p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3

Basic local alignment search tool

Altschul, S. F., Gish, W., Miller, W., Myers, E. W., & Lipman, D. J. (1990) · Journal of Molecular Biology · doi:10.1006/jmbi.1990.9999 · Cited by 98,669 · see citing works

WAF1, a potential mediator of p53 tumor suppression

El-Deiry, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, W. E., Kinzler, K. W., & Vogelstein, B. (1993) · Cell · doi:10.1016/0092-8674(93)90500-p · Cited by 8,321 · see citing works

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

Kastan, M. B., Zhan, Q., El-Deiry, W. S., Carrier, F., Jacks, T., Walsh, W. V., Plunkett, B. S., Vogelstein, B., & Fornace, A. J. (1992) · Cell · doi:10.1016/0092-8674(92)90593-2 · Cited by 3,047 · see citing works

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo.

Miyashita, T., Krajewski, S., Krajewska, M., Wang, H., Lin, H., Liebermann, D. A., Hoffman‐Liebermann, B., & Reed, J. C. (1994) · PubMed · Cited by 2,143 · see citing works

Role for DNA methylation in genomic imprinting

Li, E., Beard, C., & Jaenisch, R. (1993) · Nature · doi:10.1038/366362a0 · Cited by 2,070 · see citing works

Definition of a consensus binding site for p53

El-Deiry, W. S., Kern, S. E., Pietenpol, J. A., Kinzler, K. W., & Vogelstein, B. (1992) · Nature Genetics · doi:10.1038/ng0492-45 · Cited by 1,985 · see citing works

p53 function and dysfunction

Vogelstein, B. (1992) · Cell · doi:10.1016/0092-8674(92)90421-8 · Cited by 1,862 · see citing works

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

Baker, S. J., Markowitz, S. D., Fearon, E. R., Willson, J. K. V., & Vogelstein, B. (1990) · Science · doi:10.1126/science.2144057 · Cited by 1,742 · see citing works

Role for DNA methylation in genomic imprinting

Li, E., Beard, C., & Jaenisch, R. (1994) · Trends in Genetics · doi:10.1016/0168-9525(94)90228-3 · Cited by 1,691 · see citing works

Identification of protein coding regions by database similarity search

Gish, W. R., & States, D. J. (1993) · Nature Genetics · doi:10.1038/ng0393-266 · Cited by 1,650 · see citing works

Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma.

Herman, J. G., Latif, F., Weng, Y., Lerman, M. I., Zbar, B., Liu, S., Samid, D., Duan, D. S., Gnarra, J. R., & Linehan, W. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.21.9700 · Cited by 1,528 · see citing works

Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon

Issa, J.-P. J., Ottaviano, Y. L., Celano, P., Hamilton, S. R., Davidson, N. E., & Baylin, S. B. (1994) · Nature Genetics · doi:10.1038/ng0894-536 · Cited by 1,190 · see citing works

Identification of p53 as a Sequence-Specific DNA-Binding Protein

Kern, S. E., Kinzler, K. W., Bruskin, A. M., Jarosz, D., Friedman, P. N., Prives, C. L., & Vogelstein, B. (1991) · Science · doi:10.1126/science.2047879 · Cited by 1,085 · see citing works

p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis.

Baker, S. J., Preisinger, A. C., Jessup, J. M., Paraskeva, C., Markowitz, S. D., Willson, J. K. V., Hamilton, S. R., & Vogelstein, B. (1990) · PubMed · Cited by 1,065 · see citing works

The POZ domain: a conserved protein-protein interaction motif.Preprint

Bardwell, V. J., & Treisman, R. (1994) · Genes & Development · doi:10.1101/gad.8.14.1664 · Cited by 749 · see citing works

A Transcriptionally Active DNA-Binding Site for Human p53 Protein Complexes

Funk, W. D., Pak, D. T. S., Karas, R. H., Wright, W. E., & Shay, J. W. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.6.2866 · Cited by 732 · see citing works

Alterations of a Zinc Finger-Encoding Gene, BCL-6 , in Diffuse Large-Cell Lymphoma

Ye, B. H., Lista, F., Lo‐Coco, F., Knowles, D. M., Offit, K., Chaganti, R. S. K., & Dalla‐Favera, R. (1993) · Science · doi:10.1126/science.8235596 · Cited by 682 · see citing works

ATP-dependent nucleosome disruption at a heat-shock promoter mediated by binding of GAGA transcription factor

Tsukiyama, T., Becker, P. B., & Wu, C. C. M. (1994) · Nature · doi:10.1038/367525a0 · Cited by 666 · see citing works

Fusion between a novel Krüppel‐like zinc finger gene and the retinoic acid receptor‐alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia.

Chen, Z., Brand, N. J., Chen, A., Chen, S. J., Tong, J. H., Wang, Z. Y., Waxman, S., & Zelent, A. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05757.x · Cited by 635 · see citing works

Methylation of the estrogen receptor gene CpG island marks loss of estrogen receptor expression in human breast cancer cells.

Ottaviano, Y. L., Issa, J. J., Parl, F. F., Smith, H. S., Baylin, S. B., & Davidson, N. E. (1994) · PubMed · Cited by 481 · see citing works

Loss of imprinting of IGF2 is linked to reduced expression and abnormal methylation of H19 in Wilms' tumour

Steenman, M., Rainier, S. R., Dobry, C. J., Grundy, P., Horon, I. L., & Feinberg, A. P. (1994) · Nature Genetics · doi:10.1038/ng0794-433 · Cited by 459 · see citing works

The Drosophila Broad-Complex encodes a family of related proteins containing zinc fingers.

