The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Regulation of pancreatic β-cell growth and survival by the serine/threonine protein kinase Akt1/PKBα
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Mechanism of activation of protein kinase B by insulin and IGF-1.
Alessi, D. R., Andjelkovic, M., Caudwell, B., Cron, P., Morrice, N., Cohen, P., & Hemmings, B. A. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb01045.x · Cited by 3,004
Disruption of IRS-2 causes type 2 diabetes in mice
Withers, D. J., Gutierrez, J. S., Towery, H., Burks, D. J., Ren, J.-M., Previs, S., Zhang, Y., Bernal, D., Pons, S., Shulman, G. I., et al. (1998) · Nature · doi:10.1038/36116 · Cited by 1,775
Hanahan, D. (1985) · Nature · doi:10.1038/315115a0 · Cited by 1,281
Kulkarni, R. N., Brüning, J. C., Winnay, J. N., Postic, C., Magnuson, M. A., & Kahn, C. R. (1999) · Cell · doi:10.1016/s0092-8674(00)80546-2 · Cited by 1,148
Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation
COFFER, P. J., JIN, J., & WOODGETT, J. R. (1998) · Biochemical Journal · doi:10.1042/bj3350001 · Cited by 1,067
Streptozotocin-Induced Pancreatic Insulitis: New Model of Diabetes Mellitus
Like, A. A., & Rossini, A. A. (1976) · Science · doi:10.1126/science.180605 · Cited by 979
Le Roith, D. (1997) · New England Journal of Medicine · doi:10.1056/nejm199702273360907 · Cited by 897
Autonomous Control of Cell and Organ Size by CHICO, a Drosophila Homolog of Vertebrate IRS1–4
Böhni, R., Riesgo-Escovar, J., Oldham, S., Brogiolo, W., Stocker, H., Andruss, B. F., Beckingham, K., & Hafen, E. (1999) · Cell · doi:10.1016/s0092-8674(00)80799-0 · Cited by 835
Drosophila S6 Kinase: A Regulator of Cell Size
Montagne, J., Stewart, M. J., Stocker, H., Hafen, E., Kozma, S. C., & Thomas, G. (1999) · Science · doi:10.1126/science.285.5436.2126 · Cited by 717
Paradis, S., & Ruvkun, G. (1998) · Genes & Development · doi:10.1101/gad.12.16.2488 · Cited by 708
Disruption of the p70s6k/p85s6k gene reveals a small mouse phenotype and a new functional S6 kinase
Shima, H. (1998) · The EMBO Journal · doi:10.1093/emboj/17.22.6649 · Cited by 636
The conserved phosphoinositide 3-kinase pathway determines heart size in mice
Shioi, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.11.2537 · Cited by 604
Dynamics of β-cell Mass in the Growing Rat Pancreas: Estimation With a Simple Mathematical Model
Finegood, D. T., Scaglia, L., & Bonner-Weir, S. (1995) · Diabetes · doi:10.2337/diab.44.3.249 · Cited by 603
Pick, A., Clark, J., Kubstrup, C., Levisetti, M., Pugh, W., Bonner-Weir, S., & Polonsky, K. S. (1998) · Diabetes · doi:10.2337/diabetes.47.3.358 · Cited by 551
Self-citationIrs-2 coordinates Igf-1 receptor-mediated β-cell development and peripheral insulin signalling
Withers, D. J., Burks, D. J., Towery, H. H., Altamuro, S. L., Flint, C. L., & White, M. F. (1999) · Nature Genetics · doi:10.1038/12631 · Cited by 529
Scott, P. H., Brunn, G. J., Kohn, A. D., Roth, R. A., & Lawrence, J. C. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7772 · Cited by 479
Akt, a Pleckstrin Homology Domain Containing Kinase, Is Activated Primarily by Phosphorylation
Kohn, A. D., Takeuchi, F., & Roth, R. A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.36.21920 · Cited by 467
Hypoinsulinaemia, glucose intolerance and diminished β-cell size in S6K1-deficient mice
Pende, M., Kozma, S. C., Jaquet, M., Oorschot, V., Burcelin, R., Le Marchand-Brustel, Y., Klumperman, J., Thorens, B., & Thomas, G. (2000) · Nature · doi:10.1038/35050135 · Cited by 459
Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB
Verdu, J., Buratovich, M. A., Wilder, E. L., & Birnbaum, M. J. (1999) · Nature Cell Biology · doi:10.1038/70293 · Cited by 368
Self-citationKohn, A. D., Kovacina, K. S., & Roth, R. A. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00103.x · Cited by 355
The Drosophila insulin receptor is required for normal growth
Chen, C. (1996) · Endocrinology · doi:10.1210/en.137.3.846 · Cited by 341
Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice.
