Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-β peptides

Koistinaho, Milla, Lin, Suizhen, Wu, Xin, Esterman, Michail, Koger, Deanna, Hanson, Jeffrey, Higgs, Richard, Liu, Feng, Malkani, Seema, Bales, Kelly R, Paul, Steven M·2004·Nature Medicine

DOI 10.1038/nm1058

Cited by (569)

Items 201–300 of 569

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Brown, Madeleine R., Radford, Sheena E., Hewitt, Eric W. · 2020 · Frontiers in Molecular Neuroscience
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Rebeck, G William, LaDu, Mary Jo, Estus, Steven, Bu, Guojun, Weeber, Edwin J · 2006 · Molecular Neurodegeneration
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Attems, Johannes, Yamaguchi, Haruyasu, Saido, Takaomi C., Thal, Dietmar Rudolf · 2010 · Journal of the Neurological Sciences
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Daniel Henriques, Ricardo Moreira, Jens Christian Schwamborn, Luís Pereira de Almeida, Liliana S. Mendonça · 2019 · Frontiers in Neuroscience
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Luisa Cigliano, Carmela Regina Pugliese, Maria Stefania Spagnuolo, Rosanna Palumbo, Paolo Abrescia · 2009 · FEBS Journal