DiBello, P. R., Withers, D. A., Bayer, C. A., Fristrom, J. W., & Guild, G. M. (1991) · Genetics · doi:10.1093/genetics/129.2.385 · Cited by 447 · see citing works

LAZ3, a novel zinc–finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomas

Kerckaert, J., Deweindt, C., Tilly, H., Quief, S., Lecocq, G., & Bastard, C. (1993) · Nature Genetics · doi:10.1038/ng0993-66 · Cited by 426 · see citing works

X-chromosome inactivation and cell memory

Riggs, A. D., & Pfeifer, G. P. (1992) · Trends in Genetics · doi:10.1016/0168-9525(92)90219-t · Cited by 328 · see citing works

Analysis of the p53 gene and its expression in human glioblastoma cells.

Meir, E. G. V., Kikuchi, T., Tada, M., Li, H., Diserens, A., Wojcik, B. E., Huang, H., Friedmann, T., de Tribolet, N., & Cavenee, W. K. (1994) · PubMed · Cited by 327 · see citing works

The GLI-Kruppel family of human genes.

Ruppert, J. M., Kinzler, K. W., Wong, A. J., Bigner, S. H., Kao, F., Law, M. L., Seuánez, H. N., O’Brien, S. J., & Vogelstein, B. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.8.3104 · Cited by 300 · see citing works

Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway.

Chen, C. Y., Oliner, J., Zhan, Q., Fornace, A. J., Vogelstein, B., & Kastan, M. B. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.7.2684 · Cited by 271 · see citing works

The Role of Dna Methylation in Cancer

Jones, P. A., & Buckley, J. D. (1990) · Advances in cancer research · doi:10.1016/s0065-230x(08)60806-4 · Cited by 239 · see citing works

Mutations in p53 as potential molecular markers for human breast cancer.

Runnebaum, I. B., Nagarajan, M., Bowman, M. E., Soto, D., & Sukumar, S. V. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10657 · Cited by 222 · see citing works

The tramtrack gene encodes a Drosophila finger protein that interacts with the ftz transcriptional regulatory region and shows a novel embryonic expression pattern.

Harrison, S. D., & TRAVERS, A. A. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb08097.x · Cited by 208 · see citing works

Abnormal patterns of DNA methylation in human neoplasia: potential consequences for tumor progression.

Baylin, S. B., Makos, M., Wu, J. J., Yen, R. W. C., de Bustros, A., Vertino, P. M., & Nelkin, B. D. (1991) · PubMed · Cited by 206 · see citing works

Evidence implicating at least two genes on chromosome 17p in breast carcinogenesis

Coles, C., Thompson, A. M., Elder, P. A., Cohen, B. B., Mackenzie, I. M., Cranston, G., Mackay, J., Macdonald, M., Steel, C. M., Thompson, A. M., et al. (1990) · The Lancet · doi:10.1016/0140-6736(90)93236-i · Cited by 200 · see citing works

A retinoic acid-responsive human zinc finger gene, MZF-1, preferentially expressed in myeloid cells

Hromas, R., Collins, S. J., Hickstein, D. D., Raskind, W. H., Deaven, L. L., O’Hara, P. J., Hagen, F. S., & Kaushansky, K. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98664-3 · Cited by 177 · see citing works

Distinct hypermethylation patterns occur at altered chromosome loci in human lung and colon cancer.

Makos, M., Nelkin, B. D., Lerman, M. I., Latif, F., Zbar, B., & Baylin, S. B. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.5.1929 · Cited by 164 · see citing works

Isolation of cDNAs encoding the Drosophila GAGA transcription factor.

Soeller, W. C., Oh, C.-S., & Kornberg, T. B. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.12.7961 · Cited by 155 · see citing works

Gene involved in the 3q27 translocation associated with B-cell lymphoma, BCL5, encodes a Kruppel-like zinc-finger protein

Takashi, M. I. K. I., Kawamata, N., Hirosawa, S., & Aoki, N. (1994) · Blood · doi:10.1182/blood.v83.1.26.26 · Cited by 147 · see citing works

Loss of heterozygosity on the short arm of chromosome 17 is associated with high proliferative capacity and DNA aneuploidy in primary human breast cancer.

Chen, L., Neubauer, A., Kurisu, W., Waldman, F. M., Ljung, B., Goodson, W. H., Goldman, E. S., Moore, D. H., Balázs, M., & Liu, E. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.9.3847 · Cited by 138 · see citing works

Muscle-specific activation of a methylated chimeric actin gene

Yisraeli, J. K., Adelstein, R. S., Melloul, D., Nudel, U., Yaffe, D., & Cedar, H. (1986) · Cell · doi:10.1016/0092-8674(86)90661-6 · Cited by 128 · see citing works

Loss of heterozygosity and p53 gene mutations in breast cancer.

Deng, G., Chen, L. C., Schott, D. R., Thor, A. D., Bhargava, V., Ljung, B., Chew, K., & Smith, H. S. (1994) · PubMed · Cited by 123 · see citing works

Transcriptional repressor ZF5 identifies a new conserved domain in zina finger proteins

Numoto, M., Niwa, O., Kaplan, J., Wrong, K.-K., Merrell, K. T., Kamiya, K., Yanagihara, K., & Calame, K. L. (1993) · Nucleic Acids Research · doi:10.1093/nar/21.16.3767 · Cited by 119 · see citing works

Regional DNA hypermethylation at D17S5 precedes 17p structural changes in the progression of renal tumors.

