Fas ligand expression in islets of Langerhans does not confer immune privilege and instead targets them for rapid destruction

The Fas Death Factor

Nagata, S., & Golstein, P. (1995) · Science · doi:10.1126/science.7533326 · Cited by 3,979

Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege

Griffith, T. S., Brunner, T., Fletcher, S. M., Green, D. R., & Ferguson, T. A. (1995) · Science · doi:10.1126/science.270.5239.1189 · Cited by 2,005

Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligand

Takahashi, T., Tanaka, M., Brannan, C. I., Jenkins, N. A., Copeland, N. G., Suda, T., & Nagata, S. (1994) · Cell · doi:10.1016/0092-8674(94)90375-1 · Cited by 1,528

Dominant interfering fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome

Fisher, G. H., Rosenberg, F. J., Straus, S. E., Dale, J. K., Middelton, L. A., Lin, A. Y., Strober, W., Lenardo, M. J., & Puck, J. M. (1995) · Cell · doi:10.1016/0092-8674(95)90013-6 · Cited by 1,465

Mutations in Fas Associated with Human Lymphoproliferative Syndrome and Autoimmunity

Rieux-Laucat, F., Le Deist, F., Hivroz, C., Roberts, I. A. G., Debatin, K. M., Fischer, A., & de Villartay, J. P. (1995) · Science · doi:10.1126/science.7539157 · Cited by 1,297

Melanoma Cell Expression of Fas(Apo-1/CD95) Ligand: Implications for Tumor Immune Escape

Hahne, M., Rimoldi, D., Schröter, M., Romero, P., Schreier, M., French, L. E., Schneider, P., Bornand, T., Fontana, A., Lienard, D., et al. (1996) · Science · doi:10.1126/science.274.5291.1363 · Cited by 1,249

A role for CD95 ligand in preventing graft rejection

Bellgrau, D., Gold, D., Selawry, H., Moore, J., Franzusoff, A., & Duke, R. C. (1995) · Nature · doi:10.1038/377630a0 · Cited by 1,155

Interleukin‐8, a chemotactic and inflammatory cytokine

Baggiolini, M., & Clark-Lewis, I. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)80909-z · Cited by 989

Lymphocyte apoptosis induced by CD95 (APO–1/Fas) ligand–expressing tumor cells — A mechanism of immune evasion?

Strand, S., Hofmann, W. J., Hug, H., Müller, M., Otto, G., Strand, D., Mariani, S. M., Stremmel, W., Krammer, P. H., & Galle, P. R. (1996) · Nature Medicine · doi:10.1038/nm1296-1361 · Cited by 897

Fas and Fas ligand: lpr and gld mutations

Nagata, S., & Suda, T. (1995) · Immunology Today · doi:10.1016/0167-5699(95)80069-7 · Cited by 892

Methods in molecular biology

Deininger, P. (1991) · Analytical Biochemistry · doi:10.1016/0003-2697(91)90283-y · Cited by 888

Metalloproteinase-mediated release of human Fas ligand.

Kayagaki, N., Kawasaki, A., Ebata, T., Ohmoto, H., Ikeda, S., Inoue, S., Yoshino, K., Okumura, K., & Yagita, H. (1995) · The Journal of experimental medicine · doi:10.1084/jem.182.6.1777 · Cited by 822

Neutrophil and B Cell Expansion in Mice That Lack the Murine IL-8 Receptor Homolog

Cacalano, G., Lee, J., Kikly, K., Ryan, A. M., Pitts-Meek, S., Hultgren, B., Wood, W. I., & Moore, M. W. (1994) · Science · doi:10.1126/science.8036519 · Cited by 664

Expression of the functional soluble form of human fas ligand in activated lymphocytes.

Tanaka, M., Suda, T., Takahashi, T., & Nagata, S. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07096.x · Cited by 638

Differential expression of Fas (CD95) and Fas ligand on normal human phagocytes: implications for the regulation of apoptosis in neutrophils.

Liles, W. C., Kiener, P. A., Ledbetter, J. A., Aruffo, A., & Klebanoff, S. J. (1996) · The Journal of experimental medicine · doi:10.1084/jem.184.2.429 · Cited by 557

Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of lpr mice.

