cited by 150 · see citing works

SOS1 is the second most common Noonan gene but plays no major role in cardio-facio-cutaneous syndrome

Zenker, M., Horn, D., Wieczorek, D., Allanson, J. E., Pauli, S., van der Burgt, I., Doerr, H. G., Gaspar, H., Hofbeck, M., Gillessen‐Kaesbach, G., et al. (2007) · Journal of Medical Genetics · doi:10.1136/jmg.2007.051276 · Cited by 138 · see citing works

Molecular and clinical analysis ofRAF1in Noonan syndrome and related disorders: dephosphorylation of serine 259 as the essential mechanism for mutant activation

Kobayashi, T., Aoki, Y., Niihori, T., Cavé, H., Verloès, A., Okamoto, N., Kawame, H., Fujiwara, I., Takada, F., Ohata, T., et al. (2010) · Human Mutation · doi:10.1002/humu.21187 · Cited by 129 · see citing works

Neurological complications of cardio‐facio‐cutaneous syndrome

Yoon, G., Rosenberg, J., Blasér, S., & Rauen, K. A. (2007) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.2007.00894.x · Cited by 128 · see citing works

Genome profiling of chronic myelomonocytic leukemia: frequent alterations of RAS and RUNX1genes

Gelsi‐Boyer, V., Trouplin, V., Adélaı̈de, J., Aceto, N., Rémy, V., Pinson, S., Houdayer, C., Arnoulet, C., Sainty, D., Bentires‐Alj, M., et al. (2008) · BMC Cancer · doi:10.1186/1471-2407-8-299 · Cited by 126 · see citing works

Noonan syndrome cardiac defects are caused by PTPN11 acting in endocardium to enhance endocardial-mesenchymal transformation

Araki, T., Chan, G., Newbigging, S., Morikawa, L., Bronson, R. T., & Neel, B. G. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810053106 · Cited by 126 · see citing works

Chronic toxicology of cannabis

Reece, A. S. (2009) · Clinical Toxicology · doi:10.1080/15563650903074507 · Cited by 118 · see citing works

SPRED1 germline mutations caused a neurofibromatosis type 1 overlapping phenotype

Pasmant, É., Sabbagh, A., Hanna, N., Masliah‐Planchon, J., Jolly, E. R., Goussard, P., Ballerini, P. F., Cartault, F., Barbarot, S., Landman‐Parker, J., et al. (2009) · Journal of Medical Genetics · doi:10.1136/jmg.2008.065243 · Cited by 118 · see citing works

Deregulated Ras signaling in developmental disorders: new tricks for an old dog

Schubbert, S., Bollag, G. E., & Shannon, K. (2007) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2006.12.004 · Cited by 116 · see citing works

Hereditary Gingival Fibromatosis: Characteristics and Novel Putative Pathogenic Mechanisms

Häkkinen, L., & Csiszar, A. (2007) · Journal of Dental Research · doi:10.1177/154405910708600104 · Cited by 113 · see citing works

Isoform-Specific Ras Functions in Development and Cancer

Quinlan, M. P., & Settleman, J. E. (2009) · Future Oncology · doi:10.2217/14796694.5.1.105 · Cited by 111 · see citing works

From microcephaly to megalencephaly: determinants of brain size

Pirozzi, F., Nelson, B. R., & Mirzaa, G. (2018) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2018.20.4/gmirzaa · Cited by 110 · see citing works

Molecular and clinical characterization of cardio‐facio‐cutaneous (CFC) syndrome: Overlapping clinical manifestations with Costello syndrome

Narumi, Y., Aoki, Y., Niihori, T., Neri, G., Cavé, H., Verloès, A., Nava, C., Kavamura, M. I., Okamoto, N., Kurosawa, K., et al. (2007) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.31658 · Cited by 106 · see citing works

Ephrin-B1 forward signaling regulates craniofacial morphogenesis by controlling cell proliferation across Eph–ephrin boundariesPreprint

Bush, J. O., & Soriano, P. M. (2010) · Genes & Development · doi:10.1101/gad.1963210 · Cited by 101 · see citing works

Functional Effects of PTPN11 (SHP2) Mutations Causing LEOPARD Syndrome on Epidermal Growth Factor-Induced Phosphoinositide 3-Kinase/AKT/Glycogen Synthase Kinase 3β Signaling

Édouard, T., Combier, J., Nédélec, A., Bel-Vialar, S., Metrich, M., Conte-Auriol, F., Lyonnet, S., Parfait, B., Tauber, M., Salles, J., et al. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00646-09 · Cited by 101 · see citing works