Makos, M., Nelkin, B. D., Reiter, R. E., Gnarra, J. R., Brooks, J. D., Isaacs, W. B., Linehan, W. M., & Baylin, S. B. (1993) · PubMed · Cited by 98 · see citing works

Correlation of loss of alleles on the short arms of chromosomes 11 and 17 with metastasis of primary breast cancer to lymph nodes.

Takita, K.-I., Sato, T., Miyagi, M., Watatani, M., Akiyama, F., Sakamoto, G., Kasumi, F., Abe, R., & Nakamura, Y. (1992) · PubMed · Cited by 98 · see citing works

Evidence for a gene on 17p13.3, distal to TP53, as a target for allele loss in breast tumors without p53 mutations.

Cornelis, R. S., van Vliet, M., Vos, C. B. J., Cleton-Jansen, A. M., van de Vijver, M. J., Peterse, J. L., Khan, P. M., Børresen‐Dale, A., Cj, C., & Devilee, P. (1994) · PubMed · Cited by 87 · see citing works

Use of the single strand conformation polymorphism technique and PCR to detect p53 gene mutations in small cell lung cancer.

Hensel, C. H., Xiang, R. H., Sakaguchi, A. Y., & Naylor, S. L. (1991) · PubMed · Cited by 83 · see citing works

DNA hypermethylation is associated with 17p allelic loss in neural tumors.

Makos, M., Nelkin, B. D., Chazin, V. R., Cavenee, W. K., Brodeur, G. M., & Baylin, S. B. (1993) · PubMed · Cited by 75 · see citing works

Molecular dissection of a contiguous gene syndrome: frequent submicroscopic deletions, evolutionarily conserved sequences, and a hypomethylated "island" in the Miller-Dieker chromosome region.

Ledbetter, D. H., Ledbetter, S. A., vanTuinen, P., SUMMERS, K. M., Robinson, T. J., Nakamura, Y., Wolff, R. K., White, R. L., Barker, D. F., & Wallace, M. R. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.13.5136 · Cited by 60 · see citing works

Tumor and growth suppression of breast cancer cells by chromosome 17-associated functions.

Negrini, M., Sabbioni, S., Haldar, S., Possati, L., Castagnoli, A., Corallini, A., Bròdano, G. B., & Croce, C. M. (1994) · PubMed · Cited by 55 · see citing works

X-chromosome inactivation and cell memory

Riggs, A. D. (1992) · Trends in Genetics · doi:10.1016/0168-9525(92)90090-q · Cited by 44 · see citing works

The KUP gene, located on human chromosome 14, encodes a protein with two distant zinc fingers

Chardin, P., Courtois, G., Mattéi, M., & Gisselbrecht, S. (1991) · Nucleic Acids Research · doi:10.1093/nar/19.7.1431 · Cited by 43 · see citing works

Functional evidence for a second tumor suppressor gene on human chromosome 17

Chen, P. B., Ellmore, N., & Weissman, B. E. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.1.534 · Cited by 25 · see citing works

The Serum-Free Establishment and in Vitro Growth Properties of Classic and Variant Small Cell Lung Cancer Cell Lines

Carney, D. N., Bepler, G., & Gazdar, A. F. (1985) · Recent results in cancer research/Recent Results in Cancer Research · doi:10.1007/978-3-642-82533-0_16 · Cited by 16 · see citing works

The fundamental role of epigenetic events in cancer

Jones, P. A., & Baylin, S. B. (2002) · Nature Reviews Genetics · doi:10.1038/nrg816 · Cited by 5,648 · see citing works

Gene Silencing in Cancer in Association with Promoter Hypermethylation

Herman, J. G., & Baylin, S. B. (2003) · New England Journal of Medicine · doi:10.1056/nejmra023075 · Cited by 3,425 · see citing works

Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia

Baylln, S. B., Herman, J. G., Graff, J. R., Vertino, P. M., & Issa, J. J. (1997) · Advances in cancer research · doi:10.1016/s0065-230x(08)60702-2 · Cited by 1,913 · see citing works

Epigenetic gene silencing in cancer – a mechanism for early oncogenic pathway addiction?

Baylin, S. B., & Ohm, J. E. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1799 · Cited by 1,632 · see citing works

Epigenetic Determinants of CancerPreprint

Baylin, S. B., & Jones, P. A. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a019505 · Cited by 1,363 · see citing works

CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future

Esteller, M. (2002) · Oncogene · doi:10.1038/sj.onc.1205600 · Cited by 1,235 · see citing works

DNA methylation and gene silencing in cancer

Baylin, S. B. (2005) · Nature Clinical Practice Oncology · doi:10.1038/ncponc0354 · Cited by 1,156 · see citing works

Multiple functions of p21 in cell cycle, apoptosis and transcriptional regulation after DNA damage.

Karimian, A., Ahmadi, Y., & Yousefi, B. (2016) · DNA Repair · doi:10.1016/j.dnarep.2016.04.008 · Cited by 1,110 · see citing works

Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer

Baylin, S. B. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.7.687 · Cited by 929 · see citing works

A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer

Suzuki, H., Gabrielson, E. W., Chen, W., Anbazhagan, R., van Engeland, M., Weijenberg, M. P., Herman, J. G., & Baylin, S. B. (2002) · Nature Genetics · doi:10.1038/ng892 · Cited by 858 · see citing works

Inactivation of the E-Cadherin-Mediated Cell Adhesion System in Human Cancers

Hirohashi, S. (1998) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65575-7 · Cited by 839 · see citing works

Regulation ofp53downstream genes

El‐Deiry, W. S. (1998) · Seminars in Cancer Biology · doi:10.1006/scbi.1998.0097 · Cited by 797 · see citing works

Tumor Suppressor HIC1 Directly Regulates SIRT1 to Modulate p53-Dependent DNA-Damage Responses

Chen, W., Wang, D. H., Yen, R.-W. C., Luo, J., Gu, W. J., & Baylin, S. B. (2005) · Cell · doi:10.1016/j.cell.2005.08.011 · Cited by 649 · see citing works

The multifaceted functions of sirtuins in cancer

Chalkiadaki, A., & Guarente, L. (2015) · Nature reviews. Cancer · doi:10.1038/nrc3985 · Cited by 501 · see citing works

Epigenetic patterns in the progression of esophageal adenocarcinoma.