Pontoglio, M., Sreenan, S., Roe, M., Pugh, W., Ostrega, D., Doyen, A., Pick, A. J., Baldwin, A., Velho, G., Froguel, P., et al. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2548 · Cited by 321 · cited 1×
“The pancreas was perfused using a slightly modified protocol as describe”
MethodSelf-citationWeinkove, D., Neufeld, T. P., Twardzik, T., Waterfield, M. D., & Leevers, S. J. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80450-3 · Cited by 297
Montaña, E., Bonner-Weir, S., & Weir, G. C. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116297 · Cited by 193
O’Brien, B. A., HARMON, B. V., Cameron, D. P., & Allan, D. J. (1996) · The Journal of Pathology · doi:10.1002/(sici)1096-9896(199602)178:2<176::aid-path433>3.0.co;2-8 · Cited by 183
Apoptosis and the pathogenesis of IDDM: a question of life and death.
Mauricio, D., & Mandrup-Poulsen, T. R. (1998) · Diabetes · doi:10.2337/diabetes.47.10.1537 · Cited by 154
Genetic analysis of protein kinase B (AKT) in Drosophila
Staveley, B. E., Ruel, L., Jin, J., Stambolic, V., Mastronardi, F. G., Heitzler, P., Woodgett, J. R., & Manoukian, A. S. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70231-3 · Cited by 139
From small flies come big discoveries about size control
Edgar, B. (1999) · Nature Cell Biology · doi:10.1038/70217 · Cited by 69
Summers, S. A., Lipfert, L., Birnbaum, M. J., Whiteman, E. L., & Cho, H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.34.23858 · Cited by 58
Self-citationBiological actions of IGFs in mammalian development
Heyner, S., & Garside, W. T. (1994) · BioEssays · doi:10.1002/bies.950160109 · Cited by 24
Cited by
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
Inoki, K., Li, Y., Zhu, T., Wu, J., & Guan, K.-L. (2002) · Nature Cell Biology · doi:10.1038/ncb839 · Cited by 3,083
Shiojima, I. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24682 · Cited by 939
Advances in protein kinase B signalling: AKTion on multiple fronts
Brazil, D. P., Yang, Z.-Z., & Hemmings, B. A. (2004) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2004.03.006 · Cited by 830
Peng, X.-D., Xu, P.-Z., Chen, M.-L., Hahn-Windgassen, A., Skeen, J., Jacobs, J., Sundararajan, D., Chen, W. S., Crawford, S. E., Coleman, K. G., et al. (2003) · Genes & Development · doi:10.1101/gad.1089403 · Cited by 826
Garofalo, R. S., Orena, S. J., Rafidi, K., Torchia, A. J., Stock, J. L., Hildebrandt, A. L., Coskran, T., Black, S. C., Brees, D. J., Wicks, J. R., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16885 · Cited by 726
Metadata
- Authors
- Tuttle, R. L., Gill, N. S., Pugh, W., Lee, J.-P., Koeberlein, B., Furth, E. E., Polonsky, K. S., Naji, A., & Birnbaum, M. J.
- Venue
- Nature Medicine
- Published
- 2001-10
- Volume
- 7
- Issue
- 10
- Pages
- 1133-1137
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W1794038664
- Cited by
- 511
- References
- 30
- FWCI
- 29.50
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
