Apoptosis and Related Proteins during Parturition in Prostaglandin F Receptor-Deficient Mice
Abstract
This study investigated whether apoptosis and related proteins are involved in parturition by comparative observation of FP-deficient mice without labor and wild type mice with vaginal delivery. We examined the expression of apoptosis, Fas, FasL, active caspase-3 and bcl-2 proteins in the amnion, placenta and decidua. DNA laddering in the amnion, placenta and decidua tissue did not significantly differ between FP-deficient and wild type mice on day 18 of pregnancy. Similar TUNEL staining results were found in all tissues of FP-deficient mice compared with those of wild type mice. A higher intensity of apoptotic cells was found in the decidua basalis. The index of TUNEL-positive cells were not significantly different in the amnion, placenta and decidua of FP-deficient mice compared with that of wild type mice on day 18 of pregnancy. Specific bands for Fas were clearly observed in the amnion, placenta and decidua tissue. FasL specific bands were observed in the placenta and decidua, but a few in amnion tissue. A great number of active caspase-3 specific bands were detected in decidua, while a few such bands were detected in the placenta and few bands in the amniotic tissue. Bands for bcl-2 were detected in the amnion, placenta and decidua tissue. The weakest band was in decidual tissue. Fas, FasL, active caspase-3, and bcl-2 specific bands did not show any significant differences between the two groups. These findings demonstrate that apoptosis, Fas, FasL, caspase-3, and Bcl-2 occur in mouse term placenta that is not involved in parturition.
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Apoptosis at the decidual/uterine interface allows initial separation of the maternal/placental unit at the time of parturition.
“putatively allowing for initial separation of the maternal/placental unit at the time of parturition40–43.”
From Conditional loss of ERK1 and ERK2 results in abnormal placentation and delayed parturition in the mouse (2019) · cites this paper as [43]
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- Authors
- Mu, J., Kanzaki, T., Si, X., Tomimatsu, T., Fukuda, H., Fujii, E., Hosono, T., Murata, Y., Sugimoto, Y., & Ichikawa, A.
- Affiliations
- The University of Osaka (JP)
- Kyoto University (JP)
- Corresponding author
- Mu, Junwu
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 2002-04
- Volume
- 292
- Issue
- 3
- Pages
- 675-681
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2088012619
- Cited by
- 8
- References
- 49
- Citations by year
- 2023: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2012: 1
- FWCI
- 0.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Epidemiology › Preterm Birth and Chorioamnionitis
- Keywords
- apoptosis, childbirth, prostaglandin F receptor, Fas, Fas ligand, caspase-3, Bcl-2, decidua basalis, placenta, amniotic membrane, labor, term placenta, TUNEL staining, DNA laddering
- MeSH terms
- Amnion, Animals, Female, Humans, Labor, Obstetric, Male, Membrane Glycoproteins, Placenta, Pregnancy, Receptors, Prostaglandin, Apoptosis, Mice, Knockout, fas Receptor, Proto-Oncogene Proteins c-bcl-2, Caspases, In Situ Nick-End Labeling, Mice, Caspase 3, Fas Ligand Protein, DNA Fragmentation
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