Eads, C. A., Lord, R. V., Wickramasinghe, K. S., Long, T. I., Kurumboor, S. K., Bernstein, L., Peters, J. H., DeMeester, S. R., DeMeester, T. R., Skinner, K. A., et al. (2001) · PubMed · Cited by 500 · see citing works

Identification of differentially methylated sequences in colorectal cancer by methylated CpG island amplification.

Toyota, M., Ho, C., Ahuja, N., Jair, K. W., Li, Q., Ohe-Toyota, M., Baylin, S. B., & Issa, J. J. (1999) · PubMed · Cited by 468 · see citing works

Effects of cadmium on DNA-(Cytosine-5) methyltransferase activity and DNA methylation status during cadmium-induced cellular transformation

Takiguchi, M., Achanzar, W. E., Qu, W., Li, G., & Waalkes, M. P. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(03)00062-4 · Cited by 457 · see citing works

Methylation matters

Costello, J., & Plass, C. (2001) · Journal of Medical Genetics · doi:10.1136/jmg.38.5.285 · Cited by 449 · see citing works

SIRT1 Is Significantly Elevated in Mouse and Human Prostate Cancer

Huffman, D. M., Grizzle, W. E., Bamman, M. M., Kim, J.-S., Eltoum, I. A., Elgavish, A., & Nagy, T. R. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0085 · Cited by 428 · see citing works

The cancer epigenome—components and functional correlatesPreprint

Ting, A. H., McGarvey, K. M., & Baylin, S. B. (2006) · Genes & Development · doi:10.1101/gad.1464906 · Cited by 416 · see citing works

The Catenin p120 ctn Interacts with Kaiso, a Novel BTB/POZ Domain Zinc Finger Transcription Factor

Daniel, J. M., & Reynolds, A. B. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.5.3614 · Cited by 406 · see citing works

Short telomeres on human chromosome 17p

Martens, U. M., Zijlmans, J. M. J. M., Poon, S. S. S., Dragowska, W., Yui, J., Chavez, E. A., Ward, R. K., & Lansdorp, P. M. (1998) · Nature Genetics · doi:10.1038/ng0198-018 · Cited by 393 · see citing works

SIRT1 and p53, effect on cancer, senescence and beyond

Yi, J., & Luo, J. (2010) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2010.05.002 · Cited by 340 · see citing works

The Dual Role of Sirtuins in Cancer

Bosch‐Presegué, L., & Vaquero, A. (2011) · Genes & Cancer · doi:10.1177/1947601911417862 · Cited by 329 · see citing works

Concurrent DNA hypermethylation of multiple genes in acute myeloid leukemia.

Melki, J. R., Vincent, P., & Clark, S. J. (1999) · PubMed · Cited by 319 · see citing works

Arsenic alters cytosine methylation patterns of the promoter of the tumor suppressor gene p53 in human lung cells: a model for a mechanism of carcinogenesis

Mass, M. J., & Wang, L. (1997) · Mutation Research/Reviews in Mutation Research · doi:10.1016/s1383-5742(97)00008-2 · Cited by 310 · see citing works

Role of Sirtuin1-p53 regulatory axis in aging, cancer and cellular reprogramming

Ong, A. L. C., & Ramasamy, T. S. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.02.004 · Cited by 301 · see citing works

CpG-Island Methylation in Aging and Cancer

Issa, J. J. (2000) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-59696-4_7 · Cited by 301 · see citing works

Multistep carcinogenesis of breast cancer and tumour heterogeneity

Beckmann, M. W., Niederacher, D., Schnürch, H.-G., Gusterson, B. A., & Bender, H. (1997) · Journal of Molecular Medicine · doi:10.1007/s001090050128 · Cited by 301 · see citing works

A DNA hypermethylation module for the stem/progenitor cell signature of cancerPreprint

Easwaran, H., Johnstone, S. E., Neste, L. V., Ohm, J. E., Mosbruger, T., Wang, Q., Aryee, M. J., Joyce, P., Ahuja, N., Weisenberger, D., et al. (2012) · Genome Research · doi:10.1101/gr.131169.111 · Cited by 293 · see citing works

De Novo Methylation of CpG Island Sequences in Human Fibroblasts Overexpressing DNA (Cytosine-5-)-Methyltransferase

Vertino, P. M., Yen, R.-W. C., Gao, J.-X., & Baylin, S. B. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.8.4555 · Cited by 288 · see citing works

Molecular markers and long-term recurrences in a large cohort of patients with sporadic adrenocortical tumors.