Molecular pathogenesis of peripheral neuroblastic tumors

Janoueix‐Lerosey, I., Schleiermacher, G., & Delattre, O. (2010) · Oncogene · doi:10.1038/onc.2009.518 · Cited by 100 · see citing works

Cognitive profile of disorders associated with dysregulation of the RAS/MAPK signaling cascade

Cesarini, L., Alfieri, P., Pantaleoni, F., Vasta, I., Cerutti, M., Petrangeli, V., Mariotti, P., Leoni, C., Ricci, D., Vicari, S., et al. (2009) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.32488 · Cited by 98 · see citing works

Regulation of Cytokine Signaling by the SOCS and Spred Family Proteins

Yoshimura, A. (2009) · The Keio Journal of Medicine · doi:10.2302/kjm.58.73 · Cited by 96 · see citing works

Spred1Is Required for Synaptic Plasticity and Hippocampus-Dependent Learning

Denayer, E., Ahmed, T., Brems, H., van Woerden, G. M., Borgesius, N. Z., Callaerts‐Vegh, Z., Yoshimura, A., Hartmann, D., Elgersma, Y., D’Hooge, R., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4698-08.2008 · Cited by 96 · see citing works

Inhibitors of Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (Shp2) Based on Oxindole Scaffolds

Lawrence, H. R., Pireddu, R., Chen, L., Luo, Y., Sung, S., Szymanski, A. M., Yip, M. L. R., Guida, W. C., Sebti, S. M., Wu, J., et al. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm8002526 · Cited by 95 · see citing works

Further delineation of the phenotype resulting from BRAF or MEK1 germline mutations helps differentiate cardio‐facio‐cutaneous syndrome from Costello syndrome

Gripp, K. W., Lin, A. E., Nicholson, L., Allen, W., Cramer, A. E., Jones, K. L., Kutz, W. E., Peck, D. S., Rebolledo, M. A., Wheeler, P. G., et al. (2007) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.31815 · Cited by 95 · see citing works

Noonan and cardio-facio-cutaneous syndromes: two clinically and genetically overlapping disorders

Nyström, A., Ekvall, S., Berglund, E., Björkqvist, M., Braathen, G. J., Duchén, K., Enell, H., Holmberg, E., Holmlund, U., Olsson‐Engman, M., et al. (2008) · Journal of Medical Genetics · doi:10.1136/jmg.2008.057653 · Cited by 94 · see citing works

Kinase-activating and kinase-impaired cardio-facio-cutaneous syndrome alleles have activity during zebrafish development and are sensitive to small molecule inhibitors

Anastasaki, C., Estep, A. L., Marais, R., Rauen, K. A., & Patton, E. E. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp186 · Cited by 94 · see citing works

Elucidation of MRAS-mediated Noonan syndrome with cardiac hypertrophy

Higgins, E. M., Bos, J. M., Mason‐Suares, H., Tester, D. J., Ackerman, J. P., MacRae, C. A., Sol‐Church, K., Gripp, K. W., Urrutia, R. A., & Ackerman, M. J. (2017) · JCI Insight · doi:10.1172/jci.insight.91225 · Cited by 93 · see citing works

Clinical and molecular aspects of RAS related disorders

Denayer, E., de Ravel, T. J. L., & Legius, E. (2008) · Journal of Medical Genetics · doi:10.1136/jmg.2007.055772 · Cited by 93 · see citing works

Noonan Syndrome and Related Disorders: A Review of Clinical Features and Mutations in Genes of the RAS/MAPK Pathway

Jorge, A. A. L., Malaquias, A. C., Arnhold, I. J. P., & Mendonca, B. B. (2009) · Hormone Research in Paediatrics · doi:10.1159/000201106 · Cited by 91 · see citing works

SPRED1 mutations (Legius syndrome): another clinically useful genotype for dissecting the neurofibromatosis type 1 phenotype

Spurlock, G., Bennett, E., Chuzhanova, N. A., Thomas, N. S., Jim, H.-P., Side, L. E., Davies, S., Haan, E., Kerr, B. A., Huson, S., et al. (2009) · Journal of Medical Genetics · doi:10.1136/jmg.2008.065474 · Cited by 88 · see citing works

Distinct Binding Modes of Two Epitopes in Gab2 that Interact with the SH3C Domain of Grb2

Harkiolaki, M., Tsirka, T., Lewitzky, M., Simister, P. C., Joshi, D., Bird, L. E., Jones, E. Y., O’Reilly, N., & Feller, S. M. (2009) · Structure · doi:10.1016/j.str.2009.03.017 · Cited by 87 · see citing works