Adachi, M., Watanabe-Fukunaga, R., & Nagata, S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1756 · Cited by 505

The Role of Fas in Autoimmune Diabetes

Chervonsky, A. V., Wang, Y., Wong, F. S., Visintin, I., Flavell, R. A., Janeway, C. A., & Matis, L. A. (1997) · Cell · doi:10.1016/s0092-8674(00)80178-6 · Cited by 496

Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-gamma

Sarvetnick, N., Liggitt, D., Pitts, S. L., Hansen, S. E., & Stewart, T. A. (1988) · Cell · doi:10.1016/0092-8674(88)90414-x · Cited by 464

Prevention of Islet Allograft Rejection with Engineered Myoblasts Expressing FasL in Mice

Lau, H. T., Yu, M., Fontana, A., & Stoeckert, C. J. (1996) · Science · doi:10.1126/science.273.5271.109 · Cited by 445

ESTERASE ACTIVITY IN LEUKOCYTES DEMONSTRATED BY THE USE OF NAPHTHOL AS-D CHLOROACETATE SUBSTRATE

MOLONEY, W. C., MCPHERSON, K., & FLIEGELMAN, L. (1960) · Journal of Histochemistry & Cytochemistry · doi:10.1177/8.3.200 · Cited by 374

Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver

Adachi, M., Suematsu, S., Kondo, T., Ogasawara, J., Tanaka, T., Yoshida, N., & Nagata, S. (1995) · Nature Genetics · doi:10.1038/ng1195-294 · Cited by 374

Transgenic expression of CD95 ligand on islet β cells induces a granulocytic infiltration but does not confer immune privilege upon islet allografts

Allison, J., Georgiou, H. M., Strasser, A., & Vaux, D. L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.8.3943 · Cited by 366

Diabetes and tolerance in transgenic mice expressing class II MHC molecules in pancreatic beta cells

Lo, D., Burkly, L. C., Widera, G., Cowing, C., Flavell, R. A., Palmiter, R. D., & Brinster, R. L. (1988) · Cell · doi:10.1016/0092-8674(88)90497-7 · Cited by 340

Fas and Fas Ligand: A Death Factor and Its Receptor

Nagata, S. (1994) · Advances in Immunology · doi:10.1016/s0065-2776(08)60672-0 · Cited by 338

Differential expression of bcl-2 and susceptibility to anti-Fas- mediated cell death in peripheral blood lymphocytes, monocytes, and neutrophils

Iwai, K., Miyawaki, T., Takizawa, T., Konno, A., Ohta, K., Yachie, A., Seki, H., & Taniguchi, N. (1994) · Blood · doi:10.1182/blood.v84.4.1201.1201 · Cited by 314

Antitumor effect of locally produced CD95 ligand

Seino, K.-I., Kayagaki, N., Okumura, K., & Yagita, H. (1997) · Nature Medicine · doi:10.1038/nm0297-165 · Cited by 312

Role of early region 3 (E3) in pathogenesis of adenovirus disease.

Ginsberg, H. S., Lundholm-Beauchamp, U., Horswood, R. L., Pernis, B., Wold, W. S., Chanock, R. M., & Prince, G. A. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.10.3823 · Cited by 290

Divergent induction of apoptosis and IL-8 secretion in HT-29 cells in response to TNF-α and ligation of Fas antigen

Abreu-Martin, M. T., Vidrich, A., Lynch, D. H., & Targan, S. R. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.9.4147 · Cited by 241

The Role of APO‐1‐Mediated Apoptosis in the Immune System

Krammer, P. H., Dhein, J., Walczak, H., Behrmann, I., Mariani, S., Matiba, B., Fath, M., Daniel, P. T., Knipping, E., Westendorp, M. O., et al. (1994) · Immunological Reviews · doi:10.1111/j.1600-065x.1994.tb00889.x · Cited by 225

T-cell tolerance toward a transgenic beta-cell antigen and transcription of endogenous pancreatic genes in thymus.

