Hic1 Defines Quiescent Mesenchymal Progenitor Subpopulations with Distinct Functions and Fates in Skeletal Muscle Regeneration
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derivatives directly contribute to several mesenchymal compartments including Col22a1-expressing cells within the myotendinous junction. Collectively, these findings demonstrate that HIC1 regulates MP quiescence and identifies MP subpopulations with transient and enduring roles in muscle regeneration.
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Hic1 is a tumour suppressor and biomarker of adult mesenchymal progenitors.
“like Hic1, a tumour suppressor62 and biomarker of adult mesenchymal progenitors63,76.”
From Cell diversity and plasticity during atrioventricular heart valve EMTs (2023) · cites this paper as [63]
AV EPDCs express factors associated with EMT, along with unique genes like Hic1.
“AV EPDCs express a variety of factors associated with EMT, along with some unique genes, like Hic1, a tumour suppressor62 and biomarker of adult mesenchymal progenitors63,76.”
From Cell diversity and plasticity during atrioventricular heart valve EMTs (2023) · cites this paper as [63]
Lowering extracellular pH combined with an increase in lactic acid promotes myofibroblast differentiation via activation of TGF-β1, and lactate itself may serve as an additional energy source promoting a synthetic phenotype in mesenchymal cells.
“Lowering extracellular pH combined with an increase in lactic acid promotes myofibroblast differentiation via activation of TGF-β1 and lactate itself may serve as an additional energy source promoting a synthetic phenotype in mesenchymal cells44–46.”
From Fibrosis: from mechanisms to medicines (2020) · cites this paper as [44]
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- Authors
- Scott, R. W., Arostegui, M., Schweitzer, R., Rossi, F. M. V., & Underhill, T. M.
- Affiliations
- University of British Columbia (CA)
- Shriners Hospitals for Children - Portland (US)
- Corresponding author
- Underhill, T. Michael
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2019-12
- Volume
- 25
- Issue
- 6
- Pages
- 797-813.e9
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- PMC
- PMC6941576
- OpenAlex
- W2992810674
- Cited by
- 214
- References
- 73
- Citations by year
- 2026: 17 · 2025: 22 · 2024: 50 · 2023: 36 · 2022: 28 · 2021: 40 · 2020: 18 · 2019: 1 · 2018: 2
- FWCI
- 7.19
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Cell stem cell (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (CA231652, MOP 97856)
- Terry Fox Research Institute
- Canadian Institutes of Health Research (PJT-149026, PJT-148816, 1021, MOP 97856)
- University of British Columbia
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- HIC1, mesenchymal progenitor cells, quiescence, skeletal muscle regeneration, COL22A1, myotendinous junction, cell fate
- MeSH terms
- Animals, Cell Cycle, Cell Differentiation, Cells, Cultured, Female, Fluorescent Antibody Technique, Male, Regeneration, Wound Healing, Muscle, Skeletal, Satellite Cells, Skeletal Muscle, Cell Proliferation, Mice, Kruppel-Like Transcription Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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