Germline KRAS mutations cause Noonan syndrome

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Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

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Germline mutations in HRAS proto-oncogene cause Costello syndrome

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Mouse model of Noonan syndrome reveals cell type– and gene dosage–dependent effects of Ptpn11 mutation

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NOONAN SYNDROME AND RELATED DISORDERS: Genetics and Pathogenesis

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Nf1 deficiency causes Ras-Dediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia

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The mutational spectrum of PTPN11 in juvenile myelomonocytic leukemia and Noonan syndrome/myeloproliferative disease

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Genotype-phenotype correlations in Noonan syndrome

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Human somatic PTPN11 mutations induce hematopoietic-cell hypersensitivity to granulocyte-macrophage colony-stimulating factor

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Cell Binding Sequences in Mouse Laminin α1 Chain

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Functional analysis of leukemia-associated PTPN11 mutations in primary hematopoietic cells

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Neurofibromin GTPase-activating Protein-related Domains Restore Normal Growth in Nf1−/− Cells

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Inherited predispositions and hyperactive Ras in myeloid leukemogenesis

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Three-dimensional structures and properties of a transforming and a nontransforming glycine-12 mutant of p21H-ras

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CFC index for the diagnosis of cardiofaciocutaneous syndrome

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Biochemical Characterization of a Novel KRAS Insertion Mutation from a Human Leukemia

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Hyperactivation of protein kinase B and ERK have discrete effects on survival, proliferation, and cytokine expression in Nf1-deficient myeloid cells

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Effector Domain Mutations Dissociate p21ras Effector Function and GTPase-Activating Protein Interaction

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RAS Proteins and Their Regulators in Human Disease

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RAS oncogenes: weaving a tumorigenic web

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Hyperactive Ras in developmental disorders and cancer

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Ras oncogenes: split personalities

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Ras history: The saga continues

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Germline gain-of-function mutations in SOS1 cause Noonan syndrome

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Genetic and Epigenetic Networks in Intellectual Disabilities

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Frequency of <i>KRAS</i>, <i>BRAF</i>, and <i>NRAS</i> mutations in colorectal cancer

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KRAS Alleles: The Devil Is in the Detail

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Germline <i>BRAF</i> mutations in Noonan, LEOPARD, and cardiofaciocutaneous syndromes: Molecular diversity and associated phenotypic spectrum

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The Tyrosine Phosphatase Shp2 in Development and Cancer

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Heterozygous germline mutations in the CBL tumor-suppressor gene cause a Noonan syndrome-like phenotype

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Protein tyrosine phosphatase SHP-2: A proto-oncogene product that promotes Ras activation

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Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site

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Stops along the RAS pathway in human genetic disease

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Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders

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Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis

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SHOC2–MRAS–PP1 complex positively regulates RAF activity and contributes to Noonan syndrome pathogenesis

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Cognitive profile of disorders associated with dysregulation of the RAS/MAPK signaling cascade

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RAS variant signalling

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Molecular Basis of Gain-of-Function LEOPARD Syndrome-Associated SHP2 Mutations

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Assessment of mutation probabilities of KRAS G12 missense mutants and their long-timescale dynamics by atomistic molecular simulations and Markov state modeling

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Germline and sporadic cancers driven by the RAS pathway: parallels and contrasts

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Craniosynostosis in patients with RASopathies: Accumulating clinical evidence for expanding the phenotype

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Clinical and Functional Characterization of Atypical <i>KRAS</i> / <i>NRAS</i> Mutations in Metastatic Colorectal Cancer

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K‐<scp>Ras^V14I</scp>‐induced Noonan syndrome predisposes to tumour development in mice

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RASopathy in Patients With Isolated Sagittal Synostosis

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Clinical and molecular characterization of children with Noonan syndrome and other RASopathies in Argentina

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Spectrum of Mutations in Noonan Syndrome and Their Correlation with Phenotypes

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The RAS/MAPK syndromes: novel roles of the RAS pathway in human genetic disorders

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Clinical manifestations in patients with SOS1 mutations range from Noonan syndrome to CFC syndrome

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