Identification of RASAL1 as a Major Tumor Suppressor Gene in Thyroid Cancer

Liu, D., Yang, C., Bojdani, E., Murugan, A. K., & Xing, M. (2013) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djt249 · Cited by 86 · see citing works

LEOPARD Syndrome: Clinical Features and Gene Mutations

Martínez‐Quintana, E., & Rodríguez-González, F. (2012) · Molecular Syndromology · doi:10.1159/000342251 · Cited by 85 · see citing works

Spectrum of MEK1 and MEK2 gene mutations in cardio-facio-cutaneous syndrome and genotype–phenotype correlations

Dentici, M. L., Sárközy, A., Pantaleoni, F., Carta, C., Lepri, F. R., Ferese, R., Cordeddu, V., Martinelli, S., Briuglia, S., Digilio, M. C., et al. (2009) · European Journal of Human Genetics · doi:10.1038/ejhg.2008.256 · Cited by 86 · see citing works

DLC1: a significant GAP in the cancer genomePreprint

Lahoz, A., & Hall, A. (2008) · Genes & Development · doi:10.1101/gad.1691408 · Cited by 85 · see citing works

Distinct functions for ERKs?

Lloyd, A. C. (2006) · Journal of Biology · doi:10.1186/jbiol46 · Cited by 78 · see citing works

Growth standards of patients with Noonan and Noonan‐like syndromes with mutations in the RAS/MAPK pathway

Malaquias, A. C., Brasil, A. S., Pereira, A. C., Arnhold, I. J. P., Mendonca, B. B., Bertola, D. R., & Jorge, A. A. L. (2012) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.35519 · Cited by 80 · see citing works

Protein tyrosine phosphatase activity in the neural crest is essential for normal heart and skull development

Nakamura, T., Gulick, J. M., Colbert, M. C., & Robbins, J. M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902230106 · Cited by 79 · see citing works

Loss of MicroRNAs in Neural Crest Leads to Cardiovascular Syndromes Resembling Human Congenital Heart Defects

Huang, Z., Chen, J., Regan, J. N., Maguire, C. T., Tang, R., Dong, X. R., Majesky, M. W., & Wang, D.-Z. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.213306 · Cited by 79 · see citing works

Inhibition of the Ras-Net (Elk-3) Pathway by a Novel Pyrazole that Affects Microtubules

Wasylyk, C., Zheng, H., Castell, C., Debüssche, L., Multon, M.-C., & Wasylyk, B. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2674 · Cited by 79 · see citing works

Multiple granular cell tumors are an associated feature of LEOPARD syndrome caused by mutation in PTPN11

Schrader, K. A., Nelson, T. N., Luca, A. D., Huntsman, D. D., & McGillivray, B. (2009) · Clinical Genetics · doi:10.1111/j.1399-0004.2008.01100.x · Cited by 79 · see citing works

Linking epithelial polarity and carcinogenesis by multitasking Helicobacter pylori virulence factor CagA

Hatakeyama, M. (2008) · Oncogene · doi:10.1038/onc.2008.353 · Cited by 75 · see citing works

FGF and ERK signaling coordinately regulate mineralization-related genes and play essential roles in osteocyte differentiation

Kyono, A., Avishai, N., Ouyang, Z., Landreth, G. E., & Murakami, S. (2011) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-011-0288-2 · Cited by 70 · see citing works

Diagnosis of Noonan syndrome and related disorders using target next generation sequencing

Lepri, F. R., Scavelli, R., Digilio, M. C., Gnazzo, M., Grotta, S., Dentici, M. L., Pisaneschi, E., Sirleto, P., Capolino, R., Baban, A., et al. (2014) · BMC Medical Genetics · doi:10.1186/1471-2350-15-14 · Cited by 70 · see citing works

Globularity and language-readiness: generating new predictions by expanding the set of genes of interest

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The Protein Tyrosine Phosphatase Receptor Delta Regulates Developmental Neurogenesis

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Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1

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MAPK Signaling Determines Anxiety in the Juvenile Mouse Brain but Depression-Like Behavior in Adults

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Increased BRAF Heterodimerization Is the Common Pathogenic Mechanism for Noonan Syndrome-Associated RAF1 Mutants

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Costello syndrome H-Ras alleles regulate cortical development

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RAS-MAPK pathway disorders: important causes of congenital heart disease, feeding difficulties, developmental delay and short stature

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