Gicquel, C., BERTAGNA, X. Y., Gaston, V., Coste, J., Louvel, A., Baudin, É., Bertherat, J. Y., Chapuis, Y., Duclos, J. M., Schlumberger, M. J., et al. (2001) · PubMed · Cited by 285 · see citing works

APC Mutations in Sporadic Medulloblastomas

Huang, H., Mahler-Araujo, B. M., Sankila, A., Chimelli, L. M. C., Yonekawa, Y., Kleihues, P., & Ohgaki, H. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64747-5 · Cited by 279 · see citing works

Deletions linked to TP53 loss drive cancer through p53-independent mechanisms

Liu, Y., Chen, C., Xu, Z., Scuoppo, C., Rillahan, C. D., Gao, J., Spitzer, B. G., Bosbach, B., Kastenhuber, E. R., Baslan, T., et al. (2016) · Nature · doi:10.1038/nature17157 · Cited by 272 · see citing works

Adrenocortical cancer: pathophysiology and clinical management

Libé, R., Fratticci, A., & Bertherat, J. Y. (2007) · Endocrine Related Cancer · doi:10.1677/erc.1.01130 · Cited by 271 · see citing works

Recurrent chromosomal abnormalities in hepatocellular carcinoma detected by comparative genomic hybridization

Marchio, A., Meddeb, M., Pineau, P., Danglot, G., Tiollais, P., Bernheim, A., & Dejean, A. (1997) · Genes Chromosomes and Cancer · doi:10.1002/(sici)1098-2264(199701)18:1 · Cited by 266 · see citing works

Oncogenes and Tumor Suppressor Genes in Breast Cancer: Potential Diagnostic and Therapeutic Applications

Osborne, C., Wilson, P., & Tripathy, D. (2004) · The Oncologist · doi:10.1634/theoncologist.9-4-361 · Cited by 257 · see citing works

POZ for effect – POZ-ZF transcription factors in cancer and development

Kelly, K. F., & Daniel, J. M. (2006) · Trends in Cell Biology · doi:10.1016/j.tcb.2006.09.003 · Cited by 254 · see citing works

Classification of Epstein–Barr Virus–Positive Gastric Cancers by Definition of DNA Methylation Epigenotypes

Matsusaka, K., Kaneda, A., Nagae, G., Ushiku, T., Kikuchi, Y., Hino, R., Uozaki, H., Seto, Y., Takada, K., Aburatani, H., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-1349 · Cited by 254 · see citing works

PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes

Velasco-Miguel, S., Buckbinder, L., Jean, P., Gelbert, L., Talbott, R. L., Laidlaw, J. L., Seizinger, B. R., & Kley, N. (1999) · Oncogene · doi:10.1038/sj.onc.1202274 · Cited by 249 · see citing works

NSAIDs Modulate CDKN2A, TP53, and DNA Content Risk for Progression to Esophageal Adenocarcinoma

Galipeau, P. C., Li, X., Blount, P. L., Maley, C. C., Sanchez, C. A., Odze, R. D., Ayub, K., Rabinovitch, P. S., Vaughan, T. L., & Reid, B. J. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040067 · Cited by 250 · see citing works

The Roles of SIRT1 in Cancer

Lin, Z., & Fang, D. (2013) · Genes & Cancer · doi:10.1177/1947601912475079 · Cited by 241 · see citing works

Increased cytosine DNA-methyltransferase activity is target-cell-specific and an early event in lung cancer.

Belinsky, S. A., Nikula, K. J., Baylin, S. B., & Issa, J. J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.9.4045 · Cited by 235 · see citing works

Alterations of DNA methylation associated with abnormalities of DNA methyltransferases in human cancers during transition from a precancerous to a malignant state

Kanai, Y., & Hirohashi, S. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm206 · Cited by 221 · see citing works

Frequent promoter methylation of CDH1, DAPK, RARB, and HIC1 genes in carcinoma of cervix uteri: its relationship to clinical outcome.

Narayan, G., Arias‐Pulido, H., Koul, S., Vargas, H., Zhang, F. F., Villella, J., Schneider, A., Terry, M. B., MANSUKHANI, M. M., & Murty, V. V. V. S. (2003) · Molecular Cancer · doi:10.1186/1476-4598-2-24 · Cited by 218 · see citing works

Hic1 Defines Quiescent Mesenchymal Progenitor Subpopulations with Distinct Functions and Fates in Skeletal Muscle Regeneration

Scott, R. W., Arostegui, M., Schweitzer, R., Rossi, F. M. V., & Underhill, T. M. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.11.004 · Cited by 214 · see citing works

Expression and Genetic Analysis of XIAP-Associated Factor 1 (XAF1) in Cancer Cell Lines

Fong, W. G., Liston, P., Rajcan‐Separovic, E., Jean, M. S., Craig, C. G., & Korneluk, R. G. (2000) · Genomics · doi:10.1006/geno.2000.6364 · Cited by 213 · see citing works

Cys2His2 zinc finger protein family: Classification, functions, and major members

Razin, S., Borunova, V., Maksimenko, O., & Kantidze, O. (2012) · Biochemistry (Moscow) · doi:10.1134/s0006297912030017 · Cited by 186 · see citing works

Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors

Chen, W., Zeng, X., Carter, M. G., Morrell, C. N., Yen, R.-W. C., Esteller, M., Watkins, D. N., Herman, J. G., Mankowski, J. L., & Baylin, S. B. (2003) · Nature Genetics · doi:10.1038/ng1077 · Cited by 201 · see citing works

Novel and Highly Recurrent Chromosomal Alterations in Sezary Syndrome

Vermeer, M. H., van Doorn, R., Dijkman, R., Mao, X., Whittaker, S. J., Vader, P. C. V. V., Gerritsen, M. P., Geerts, M., Gellrich, S., Söderberg, O., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6398 · Cited by 196 · see citing works

In-Depth Mutational Analysis of the Promyelocytic Leukemia Zinc Finger BTB/POZ Domain Reveals Motifs and Residues Required for Biological and Transcriptional Functions