Jolicoeur, C., Hanahan, D., & Smith, K. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.14.6707 · Cited by 222

Regulation of cell surface APO‐1/Fas (CD95) ligand expression by metalloproteases

Mariani, S. M., Matiba, B., Bäumler, C., & Krammer, P. H. (1995) · European Journal of Immunology · doi:10.1002/eji.1830250828 · Cited by 217

Mouse islet cell lysis mediated by interleukin-1-induced Fas

Yamada, K., Takane-Gyotoku, N., Yuan, X., Ichikawa, F., Inada, C., & Nonaka, K. (1996) · Diabetologia · doi:10.1007/s001250050574 · Cited by 183

Overexpression of hexokinase I in isolated islets of Langerhans via recombinant adenovirus. Enhancement of glucose metabolism and insulin secretion at basal but not stimulatory glucose levels.

Becker, T. C., BeltrandelRio, H., Noel, R. J., Johnson, J. H., & Newgard, C. B. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31953-1 · Cited by 152

Pancreas and islet transplantation

Sutherland, D. E. R. (1981) · Diabetologia · doi:10.1007/bf00253405 · Cited by 151

Pancreas and islet transplantation: I. Experimental studies

Sutherland, D. E. R. (1981) · Diabetologia · doi:10.1007/bf00252624 · Cited by 140

Fas ligand and immune evasion

Nagata, S. (1996) · Nature Medicine · doi:10.1038/nm1296-1306 · Cited by 119

Regulation of apoptosis in neutrophils--Fas track to death?

Liles, W. C., & Klebanoff, S. J. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.7.3289 · Cited by 115

Fas-Mediated Stimulation Induces IL-8 Secretion by Rheumatoid Arthritis Synoviocytes Independently of CPP32-Mediated Apoptosis

Sekine, C., Yagita∥, H., Kobata, T., et al. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.1610 · Cited by 63

Identification of a cis-Acting Sequence in the Human Plasminogen Activator Inhibitor Type-1 Gene That Mediates Transforming Growth Factor-β1 Responsiveness in Endothelium in Vivo

Dong, G., Schulick, A. H., DeYoung, M. B., et al. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.47.29969 · Cited by 42

HUMAN PERIPHERAL BLOOD LYMPHOCYTE RECONSTITUTED SEVERE COMBINED IMMUNODEFICIENT (hu-PBL-SCID) MICE

Shiroki, R., Poindexter, N. J., Woodle, E. S., Hussain, M. S., Mohanakumar, T., & Scharp, D. W. (1994) · Transplantation · doi:10.1097/00007890-199457110-00004 · Cited by 38

HUMAN PERIPHERAL BLOOD LYMPHOCYTE RECONSTITUTED SEVERE COMBINED IMMUNODEFICIENT (hu-PBL-SCID) MICE

Shiroki, R., Poindexter, N. J., Woodle, E. S., Hussain, M. S., Mohanakumar, T., & Scharp, D. W. (1994) · Transplantation · doi:10.1097/00007890-199406150-00004 · Cited by 34

Sexual Dimorphism of Pancreatic β-Cell Degeneration in Transgenic Mice Expressing an Insulin-rasHybrid Gene*

Efrat, S. (1991) · Endocrinology · doi:10.1210/endo-128-2-897 · Cited by 31

CD8α+ and CD8α− Subclasses of Dendritic Cells Direct the Development of Distinct T Helper Cells In Vivo

Maldonado-López, R., De Smedt, T., Michel, P., Godfroid, J., Pajak, B., Heirman, C., Thielemans, K., Leo, O., Urbain, J., & Moser, M. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.3.587 · Cited by 984

The many roles of FAS receptor signaling in the immune system

Strasser, A., Jost, P. J., & Nagata, S. (2009) · Immunity · doi:10.1016/j.immuni.2009.01.001 · Cited by 968

A choice of death - the signal-transduction of immune-mediated beta-cell apoptosis

Eizirik, D. L., & Mandrup-Poulsen, T. (2001) · Diabetologia · doi:10.1007/s001250100021 · Cited by 888

Cardiomyocyte Grafting for Cardiac Repair: Graft Cell Death and Anti-Death Strategies

Zhang, M., Methot, D., Poppa, V., Fujio, Y., Walsh, K., & Murry, C. E. (2001) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2001.1367 · Cited by 878

Ocular immune privilege: therapeutic opportunities from an experiment of nature

Streilein, J. W. (2003) · Nature Reviews Immunology · doi:10.1038/nri1224 · Cited by 807