CSF tau is associated with impaired cortical plasticity, cognitive decline and astrocyte survival only in APOE4-positive Alzheimer’s disease
Open accessAbstract
In Alzheimer’s disease (AD) patients, apopoliprotein (APOE) polymorphism is the main genetic factor associated with more aggressive clinical course. However, the interaction between cerebrospinal fluid (CSF) tau protein levels and APOE genotype has been scarcely investigated. A possible key mechanism invokes the dysfunction of synaptic plasticity. We investigated how CSF tau interacts with APOE genotype in AD patients. We firstly explored whether CSF tau levels and APOE genotype influence disease progression and long-term potentiation (LTP)-like cortical plasticity as measured by transcranial magnetic stimulation (TMS) in AD patients. Then, we incubated normal human astrocytes (NHAs) with CSF collected from sub-groups of AD patients to determine whether APOE genotype and CSF biomarkers influence astrocytes survival. LTP-like cortical plasticity differed between AD patients with apolipoprotein E4 (APOE4) and apolipoprotein E3 (APOE3) genotype. Higher CSF tau levels were associated with more impaired LTP-like cortical plasticity and faster disease progression in AD patients with APOE4 but not APOE3 genotype. Apoptotic activity was higher when cells were incubated with CSF from AD patients with APOE4 and high tau levels. CSF tau is detrimental on cortical plasticity, disease progression and astrocyte survival only when associated with APOE4 genotype. This is relevant for new therapeutic approaches targeting tau.
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p-tau in the CSF has been shown to not correlate to any neuropsychological changes and is not associated with AD progression in APOE3-carrying AD patients.
“Furthermore, p-tau in the CSF has been shown to not correlate to any neuropsychological changes [53], and are not associated with AD progression in APOE3-carrying AD patients [77].”
From DNA repair deficiency and senescence in concussed professional athletes involved in contact sports (2019) · cites this paper as [77]
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Associations Between APOE Variants, Tau and α-Synuclein
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Synaptic Effects of Palmitoylethanolamide in Neurodegenerative Disorders
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Self-citationE, K, B5, B6, and B9 vitamins and their specific immunological effects evaluated by flow cytometry
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- Authors
- Koch, G., Di Lorenzo, F., Loizzo, S., Motta, C., Travaglione, S., Baiula, M., Rimondini, R., Ponzo, V., Bonnì, S., Toniolo, S., Sallustio, F., Bozzali, M., Caltagirone, C., Campana, G., & Martorana, A.
- Affiliations
- Policlinico Tor Vergata (IT)
- Istituto Superiore di Sanità (IT)
- University of Rome Tor Vergata (IT)
- University of Bologna (IT)
- Fondazione Santa Lucia (IT)
- Corresponding author
- Koch, Giacomo
- ORCID
- Venue
- Scientific Reports
- Published
- 2017-10-23
- Volume
- 7
- Issue
- 1
- Pages
- 13728-13728
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC5653826
- OpenAlex
- W2767087329
- Cited by
- 64
- References
- 60
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 3 · 2023: 7 · 2022: 10 · 2021: 16 · 2020: 12 · 2019: 8 · 2018: 1
- FWCI
- 4.25
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Sussex Research Online (University of Sussex) (submittedVersion, cc-by)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- IRIS eCampus Telematic University (Università degli Studi eCampus) (submittedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion, cc-by)
- Funders
- Alzheimer's Drug Discovery Foundation
- Ministero della Salute (RF 2010, RF- 2010-2311484, 47/RF-2010-2311484)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Keywords
- Alzheimer's disease, cerebrospinal fluid tau, APOE ε4, APOE3, cortical plasticity, long-term potentiation, astrocyte survival, astrocyte apoptosis, cognitive decline, disease progression, tau-targeted therapy
- MeSH terms
- Aged, Alzheimer Disease, Astrocytes, Cell Survival, Female, Genotype, Humans, Male, Neuronal Plasticity, tau Proteins, Apoptosis, Apolipoprotein E4, Cognitive Dysfunction
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