Melnick, A. M., Ahmad, K. F., Arai, S., Polinger, A., Ball, H. J., Borden, K. L. B., Carlile, G. W., Privé, G. G., & Licht, J. D. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.17.6550-6567.2000 · Cited by 195 · see citing works

Proteomic Analysis of Laser-Captured Paraffin-Embedded Tissues: A Molecular Portrait of Head and Neck Cancer Progression

Patel, V., Hood, B. L., Molinolo, A., Lee, N. H., Conrads, T. P., Braisted, J. C., Krizman, D. B., Veenstra, T. D., & Gutkind, J. S. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-1497 · Cited by 192 · see citing works

Methylation of Serum DNA Is an Independent Prognostic Marker in Colorectal Cancer

Wallner, M., Herbst, A., Behrens, A., Crispin, A., Stieber, P., Göke, B., Lamerz, R., & Kolligs, F. T. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-1264 · Cited by 183 · see citing works

A novel p53‐inducible gene, PAG608, encodes a nuclear zinc finger protein whose overexpression promotes apoptosis

Israeli, D., Tessler, E., Haupt, Y., Elkeles, A., Wilder, S., Amson, R. B., Telerman, A., & Oren, M. (1997) · The EMBO Journal · doi:10.1093/emboj/16.14.4384 · Cited by 172 · see citing works

Class II Histone Deacetylases Are Directly Recruited by BCL6 Transcriptional Repressor

Lemercier, C., Brocard, M.-P., Puvion-dutilleul, F., Kao, H., Albagli, O., & Khochbin, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201736200 · Cited by 172 · see citing works

Inhibition of tumorigenesis by a cytosine–DNA, methyltransferase, antisense oligodeoxynucleotide

Ramchandani, S., MacLeod, A. R., Pinard, M., Hofe, E. V., & Moshe Szyf, A. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.2.684 · Cited by 171 · see citing works

Fold prediction and evolutionary analysis of the POZ domain: structural and evolutionary relationship with the potassium channel tetramerization domain 1 1Edited by F. Cohen

Aravind, L., & Koonin, E. V. (1999) · Journal of Molecular Biology · doi:10.1006/jmbi.1998.2394 · Cited by 172 · see citing works

Molecular genetics of adrenocortical tumours, from familial to sporadic diseases

Libé, R., & Bertherat, J. (2005) · European Journal of Endocrinology · doi:10.1530/eje.1.02004 · Cited by 168 · see citing works

Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis

Chen, W., Cooper, T. K., Zahnow, C. A., Overholtzer, M., Zhao, Z., Ladanyi, M., Karp, J. E., Gökgöz, N., Wunder, J. S., Andrulis, I. L., et al. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.08.030 · Cited by 162 · see citing works

A Novel p53/microRNA‐22/Cyr61 Axis in Synovial Cells Regulates Inflammation in Rheumatoid Arthritis

Lin, J., Huo, R., Xiao, L., Zhu, X., Xie, J., Sun, S., He, Y., Zhang, J., Sun, Y., Zhou, Z., et al. (2013) · Arthritis & Rheumatology · doi:10.1002/art.38142 · Cited by 161 · see citing works

Inactivation of CACNA1G, a T-type calcium channel gene, by aberrant methylation of its 5' CpG island in human tumors.

Toyota, M., Ho, C., Ohe-Toyota, M., Baylin, S. B., & Issa, J. J. (1999) · PubMed · Cited by 154 · see citing works

An Acetylation/Deacetylation-SUMOylation Switch through a Phylogenetically Conserved ψKXEP Motif in the Tumor Suppressor HIC1 Regulates Transcriptional Repression Activity

Stankovic‐Valentin, N., Deltour, S., Seeler, J.-S., Pinte, S., Vergoten, G., Guérardel, C., Dejean, A., & Leprince, D. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01098-06 · Cited by 153 · see citing works

Array CGH identifies distinct DNA copy number profiles of oncogenes and tumor suppressor genes in chromosomal- and microsatellite-unstable sporadic colorectal carcinomas

Laßmann, S., Weis, R., Makowiec, F., Roth, J., Danciu, M., Hopt, U. T., & Werner, M. (2006) · Journal of Molecular Medicine · doi:10.1007/s00109-006-0126-5 · Cited by 152 · see citing works

Comparative Genomic Hybridization Analysis of Adrenocortical Tumors

Sidhu, S. B., Marsh, D. J., Theodosopoulos, G., Philips, J. N., Bambach, C. P., Campbell, P. R., Magarey, C. J., Russell, C. F. J., Schulte, K., Röher, H. D., et al. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.7.8697 · Cited by 144 · see citing works

Hypermethylation in the retinoblastoma gene is associated with unilateral, sporadic retinoblastoma

Ohtani‐Fujita, N., Dryja, T. P., Rapaport, J. M., Fujita, T., Matsumura, S., Ozasa, K., Watanabe, Y., Hayashi, K., Maeda, K., Kinoshita, S., et al. (1997) · Cancer Genetics and Cytogenetics · doi:10.1016/s0165-4608(96)00395-0 · Cited by 144 · see citing works

Suppression of Tumorigenicity in Breast Cancer Cells by the Microfilament Protein Profilin 1

Janke, J., Schlüter, K., Jandrig, B., Theile, M., Kölble, K., Arnold, W., Grinstein, E., Schwartz, A., Estévéz‐Schwarz, L., Schlag, P. M., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.10.1675 · Cited by 143 · see citing works

Frequent Aberrant Methylation of p16INK4a in Primary Rat Lung Tumors

Swafford, D. S., Middleton, S. K., Palmisano, W. A., Nikula, K. J., Tesfaigzi, Y., Baylin, S. B., Herman, J. G., & Belinsky, S. A. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.3.1366 · Cited by 142 · see citing works

Dual targeting of epigenetic therapy in cancer

Hellebrekers, D. M. E. I., Griffioen, A. W., & van Engeland, M. (2006) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2006.07.003 · Cited by 141 · see citing works

Methylation and colorectal cancer

Jubb, A. M., Bell, S. M., & Quirke, P. (2001) · The Journal of Pathology · doi:10.1002/path.923 · Cited by 133 · see citing works

Epigenetic Changes in Solid and Hematopoietic Tumors

Toyota, M., & Issa, J. J. (2005) · Seminars in Oncology · doi:10.1053/j.seminoncol.2005.07.003 · Cited by 133 · see citing works

Highly Methylated Genes in Colorectal Neoplasia: Implications for Screening

Zou, H., Harrington, J. J., Shire, A. M., Rego, R. L., Wang, L., Campbell, M. E., Oberg, A. L., & Ahlquist, D. A. (2007) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-07-0518 · Cited by 131 · see citing works

A Novel BTB/POZ Transcriptional Repressor Protein Interacts With the Fanconi Anemia Group C Protein and PLZF

Hoatlin, M. E., Zhi, Y., Ball, H. J., Silvey, K. V., Melnick, A. M., Stone, S., Arai, S., Hawe, N., Owen, G. I., Zelent, A., et al. (1999) · Blood · doi:10.1182/blood.v94.11.3737 · Cited by 131 · see citing works

The BTB-ZF transcription factors

Siggs, O. M., & Beutler, B. (2012) · Cell Cycle · doi:10.4161/cc.21277 · Cited by 127 · see citing works

Analysis of promoter methylation in stool: A novel method for the detection of colorectal cancer

Lenhard, K., Bommer, G. T., Asutay, S., Schauer, R. J., Brabletz, T., Göke, B., Lamerz, R., & Kolligs, F. T. (2005) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(04)00624-x · Cited by 127 · see citing works

Structure and Methylation-Based Silencing of a Gene (DBCCR1) within a Candidate Bladder Cancer Tumor Suppressor Region at 9q32–q33

Habuchi, T., Luscombe, M., Elder, P. A., & Knowles, M. A. (1998) · Genomics · doi:10.1006/geno.1997.5165 · Cited by 127 · see citing works

Dancing in and out of the nucleus: p120ctn and the transcription factor Kaiso

Daniel, J. M. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.08.052 · Cited by 126 · see citing works

Mice deficient in the candidate tumor suppressor gene Hic1 exhibit developmental defects of structures affected in the Miller-Dieker syndrome

Carter, M. G. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.3.413 · Cited by 125 · see citing works

The Human Candidate Tumor Suppressor Gene HIC1 Recruits CtBP through a Degenerate GLDLSKK Motif

Deltour, S., Pinte, S., Guérardel, C., Wasylyk, B., & Leprince, D. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.13.4890-4901.2002 · Cited by 117 · see citing works

RPS6KA2, a putative tumour suppressor gene at 6q27 in sporadic epithelial ovarian cancer

Bignone, P. A., Lee, K. Y., Liu, Y., Emilion, G., Finch, J., Soosay, A. E. R., Charnock, F. M. L., Beck, S., Dunham, I., Mungall, A. J. J., et al. (2006) · Oncogene · doi:10.1038/sj.onc.1209827 · Cited by 115 · see citing works

Characteristic promoter hypermethylation signatures in male germ cell tumors.

Koul, S., Houldsworth, J., MANSUKHANI, M. M., Donadio, A., McKiernan, J. M., Reuter, V. E., Bosl, G. J., Chaganti, R. S. K., & Murty, V. V. V. S. (2002) · Molecular Cancer · doi:10.1186/1476-4598-1-8 · Cited by 113 · see citing works

Nucleoredoxin, a Novel Thioredoxin Family Member Involved in Cell Growth and Differentiation

Funato, Y., & Miki, H. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1550 · Cited by 114 · see citing works

Hypermethylation of HIC-1 and 17p allelic loss in medulloblastoma.

Rood, B. R., Zhang, H., Weitman, D. M., & Cogen, P. H. (2002) · PubMed · Cited by 110 · see citing works

Metastasis-Associated Protein 1/Nucleosome Remodeling and Histone Deacetylase Complex in Cancer

Li, D., Pakala, S. B., Nair, S. S., Eswaran, J., & Kumar, R. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-2345 · Cited by 108 · see citing works

Dna Hypermethylation At the D17s5 Locus and Reduced Hic–1 Mrna Expression Are Associated With Hepatocarcinogenesis

Kanai, Y., Hui, A., Sun, L., Ushijima, S., Sakamoto, M., Tsuda, H., & Hirohashi, S. (1999) · Hepatology · doi:10.1002/hep.510290338 · Cited by 109 · see citing works

A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53

Zhang, Q., Zeng, S. X., Zhang, Y., Zhang, Y.-W., Ding, D., Ye, Q.-Z., Meroueh, S. O., & Lu, H. (2012) · EMBO Molecular Medicine · doi:10.1002/emmm.201100211 · Cited by 110 · see citing works

Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: The case of HIC-1 and γFBP-B

Deltour, S., Guérardel, C., & Leprince, D. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.14831 · Cited by 108 · see citing works

Enhancement of In vitro and In vivo Tumor Cell Radiosensitivity by the DNA Methylation Inhibitor Zebularine

Dote, H., Cerna, D., Burgan, W. E., Carter, D. J., Cerra, M. A., Hollingshead, M. G., Camphausen, K. A., & Tofilon, P. J. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-0050 · Cited by 105 · see citing works

IGFBP7 is a p53-responsive gene specifically silenced in colorectal cancer with CpG island methylator phenotype

Suzuki, H., Igarashi, S., Nojima, M., Maruyama, R., Yamamoto, E., Kai, M., Akashi, H., Watanabe, Y., Yamamoto, H., Sasaki, Y., et al. (2009) · Carcinogenesis · doi:10.1093/carcin/bgp179 · Cited by 104 · see citing works

Aberrant promoter methylation of the transcription factor genes PAX5 alpha and beta in human cancers.

Palmisano, W. A., Crume, K. P., Grimes, M. J., Winters, S. A., Toyota, M., Esteller, M., Joste, N. E., Baylin, S. B., & Belinsky, S. A. (2003) · PubMed · Cited by 103 · see citing works

Characterization of the Human TESTIN Gene Localized in the FRA7G Region at 7q31.2

Tatarelli, C., Linnenbach, A. J., Mimori, K., & Croce, C. M. (2000) · Genomics · doi:10.1006/geno.2000.6272 · Cited by 101 · see citing works

Silencing of the UCHL1 gene in human colorectal and ovarian cancers

Okochi‐Takada, E., Nakazawa, K., Wakabayashi, M., Mori, A., Ichimura, S., Yasugi, T., & Ushijima, T. (2006) · International Journal of Cancer · doi:10.1002/ijc.22025 · Cited by 98 · see citing works

APM‐1, a novel human gene, identified by aberrant co‐transcription with papillomavirus oncogenes in a cervical carcinoma cell line, encodes a BTB/POZ‐zinc finger protein with growth inhibitory activity

Reuter, S., Bartelmann, M., Vogt, M., Geisen, C., Napierski, I., Kahn, T., Delius, H., Lichter, P., Weitz, S., Korn, B., et al. (1998) · The EMBO Journal · doi:10.1093/emboj/17.1.215 · Cited by 97 · see citing works

Current treatment of medulloblastoma: Recent advances and future challenges

Rood, B. R., MacDonald, T. J., & Packer, R. J. (2004) · Seminars in Oncology · doi:10.1053/j.seminoncol.2004.07.009 · Cited by 95 · see citing works

p53 abnormalities in CLL are associated with excess of prolymphocytes and poor prognosis

Lens, D., Dyer, M. J. S., Garcia‐Marco, J. M., Schouwer, P. J. J. C. D., Hamoudi, R., Jones, D., Farahat, N. M. G., Matutes, E., & Catovsky, D. (1997) · British Journal of Haematology · doi:10.1046/j.1365-2141.1997.4723278.x · Cited by 95 · see citing works

Distinct HIC1-SIRT1-p53 Loop Deregulation in Lung Squamous Carcinoma and Adenocarcinoma Patients

Tseng, R., Lee, C.-C., Hsu, H., Tzao, C., & Wang, Y. (2009) · Neoplasia · doi:10.1593/neo.09470 · Cited by 94 · see citing works

Increased DNA Methyltransferase Expression Is Associated with an Early Stage of Human Hepatocarcinogenesis

Sun, L., Hui, A., Kanai, Y., Sakamoto, M., & Hirohashi, S. (1997) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1997.tb00345.x · Cited by 94 · see citing works

RP58 Associates with Condensed Chromatin and Mediates a Sequence-specific Transcriptional Repression

Aoki, K., Meng, G., Suzuki, K., Takashi, T., Kameoka, Y., Nakahara, K., Ishida, R., & Kasai, M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.41.26698 · Cited by 92 · see citing works

Structural and functional properties of genes involved in human cancer

Furney, S. J., Higgins, D. G., Ouzounis, C. A., & López-Bigas, N. (2006) · BMC Genomics · doi:10.1186/1471-2164-7-3 · Cited by 90 · see citing works

Differential Regulation of HIC1 Target Genes by CtBP and NuRD, via an Acetylation/SUMOylation Switch, in Quiescent versus Proliferating Cells

Rechem, C. V., Boulay, G., Pinte, S., Stankovic‐Valentin, N., Guérardel, C., & Leprince, D. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00582-09 · Cited by 91 · see citing works

Identification of the p53 family-responsive element in the promoter region of the tumor suppressor gene hypermethylated in cancer 1

Britschgi, C., Rizzi, M., Grob, T. J., Tschan, M. P., Hügli, B., Reddy, V. A., Andres, A. ‐., Torbett, B. E., Tobler, A., & Fey, M. F. (2005) · Oncogene · doi:10.1038/sj.onc.1209240 · Cited by 49 · see citing works

Inactivation of the hypermethylated in cancer 1 tumour suppressor – not just a question of promoter hypermethylation?

Jenal, M., Britschgi, C., Fey, M., & Tschan, M. P. (2010) · Swiss Medical Weekly · doi:10.4414/smw.2010.13106 · Cited by 17 · see citing works

HIC1 : le nœud du problème en 17p13.3 ?

Chopin, V., & Leprince, D. (2006) · médecine/sciences · doi:10.1051/medsci/200622154 · Cited by 9 · see citing works

P53 and HIC1 in Brain Cancer Gliomas

Kumar, S. (2016) · Journal of Headache & Pain Management · doi:10.4172/2472-1913.100018

HIC1 (Hypermethylated in Cancer 1) epigenetic silencing in tumors

Rechem, C. V., Touka, M., Boulay, G., Guérardel, C., Rood, B. R., & Leprince, D. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.05.028 · Cited by 90 · see citing works